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1. 发明授权

US08870814B2 Implantable or insertable medical devices containing silicone copolymer for controlled delivery of therapeutic agent 有权
标题翻译：可植入或可插入的含有共聚物的硅氧烷共聚物，用于治疗剂的控制递送
公开(公告)号：US08870814B2
公开(公告)日：2014-10-28
申请号：US10632008
申请日：2003-07-31
申请人： Robert E. Richard , Marlene C. Schwarz , Frederick H. Strickler
发明人： Robert E. Richard , Marlene C. Schwarz , Frederick H. Strickler
IPC分类号： A61K9/22 , A61M37/00 , A61L33/00 , A61L31/10 , A61L31/06 , A61L29/06 , A61L29/08 , A61L31/16 , A61L29/16 , A61K9/00
CPC分类号： A61K9/0024 , A61L29/06 , A61L29/085 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/602 , C08L83/04
摘要： Implantable or insertable medical devices are described. The medical devices comprise (a) a therapeutic agent and (b) a polymeric release region, which controls the release of the therapeutic agent upon administration to a patient. The polymeric release region further comprises a silicone copolymer that contains a plurality of siloxane units and a plurality of non-siloxane units. Also described are methods for administering a therapeutic agent to a patient using the above implantable or insertable medical devices as well as methods of making the above devices.
摘要翻译：描述了可植入或可插入的医疗装置。医疗装置包括（a）治疗剂和（b）聚合物释放区域，其在施用于患者时控制治疗剂的释放。聚合物释放区域还包含含有多个硅氧烷单元和多个非硅氧烷单元的硅氧烷共聚物。还描述了使用上述可植入或可插入医疗装置向患者施用治疗剂的方法以及制备上述装置的方法。

2. 发明授权

US08535702B2 Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility 有权
标题翻译：具有用于受控药物递送和调节的生物相容性的多孔聚合物区域的医疗装置
公开(公告)号：US08535702B2
公开(公告)日：2013-09-17
申请号：US11048616
申请日：2005-02-01
申请人： Robert E. Richard , Frederick H. Strickler , Marlene C. Schwarz , Rudolf Faust , Shrirang V. Ranade , Michael N. Helmus
发明人： Robert E. Richard , Frederick H. Strickler , Marlene C. Schwarz , Rudolf Faust , Shrirang V. Ranade , Michael N. Helmus
IPC分类号： A61F2/00
CPC分类号： A61L31/129 , A61L27/48 , A61N1/05
摘要： The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrable polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.
摘要翻译：本发明涉及相分离的聚合物区域以及它们与可植入或可插入的医疗装置结合使用。在本发明的一些方面，提供了相分离的聚合物区域，其包括（a）至少一个生物稳定的聚合物相和（b）至少一个具有纳米级尺寸并且经历生物整合的生物分解聚合物相，并且经历相分离的聚合物区域在体内成为纳米孔聚合物区域。本发明的其它方面涉及制造具有至少一个纳米多孔聚合物区域的可植入或可插入医疗器械的方法。这些方法包括（a）提供包含稳定聚合物相和纳米尺度的可分解聚合物相的相分离聚合物区域，（b）选择性地除去可分解的聚合物相，从而制备纳米多孔聚合物区域。在另外的方面，提供了可植入或可插入的医疗装置，其具有相分离的聚合物区域，其包括（a）至少一种具有至少一种生物稳定聚合物嵌段和至少一种生物可分解聚合物嵌段的嵌段共聚物和（b）至少一种治疗在植入或插入医疗装置时在体内释放的药剂。

