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1. 发明授权

US4675292A Stabilization of glucose isomerase 失效
标题翻译：葡萄糖异构酶稳定
公开(公告)号：US4675292A
公开(公告)日：1987-06-23
申请号：US707774
申请日：1985-03-04
申请人： Robert A. Houtchens , Roberta C. Cheng , Karen M. McCoy , Carol C. Epstein , Norman G. Moll
发明人： Robert A. Houtchens , Roberta C. Cheng , Karen M. McCoy , Carol C. Epstein , Norman G. Moll
IPC分类号： C12N11/00 , C12N9/96 , C12N11/04 , C12N11/08 , C12P19/24
CPC分类号： C12N11/08 , C12N11/04 , C12N9/96 , C12P19/24
摘要： Extracellular enzymes are stabilized with a carboxyalkylated or phosphonoalkylated polymer having a molecular weight of at least 500 Daltons. Exemplified is the stabilization of the enzyme glucose isomerase used in a process to convert D-glucose to D-fructose. In a preferred embodiment of the invention the feedstream containing the substrate is contacted initially with the stabilizer and then with the enzyme. In this system the stabilizer and enzyme are maintained in separate reactors. This separation, advantageously, results in a higher half-life for the enzyme.
摘要翻译：用分子量至少为500道尔顿的羧基烷基化或膦酰基烷基化聚合物稳定细胞外酶。示例是用于将D-葡萄糖转化为D-果糖的方法中使用的酶葡萄糖异构酶的稳定化。在本发明的优选实施方案中，含有底物的进料流最初与稳定剂接触，然后与酶接触。在该系统中，稳定剂和酶保持在单独的反应器中。这种分离有利地导致酶的较长的半衰期。

2. 发明授权

US4950596A Stabilization of intracellular enzymes 失效
标题翻译：稳定细胞内酶
公开(公告)号：US4950596A
公开(公告)日：1990-08-21
申请号：US20407
申请日：1987-03-02
申请人： Roberta C. Cheng , Norman G. Moll , Robert A. Houtchens , Karen M. McCoy
发明人： Roberta C. Cheng , Norman G. Moll , Robert A. Houtchens , Karen M. McCoy
IPC分类号： C12N1/04 , C12N9/96 , C12N11/02 , C12N11/04 , C12P19/24
CPC分类号： C12P19/24 , C12N1/04 , C12N11/02 , C12N11/04 , C12N9/96
摘要： The subject invention concerns a process for stabilizing intact or ruptured microbial cells having glucose isomerase associated therewith. Specifically exemplified is a process for stabilizing glucose isomerase producing cells of a microorganism belonging to the genus Ampullariella. In the invention process the whole or ruptured microbial cells are contacted with a partially carboxyalkylated- or partially phosphonoalkylated-cationic polyelectrolyte, for example, a partially carboxymethylated polyethyleneimine to flocculate and stabilize the cells. The flocculated cells are further stabilized by encapsulation with a partially carboxyalkylated- or partially phosphonoalkylated-cationic polyelectrolyte. The encapsulation can be done prior to or after the flocculated cells are crosslinked. The net effect is manifested by a dramatic increase in the half-life of the glucose isomerase.
摘要翻译：本发明涉及用于稳定具有与其相关的葡萄糖异构酶的完整或破裂的微生物细胞的方法。具体举例说明了稳定葡萄糖异构酶产生细胞的方法，该细胞属于安瓿属（Ampullariella）属。在本发明方法中，将全部或破裂的微生物细胞与部分羧烷基化或部分膦酰烷基化阳离子聚电解质（例如部分羧甲基化的聚乙烯亚胺）接触以使细胞絮凝和稳定。通过用部分羧烷基化或部分膦酰烷基化阳离子聚电解质包封进一步稳定絮凝的细胞。可以在絮凝的细胞交联之前或之后进行封装。净效应表现在葡萄糖异构酶的半衰期急剧增加。

