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1. 发明申请

US20080030713A1 Uncaging devices 有权
标题翻译：取消启动设备
公开(公告)号：US20080030713A1
公开(公告)日：2008-02-07
申请号：US11893012
申请日：2007-08-13
申请人： Frank Witney , Gary McMaster , Quan Nguyen , Steve Chen
发明人： Frank Witney , Gary McMaster , Quan Nguyen , Steve Chen
IPC分类号： G01J3/00 , G01J1/00
CPC分类号： G01N21/6452
摘要： Uncaging devices that can be used to uncage photoactivatable caged components are provided. Consistent, uniform and/or high throughput processing of reactions and assays that include caged components is provided. Masked multiwell plates that can be used for uncaging photoactivatable caged components are provided. Methods and apparatus for initiating assays involving caged components are provided.
摘要翻译：提供了可用于解除可光灭活的笼式组件的非屏蔽设备。提供了包括笼式组件的反应和测定的一致，均匀和/或高通量处理。提供可用于解码可光致灭活笼式组件的蒙版多孔板。提供了用于启动包含笼式组件的测定的方法和装置。

2. 发明授权

US07551271B2 Uncaging devices 有权
标题翻译：取消启动设备
公开(公告)号：US07551271B2
公开(公告)日：2009-06-23
申请号：US11893012
申请日：2007-08-13
申请人： Frank Witney , Gary McMaster , Quan Nguyen , Steve Chen
发明人： Frank Witney , Gary McMaster , Quan Nguyen , Steve Chen
IPC分类号： G01J1/00
CPC分类号： G01N21/6452
摘要： Uncaging devices that can be used to uncage photoactivatable caged components are provided. Consistent, uniform and/or high throughput processing of reactions and assays that include caged components is provided. Masked multiwell plates that can be used for uncaging photoactivatable caged components are provided. Methods and apparatus for initiating assays involving caged components are provided.
摘要翻译：提供了可用于解除可光灭活的笼式组件的非屏蔽设备。提供了包括笼式组件的反应和测定的一致，均匀和/或高通量处理。提供可用于解码可光致灭活笼式组件的蒙版多孔板。提供了用于启动包含笼式组件的测定的方法和装置。

3. 发明申请

US20050059028A1 RNAi-based sensors, caged interfering RNAs, and methods of use thereof 审中-公开
标题翻译：基于RNAi的传感器，笼式干扰RNA及其使用方法
公开(公告)号：US20050059028A1
公开(公告)日：2005-03-17
申请号：US10716393
申请日：2003-11-17
申请人： Quan Nguyen , Gary McMaster
发明人： Quan Nguyen , Gary McMaster
IPC分类号： A61K48/00 , C07H21/02 , C12N15/85 , C12Q1/00 , C12Q1/37 , C12Q1/48 , C12Q1/68 , G01N33/542 , G01N33/573
CPC分类号： C12Q1/485 , B82Y5/00 , B82Y10/00 , C12Q1/37 , C12Q1/6818 , G01N33/542 , G01N33/573 , C12Q2537/1373 , C12Q2525/207
摘要： Methods of using labeled interfering RNAs to detect and/or quantitate target mRNAs in cells are provided. Related compositions, systems, and kits are also provided. Caged interfering RNAs (e.g., photoactivatable interfering RNAs), methods of using such caged RNAs, and related systems and kits are also provided. Methods and compositions for introducing interfering RNAs into cells, using RNAs covalently associated with protein transduction domains and/or lipids, are provided. Also provided are methods and compositions for selectively attenuating expression of a target mRNA by controlling expression of an interfering RNA.
摘要翻译：提供了使用标记的干扰RNA来检测和/或定量细胞中靶mRNA的方法。还提供了相关的组合物，系统和试剂盒。还提供了笼式干扰RNA（例如可光活化干扰RNA），使用这种笼式RNA的方法以及相关系统和试剂盒。提供了使用与蛋白质转导结构域和/或脂质共价缔合的RNA将干扰RNA引入细胞的方法和组合物。还提供了通过控制干扰RNA的表达来选择性地减弱靶mRNA表达的方法和组合物。

