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1. 发明申请

US20100324628A1 METHOD AND APPARATUS FOR OPTIMIZING VAGAL NERVE STIMULATION USING LARYNGEAL ACTIVITY 有权
标题翻译：使用Larynge活动优化VAGAL神经刺激的方法和装置
公开(公告)号：US20100324628A1
公开(公告)日：2010-12-23
申请号：US12872408
申请日：2010-08-31
申请人： Randy Westlund , Anthony V. Caparso , Mark Bly
发明人： Randy Westlund , Anthony V. Caparso , Mark Bly
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61B5/04001 , A61B5/0402 , A61B5/1104 , A61B5/6822 , A61B5/7203 , A61N1/0551 , A61N1/36114 , A61N1/36542 , A61N1/37247 , A61N1/37288
摘要： A neural stimulation system delivers neural stimulation to the vagus nerve and senses a signal indicative of laryngeal activity resulting from the neural stimulation. The signal indicative of laryngeal activity is used, for example, to guide electrode placement, determine stimulation threshold, detect lead/electrode problems, detect neural injury, and monitor healing processing following the electrode placement inside the body of a patient.
摘要翻译：神经刺激系统将神经刺激传递给迷走神经，并感测到指示由神经刺激引起的喉部活动的信号。例如，使用指示喉部活动的信号来引导电极放置，确定刺激阈值，检测铅/电极问题，检测神经损伤，以及在患者体内的电极放置之后监测愈合过程。

2. 发明申请

US20080058874A1 METHOD AND APPARATUS FOR OPTIMIZING VAGAL NERVE STIMULATION USING LARYNGEAL ACTIVITY 有权
标题翻译：使用Larynge活动优化VAGAL神经刺激的方法和装置
公开(公告)号：US20080058874A1
公开(公告)日：2008-03-06
申请号：US11469551
申请日：2006-09-01
申请人： Randy Westlund , Anthony V. Caparso , Mark Bly
发明人： Randy Westlund , Anthony V. Caparso , Mark Bly
IPC分类号： A61N1/18
CPC分类号： A61N1/36053 , A61B5/04001 , A61B5/0402 , A61B5/1104 , A61B5/6822 , A61B5/7203 , A61N1/0551 , A61N1/36114 , A61N1/36542 , A61N1/37247 , A61N1/37288
摘要： A neural stimulation system delivers neural stimulation to the vagus nerve and senses a signal indicative of laryngeal activity resulting from the neural stimulation. The signal indicative of laryngeal activity is used, for example, to guide electrode placement, determine stimulation threshold, detect lead/electrode problems, detect neural injury, and monitor healing processing following the electrode placement inside the body of a patient.
摘要翻译：神经刺激系统将神经刺激传递给迷走神经，并感测到指示由神经刺激引起的喉部活动的信号。例如，使用指示喉部活动的信号来引导电极放置，确定刺激阈值，检测铅/电极问题，检测神经损伤，以及在患者体内的电极放置之后监测愈合过程。

3. 发明授权

US08290584B2 Method and apparatus for optimizing vagal nerve stimulation using laryngeal activity 有权
标题翻译：使用喉部活动优化迷走神经刺激的方法和装置
公开(公告)号：US08290584B2
公开(公告)日：2012-10-16
申请号：US12872408
申请日：2010-08-31
申请人： Randy Westlund , Anthony V. Caparso , Mark Bly
发明人： Randy Westlund , Anthony V. Caparso , Mark Bly
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61B5/04001 , A61B5/0402 , A61B5/1104 , A61B5/6822 , A61B5/7203 , A61N1/0551 , A61N1/36114 , A61N1/36542 , A61N1/37247 , A61N1/37288
摘要： A neural stimulation system delivers neural stimulation to the vagus nerve and senses a signal indicative of laryngeal activity resulting from the neural stimulation. The signal indicative of laryngeal activity is used, for example, to guide electrode placement, determine stimulation threshold, detect lead/electrode problems, detect neural injury, and monitor healing processing following the electrode placement inside the body of a patient.
摘要翻译：神经刺激系统将神经刺激传递给迷走神经，并感测到指示由神经刺激引起的喉部活动的信号。例如，使用指示喉部活动的信号来引导电极放置，确定刺激阈值，检测铅/电极问题，检测神经损伤，以及在患者体内的电极放置之后监测愈合过程。