3. 发明授权

US5714166A Bioactive and/or targeted dendrimer conjugates 失效
标题翻译：生物活性和/或靶向树枝状大分子缀合物
公开(公告)号：US5714166A
公开(公告)日：1998-02-03
申请号：US400203
申请日：1995-03-07
申请人： Donald A. Tomalia , James R. Baker , Roberta C. Cheng , Anna U. Bielinska , Michael J. Fazio , David M. Hedstrand , Jennifer A. Johnson , Donald A. Kaplan, deceased , Scott L. Klakamp , William J. Kruper, Jr. , Jolanta Kukowska-Latallo , Bartley D. Maxon , Lars T. Piehler , Ian A. Tomlinson , Larry R. Wilson , Rui Yin , Herbert M. Brothers, II
发明人： Donald A. Tomalia , James R. Baker , Roberta C. Cheng , Anna U. Bielinska , Michael J. Fazio , David M. Hedstrand , Jennifer A. Johnson , Donald A. Kaplan, deceased , Scott L. Klakamp , William J. Kruper, Jr. , Jolanta Kukowska-Latallo , Bartley D. Maxon , Lars T. Piehler , Ian A. Tomlinson , Larry R. Wilson , Rui Yin , Herbert M. Brothers, II
IPC分类号： C12N15/02 , A01N25/10 , A61K20060101 , A61K31/70 , A61K38/00 , A61K39/385 , A61K39/44 , A61K45/00 , A61K47/34 , A61K47/48 , A61K48/00 , A61K49/00 , A61K51/00 , C07C211/29 , C07C233/11 , C07C237/20 , C07K20060101 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/555 , C07K17/06 , C07K17/08 , C08G73/00 , C08G83/00 , C08L101/00 , C12N20060101 , C12N5/10 , C12N15/09 , C12N15/57 , C12N15/87 , C12P21/02 , C12P21/08 , C12R1/91 , A61K31/74 , A61K9/14 , A61K31/785
CPC分类号： A01N25/10 , A61K47/48192 , A61K47/48207 , A61K47/4823 , A61K47/48961 , A61K49/085 , A61K49/124 , B82Y5/00 , C07C211/29 , C07C233/11 , C07C237/20 , C08G83/003 , C08L101/005 , C12N15/87 , Y10S424/16
摘要： Dendritic polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried material, where the carrier material can be a biological response modifier, have been prepared. The conjugate can also have a target director present, and when it is present then the carried material may be a bioactive agent. Preferred dendritic polymers are dense star polymers, which have been complexed with biological response modifiers. These conjugates and complexes have particularly advantageous properties due to their unique characteristics.
摘要翻译：已经制备了由载体材料可以是生物反应调节剂的至少一种携带材料的至少一个单元组成的树枝状聚合物共轭物。缀合物还可以存在目标导向剂，并且当其存在时，所携带的材料可以是生物活性剂。优选的树枝状聚合物是与生物反应调节剂复合的致密星形聚合物。这些共轭物和配合物由于其独特的特性而具有特别有利的性质。

4. 发明授权

US5435990A Macrocyclic congugates and their use as diagnostic and therapeutic agents 失效
标题翻译：大环偶联物及其作为诊断和治疗剂的用途
公开(公告)号：US5435990A
公开(公告)日：1995-07-25
申请号：US962168
申请日：1992-10-15
申请人： Roberta C. Cheng , William A. Fordyce , William F. Goeckleler , William J. Kruper, Jr. , Richard K. Frank , Joseph R. Garlich , Garry E. Kiefer , Kenneth McMillan , Jaime Simon , David A. Wilson , Sharon Braughman
发明人： Roberta C. Cheng , William A. Fordyce , William F. Goeckleler , William J. Kruper, Jr. , Richard K. Frank , Joseph R. Garlich , Garry E. Kiefer , Kenneth McMillan , Jaime Simon , David A. Wilson , Sharon Braughman
IPC分类号： A61K9/08 , A61K9/107 , A61K31/395 , A61K39/395 , A61K51/00 , A61K51/04 , A61K51/10 , A61P35/00 , C07D257/02 , C07K16/00 , A61M36/06 , C07K16/30
CPC分类号： C07D257/02 , A61K51/0482 , A61K51/1045 , A61K51/109 , A61K2121/00 , A61K2123/00
摘要： A group of functionalized macrocyclic polyaminocarboxylate chelants that form complexes with rare earth-type metal ions are disclosed. The complexes, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes for cancer.
摘要翻译：公开了与稀土类金属离子形成络合物的一组官能化的大环多胺羧酸盐螯合剂。与抗体或抗体片段共价连接的复合物可用于癌症的治疗和/或诊断目的。