4. 发明授权

US07541193B2 Caged sensors, regulators and compounds and uses thereof 有权
标题翻译：笼式传感器，调节器和化合物及其用途
公开(公告)号：US07541193B2
公开(公告)日：2009-06-02
申请号：US10716174
申请日：2003-11-17
申请人： Quan Nguyen , Gary McMaster
发明人： Quan Nguyen , Gary McMaster
IPC分类号： G01N21/76
CPC分类号： C12Q1/485 , B82Y5/00 , B82Y10/00 , C12Q1/37 , C12Q1/6818 , G01N33/542 , G01N33/573 , C12Q2537/1373 , C12Q2525/207
摘要： A number of caged (e.g., photoactivatable) compositions are provided, for example, caged enzyme sensors, caged binding sensors, caged nucleic acid probes, caged interfering RNAs, caged antisense nucleic acids, caged ribozymes, caged biomolecular analogs, caged transcription factors, caged antibodies, caged molecular decoys, and caged aptamers. Compositions comprising a plurality of caged components are also provided, as are labeled and optionally caged modulators. Also provided are kits for making the caged compositions and methods for making and for using the caged compositions. Related systems and devices are also provided (e.g., an uncaging device that can trigger photoactivatable assays and optionally detect signals from the assays).
摘要翻译：提供了许多笼状（例如，可光活化的）组合物，例如笼式酶传感器，笼式结合传感器，笼式核酸探针，笼式干扰RNA，笼式反义核酸，笼式核酶，笼式生物分子类似物，笼状转录因子，笼养抗体，笼状分子诱饵和笼状适体。还提供了包括多个笼状组分的组合物，如标记的和任选的笼式调节剂。还提供了用于制备笼形组合物和制备和使用笼形组合物的方法的试剂盒。还提供了相关系统和装置（例如，能够触发可光活化测定并且可选地检测来自测定的信号的解开装置）。

5. 发明授权

US07271886B2 Uncaging device 有权
标题翻译：无效设备
公开(公告)号：US07271886B2
公开(公告)日：2007-09-18
申请号：US10716176
申请日：2003-11-17
申请人： Frank Witney , Gary McMaster , Quan Nguyen , Steve Chen
发明人： Frank Witney , Gary McMaster , Quan Nguyen , Steve Chen
IPC分类号： G01J1/00
CPC分类号： G01N21/6452
摘要： Uncaging devices that can be used to uncage photoactivatable caged components are provided. Consistent, uniform and/or high throughput processing of reactions and assays that include caged components is provided. Masked multiwell plates that can be used for uncaging photoactivatable caged components are provided. Methods and apparatus for initiating assays involving caged components are provided.
摘要翻译：提供了可用于解除可光灭活的笼式组件的非屏蔽设备。提供了包括笼式组件的反应和测定的一致，均匀和/或高通量处理。提供了可用于解码可光致灭活笼式组件的蒙版多孔板。提供了用于启动包含笼式组件的测定的方法和装置。

6. 发明申请

US20050282203A1 Caged RNAs and methods of use thereof 审中-公开
标题翻译：笼状RNA及其使用方法
公开(公告)号：US20050282203A1
公开(公告)日：2005-12-22
申请号：US11134851
申请日：2005-05-17
申请人： Quan Nguyen , Gary McMaster , Frank Witney
发明人： Quan Nguyen , Gary McMaster , Frank Witney
IPC分类号： A61K48/00 , C07H21/02 , C12Q1/68 , G01J1/00 , G01J1/42 , G01J3/30 , G01N20060101 , H01J40/14
CPC分类号： G01N21/6452
摘要： Methods of using labeled interfering RNAs to detect and/or quantitate target mRNAs in cells are provided. Related compositions, systems, and kits are also provided. Caged interfering RNAs (e.g., photoactivatable interfering RNAs), methods of using such caged RNAs, and related systems and kits are also provided. Caged RNAs capable of repressing translation of a target mRNA or silencing transcription of a target gene are also provided, along with related methods, systems, and kits. Methods and compositions for introducing RNAs into cells, using RNAs covalently associated with protein transduction domains and/or lipids, are provided. Also provided are methods and compositions for selectively attenuating expression of a target mRNA by controlling expression of an interfering RNA, an RNA capable of initiating translation repression, or an RNA capable of initiating transcriptional silencing.
摘要翻译：提供了使用标记的干扰RNA来检测和/或定量细胞中靶mRNA的方法。还提供了相关的组合物，系统和试剂盒。还提供了笼式干扰RNA（例如可光活化干扰RNA），使用这种笼式RNA的方法以及相关系统和试剂盒。还提供能够抑制靶mRNA翻译或沉默靶基因转录的笼状RNA以及相关方法，系统和试剂盒。提供了使用与蛋白质转导结构域和/或脂质共价缔合的RNA将RNA引入细胞的方法和组合物。还提供了通过控制干扰RNA的表达，能够启动翻译抑制的RNA或能够启动转录沉默的RNA来选择性减弱靶mRNA表达的方法和组合物。

