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1. 发明授权

US08448534B2 Method and apparatus for dispersing a sample of particulate material 失效
标题翻译：用于分散颗粒材料样品的方法和装置
公开(公告)号：US08448534B2
公开(公告)日：2013-05-28
申请号：US12451563
申请日：2008-05-19
申请人： Nicholas Craig Davidson , Margaret Ellen Dyson , Jonathan Powell , Andrew John Prior
发明人： Nicholas Craig Davidson , Margaret Ellen Dyson , Jonathan Powell , Andrew John Prior
IPC分类号： G01N15/00
CPC分类号： G01N1/2813 , G01N1/286
摘要： An apparatus for dispersing a sample of particulate material, includes a carrier (31;35;37;38;39) having a sample-bearing surface on which to place the sample, and a housing (10;44;48) for forming a dispersion chamber (17), at least when closed off at a base (46;51). The carrier is arranged such that the sample-bearing surface is removed from contact with the sample upon application of a sufficient pressure differential across the carrier between the sample-bearing surface and an opposite side of the carrier. The housing (10;44;48) has an inlet (26) at least partially facing the base (46;51). The apparatus includes an apparatus (15;16) for passing a volume of fluid past the carrier (31;35;37;38;39) through the inlet (26) by subjecting the carrier (31;35;37;38;39) to a pulsed positive pressure differential relative to the dispersion chamber (17).
摘要翻译：一种用于分散颗粒材料样品的装置，包括具有放置样品的样品承载表面的载体（31; 35; 37; 38; 39）和用于形成至少在基部（46; 51）处封闭时分散室（17）。载体被布置成使得在载体表面和承载体的相对侧之间施加足够的压力差，载体表面与样品脱离接触。壳体（10; 44; 48）具有至少部分地面向基部（46; 51）的入口（26）。该装置包括一个装置（15; 16），用于使一定体积的流体经过载体（31; 35; 37; 38; 39）穿过入口（26），使载体（31; 35; 37; 38; 39 ）相对于分散室（17）的脉冲正压差。

2. 发明申请

US20100326213A1 METHOD AND APPARATUS FOR DISPERSING A SAMPLE OF PARTICULATE MATERIAL 失效
标题翻译：分散颗粒物质样品的方法和装置
公开(公告)号：US20100326213A1
公开(公告)日：2010-12-30
申请号：US12451563
申请日：2008-05-19
申请人： Nicholas Craig Davidson , Margaret Ellen Dyson , Jonathan Powell , Andrew John Prior
发明人： Nicholas Craig Davidson , Margaret Ellen Dyson , Jonathan Powell , Andrew John Prior
IPC分类号： G01N1/28 , B01L3/00
CPC分类号： G01N1/2813 , G01N1/286
摘要： An apparatus for dispersing a sample of particulate material, includes a carrier (31;35;37;38;39) having a sample-bearing surface on which to place the sample, and a housing (10;44;48) for forming a dispersion chamber (17), at least when closed off at a base (46;51). The carrier is arranged such that the sample-bearing surface is removed from contact with the sample upon application of a sufficient pressure differential across the carrier between the sample-bearing surface and an opposite side of the carrier. The housing (10;44;48) has an inlet (26) at least partially facing the base (46;51). The apparatus includes an apparatus (15;16) for passing a volume of fluid past the carrier (31;35;37;38;39) through the inlet (26) by subjecting the carrier (31;35;37;38;39) to a pulsed positive pressure differential relative to the dispersion chamber (17).
摘要翻译：一种用于分散颗粒材料样品的装置，包括具有放置样品的样品承载表面的载体（31; 35; 37; 38; 39）和用于形成至少在基部（46; 51）处封闭时分散室（17）。载体被布置成使得在载体表面和承载体的相对侧之间施加足够的压力差，载体表面与样品脱离接触。壳体（10; 44; 48）具有至少部分地面向基部（46; 51）的入口（26）。该装置包括一个装置（15; 16），用于使一定体积的流体经过载体（31; 35; 37; 38; 39）穿过入口（26），使载体（31; 35; 37; 38; 39 ）相对于分散室（17）的脉冲正压差。