5. 发明授权

US06177414B1 Starburst conjugates 失效
标题翻译：星爆共轭体
公开(公告)号：US06177414B1
公开(公告)日：2001-01-23
申请号：US09521409
申请日：2000-03-08
申请人： Donald A. Tomalia , William J. Kruper , Roberta C. Cheng , Ian A. Tomlinson , Michael J. Fazio , David M. Hedstrand , Larry R. Wilson , Donald A. Kaplan
发明人： Donald A. Tomalia , William J. Kruper , Roberta C. Cheng , Ian A. Tomlinson , Michael J. Fazio , David M. Hedstrand , Larry R. Wilson , Donald A. Kaplan
IPC分类号： A61K3160
CPC分类号： A01N25/10 , A61K47/59 , A61K47/6885 , A61K47/6949 , B82Y5/00 , C07C211/29 , C07C233/11 , C07C237/20 , C08G73/02 , C08G83/003 , C08L101/005 , C12N15/87 , Y10S424/16
摘要： Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.
摘要翻译：已经制备了由至少一种树枝状大分子与携带的农业，药物或其它材料的至少一个单元组合的星状共轭体。由于树枝状聚合物的独特特征，这些共轭物具有特别有利的性质。

6. 发明授权

US5527524A Dense star polymer conjugates 失效
标题翻译：密集聚合物共轭物
公开(公告)号：US5527524A
公开(公告)日：1996-06-18
申请号：US43198
申请日：1993-04-05
申请人： Donald A. Tomalia , Larry R. Wilson , David M. Hedstrand , Ian A. Tomlinson , Michael J. Fazio , William J. Kruper, Jr. , Donald A. Kaplan , Roberta C. Cheng , David S. Edwards , Chu W. Jung
发明人： Donald A. Tomalia , Larry R. Wilson , David M. Hedstrand , Ian A. Tomlinson , Michael J. Fazio , William J. Kruper, Jr. , Donald A. Kaplan , Roberta C. Cheng , David S. Edwards , Chu W. Jung
IPC分类号： A01N25/10 , A61K47/48 , C07C211/29 , C07C233/11 , C07C237/20 , C08G73/02 , C08G83/00 , C08L101/00 , C12N15/87 , A61K31/74 , A61K9/14 , A61K31/785
CPC分类号： A01N25/10 , A61K47/48192 , A61K47/48207 , A61K47/487 , A61K47/48961 , B82Y5/00 , C07C211/29 , C07C233/11 , C07C237/20 , C08G73/02 , C08G83/003 , C08L101/005 , C12N15/87 , Y10S424/16
摘要： Dense star polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.
摘要翻译：已经制备了由携带的农业，药物或其它材料的至少一个单元组成的至少一个树枝状大分子组成的密集聚合物共轭物。由于树枝状聚合物的独特特征，这些共轭物具有特别有利的性质。

7. 发明授权

US4582805A Immobilization of biological matter via copolymers of isocyanatoalkyl esters 失效
标题翻译：通过异氰酸酯基烷基酯的共聚物固定生物物质
公开(公告)号：US4582805A
公开(公告)日：1986-04-15
申请号：US567125
申请日：1983-12-29
申请人： John W. Bozzelli , Roberta C. Cheng
发明人： John W. Bozzelli , Roberta C. Cheng
IPC分类号： C08G18/64 , C08G18/72 , C12N11/08 , C12N11/02 , C12N11/06
CPC分类号： C08G18/728 , C08G18/6446 , C12N11/08
摘要： A process is disclosed for the chemical immobilization of biological material such as bacteria and enzymes containing an active hydrogen with a vinyl addition polymer of an isocyanatoalkyl ester of an ethylenically unsaturated carboxylic acid. The vinyl addition polymer is versatile in that it can be copolymerized with varying amounts and types of comonomers.
摘要翻译：公开了一种用于化学固定生物材料例如细菌和含有活性氢的酶与烯键式不饱和羧酸的异氰酸烷基酯的乙烯基加成聚合物的方法。乙烯基加成聚合物是通用的，因为它可以与不同量的和类型的共聚单体共聚。