3. 发明授权

US09114199B2 Implantable or insertable medical devices containing acrylic copolymer for controlled delivery of therapeutic agent 有权
标题翻译：含有丙烯酸共聚物的可植入或可插入的医疗器械用于治疗剂的控制递送
公开(公告)号：US09114199B2
公开(公告)日：2015-08-25
申请号：US10632061
申请日：2003-07-31
申请人： Robert E. Richard , Marlene C. Schwarz
发明人： Robert E. Richard , Marlene C. Schwarz
IPC分类号： A61L31/10 , A61L27/34 , C08L53/02 , A61L31/16 , A61L27/54 , A61L29/08 , A61L29/16
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/602 , C08L53/02
摘要： Implantable or insertable medical devices are described. The medical devices comprise (a) a therapeutic agent and (b) a polymeric release region, which controls the release of the therapeutic agent upon administration to a patient. The polymeric release region further comprises an acrylic copolymer, which comprises (i) a plurality of rubbery acrylic units and (ii) a plurality of hard units. Also described are methods for administering a therapeutic agent to a patient using the above implantable or insertable medical devices as well as methods of making the above devices.
摘要翻译：描述了可植入或可插入的医疗装置。医疗装置包括（a）治疗剂和（b）聚合物释放区域，其在施用于患者时控制治疗剂的释放。聚合物释放区还包括丙烯酸共聚物，其包含（i）多个橡胶状丙烯酸单元和（ii）多个硬单元。还描述了使用上述可植入或可插入医疗装置向患者施用治疗剂的方法以及制备上述装置的方法。

4. 发明授权

US08992512B2 Medical devices having polymeric regions with copolymers containing hydrocarbon and heteroatom-containing monomeric species 有权
标题翻译：具有聚合物区域的医疗器械具有含有烃和含杂原子的单体物质的共聚物
公开(公告)号：US08992512B2
公开(公告)日：2015-03-31
申请号：US13314726
申请日：2011-12-08
申请人： Robert E. Richard , Marlene C. Schwarz , Rudolf Faust
发明人： Robert E. Richard , Marlene C. Schwarz , Rudolf Faust
IPC分类号： A61K9/22 , A61F2/00 , C08F8/00 , C08F297/02 , A61L31/06 , A61L27/16 , A61L27/34 , A61L29/06 , A61L29/08 , A61L31/10
CPC分类号： A61L31/06 , A61L27/16 , A61L27/34 , A61L29/06 , A61L29/085 , A61L31/10 , C08L53/00
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes the following: (a) one or more unsaturated hydrocarbon monomer species and (b) one or more heteroatom-containing monomer species.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域。这些聚合物区域又包含一种或多种聚合物，其中至少一种是包含以下物质的共聚物：（a）一种或多种不饱和烃单体物质和（b）一种或多种含杂原子的单体物质。

5. 发明授权

US07727541B2 Medical devices having polymeric regions based on vinyl ether block copolymers 失效
标题翻译：具有基于乙烯基醚嵌段共聚物的聚合物区域的医疗装置
公开(公告)号：US07727541B2
公开(公告)日：2010-06-01
申请号：US11436813
申请日：2006-05-18
申请人： Robert E. Richard , Marlene C. Schwarz , Mark Boden
发明人： Robert E. Richard , Marlene C. Schwarz , Mark Boden
IPC分类号： A61F2/86 , A61F2/82 , A61K47/32
CPC分类号： A61L27/34 , A61L27/16 , A61L31/10 , C08L53/00 , C08L35/08
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions, which in turn contain at least one block copolymer. The block copolymer includes (a) at least one high Tg (glass transition temperature) polymer block that contains at least one high Tg vinyl ether monomer and (b) at least one low Tg polymer block that contains at least one low Tg vinyl ether monomer.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域，其又包含至少一个嵌段共聚物。嵌段共聚物包括（a）含有至少一种高Tg乙烯基醚单体的至少一种高Tg（玻璃化转变温度）聚合物嵌段和（b）含有至少一种低Tg乙烯基醚单体的至少一种低Tg聚合物嵌段。

