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1. 发明授权

US07348004B2 Immunoglobulin chimeric monomer-dimer hybrids 有权
标题翻译：免疫球蛋白嵌合单体 - 二聚体杂交体
公开(公告)号：US07348004B2
公开(公告)日：2008-03-25
申请号：US11029003
申请日：2005-01-05
申请人： Robert T. Peters , Adam R. Mezo , Daniel S. Rivera , Alan J. Bitonti , Susan C. Low , James Stattel
发明人： Robert T. Peters , Adam R. Mezo , Daniel S. Rivera , Alan J. Bitonti , Susan C. Low , James Stattel
IPC分类号： A61K39/00 , C07K16/00 , C07K1/00 , C07K14/00 , C12P21/08
CPC分类号： C07K14/505 , A61K38/00 , C07K5/0806 , C07K5/1013 , C07K7/06 , C07K7/08 , C07K14/475 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/745 , C07K2319/00 , C07K2319/30 , C07K2319/43 , C07K2319/73 , C12N9/6437 , C12N9/644 , C12N9/647 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
摘要翻译：本发明涉及嵌合单体 - 二聚体杂合蛋白，其中所述蛋白质包含第一和第二多肽链，所述第一多肽链包含至少一部分免疫球蛋白恒定区和生物活性分子，所述第二多肽链包含至少一部分没有第一链的生物活性分子的免疫球蛋白恒定区。本发明还涉及制备本发明的嵌合单体 - 二聚体杂交蛋白质的方法和方法。

2. 发明申请

US20110182919A1 Immunoglobulin Chimeric Monomer-Dimer Hybrids 有权
标题翻译：免疫球蛋白嵌合单体二聚体杂交体
公开(公告)号：US20110182919A1
公开(公告)日：2011-07-28
申请号：US12952551
申请日：2010-11-23
申请人： Robert T. PETERS , Adam R. Mezo , Daniel S. Rivera , Alan J. Bitonti , James Stattel , Susan C. Low
发明人： Robert T. PETERS , Adam R. Mezo , Daniel S. Rivera , Alan J. Bitonti , James Stattel , Susan C. Low
IPC分类号： A61K39/395 , C07K19/00 , C12N9/96 , A61P7/04
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
摘要翻译：本发明涉及嵌合单体 - 二聚体杂合蛋白，其中所述蛋白质包含第一和第二多肽链，所述第一多肽链包含至少一部分免疫球蛋白恒定区和生物活性分子，所述第二多肽链包含至少一部分没有第一链的生物活性分子的免疫球蛋白恒定区。本发明还涉及制备本发明的嵌合单体 - 二聚体杂交蛋白质的方法和方法。

3. 发明授权

US08815246B2 Fc receptor binding proteins 有权
标题翻译： Fc受体结合蛋白
公开(公告)号：US08815246B2
公开(公告)日：2014-08-26
申请号：US13617498
申请日：2012-09-14
申请人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
发明人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
IPC分类号： C07K16/28 , G01N33/68
CPC分类号： C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535
摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
摘要翻译：本公开尤其提供结合FcRn的蛋白质，例如以高亲和力和选择性抑制FcRn的免疫球蛋白。 FcRn结合蛋白可用于治疗多种疾病，包括自身免疫性疾病。

4. 发明申请

US20130078262A1 FC RECEPTOR BINDING PROTEINS 有权
公开(公告)号：US20130078262A1
公开(公告)日：2013-03-28
申请号：US13617498
申请日：2012-09-14
申请人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato , Malini Viswanathan
发明人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato , Malini Viswanathan
IPC分类号： C07K16/28 , G01N33/68
CPC分类号： C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535
摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

5. 发明申请

US20130045218A1 FC RECEPTOR BINDING PROTEINS 审中-公开
公开(公告)号：US20130045218A1
公开(公告)日：2013-02-21
申请号：US13584221
申请日：2012-08-13
申请人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato , Malini Viswanathan
发明人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato , Malini Viswanathan
IPC分类号： C07K16/28 , A61P19/02 , A61P21/04 , G01N33/566 , A61P25/00 , A61P1/04 , A61P37/00 , A61P1/00 , A61K39/395 , A61P3/10
摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

6. 发明授权

US08273351B2 Fc receptor binding proteins 有权
标题翻译： Fc受体结合蛋白
公开(公告)号：US08273351B2
公开(公告)日：2012-09-25
申请号：US12429529
申请日：2009-04-24
申请人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato
发明人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , G01N33/53
CPC分类号： C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535
摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
摘要翻译：本公开尤其提供结合FcRn的蛋白质，例如以高亲和力和选择性抑制FcRn的免疫球蛋白。 FcRn结合蛋白可用于治疗多种疾病，包括自身免疫性疾病。