8. 发明授权

US06312679B1 Dense star polymer conjugates as dyes 失效
标题翻译：密集星形聚合物共轭物作为染料
公开(公告)号：US06312679B1
公开(公告)日：2001-11-06
申请号：US08036644
申请日：1993-03-24
申请人： Donald A. Tomalia , Donald A. Kaplan , William J. Kruper, Jr. , Roberta C. Cheng , Ian A. Tomlinson , Michael J. Fazio , David M. Hedstrand , Larry R. Wilson
发明人： Donald A. Tomalia , Donald A. Kaplan , William J. Kruper, Jr. , Roberta C. Cheng , Ian A. Tomlinson , Michael J. Fazio , David M. Hedstrand , Larry R. Wilson
IPC分类号： A61K31785
CPC分类号： A01N25/10 , A61K47/59 , A61K47/6885 , A61K47/6949 , B82Y5/00 , C07C211/29 , C07C233/11 , C07C237/20 , C08G73/02 , C08G83/003 , C08L101/005 , C12N15/87 , Y10S424/16
摘要： Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.
摘要翻译：已经制备了由至少一种树枝状大分子与携带的农业，药物或其它材料的至少一个单元组合的星状共轭体。由于树枝状聚合物的独特特征，这些共轭物具有特别有利的性质。

9. 发明授权

US5338532A Starburst conjugates 失效
标题翻译：星爆共轭体
公开(公告)号：US5338532A
公开(公告)日：1994-08-16
申请号：US654851
申请日：1991-02-13
申请人： Donald A. Tomalia , Donald A. Kaplan , William J. Kruper, Jr. , Roberta C. Cheng , Ian A. Tomlinson , Michael J. Fazio , David M. Hedstrand , Larry R. Wilson
发明人： Donald A. Tomalia , Donald A. Kaplan , William J. Kruper, Jr. , Roberta C. Cheng , Ian A. Tomlinson , Michael J. Fazio , David M. Hedstrand , Larry R. Wilson
IPC分类号： A01N25/10 , A61K47/48 , C07C211/29 , C07C233/11 , C07C237/20 , C08G73/02 , C08G83/00 , C08L101/00 , C12N15/87 , A61K43/00 , A61K31/74 , A61K31/785 , A61K31/80
CPC分类号： B82Y5/00 , A01N25/10 , A61K47/48192 , A61K47/48207 , A61K47/487 , A61K47/48961 , C07C211/29 , C07C233/11 , C07C237/20 , C08G73/02 , C08G83/003 , C08L101/005 , C12N15/87 , Y10S436/806 , Y10T436/24
摘要： Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.
摘要翻译：已经制备了由至少一种树枝状大分子与携带的农业，药物或其它材料的至少一个单元组合的星状共轭体。由于树枝状聚合物的独特特征，这些共轭物具有特别有利的性质。

10. 发明授权

US4929556A Enzyme immobilization with polysulfonium salts 失效
标题翻译：用多锍盐固定酶
公开(公告)号：US4929556A
公开(公告)日：1990-05-29
申请号：US216916
申请日：1988-07-08
申请人： Roberta C. Cheng , Ritchie A. Wessling , Donald L. Schmidt
发明人： Roberta C. Cheng , Ritchie A. Wessling , Donald L. Schmidt
IPC分类号： C12N11/02 , C12N11/12 , C12P19/24
CPC分类号： C12P19/24 , C12N11/02 , C12N11/12
摘要： Polysulfonium salts that can react with nucleophilic groups and covalently cross-link are used to immobilize enzymes or enzyme-containing cellular material. Some of the polysulfonium salts can both flocculate and covalently cross-link. Replacement of the cross-linker, glutaraldehyde, with the polysulfonium salt results in greater retention of enzyme activity during immobilization. Immobilization is carried out by forming a mixture of an enzyme or enzyme-containing cellular material and the polysulfonium salt and subjecting the mixture to conditions such that sulfonium ions react with nucleophilic groups contained by the enzyme or cellular material to form a covalently cross-linked and water insoluble product. The enzyme or cellular material may be flocculated with a flocculating agent prior to cross-linking with the polysulfonium salt. The polysulfonium salt can be a polymer containing sulfonium groups.
摘要翻译：可与亲核基团反应并共价交联的聚锍盐用于固定酶或含酶细胞材料。一些聚锍盐可以絮凝和共价交联。用聚锍盐替代交联剂戊二醛导致固定期间酶活性的更大保留。通过形成酶或含酶细胞材料和聚锍盐的混合物进行固定，并使混合物经受使锍离子与酶或细胞材料所含的亲核基团反应以形成共价交联和水不溶物。在与多锍盐交联之前，酶或细胞材料可以用絮凝剂絮凝。聚锍盐可以是含有锍基团的聚合物。

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