7. 发明申请

US20050051706A1 Uncaging device 有权
标题翻译：无效设备
公开(公告)号：US20050051706A1
公开(公告)日：2005-03-10
申请号：US10716176
申请日：2003-11-17
申请人： Frank Witney , Gary McMaster , Quan Nguyen , Steve Chen
发明人： Frank Witney , Gary McMaster , Quan Nguyen , Steve Chen
IPC分类号： A61K48/00 , C07H21/02 , C12Q1/68 , G01J1/00 , G01J1/42 , G01J3/30 , G01N20060101 , H01J40/14
CPC分类号： G01N21/6452
摘要： Uncaging devices that can be used to uncage photoactivatable caged components are provided. Consistent, uniform and/or high throughput processing of reactions and assays that include caged components is provided. Masked multiwell plates that can be used for uncaging photoactivatable caged components are provided. Methods and apparatus for initiating assays involving caged components are provided.
摘要翻译：提供了可用于解除可光灭活的笼式组件的非屏蔽设备。提供了包括笼式组件的反应和测定的一致，均匀和/或高通量处理。提供了可用于解码可光致灭活笼式组件的蒙版多孔板。提供了用于启动包含笼式组件的测定的方法和装置。

8. 发明申请

US20110171644A1 Multiplex capture of nucleic acids 有权
标题翻译：多重捕获核酸
公开(公告)号：US20110171644A1
公开(公告)日：2011-07-14
申请号：US12930041
申请日：2010-12-23
申请人： Yuling Luo , Yunqing Ma , Gary McMaster , Quan Ngoc Nguyen , Frank Witney , Wen Yang
发明人： Yuling Luo , Yunqing Ma , Gary McMaster , Quan Ngoc Nguyen , Frank Witney , Wen Yang
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/6874 , C12Q1/6832 , C12Q1/6834 , C12Q1/6837 , C12Q2537/143 , C12Q2563/143 , C12Q2563/149
摘要： Methods of capturing two or more nucleic acids simultaneously from a single sample are provided. Different nucleic acids are captured through cooperative hybridization events on different subsets of particles or at different selected positions on a spatially addressable solid support. Methods of capturing one or more long nucleic acids and methods of capturing one or more nucleic acid for sequencing are also provided. Compositions, kits, and systems related to the methods are also described.
摘要翻译：提供了从单个样品同时捕获两种或更多种核酸的方法。通过在不同的颗粒子集上或在空间上可寻址的固体支持物上的不同选择位置上的协同杂交事件捕获不同的核酸。还提供了捕获一种或多种长核酸的方法和捕获一种或多种核酸进行测序的方法。还描述了与方法相关的组合物，试剂盒和系统。

9. 发明申请

US20080176242A1 Two stage nucleic acid amplification using an amplification oligomer 有权
标题翻译：使用扩增寡聚物的两阶段核酸扩增
公开(公告)号：US20080176242A1
公开(公告)日：2008-07-24
申请号：US11983216
申请日：2007-11-06
申请人： Gary McMaster , Yunqing Ma
发明人： Gary McMaster , Yunqing Ma
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/682 , C12Q1/6837 , C12Q2563/103 , C12Q2537/162 , C12Q2531/113
摘要： This invention provides methods, compositions and systems to detect a nucleic acid of interest in a two-stage amplification. The two-stage amplification begins with a first non-enzymatic accumulation of an amplification oligomer that is the target substrate for a second nucleic acid amplification or assay. Two or more amplification oligomers can be used to allow multiplexed amplifications of two or more nucleic acids of interest with deconvolution based on unique detection signals or unique signal locations.
摘要翻译：本发明提供在两级扩增中检测感兴趣的核酸的方法，组合物和系统。两步扩增开始于作为第二次核酸扩增或测定的靶底物的扩增寡聚物的第一非酶积累。可以使用两个或更多个扩增寡聚体，以基于独特的检测信号或唯一的信号位置，通过去卷积来允许两个或多个感兴趣的核酸的多重扩增。

10. 发明授权

US07927798B2 Detection of nucleic acids from whole blood 有权
标题翻译：检测全血核酸
公开(公告)号：US07927798B2
公开(公告)日：2011-04-19
申请号：US11543752
申请日：2006-10-04
申请人： Zhi Zheng , Yuling Luo , Gary McMaster
发明人： Zhi Zheng , Yuling Luo , Gary McMaster
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6816 , C12Q1/6837 , C12Q2537/143 , C12Q2537/125 , C12Q2525/313
摘要： Methods of detecting one or more nucleic acids from whole blood or plasma are provided. The nucleic acids are captured on a solid support and detected. Compositions, kits, and systems related to the methods are also described.
摘要翻译：提供从全血或血浆中检测一种或多种核酸的方法。将核酸捕获在固体支持物上并检测。还描述了与方法相关的组合物，试剂盒和系统。

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