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1. 发明申请

US20140187529A1 AMINOPYRAZINE COMPOUNDS 有权
标题翻译：氨基吡嗪化合物
公开(公告)号：US20140187529A1
公开(公告)日：2014-07-03
申请号：US14001936
申请日：2012-02-29
申请人： Rupa S. Shetty , Martha J. Kelly , Bin Liu , Jinming Zou , Kristopher K. Moffett , Younghee Lee
发明人： Rupa S. Shetty , Kevin J. Moriarity , Martha J. Kelly , Bin Liu , Jinming Zou , Kristopher K. Moffett , Younghee Lee
IPC分类号： C07D413/14 , C07D401/12 , C07D401/14
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/14 , C07D409/14 , C07D417/14 , C07D487/04 , C07D491/056
摘要： A compound of formula (I): wherein all symbols have the same meanings as defined in the specification; a salt thereof, a solvate thereof, an N-oxide thereof, or a prodrug thereof, has an Itk inhibitory activity, and is useful as a method for preventing and/or treating atopic dermatitis, and the like.
摘要翻译：式（I）的化合物：其中所有符号具有与说明书中定义的相同的含义; 其盐，其溶剂合物，N-氧化物或其前药具有Itk抑制活性，可用作预防和/或治疗特应性皮炎等的方法。

2. 发明授权

US08962623B2 Aminopyrazine compounds 有权
标题翻译：氨基吡嗪化合物
公开(公告)号：US08962623B2
公开(公告)日：2015-02-24
申请号：US14001936
申请日：2012-02-29
申请人： Rupa S. Shetty , Martha J. Kelly , Bin Liu , Jinming Zou , Kristofer K. Moffett , Younghee Lee , Dora Do-York Wong
发明人： Rupa S. Shetty , Kevin J. Moriarity , Martha J. Kelly , Bin Liu , Jinming Zou , Kristofer K. Moffett , Younghee Lee
IPC分类号： A61K31/5377 , C07D487/04 , C07D491/056 , C07D401/12 , C07D413/14 , C07D403/12 , C07D401/14 , C07D407/14 , C07D409/14 , C07D417/14
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/14 , C07D409/14 , C07D417/14 , C07D487/04 , C07D491/056
摘要： A compound of formula (I): wherein all symbols have the same meanings as defined in the specification; a salt thereof, a solvate thereof, an N-oxide thereof, or a prodrug thereof, has an Itk inhibitory activity, and is useful as a method for preventing and/or treating atopic dermatitis, and the like.
摘要翻译：式（I）的化合物：其中所有符号具有与说明书中定义的相同的含义; 其盐，其溶剂合物，N-氧化物或其前药具有Itk抑制活性，可用作预防和/或治疗特应性皮炎等的方法。

3. 发明授权

US07741479B2 Urea inhibitors of MAP kinases 失效
标题翻译： MAP激酶的尿素抑制剂
公开(公告)号：US07741479B2
公开(公告)日：2010-06-22
申请号：US11295638
申请日：2005-12-07
申请人： Enrique Luis Michelotti , Eric Bruce Springman , Duyan Nguyen , Rupa S. Shetty , Younghee Lee , Kristofer Kent Moffett , Jennifer Lee Ludington , Ted Tsutomis Fujimoto , Zenon D. Konteatis , Bin Liu , Frank Hollinger , Bruce D. Dorsey
发明人： Enrique Luis Michelotti , Eric Bruce Springman , Duyan Nguyen , Rupa S. Shetty , Younghee Lee , Kristofer Kent Moffett , Jennifer Lee Ludington , Ted Tsutomis Fujimoto , Zenon D. Konteatis , Bin Liu , Frank Hollinger , Bruce D. Dorsey
IPC分类号： C07D273/06
CPC分类号： C07D333/38 , C07D231/40 , C07D243/08 , C07D277/48 , C07D277/56 , C07D295/192 , C07D333/36 , C07D403/06 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/14 , C07D495/04
摘要： The present invention is directed to a compound having the formula wherein R1, R2, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases such as MAP kinases, in particular p38 kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease. The present invention is also directed to a method of treating or preventing a protein kinase-mediated condition.
摘要翻译：本发明涉及具有下式的化合物：其中R1，R2，G和Q如本文所定义。本发明的化合物可用作蛋白激酶如MAP激酶，特别是p38激酶的抑制剂。本发明还涉及包含根据上式的化合物的组合物。本文所述的化合物和组合物可用于治疗和预防炎性疾病或疾病。本发明还涉及治疗或预防蛋白激酶介导的病症的方法。

