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1. 发明申请

US20060030811A1 Method and device for enhancing transdermal agent flux 审中-公开
标题翻译：增强透皮剂通量的方法和装置
公开(公告)号：US20060030811A1
公开(公告)日：2006-02-09
申请号：US10910915
申请日：2004-08-03
申请人： Patrick Wong , Peter Daddona
发明人： Patrick Wong , Peter Daddona
IPC分类号： A61B17/20
CPC分类号： A61B17/205
摘要： A microprojection array having at least first and second microprojections, the first and second microprojections having inner and outer faces, the first microprojection inner face being disposed substantially parallel to the second microprojection inner face; and a biocompatible coating disposed on the first and second microprojection inner faces, the first and second microprojections being adapted to substantially restrict contact of the coating with biological tissue during insertion of the first and second microprojections into the tissue.
摘要翻译：一种具有至少第一和第二微突出物的微突出物阵列，所述第一和第二微突出物具有内表面和外表面，所述第一微突出物内表面基本上平行于所述第二微突出物内表面设置; 以及设置在所述第一和第二微突出物内表面上的生物相容性涂层，所述第一和第二微突出物适于在将所述第一和第二微突出物插入所述组织期间基本上限制所述涂层与生物组织的接触。

2. 发明申请

US20050031676A1 Method and device for enhancing transdermal agent flux 审中-公开
标题翻译：增强透皮剂通量的方法和装置
公开(公告)号：US20050031676A1
公开(公告)日：2005-02-10
申请号：US10910889
申请日：2004-08-03
申请人： Patrick Wong , Peter Daddona
发明人： Patrick Wong , Peter Daddona
IPC分类号： A61B10/00 , A61B17/20 , A61M37/00 , A61K38/19 , A61L15/16
CPC分类号： A61M37/0015 , A61B10/0064 , A61B17/205 , A61B2010/0009 , A61M2037/003 , A61M2037/0053
摘要： A porous microprojection member for insertion into biological tissue surrounded by interstitial fluid having a wall that includes interior and exterior surfaces, the exterior surface substantially enclosing the interior surface; and a biocompatible coating disposed on the interior surface, the microprojection member being adapted to substantially restrict contact of the coating with the tissue during insertion of the microprojection member into the tissue, the microprojection member having sufficient porosity to allow migration of the interstitial fluid through the wall of the microprojection member.
摘要翻译：一种用于插入由间隙液包围的生物组织的多孔微突出构件，其具有包括内表面和外表面的壁，所述外表面基本上包围所述内表面; 以及设置在所述内表面上的生物相容性涂层，所述微突出物构件适于基本上限制所述涂层与所述组织在所述微突出物构件插入所述组织期间的接触，所述微突出物构件具有足够的孔隙率以允许所述间质液体通过微突起构件的壁。

3. 发明申请

US20050049549A1 Method and device for enhancing transdermal agent flux 审中-公开
标题翻译：增强透皮剂通量的方法和装置
公开(公告)号：US20050049549A1
公开(公告)日：2005-03-03
申请号：US10911299
申请日：2004-08-03
申请人： Patrick Wong , Peter Daddona
发明人： Patrick Wong , Peter Daddona
IPC分类号： A61B10/00 , A61B17/20 , A61M37/00 , A61M25/00
CPC分类号： A61M37/0015 , A61B10/0064 , A61B17/205 , A61B2010/0009 , A61M2037/003 , A61M2037/0053
摘要： A substantially conical shaped microprojection having a wall defining an interior region, said microprojection wall including a plurality of openings; and a biocompatible coating disposed on the interior region of the microprojection. In a preferred embodiment, the microprojection is formed by deforming a region of a substantially planar sheet.
摘要翻译：具有限定内部区域的壁的基本圆锥形的微喷射体，所述微突出物壁包括多个开口; 以及设置在微喷射体的内部区域上的生物相容性涂层。在优选实施例中，通过使基本上平面的片材的区域变形来形成微喷射体。

4. 发明申请

US20070243254A1 NOVEL DRUG COMPOSITIONS AND DOSAGE FORMS OF TOPIRAMATE 审中-公开
标题翻译：新型药物组合物及其用量
公开(公告)号：US20070243254A1
公开(公告)日：2007-10-18
申请号：US11737829
申请日：2007-06-28
申请人： David Edgren , Frank Jao , Rhea Kimbel , Padmaja Shivanand , Atul Ayer , Gurdish Bhatti , Andrew Lam , Shu Li , Robert Skluzacek , Winnie To , Patrick Wong , Shaoling Li , Noymi Yam , Sylvia Serofff
发明人： David Edgren , Frank Jao , Rhea Kimbel , Padmaja Shivanand , Atul Ayer , Gurdish Bhatti , Andrew Lam , Shu Li , Robert Skluzacek , Winnie To , Patrick Wong , Shaoling Li , Noymi Yam , Sylvia Serofff
IPC分类号： A61K9/24 , A61P25/06 , A61P25/08
CPC分类号： A61K9/0004
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
摘要翻译：本发明涉及包含所述药物组合物的新型药物组合物和剂型。本发明的药物组合物包含药剂和增溶剂。本发明的药物组合物特别适用于低溶解度和/或低溶解速率的药剂。本发明还涉及制备所述药物组合物和剂型的方法。本发明进一步涉及包括施用所述药物组合物和剂型的治疗方法。