6. 发明授权

US08075906B2 Medical devices having polymeric regions with copolymers containing hydrocarbon and heteroatom-containing monomeric species 有权
标题翻译：具有聚合物区域的医疗器械具有含有烃和含杂原子的单体物质的共聚物
公开(公告)号：US08075906B2
公开(公告)日：2011-12-13
申请号：US11048613
申请日：2005-02-01
申请人： Robert E. Richard , Marlene C. Schwarz , Rudolf Faust
发明人： Robert E. Richard , Marlene C. Schwarz , Rudolf Faust
IPC分类号： A61F2/24 , A61M1/12
CPC分类号： A61L31/06 , A61L27/16 , A61L27/34 , A61L29/06 , A61L29/085 , A61L31/10 , C08L53/00
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes the following: (a) one or more unsaturated hydrocarbon monomer species and (b) one or more heteroatom-containing monomer species.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域。这些聚合物区域又包含一种或多种聚合物，其中至少一种是包含以下物质的共聚物：（a）一种或多种不饱和烃单体物质和（b）一种或多种含杂原子的单体物质。

7. 发明授权

US07939094B2 Multiphase polymeric drug release region 失效
标题翻译：多相聚合物药物释放区
公开(公告)号：US07939094B2
公开(公告)日：2011-05-10
申请号：US10175526
申请日：2002-06-19
申请人： Marlene C. Schwarz , Robert E. Richard
发明人： Marlene C. Schwarz , Robert E. Richard
IPC分类号： A61F2/00 , A61K47/32 , A61K9/14
CPC分类号： A61L31/10 , A61K9/0024 , A61K31/337 , A61L31/16 , A61L2300/602
摘要： A method is provided for modulating the rate of release of a therapeutic agent from a release region, which constitutes at least a portion of an implantable or insertable medical device and which controls the rate at which the therapeutic is released from the medical device. The method comprises: (a) providing a release region that comprises (i) a therapeutic agent and (ii) polymer composition comprising two or more immiscible phases; and (b) modulating the rate of release of the therapeutic agent by changing the volume that is occupied by at least one of the immiscible polymer phases relative to the total volume of the release region that is formed. The release region can be, for example, a carrier layer, which comprises the therapeutic agent, or a barrier layer, which is disposed over a region that contains the therapeutic agent. In preferred embodiments, the release region is formed by a process comprising: (a) providing a solution comprising (i) a solvent and (ii) the polymer composition; and (b) forming the release region from the solution by removing the solvent from the solution.
摘要翻译：提供了一种用于调节治疗剂从释放区域的释放速率的方法，该释放区域构成可植入或可插入的医疗装置的至少一部分并且其控制治疗剂从医疗装置释放的速率。该方法包括：（a）提供释放区，其包含（i）治疗剂和（ii）包含两个或更多个不混溶相的聚合物组合物; 和（b）相对于形成的释放区域的总体积，通过改变至少一个不混溶的聚合物相占据的体积来调节治疗剂的释放速率。释放区域可以是例如包含治疗剂的载体层或设置在含有治疗剂的区域上的阻挡层。在优选的实施方案中，通过包括以下方法形成释放区域：（a）提供包含（i）溶剂和（ii）聚合物组合物的溶液; 和（b）通过从溶液中除去溶剂从溶液中形成释放区。