4. 发明申请

US20060270686A1 Anti-cancer agents and uses thereof 失效
标题翻译：抗癌剂及其用途
公开(公告)号：US20060270686A1
公开(公告)日：2006-11-30
申请号：US10928401
申请日：2004-08-30
申请人： Martha Kelly , Younghee Lee , Bin Liu , Ted Fujimoto , Joel Freundlich , Bruce Dorsey , Gary Flynn , Arifa Husain
发明人： Martha Kelly , Younghee Lee , Bin Liu , Ted Fujimoto , Joel Freundlich , Bruce Dorsey , Gary Flynn , Arifa Husain
IPC分类号： A61K31/497 , A61K31/44 , C07D403/02
CPC分类号： C07D209/08 , C07D213/74 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/10
摘要： The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula I: and solvates, hydrates and pharmaceutically-acceptable salts thereof, wherein A1 is N or CR1; A3 is N or CR3; A5 is N or CR5; R1, R3—R6 and L are defined in the specification; n is 0 or 1; and X is an optionally-substituted aryl group having 6-10 carbons in the ring portion, an optionally-substituted 6-membered heteroaryl group having 1-3 nitrogen atoms in the ring portion, an optionally-substituted 5-membered heteroaryl group having 0-4 nitrogen atoms in the ring portion and optionally having 1 sulfur atom or 1 oxygen atom in the ring portion, or an optionally-substituted heteroaryl group in which a 6-membered ring is fused either to a 5-membered ring or to a 6-membered ring, wherein in each case 1, 2, 3 or 4 ring atoms are heteroatoms independently selected from nitrogen, oxygen and sulfur. They are effective against a broad range of cancers, especially leukemia, non-small cell lung and colon.
摘要翻译：本发明涉及新型化合物及其盐，其合成及其作为抗癌剂的用途。化合物包括式I化合物及其溶剂合物，水合物及其药学上可接受的盐，其中A 1是N或CR 1; N 3或N 3是N或CR 3; A <5>为N或CR 5; 在说明书中定义了R 1，R 3，R 6和L 6; n为0或1; 并且X是在环部分中具有6-10个碳的任选取代的芳基，在环部分中具有1-3个氮原子的任选取代的6元杂芳基，任选取代的5元杂芳基具有0 -4个氮原子，并且在环部分中任选具有1个硫原子或1个氧原子，或任选取代的杂芳基，其中6元环稠合到5元环或6元环其中在每种情况下，1,2,3或4个环原子是独立地选自氮，氧和硫的杂原子。它们对广泛的癌症尤其是白血病，非小细胞肺和结肠有效。

5. 发明申请

US20060167247A1 Urea inhibitors of MAP kinases 失效
标题翻译： MAP激酶的尿素抑制剂
公开(公告)号：US20060167247A1
公开(公告)日：2006-07-27
申请号：US11295638
申请日：2005-12-07
申请人： Enrique Michelotti , Eric Springman , Duyan Nguyen , Rupa Shetty , Younghee Lee , Kristofer Moffett , Jennifer Ludington , Ted Fujimoto , Zenon Konteatis , Bin Liu , Frank Hollinger , Bruce Dorsey
发明人： Enrique Michelotti , Eric Springman , Duyan Nguyen , Rupa Shetty , Younghee Lee , Kristofer Moffett , Jennifer Ludington , Ted Fujimoto , Zenon Konteatis , Bin Liu , Frank Hollinger , Bruce Dorsey
IPC分类号： C07D417/02 , C07D413/02 , C07D409/02
CPC分类号： C07D333/38 , C07D231/40 , C07D243/08 , C07D277/48 , C07D277/56 , C07D295/192 , C07D333/36 , C07D403/06 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/14 , C07D495/04
摘要： The present invention is directed to a compound having the formula wherein R1, R2, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases such as MAP kinases, in particular p38 kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease. The present invention is also directed to a method of treating or preventing a protein kinase-mediated condition.
摘要翻译：本发明涉及具有下式的化合物：其中R 1，R 2，G和Q在本文中定义。本发明的化合物可用作蛋白激酶如MAP激酶，特别是p38激酶的抑制剂。本发明还涉及包含根据上式的化合物的组合物。本文所述的化合物和组合物可用于治疗和预防炎性疾病或疾病。本发明还涉及治疗或预防蛋白激酶介导的病症的方法。