4. 发明授权

US07801603B2 Method and apparatus for optimizing vagal nerve stimulation using laryngeal activity 有权
标题翻译：使用喉部活动优化迷走神经刺激的方法和装置
公开(公告)号：US07801603B2
公开(公告)日：2010-09-21
申请号：US11469551
申请日：2006-09-01
申请人： Randy Westlund , Anthony V. Caparso , Mark Bly
发明人： Randy Westlund , Anthony V. Caparso , Mark Bly
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61B5/04001 , A61B5/0402 , A61B5/1104 , A61B5/6822 , A61B5/7203 , A61N1/0551 , A61N1/36114 , A61N1/36542 , A61N1/37247 , A61N1/37288
摘要： A neural stimulation system delivers neural stimulation to the vagus nerve and senses a signal indicative of laryngeal activity resulting from the neural stimulation. The signal indicative of laryngeal activity is used, for example, to guide electrode placement, determine stimulation threshold, detect lead/electrode problems, detect neural injury, and monitor healing processing following the electrode placement inside the body of a patient.
摘要翻译：神经刺激系统将神经刺激传递给迷走神经，并感测到指示由神经刺激引起的喉部活动的信号。例如，使用指示喉部活动的信号来引导电极放置，确定刺激阈值，检测铅/电极问题，检测神经损伤，以及在患者体内的电极放置之后监测愈合过程。

5. 发明授权

US08684925B2 Injectable device for physiological monitoring 有权
标题翻译：用于生理监测的注射装置
公开(公告)号：US08684925B2
公开(公告)日：2014-04-01
申请号：US12209430
申请日：2008-09-12
申请人： Yatheendhar D. Manicka , Badri Amurthur , Mark Bly , Kristofer James , Imad Libbus , Scott Mazar , Jerry Wang
发明人： Yatheendhar D. Manicka , Badri Amurthur , Mark Bly , Kristofer James , Imad Libbus , Scott Mazar , Jerry Wang
IPC分类号： A61B5/00 , A61B5/145
CPC分类号： A61B5/7282 , A61B5/0031 , A61B5/0205 , A61B5/02055 , A61B5/0422 , A61B5/053 , A61B5/07 , A61B5/076 , A61B5/1118 , A61B5/14503 , A61B5/4875 , A61B5/686 , A61B5/7232 , A61B2560/0214 , A61B2560/0468 , A61B2562/0219 , A61B2562/04 , A61B2562/06 , A61B2562/16 , A61N1/37205 , G06F19/00
摘要： An injectable detecting device is provided for use in physiological monitoring. The device includes a plurality of sensors axially spaced along a body that provide an indication of at least one physiological event of a patient, a monitoring unit within the body coupled to the plurality of sensors configured to receive data from the plurality of sensors and create processed patient data, a power source within the body coupled to the monitoring unit, and a communication antenna external to the body coupled to the monitoring unit configured to transfer data to/from other devices.
摘要翻译：提供可用于生理监测的可注射检测装置。该装置包括沿主体轴向间隔开的多个传感器，其提供患者的至少一个生理事件的指示;耦合到多个传感器的身体内的监测单元，其配置成从多个传感器接收数据并产生处理患者数据，耦合到监测单元的身体内的电源，以及耦合到监视单元的身体外部的通信天线，该通信天线被配置为向/从其他设备传送数据。

6. 发明申请

US20080103523A1 INFUSION TREATMENT AGENTS, CATHETERS, FILTER DEVICES, AND OCCLUSION DEVICES, AND USE THEREOF 审中-公开
公开(公告)号：US20080103523A1
公开(公告)日：2008-05-01
申请号：US11923332
申请日：2007-10-24
申请人： Jessica Chiu , Gregory Chan , Gabriel Asongwe , Robert Esselstein , Douglas Gesswein , Srinivasan Sridharan , Nianjiong Bei , William Webler , Stephen Schaible , Mina Chow , Yan Shen , Hongzhi Bai , Mark Bly , Thomas Hatten
发明人： Jessica Chiu , Gregory Chan , Gabriel Asongwe , Robert Esselstein , Douglas Gesswein , Srinivasan Sridharan , Nianjiong Bei , William Webler , Stephen Schaible , Mina Chow , Yan Shen , Hongzhi Bai , Mark Bly , Thomas Hatten
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61M25/1002 , A61M2025/1052
摘要： Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.