5. 发明申请

US20070207204A1 Dosage Form for Time-Varying Patterns of Drug Delivery 审中-公开
标题翻译：药物递送时间变化模式的剂型
公开(公告)号：US20070207204A1
公开(公告)日：2007-09-06
申请号：US11744999
申请日：2007-05-07
申请人： David Edgren , Patrick Wong , Shu Li
发明人： David Edgren , Patrick Wong , Shu Li
IPC分类号： A61K9/66
CPC分类号： A61K9/0004 , A61K31/277
摘要： The present invention provides a multi-release oral drug delivery system that initiates drug release following an initial drug-free release interval, after administration to a subject, and a second drug-free release period before release of another dose of drug. The system has (1) inner compartments enclosed within a semipermeable membrane, and (2) a drug coating on the exterior of the semipermeable membrane surrounded by a microporous membrane, which microporous membrane is permeable to fluid and drug. The drug coating is released after the initial drug-free release interval. An inner compartment drug is released after a second drug-free release interval provided by a drug-free inner compartment.
摘要翻译：本发明提供一种多次释放的口服药物递送系统，其在给予受试者之后，在初始无药物释放间隔之后启动药物释放，以及释放另一剂量药物之前的第二无药物释放期。该系统具有（1）封闭在半透膜内的内隔室，（2）由微孔膜包围的半透膜外部的药物涂层，该微孔膜可渗透流体和药物。药物涂层在初始无药物释放间隔后释放。在由无药物的内隔室提供的第二无药物释放间隔后释放内室药物。

6. 发明申请

US20070184112A1 Volume Efficient Controlled Release Dosage Form 审中-公开
标题翻译：体积有效的控制释放剂型
公开(公告)号：US20070184112A1
公开(公告)日：2007-08-09
申请号：US11684821
申请日：2007-03-12
申请人： Patrick Wong , Francisco Jao , David Edgren , Robert Skluzacek , Shu Li
发明人： Patrick Wong , Francisco Jao , David Edgren , Robert Skluzacek , Shu Li
IPC分类号： A61K9/24
CPC分类号： A61K9/0004
摘要： A dosage form that facilitates the controlled release of an active agent at a desired release rate or release rate profile includes a bi-layer membrane system and an osmotic core. The bi-layer membrane system includes a semipermeable membrane and an osmosensitive membrane and forms an internal compartment occupied by the osmotic core. The osmotic core includes an active agent composition and a light push layer. A passageway is formed through the bi-layer membrane system and permits expulsion of the active agent composition from the dosage form during operation. The bi-layer membrane system and the osmotic core are formulated and formed to provide controlled release of the active agent included in the active agent composition, while simultaneously facilitating increased loading of active agent within a dosage form of given dimension and increasing the delivery efficiency of such active agent relative to prior osmotic dosage forms including a push layer.
摘要翻译：有利于以期望的释放速率或释放速率曲线控制释放活性剂的剂型包括双层膜系统和渗透核。双层膜系统包括半透膜和渗透膜，并形成由渗透芯占据的内部隔室。渗透芯包括活性剂组合物和轻推层。通过双层膜系统形成通道，并允许活性剂组合物在操作期间从剂型中排出。双层膜系统和渗透芯被配制和形成以提供包含在活性剂组合物中的活性剂的受控释放，同时促进活性剂在给定维度的剂型中的负载增加，并且提高这种活性剂相对于包括推层的先前的渗透剂型。

7. 发明申请

US20060094782A9 Compositions and dosage forms for enhanced absorption 审中-公开
标题翻译：用于增强吸收的组合物和剂型
公开(公告)号：US20060094782A9
公开(公告)日：2006-05-04
申请号：US10978139
申请日：2004-10-29
申请人： Patrick Wong , Dong Yan , George Guittard
发明人： Patrick Wong , Dong Yan , George Guittard
IPC分类号： A61K31/185 , B65D88/76
CPC分类号： A61K31/662 , A61K9/0004 , A61K31/155 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/295 , A61K31/66 , A61K33/26 , A61K47/541 , A61K47/585 , A61K2300/00
摘要： Disclosed is controlled delivery of pharmaceutical agents and methods, dosage forms and devices therefore. In particular, formulation, dosage forms, methods and devices for enhanced absorption and controlled delivery drug compounds are disclosed.
摘要翻译：公开了药剂和方法的控制递送，剂型和装置。特别地，公开了用于增强吸收和控制递送的药物化合物的制剂，剂型，方法和装置。