6. 发明申请

US20080280891A1 Anti-cancer agents and uses thereof 审中-公开
标题翻译：抗癌剂及其用途
公开(公告)号：US20080280891A1
公开(公告)日：2008-11-13
申请号：US11819494
申请日：2007-06-27
申请人： Martha Kelly , Younghee Lee , Bin Liu , Ted Fujimoto , Joel Freundlich , Bruce D. Dorsey , Gary A. Flynn , Arifa Husain , William R. Moore, Jr.
发明人： Martha Kelly , Younghee Lee , Bin Liu , Ted Fujimoto , Joel Freundlich , Bruce D. Dorsey , Gary A. Flynn , Arifa Husain , William R. Moore, Jr.
IPC分类号： A61K31/541 , A61K31/404 , C07D209/42 , C07D401/02 , C07D417/14 , A61K31/44 , A61P35/00 , A61K31/4439 , A61K31/5377 , C07D413/14
CPC分类号： A61K31/404 , A61K31/44 , A61K31/4439 , A61K31/5377 , A61K31/541 , C07D213/74 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/12 , C07D498/04
摘要： The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula I: and solvates, hydrates and pharmaceutically-acceptable salts thereof, wherein A1 is N or CR1; A3 is N or CR3; A5 is N or CR5; R1, R3-R6 and L are defined in the specification; n is 0 or 1; and X is an optionally-substituted aryl group having 6-10 carbons in the ring portion, an optionally-substituted 6-membered heteroaryl group having 1-3 nitrogen atoms in the ring portion, an optionally-substituted 5-membered heteroaryl group having 0-4 nitrogen atoms in the ring portion and optionally having 1 sulfur atom or 1 oxygen atom in the ring portion, or an optionally-substituted heteroaryl group in which a 6-membered ring is fused either to a 5-membered ring or to a 6-membered ring, wherein in each case 1, 2, 3 or 4 ring atoms are heteroatoms independently selected from nitrogen, oxygen and sulfur. They are effective against a broad range of cancers, especially leukemia, prostate, non-small cell lung and colon. They are additionally useful in the treatment of proliferative retinopathies such as diabetic neuropathy and macular degeneration.
摘要翻译：本发明涉及新型化合物及其盐，其合成及其作为抗癌剂的用途。化合物包括式I化合物及其溶剂合物，水合物及其药学上可接受的盐，其中A 1是N或CR 1; N 3或N 3是N或CR 3; A <5>为N或CR 5; 在说明书中定义了R 1，R 3，R 6和L 6; n为0或1; 并且X是在环部分中具有6-10个碳的任选取代的芳基，在环部分中具有1-3个氮原子的任选取代的6元杂芳基，任选取代的5元杂芳基具有0 -4个氮原子，并且在环部分中任选具有1个硫原子或1个氧原子，或任选取代的杂芳基，其中6元环稠合到5元环或6元环其中在每种情况下，1,2,3或4个环原子是独立地选自氮，氧和硫的杂原子。它们对广泛的癌症尤其是白血病，前列腺，非小细胞肺和结肠有效。它们还可用于治疗增殖性视网膜病变，例如糖尿病性神经病变和黄斑变性。

7. 发明申请

US20150090247A1 Cooking Device With Pyrolysis Function 审中-公开
标题翻译：具有热解功能的烹饪装置
公开(公告)号：US20150090247A1
公开(公告)日：2015-04-02
申请号：US14348890
申请日：2013-10-01
申请人： Younghee Lee
发明人： Younghee Lee
IPC分类号： F24C15/20
CPC分类号： F24C15/2014 , F24C14/025 , F24C15/322
摘要： The cooking device with pyrolysis function includes a cooking cavity, a heating means located within the cooking cavity for emitting heat, a combustion tube having a hollow portion formed to surround the heating means, the combustion tube being heated by the heating means and radiates its heat to the center of the cooking cavity, a combustion space formed between the heating means and the combustion tube in which cooking fumes are decomposed by the heat from the heating means, a fan adapted to withdraw air from the cooking cavity and to discharge a part or ail of the air through the connection tube into the combustion space, a connection tube for connecting fluid communication between the combustion tube and the fan, and a gas outlet for venting the steam and air in the combustion space to the outside of the cooking device.
摘要翻译：具有热分解功能的烹调装置包括烹饪腔，位于烹饪腔内用于发热的加热装置，具有形成为围绕加热装置的中空部分的燃烧管，燃烧管由加热装置加热并辐射其热量到烹饪腔的中心，形成在加热装置和燃烧管之间的燃烧空间，其中烹饪烟雾通过来自加热装置的热分解，风扇，其适于从烹饪腔抽出空气并排出部分，空气通过连接管进入燃烧空间，用于连接燃烧管和风扇之间的流体连通的连接管和用于将燃烧空间中的蒸汽和空气排放到烹饪装置的外部的气体出口。