8. 发明申请

US20080311173A1 IMPLANTABLE OR INSERTABLE MEDICAL DEVICES FOR CONTROLLED DELIVERY OF A THERAPEUTIC AGENT 审中-公开
标题翻译：用于控制输送治疗药物的可植入或插入式医疗装置
公开(公告)号：US20080311173A1
公开(公告)日：2008-12-18
申请号：US12192879
申请日：2008-08-15
申请人： Marlene C. Schwarz , Robert E. Richard
发明人： Marlene C. Schwarz , Robert E. Richard
IPC分类号： A61K9/22 , A61M1/00 , A61P43/00 , A61F2/06 , A61M25/10 , A61M25/00
CPC分类号： A61L29/16 , A61L27/34 , A61L27/56 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602
摘要： The present invention is directed to novel implantable or insertable medical devices that provide release of a therapeutic agent. According to a first aspect of the present invention, a therapeutic-agent-releasing medical device is provided, which comprises: (a) an implantable or insertable medical device; (b) a release layer disposed over at least a portion of the implantable or insertable medical device, and (c) a therapeutic agent. The release layer regulates the rate of release of the therapeutic agent from the medical device upon implantation or insertion of the device into a patient. The release layer comprises (i) a first polymer comprising one or more polymer chains that form one or more polymer phase domains when the first polymer is in a pure solid-state form; and (ii) a second polymer comprising two or more polymer chains that form two or more phase domains when the second polymer is in a pure solid-state form. The first and second polymers are preferably selected such that at least one polymer chain in the second polymer is compatible with at least one polymer chain in the first polymer. The present invention is also directed to methods of forming the above implantable or insertable medical devices, methods of administering a therapeutic agent to a patient using such devices, and methods of modulating the release of therapeutic agents from implantable or insertable medical devices.
摘要翻译：本发明涉及提供治疗剂释放的新型可植入或可插入的医疗装置。根据本发明的第一方面，提供了一种治疗剂释放医疗装置，其包括：（a）可植入或可插入的医疗装置; （b）设置在所述可植入或可插入医疗装置的至少一部分上的释放层，和（c）治疗剂。释放层调节在将装置植入或插入患者体内治疗剂从医疗装置释放的速率。释放层包含（i）第一聚合物，其包含当第一聚合物处于纯固态形式时形成一个或多个聚合物相域的一个或多个聚合物链; 和（ii）当第二聚合物处于纯固态形式时，包含两个或更多个形成两个或多个相域的聚合物链的第二聚合物。优选选择第一和第二聚合物，使得第二聚合物中的至少一个聚合物链与第一聚合物中的至少一个聚合物链相容。本发明还涉及形成上述可植入或可插入的医疗装置的方法，使用这种装置向患者施用治疗剂的方法，以及调节治疗剂从可植入或可插入医疗装置释放的方法。

9. 发明申请

US20070269485A1 Medical devices having polymeric regions based on vinyl ether block copolymers 失效
标题翻译：具有基于乙烯基醚嵌段共聚物的聚合物区域的医疗装置
公开(公告)号：US20070269485A1
公开(公告)日：2007-11-22
申请号：US11436813
申请日：2006-05-18
申请人： Robert E. Richard , Marlene C. Schwarz , Mark Boden
发明人： Robert E. Richard , Marlene C. Schwarz , Mark Boden
IPC分类号： A61F2/02
CPC分类号： A61L27/34 , A61L27/16 , A61L31/10 , C08L53/00 , C08L35/08
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions, which in turn contain at least one block copolymer. The block copolymer includes (a) at least one high Tg (glass transition temperature) polymer block that contains at least one high Tg vinyl ether monomer and (b) at least one low Tg polymer block that contains at least one low Tg vinyl ether monomer.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域，其又包含至少一个嵌段共聚物。嵌段共聚物包括（a）至少一种高Tg（玻璃化转变温度）聚合物嵌段，其含有至少一种高级乙烯基醚单体和（b）在含有至少一个低级乙烯基醚单体的至少一个低聚合物嵌段。

10. 发明授权

US07771740B2 Medical devices containing copolymers with graft copolymer endblocks for drug delivery 有权
标题翻译：包含具有用于药物递送的接枝共聚物末端嵌段的共聚物的医疗装置
公开(公告)号：US07771740B2
公开(公告)日：2010-08-10
申请号：US10894397
申请日：2004-07-19
申请人： Frederick H. Strickler , Robert E. Richard
发明人： Frederick H. Strickler , Robert E. Richard
IPC分类号： A61F2/00 , A61F2/06 , A61K9/22
CPC分类号： A61L31/16 , A61L29/041 , A61L29/16 , A61L31/048 , A61L2300/602
摘要： The present invention provides a medical device comprising a release region and a therapeutic agent disposed within or beneath the release region, and the release region includes a copolymer comprising a low Tg block and at least one graft copolymer endblock having a main chain and a plurality of side chains.
摘要翻译：本发明提供一种医疗装置，其包括设置在释放区域内或下面的释放区域和治疗剂，并且释放区域包括共聚物，其包含低Tg嵌段和至少一个具有主链的接枝共聚物端嵌段和多个侧链。

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