7. 发明申请

US20090324614A1 FC RECEPTOR BINDING PROTEINS 有权
标题翻译： FC受体结合蛋白
公开(公告)号：US20090324614A1
公开(公告)日：2009-12-31
申请号：US12429529
申请日：2009-04-24
申请人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato
发明人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , G01N33/53 , A61P37/00
CPC分类号： C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535
摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
摘要翻译：本公开尤其提供结合FcRn的蛋白质，例如以高亲和力和选择性抑制FcRn的免疫球蛋白。 FcRn结合蛋白可用于治疗多种疾病，包括自身免疫性疾病。

8. 发明申请

US20050281829A1 Fc chimeric proteins with anti-HIV drugs 审中-公开
标题翻译： Fc嵌合蛋白与抗HIV药物
公开(公告)号：US20050281829A1
公开(公告)日：2005-12-22
申请号：US10841956
申请日：2004-05-06
申请人： Cristina Hehir , Adam Mezo , Robert Peters , James Stattel , Vito Palombella , Alan Bitonti
发明人： Cristina Hehir , Adam Mezo , Robert Peters , James Stattel , Vito Palombella , Alan Bitonti
IPC分类号： A61K38/16 , A61K39/42 , C07K14/16 , C07K16/10 , C12N20060101
CPC分类号： C07K14/005 , A61K38/162 , C07K2319/00 , C07K2319/30 , C12N2740/16122
摘要： The invention relates to anti viral agents comprised of viral fusion inhibitors and at least a portion of an immunoglobulin constant region. The invention further relates to anti viral agents comprised HIV viral fusion inhibitors and an Fc fragment of an immunoglobulin. The invention also relates to methods of treating a viral infection, including HIV infection.
摘要翻译：本发明涉及由病毒融合抑制剂和至少一部分免疫球蛋白恒定区组成的抗病毒剂。本发明还涉及包含HIV病毒融合抑制剂和免疫球蛋白的Fc片段的抗病毒剂。本发明还涉及治疗包括HIV感染在内的病毒感染的方法。

9. 发明申请

US20050037947A1 INHIBITION OF DRUG BINDING TO SERUM ALBUMIN 审中-公开
标题翻译：药物结合抑制血清ALBUMIN
公开(公告)号：US20050037947A1
公开(公告)日：2005-02-17
申请号：US10841949
申请日：2004-05-06
申请人： Alan Bitonti , Vito Palombella , James Stattel , Robert Peters
发明人： Alan Bitonti , Vito Palombella , James Stattel , Robert Peters
IPC分类号： A61K20060101 , A61K31/00
CPC分类号： C07K14/765 , C07K2319/30
摘要： The invention relates to improved therapeutics for treating diseases or conditions that provide greater bioavailabilty and more predictable dosing. The invention relates to a chimeric protein comprised of a biologically active molecule linked to an Fc fragment of an immunoglobulin, wherein the chimeric protein binds less serum albumin compared to the same biologically active molecule of the chimeric protein not linked to an Fc fragment of an immunoglobulin. The invention also relates to a method of treating a disease or condition said method comprising administering a chimeric protein comprising a biologically active molecule linked to an Fc fragment of an immunoglobulin, wherein the chimeric protein binds less serum albumin compared to the same biologically active molecule of the chimeric protein not linked to an Fc fragment of an immunoglobulin
摘要翻译：本发明涉及用于治疗提供更大生物利用度和更可预测剂量的疾病或病症的改进治疗剂。本发明涉及由连接于免疫球蛋白Fc片段的生物活性分子组成的嵌合蛋白质，其中嵌合蛋白质与不与免疫球蛋白Fc片段连接的嵌合蛋白质的相同生物活性分子相比结合较少的血清白蛋白。本发明还涉及一种治疗疾病或病症的方法，所述方法包括给予包含与免疫球蛋白Fc片段连接的生物活性分子的嵌合蛋白，其中所述嵌合蛋白与相同的生物活性分子未与免疫球蛋白的Fc片段连接的嵌合蛋白

10. 发明申请

US20050032174A1 Immunoglobulin chimeric monomer-dimer hybrids 有权
公开(公告)号：US20050032174A1
公开(公告)日：2005-02-10
申请号：US10841250
申请日：2004-05-06
申请人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , James Stattel , Susan Low
发明人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , James Stattel , Susan Low
IPC分类号： A61K39/395 , C07H21/04 , C07K1/02 , C07K1/06 , C07K1/10 , C07K1/107 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/745 , C07K16/00 , C07K16/44 , C07K16/46 , C12N20060101 , C12N5/06 , C12N9/64 , C12P21/00 , C12P21/04
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

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