8. 发明申请

US20060057206A1 Controlled release nanoparticle active agent formulation dosage forms and methods 审中-公开
标题翻译：控制释放纳米粒子活性剂配方剂型及方法
公开(公告)号：US20060057206A1
公开(公告)日：2006-03-16
申请号：US11198717
申请日：2005-08-04
申请人： Patrick Wong , Liang-Chang Dong , Ruiping Zhao , Crystal Pollock-Dove
发明人： Patrick Wong , Liang-Chang Dong , Ruiping Zhao , Crystal Pollock-Dove
IPC分类号： A61K9/24
CPC分类号： A61K9/1075 , A61K9/0004 , A61K9/143 , A61K9/146 , A61K9/1611 , A61K9/2009 , A61K9/2013 , A61K9/2031
摘要： Controlled release of self-dispersing nanoparticle active agent formulations is provided by dispersing porous particles into which have been sorbed a self-dispersing nanoparticle active agent formulation in osmotic, push-layer dosage forms. The dosage forms may provide for continuous or pulsatile delivery of active agents.
摘要翻译：自分散纳米颗粒活性剂制剂的控制释放通过分散多孔颗粒提供，其中已经吸收了渗透型推层剂型中的自分散纳米颗粒活性剂制剂。剂型可以提供活性剂的连续或脉动递送。

9. 发明申请

US20050158374A1 Compositions and dosage forms for enhanced absorption of metformin 审中-公开
标题翻译：用于增强二甲双胍吸收的组合物和剂型
公开(公告)号：US20050158374A1
公开(公告)日：2005-07-21
申请号：US10978141
申请日：2004-10-29
申请人： Patrick Wong , Dong Yan , George Guittard
发明人： Patrick Wong , Dong Yan , George Guittard
IPC分类号： A61K9/00 , A61K9/127 , A61K9/20 , A61K9/22 , A61K9/24 , A61K31/155 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/205 , A61K31/295 , A61K31/66 , A61K33/26 , A61K47/48 , B65D88/76 , C07C53/126 , C07C229/08 , C07C229/28 , C07C229/34 , C07C279/00
CPC分类号： A61K31/662 , A61K9/0004 , A61K31/155 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/295 , A61K31/66 , A61K33/26 , A61K47/541 , A61K47/585 , A61K2300/00
摘要： A complex comprised of metformin and a transport moiety, such as a fatty acid, is described. The complex has an enhanced absorption in the gastrointestinal tract, particularly the lower gastrointestinal tract. The complex, and compositions and dosage forms prepared using the complex, provide for absorption by the body of the drug through a period of ten to twenty-four hours, thus enabling a once-daily dosage form for metformin.
摘要翻译：描述了由二甲双胍和运输部分组成的复合物，例如脂肪酸。该复合物在胃肠道，特别是下胃肠道中具有增强的吸收。使用复合物制备的复合物，组合物和剂型可以使药物的体内吸收十到二十四小时，从而能够每日一次的二甲双胍剂型。

10. 发明申请

US20050118246A1 Dosage forms and layered deposition processes for fabricating dosage forms 审中-公开
标题翻译：用于制备剂型的剂量形式和分层沉积方法
公开(公告)号：US20050118246A1
公开(公告)日：2005-06-02
申请号：US10976589
申请日：2004-10-29
申请人： Patrick Wong , B. Silber
发明人： Patrick Wong , B. Silber
IPC分类号： A61K9/00 , A61K9/70 , A61K9/14
CPC分类号： A61K9/0065 , A61F2013/0296 , A61K9/703 , A61K9/7084 , A61K9/7092
摘要： Disclosed are transdermal or transmucosal dosage forms which include a matrix and a drug where the total amount of drug present in the dosage form exceeds the solubility limit of the drug in the matrix. Also disclosed are transdermal or transmucosal dosage forms which include two or more drug-containing layers and one or more intervening hydrophilic layers where the two or more drug-containing layers being separated from one another by the one or more intervening hydrophilic layers. Methods for delaying release and delivery of an active from an active layer disposed in a transdermal or transmucosal dosage form are also disclosed, as well as methods for manufacturing transdermal or transmucosal dosage forms by providing a substrate and disposing at least one transdermal or transmucosal dosage form layer on the substrate using a printing process.
摘要翻译：公开了透皮或透粘膜剂型，其包括基质和药物，其中存在于剂型中的药物的总量超过药物在基质中的溶解度极限。还公开了透皮或透粘膜剂型，其包括两个或更多个药物含有层和一个或多个中间亲水层，其中两个或更多个药物含有层通过一个或多个中间亲水层彼此分离。还公开了延缓活性物质从透皮或经粘膜剂型形成的活性层的释放和递送的方法，以及通过提供底物和设置至少一种透皮或透粘膜剂型形成透皮或经粘膜剂型的方法使用印刷方法在基板上。

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