7. 发明申请

US20070225784A1 MEDICAL LEAD HAVING A VARIABLE CHANGE IN STIFFNESS 有权
标题翻译：具有可变性的医疗领域
公开(公告)号：US20070225784A1
公开(公告)日：2007-09-27
申请号：US11277333
申请日：2006-03-23
申请人： Mark Bly , Brian Soltis , Bruce Tockman , Avram Scheiner
发明人： Mark Bly , Brian Soltis , Bruce Tockman , Avram Scheiner
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/0585
摘要： According to one embodiment, the present invention includes an elongate implantable medical lead having a distal portion that is relatively flexible, a proximal portion that is relatively stiff, and a transition portion which has a variable transition stiffness. The transition stiffness varies over the length of the transition portion that generally decreases in a distal direction. The relatively stiff proximal portion of the lead gives the lead steerability while the gradual change in stiffness in the transition portion reduces the likelihood that the lead will prolapse when it is guided into a branch vein. The distal stiffness is less than the proximal stiffness giving the lead a safe end that is unlikely to puncture vascular walls and is able to maneuver around various tortuosities when the lead is implanted into a patient.
摘要翻译：根据一个实施例，本发明包括细长的可植入医疗引线，其具有相对柔性的远侧部分，相对刚性的近端部分和具有可变过渡刚度的过渡部分。过渡刚度在远端方向上通常减小的过渡部分的长度上变化。引线的相对刚性的近端部分具有引导操纵性，而过渡部分中刚度的逐渐变化降低了当引导到分支静脉时引线脱垂的可能性。远端刚度小于近端刚度，使得引线成为不可能穿透血管壁的安全端，并且当铅被植入患者时能够围绕各种曲折进行操纵。

8. 发明授权

US09186089B2 Injectable physiological monitoring system 有权
标题翻译：注射生理监测系统
公开(公告)号：US09186089B2
公开(公告)日：2015-11-17
申请号：US12209479
申请日：2008-09-12
申请人： Scott Mazar , Mark Bly
发明人： Scott Mazar , Mark Bly
IPC分类号： A61B5/02 , A61B5/07 , A61B5/00 , A61B5/145 , A61B5/0205 , A61B5/053 , A61N1/372
CPC分类号： A61B5/7282 , A61B5/0031 , A61B5/0205 , A61B5/02055 , A61B5/0422 , A61B5/053 , A61B5/07 , A61B5/076 , A61B5/1118 , A61B5/14503 , A61B5/4875 , A61B5/686 , A61B5/7232 , A61B2560/0214 , A61B2560/0468 , A61B2562/0219 , A61B2562/04 , A61B2562/06 , A61B2562/16 , A61N1/37205 , G06F19/00
摘要： A system and method for decompensation prediction of a heart failure patient with one or more injectable detecting systems communicating wirelessly with a remote monitoring system. The system includes one or more injectable detecting systems having a plurality of sensors that provide an indication of at least one physiological event of a patient, a wireless communication device coupled to the one or more injectable detecting systems and configured to transfer patient data directly or indirectly from the one or more injectable detecting systems to a remote monitoring system, and a remote monitoring system coupled to the wireless communication device, the remote monitoring system using processed data to determine heart failure status and predict impending decompensation of the patient.
摘要翻译：一种用于与一个或多个与远程监测系统无线通信的可注射检测系统的心力衰竭患者的失代偿预测的系统和方法。该系统包括一个或多个可注射检测系统，其具有提供患者至少一个生理事件的指示的多个传感器，耦合到该一个或多个可注射检测系统并被配置为直接或间接转移患者数据的无线通信设备从所述一个或多个可注射检测系统到远程监控系统以及耦合到所述无线通信设备的所述远程监控系统，所述远程监控系统使用处理的数据来确定心力衰竭状态并预测所述患者的即将失代偿失调。