3. 发明授权

US08551481B2 Anti-cancer vaccine composition comprising an anti-CD223 antibody and kit comprising an anti-cancer vaccine and an anti-CD223 antibody 有权
标题翻译：包含抗-CD223抗体和包含抗癌疫苗和抗-CD223抗体的试剂盒的抗癌疫苗组合物
公开(公告)号：US08551481B2
公开(公告)日：2013-10-08
申请号：US12578887
申请日：2009-10-22
申请人： Drew M Pardoll , Ching-Tai Huang , Jonathan Powell , Charles Drake , Dario A Vignali , Creg J Workman
发明人： Drew M Pardoll , Ching-Tai Huang , Jonathan Powell , Charles Drake , Dario A Vignali , Creg J Workman
IPC分类号： A61K39/00 , A61K39/395 , A61K39/38 , C12P21/08
CPC分类号： C07K16/2803 , A01K67/0271 , A01K67/0276 , A01K2267/0381 , A61K39/0011 , A61K39/3955 , A61K39/39558 , A61K2035/122 , A61K2039/505 , A61K2039/507 , A61K2039/5156 , A61K2039/55516 , C07K14/70503 , C07K16/18 , C07K16/42 , C12N5/0636 , C12N2501/599 , C12N2510/00 , C12N2799/027
摘要： Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Treg in vivo requires identification of Treg selective receptors. A comparative analysis of gene expression arrays from antigen specific CD4+ T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg selective expression of LAG-3 (CD223), a CD4-related molecule that binds MHC class II. LAG-3 expression on CD4+ T cells correlates with the cells' in vitro suppressor activity, and ectopic expression of LAG-3 on CD4 T cells confers suppressor activity on the T cells. Antibodies to LAG-3 inhibit suppression both in vitro and in vivo. LAG-3 marks regulatory T cell populations and contributes to their suppressor activity.
摘要翻译：调节性T细胞（Treg）限制自身免疫，但也可以减弱抗病原体和抗肿瘤免疫的程度。了解Treg功能的机制和体内Treg的治疗操作需要鉴定Treg选择性受体。分化为效应物/记忆或调节表型的抗原特异性CD4 + T细胞的基因表达阵列的比较分析揭示了TAG选择性表达LAG-3（CD223），一种结合MHC II类的CD4相关分子。 CD4 + T细胞上的LAG-3表达与细胞的体外抑制活性相关，LAG-3在CD4T细胞上的异位表达赋予T细胞抑制活性。 LAG-3的抗体在体外和体内均抑制抑制。 LAG-3标记调节性T细胞群体并有助于其抑制活性。

4. 发明申请

US20060206426A1 Promise to purchase real estate system and method 审中-公开
标题翻译：承诺购买房地产系统和方法
公开(公告)号：US20060206426A1
公开(公告)日：2006-09-14
申请号：US11289778
申请日：2005-11-29
申请人： Jonathan Powell
发明人： Jonathan Powell
IPC分类号： G06Q40/00
CPC分类号： G06Q40/02 , G06Q20/102
摘要： The present system and method seeks to lessen impacts of market fluctuations, transaction costs, and other detrimental factors associated with conventional dwelling purchases while seeking also to provide more options in selection of dwellings to choose from by the household seeking such a dwelling. An exemplary implementation involves an initial purchaser and a subsequent purchaser who execute a promise to purchase agreement. The process further involves an initial seller, a bank, and an escrow agent. In some implementations, the subsequent purchaser is a real estate brokerage company with one or more brokers being licensed as real estate agents. The promise to purchase agreement between the initial purchaser and the subsequent purchaser governs certain actions by the initial purchaser and other actions by the subsequent purchaser regarding a particular real estate property.
摘要翻译：目前的制度和方法旨在减少与传统住宅购买相关的市场波动，交易成本和其他有害因素的影响，同时寻求提供更多的选择选择住宅的选择，以供住房寻求这样的住宅选择。一个示例性的实施包括执行承诺购买协议的初始购买者和后续购买者。该过程还涉及初始卖家，银行和托管代理。在一些实施中，后续购买者是一家房地产经纪公司，一家或多家经纪人被许可为房地产代理。初始购买者和后续购买者之间购买协议的承诺将由初始购买者采取某些行动以及后续购买者对特定房地产的其他行为。