8. 发明授权

US06416861B1 Organosilicon compounds and uses thereof 失效
标题翻译：有机硅化合物及其用途
公开(公告)号：US06416861B1
公开(公告)日：2002-07-09
申请号：US09504217
申请日：2000-02-15
申请人： Younghee Lee , Richard B. Silverman
发明人： Younghee Lee , Richard B. Silverman
IPC分类号： B32B2520
CPC分类号： C07F7/0812 , C07B2200/11 , C07F7/081 , C40B40/00 , Y10T428/2962 , Y10T428/2995
摘要： A compound of the formula: and a resin-bound compound of the formula: and their use in combinatorial chemistry and in the synthesis of compounds comprising at least one aromatic moiety is described, where R1, R2, R3, R4, R5, R6, R7, L1, P, Ar1, and X are as herein defined.
摘要翻译：描述了下式的化合物和下式的树脂结合化合物及其在组合化学中的用途和合成含有至少一个芳族部分的化合物，其中R 1，R 2，R 3，R 4，R 5，R 6， R7，L1，P，Ar1和X如本文所定义。

9. 发明申请

US20100247909A1 Manufacturing process of porous carbon nanofiber using a volatile organic matter 审中-公开
标题翻译：使用挥发性有机物的多孔碳纳米纤维的制造工艺
公开(公告)号：US20100247909A1
公开(公告)日：2010-09-30
申请号：US11647863
申请日：2006-12-29
申请人： Younghee Lee , Kayhyeok An , Eunju Ra
发明人： Younghee Lee , Kayhyeok An , Eunju Ra
IPC分类号： D02G3/02 , D01F9/12 , B29C47/36
CPC分类号： D01F1/08 , D01D5/0038 , D01F9/14 , Y10T428/2918
摘要： The present invention provides a process for manufacturing a carbon nanofiber comprising: (a) mixing a carbon nanofiber precursor and camphor in a solvent to prepare a solution; (b) electric spinning the solution to obtain a nanofiber; (c) oxidative stabilizing the nanofiber; and (d) carbonizing the oxidative stabilized nanofiber, wherein camphor is volatilized to form micropores in the oxidative stabilization and carbonization. The present invention also provides a carbon nanofiber manufactured by the same.
摘要翻译：本发明提供一种制造碳纳米纤维的方法，包括：（a）将碳纳米纤维前体和樟脑在溶剂中混合以制备溶液; （b）电解纺丝以获得纳米纤维; （c）氧化稳定纳米纤维; 和（d）将氧化稳定的纳米纤维碳化，其中樟脑在氧化稳定化和碳化中挥发以形成微孔。本发明还提供一种由其制造的碳纳米纤维。

10. 发明授权

US08046698B1 System and method for providing collaboration of a graphics session 有权
标题翻译：用于提供图形会话协作的系统和方法
公开(公告)号：US08046698B1
公开(公告)日：2011-10-25
申请号：US10112366
申请日：2002-03-29
申请人： Alex Chalfin , Younghee Lee , Ryan Smith
发明人： Alex Chalfin , Younghee Lee , Ryan Smith
IPC分类号： G06F3/00
CPC分类号： H04L12/1822
摘要： A visual server system (10) includes a visual server (12) that provides graphics images through execution of a graphics application (20). A local terminal (16) may interact with the graphics application (20) through a server application (30) in response to possession of input control. A remote client terminal (14) may interact with the graphics application (20) through a session application (22) in response to possession of the input control. The input control is passed between the local terminal (16) and the remote client terminal (14) in order to provide collaboration of a graphics session. The local terminal (16) and the remote client terminal (14) receive the same view of the graphics application (20). Interactions with the graphics application (20) performed by either the local terminal (16) or the remote client terminal (14) are viewable by the other terminal. Interactions with the graphics application (20) by either the local terminal (16) or the remote client terminal (14) that does not have the input control are blocked.
摘要翻译：视觉服务器系统（10）包括通过执行图形应用（20）来提供图形图像的视觉服务器（12）。响应于拥有输入控制，本地终端（16）可以通过服务器应用（30）与图形应用（20）交互。响应于拥有输入控件，远程客户终端（14）可以通过会话应用（22）与图形应用（20）交互。输入控制在本地终端（16）和远程客户终端（14）之间传递，以提供图形会话的协作。本地终端（16）和远程客户终端（14）接收图形应用程序（20）的相同视图。由本地终端（16）或远程客户终端（14）执行的与图形应用（20）的交互可由另一终端查看。由本地终端（16）或不具有输入控制的远程客户终端（14）与图形应用程序（20）的交互被阻止。

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