9. 发明申请

US20090076410A1 System and Methods for Wireless Body Fluid Monitoring 有权
标题翻译：无线体液监测系统与方法
公开(公告)号：US20090076410A1
公开(公告)日：2009-03-19
申请号：US12210078
申请日：2008-09-12
申请人： Imad Libbus , Mark Bly
发明人： Imad Libbus , Mark Bly
IPC分类号： A61B5/053
CPC分类号： A61B5/02028 , A61B5/0002 , A61B5/0004 , A61B5/0006 , A61B5/0008 , A61B5/01 , A61B5/02055 , A61B5/02405 , A61B5/0245 , A61B5/04012 , A61B5/04085 , A61B5/04087 , A61B5/044 , A61B5/0452 , A61B5/0531 , A61B5/0535 , A61B5/0537 , A61B5/08 , A61B5/0816 , A61B5/1114 , A61B5/1116 , A61B5/1118 , A61B5/443 , A61B5/4875 , A61B5/6833 , A61B5/6843 , A61B5/6885 , A61B5/7264 , A61B5/7275 , A61B5/7282 , A61B5/746 , A61B2560/0412 , A61B2560/0468 , A61B2562/0209 , A61B2562/0214 , A61B2562/043 , A61B2562/164 , G06F19/00 , G06F19/3418 , G16H50/30
摘要： An adherent device to monitor a tissue hydration of a patient comprises an adhesive patch to adhere to a skin of the patient. At least four electrodes are connected to the patch and capable of electrically coupling to the patient. Impedance circuitry is coupled to the at least four electrodes to measure a tissue resistance of the patient, where the circuitry is configured to determine the tissue hydration in response to tissue resistance. The circuitry may comprise a processor system and the tissue resistance may correspond to a change in patient body fluid. The impedance circuitry is configured to measure the hydration signal using at least one low measurement frequency, which may be in the range of 0 to 10 kHz. Multiple measurement frequencies may be used and the hydration signal may include a tissue reactance measurement.
摘要翻译：用于监测患者的组织水合的粘附装置包括粘附到患者皮肤上的粘合贴片。至少四个电极连接到贴片并且能够电耦合到患者。阻抗电路耦合到至少四个电极以测量患者的组织电阻，其中电路被配置为响应于组织电阻确定组织水合。电路可以包括处理器系统，并且组织电阻可以对应于患者体液的变化。阻抗电路被配置为使用至少一个低测量频率来测量水合信号，该低测量频率可以在0至10kHz的范围内。可以使用多个测量频率，并且水合信号可以包括组织电抗测量。

10. 发明申请

US20080041516A1 INFUSION TREATMENT AGENTS, CATHETERS, FILTER DEVICES, AND OCCLUSION DEVICES, AND USE THEREOF 有权
标题翻译：输液治疗剂，过滤器，过滤器和消毒装置及其用途
公开(公告)号：US20080041516A1
公开(公告)日：2008-02-21
申请号：US11923258
申请日：2007-10-24
申请人： Jessica Chiu , Gregory Chan , Gabriel Asongwe , Robert Esselstein , Douglas Gesswein , Srinivasan Sridharan , Nianjiong Bei , William Webler , Stephen Schaible , Mina Chow , Yan Shen , Hongzhi Bai , Mark Bly , Thomas Hatten
发明人： Jessica Chiu , Gregory Chan , Gabriel Asongwe , Robert Esselstein , Douglas Gesswein , Srinivasan Sridharan , Nianjiong Bei , William Webler , Stephen Schaible , Mina Chow , Yan Shen , Hongzhi Bai , Mark Bly , Thomas Hatten
IPC分类号： B29C53/60
CPC分类号： A61M25/10 , A61M25/1002 , A61M2025/1052
摘要： Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.
摘要翻译：实施例包括具有输送导管的输液阻塞系统，适于接收输送导管的引导导管，以及具有适于容纳在引导导管内的闭塞装置的导丝。导管套件的引导导管可以在引导导管的远端处设置有闭塞装置。输送导管可以具有附件腔，同轴或共线腔，支撑心轴或其远端处的闭塞装置。此外，根据一些实施例，闭塞装置可以是具有内衬和不同材料外层的单一材料或复合球囊，高顺应性低压气球或限制颗粒通过但不限制的过滤装置限制流体，如血液。可以使用具有大体积和低体积注射器的充气装置来使气囊膨胀。

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