5. 发明申请

US20080005018A1 Systems And Methods For Implementing Direct Issuer - Merchant Relationships Over A General Purpose Bankcard Network 审中-公开
标题翻译：在通用银行卡网络上实施直接发行人 - 商户关系的系统和方法
公开(公告)号：US20080005018A1
公开(公告)日：2008-01-03
申请号：US11670869
申请日：2007-02-02
申请人： Jonathan Powell
发明人： Jonathan Powell
IPC分类号： G06Q40/00
CPC分类号： G06Q30/02 , G06Q20/10
摘要： Systems and methods for implementing customized issuer-merchant relationships or programs in the payment-by-card industry are provided. The systems and methods utilize the multi-party bankcard networks common in the industry for processing card transactions, but provide direct connectivity between issuers and merchants bypassing merchant acquirers for processing card transactions covered by the customized issuer-merchant relationships.
摘要翻译：提供了用于在逐卡支付行业中实现定制的发行商 - 商家关系或程序的系统和方法。系统和方法利用行业中常见的多方银行卡网络来处理卡交易，但是提供发行商和商家之间的直接连接，绕过商家收单者处理由定制的发行商 - 商家关系所涵盖的卡交易。

6. 发明申请

US20050124519A1 Method, articles and compositions for cleaning bathroom surfaces 有权
标题翻译：方法，用于清洁浴室表面的物品和组合物
公开(公告)号：US20050124519A1
公开(公告)日：2005-06-09
申请号：US11002408
申请日：2004-12-02
申请人： Alan Sherry , Jonathan Powell , Antonio Quintieri , Francis Ford
发明人： Alan Sherry , Jonathan Powell , Antonio Quintieri , Francis Ford
IPC分类号： C11D11/00 , C11D17/04 , C11D1/00
CPC分类号： C11D17/049 , C11D11/0023 , Y10T442/2279
摘要： The present invention relates to a disposable cleaning article for cleaning a bathroom surfaces which includes a layer of nonwoven substrate and a cleaning composition which can be either in a liquid or paste form. The cleaning article is water activate. The present invention also relates to a method of cleaning a hard surface by adding water to a disposable cleaning article impregnated with a cleaning composition and then wiping the bathroom surface.
摘要翻译：本发明涉及一种用于清洁卫生间表面的一次性清洁制品，其包括非织造基底层和可以是液体或糊状形式的清洁组合物。清洁用品是水活化的。本发明还涉及一种通过向浸渍有清洁组合物的一次性清洁制品中加水并且然后擦拭浴室表面来清洁硬表面的方法。

7. 发明申请

US20100196394A1 ANTI-CANCER VACCINE COMPOSITION 有权
标题翻译：抗癌药物组合物
公开(公告)号：US20100196394A1
公开(公告)日：2010-08-05
申请号：US12578887
申请日：2009-10-22
申请人： Drew M. Pardoll , Ching-Tai Huang , Dario A. Vignali , Creg J. Workman , Jonathan Powell , Charles C. Drake
发明人： Drew M. Pardoll , Ching-Tai Huang , Dario A. Vignali , Creg J. Workman , Jonathan Powell , Charles C. Drake
IPC分类号： A61K39/395 , A61P35/00 , A61K31/7052
CPC分类号： C07K16/2803 , A01K67/0271 , A01K67/0276 , A01K2267/0381 , A61K39/0011 , A61K39/3955 , A61K39/39558 , A61K2035/122 , A61K2039/505 , A61K2039/507 , A61K2039/5156 , A61K2039/55516 , C07K14/70503 , C07K16/18 , C07K16/42 , C12N5/0636 , C12N2501/599 , C12N2510/00 , C12N2799/027
摘要： Combinations of anti-cancer vaccines and inhibitory antibodies to CD223 overcome immune suppression in cancer patients. The vaccines may be isolated antigens, groups of antigens, or whole tumor cells. The inhibitory antibodies may be generated in an animal by injection of fragments of CD223. Antibodies may be monoclonal antibodies or single chain antibodies or humanized antibodies.
摘要翻译：抗癌疫苗和CD223抑制性抗体的组合克服了癌症患者的免疫抑制。疫苗可以是分离的抗原，抗原组或全部肿瘤细胞。可以通过注射CD223片段在动物体内产生抑制性抗体。抗体可以是单克隆抗体或单链抗体或人源化抗体。

8. 发明申请

US20060240024A1 T cell regulation 审中-公开
标题翻译： T细胞调节
公开(公告)号：US20060240024A1
公开(公告)日：2006-10-26
申请号：US10547371
申请日：2004-03-01
申请人： Drew Pardoll , Ching-Tai Huang , Dario Vignali , Creg Workman , Jonathan Powell , Charles Drake
发明人： Drew Pardoll , Ching-Tai Huang , Dario Vignali , Creg Workman , Jonathan Powell , Charles Drake
IPC分类号： A61K39/395
CPC分类号： C07K16/2803 , A01K67/0271 , A01K67/0276 , A01K2267/0381 , A61K39/0011 , A61K39/3955 , A61K39/39558 , A61K2035/122 , A61K2039/505 , A61K2039/507 , A61K2039/5156 , A61K2039/55516 , C07K14/70503 , C07K16/18 , C07K16/42 , C12N5/0636 , C12N2501/599 , C12N2510/00 , C12N2799/027
摘要： Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Treg in vivo requires identification of Treg selective receptors. A comparative analysis of gene expression arrays from antigen specific CD4+ T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg selective expression of LAG-3 (CD223), a CD4-related molecule that binds MHC class II. LAG-3 expression on CD4+ T cells correlates with the cells' in vitro suppressor activity, and ectopic expression of LAG-3 on CD4 T cells confers suppressor activity on the T cells. Antibodies to LAG-3 inhibit suppression both in vitro and in vivo. LAG-3 marks regulatory T cell populations and contributes to their suppressor activity.
摘要翻译：调节性T细胞（Treg）限制自身免疫，但也可以减弱抗病原体和抗肿瘤免疫的程度。了解Treg功能的机制和体内Treg的治疗操作需要鉴定Treg选择性受体。分化为效应物/记忆或调节表型的抗原特异性CD4 + T细胞的基因表达阵列的比较分析揭示了TAG选择性表达LAG-3（CD223），一种结合MHC II类的CD4相关分子。 CD4 + T细胞上的LAG-3表达与细胞的体外抑制活性相关，LAG-3在CD4T细胞上的异位表达赋予T细胞抑制活性。 LAG-3的抗体在体外和体内均抑制抑制。 LAG-3标记调节性T细胞群体并有助于其抑制活性。

9. 发明申请

US20050120497A1 Disposable, nonwoven cleaning wipes, and kits comprising them 审中-公开
标题翻译：一次性，非织造清洁擦拭物和包含它们的试剂盒
公开(公告)号：US20050120497A1
公开(公告)日：2005-06-09
申请号：US10994959
申请日：2004-11-22
申请人： Kenton Lynde , Jonathan Powell , Neil Rogers , Nicola Policicchio , Christine Kurjan , Adrian James
发明人： Kenton Lynde , Jonathan Powell , Neil Rogers , Nicola Policicchio , Christine Kurjan , Adrian James
IPC分类号： A47L13/16 , A47L13/17 , A47L13/18 , A47L13/19 , A47L13/20
CPC分类号： A47L13/20
摘要： The present invention relates to a disposable wipe for cleaning hard surfaces, comprising a cleaning substrate comprising a nonwoven material, the cleaning substrate having a longitudinal axis, an upper surface and a lower surface; and at least one attachment means; wherein said at least one attachment means is a pocket formed on the upper surface or the lower surface of said cleaning substrate, said pocket covering from about 2% to about 90% of the surface area of said upper surface, and having at least one opening. There is also provided a kit comprising the disposable cleaning wipe; and a cleaning implement comprising a mop head.
摘要翻译：本发明涉及一种用于清洁硬表面的一次性擦拭物，其包括清洁基底，该清洁基底包括非织造材料，所述清洁基底具有纵向轴线，上表面和下表面; 和至少一个附接装置; 其中所述至少一个附接装置是形成在所述清洁基板的上表面或下表面上的凹穴，所述凹穴覆盖所述上表面的表面积的约2％至约90％，并且具有至少一个开口。还提供了包括一次性清洁擦拭物的试剂盒; 以及包括拖把头的清洁工具。

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