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1. 发明授权

US07238519B2 Automated immunoassay cassette, apparatus and method 有权
标题翻译：自动免疫测定盒，仪器和方法
公开(公告)号：US07238519B2
公开(公告)日：2007-07-03
申请号：US11016016
申请日：2004-12-17
申请人： Neal F. Bellet , Jeffrey Shindelman , Thomas E. Worthy , Kimberly Haley , Richard K-T Lee , Jane Eunhee Kyung , Suyue Qian
发明人： Neal F. Bellet , Jeffrey Shindelman , Thomas E. Worthy , Kimberly Haley , Richard K-T Lee , Jane Eunhee Kyung , Suyue Qian
IPC分类号： C12M1/34
CPC分类号： G01N21/03 , B01L3/5023 , B01L9/52 , B01L2200/0668 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B01L2400/0633 , G01N33/54306 , G01N33/54366 , G01N33/54386 , G01N2035/00108 , G01N2035/00128 , G01N2035/0436 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/81
摘要： An immunoassay cassette, apparatus, and method for detecting an analyte in a liquid body-fluid sample are disclosed. The cassette has a body and a support mounted on the body, for movement relative to the body to first and second transfer positions. Sample supplied to a sample well in the cassette body is transferred to a reagent reservoir on the cassette body, by moving the support to its first transfer position. Here the sample reacts with a first reagent composition in the reservoir effective to form a modified sample. The modified sample is then transferred to a reagent strip on the support by moving the support to its second transfer position. The reagent strip has a transfer zone at which sample material is transferred to the strip, a second reagent composition effective to react with the modified sample to form a detectable analyte-dependent product, and a detection zone located downstream at which the detectable product can be observed. By controlling movement of the support to its first and second positions, the cassette can effectively handle a variety of samples having different flow rates.
摘要翻译：公开了用于检测液体体液样品中的分析物的免疫测定盒，装置和方法。盒具有主体和安装在主体上的支撑件，用于相对于主体移动到第一和第二转移位置。通过将支撑件移动到其第一转移位置，提供给盒体中的样品阱的样品被转移到盒体上的试剂容器。这里样品与存储器中的第一试剂组合物反应，有效地形成修饰的样品。然后通过将支撑件移动到其第二转移位置，将改性样品转移到支撑体上的试剂条。试剂条具有将样品材料转移到条带上的转移区域，有效与经修饰的样品反应以形成可检测的分析物依赖产物的第二试剂组合物，以及位于下游的检测区域，可检测产物可以观察到的。通过控制支撑件到其第一和第二位置的移动，盒可以有效地处理具有不同流速的各种样品。

2. 发明申请

US20050147532A1 Automated immunoassay cassette, apparatus and method 有权
标题翻译：自动免疫测定盒，仪器和方法
公开(公告)号：US20050147532A1
公开(公告)日：2005-07-07
申请号：US11016016
申请日：2004-12-17
申请人： Neal Bellet , Jeffrey Shindelman , Thomas Worthy , Kimberly Haley , Richard Lee , Jane Kyung , Suyue Qian
发明人： Neal Bellet , Jeffrey Shindelman , Thomas Worthy , Kimberly Haley , Richard Lee , Jane Kyung , Suyue Qian
IPC分类号： B01L3/00 , B01L9/00 , G01N33/543 , G01N21/00
CPC分类号： G01N21/03 , B01L3/5023 , B01L9/52 , B01L2200/0668 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B01L2400/0633 , G01N33/54306 , G01N33/54366 , G01N33/54386 , G01N2035/00108 , G01N2035/00128 , G01N2035/0436 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/81
摘要： An immunoassay cassette, apparatus, and method for detecting an analyte in a liquid body-fluid sample are disclosed. The cassette has a body and a support mounted on the body, for movement relative to the body to first and second transfer positions. Sample supplied to a sample well in the cassette body is transferred to a reagent reservoir on the cassette body, by moving the support to its first transfer position. Here the sample reacts with a first reagent composition in the reservoir effective to form a modified sample. The modified sample is then transferred to a reagent strip on the support by moving the support to its second transfer position. The reagent strip has a transfer zone at which sample material is transferred to the strip, a second reagent composition effective to react with the modified sample to form a detectable analyte-dependent product, and a detection zone located downstream at which the detectable product can be observed. By controlling movement of the support to its first and second positions, the cassette can effectively handle a variety of samples having different flow rates.
摘要翻译：公开了用于检测液体体液样品中的分析物的免疫测定盒，装置和方法。盒具有主体和安装在主体上的支撑件，用于相对于主体移动到第一和第二转移位置。通过将支撑件移动到其第一转移位置，提供给盒体中的样品阱的样品被转移到盒体上的试剂容器。这里样品与存储器中的第一试剂组合物反应，有效地形成修饰的样品。然后通过将支撑件移动到其第二转移位置，将改性样品转移到支撑体上的试剂条。试剂条具有将样品材料转移到条带上的转移区域，有效与经修饰的样品反应以形成可检测的分析物依赖产物的第二试剂组合物，以及位于下游的检测区域，可检测产物可以观察到的。通过控制支撑件到其第一和第二位置的移动，盒可以有效地处理具有不同流速的各种样品。

3. 发明授权

US07186566B2 Combining transmittance detection and chromatographic strip techniques for quantification of analyte in biological fluids 失效
标题翻译：结合透射检测和色谱条技术，用于定量生物液体中的分析物
公开(公告)号：US07186566B2
公开(公告)日：2007-03-06
申请号：US10628670
申请日：2003-07-28
申请人： Suyue Qian
发明人： Suyue Qian
IPC分类号： G01N33/551
CPC分类号： G01N21/8483 , B01L3/502 , B01L2300/0654 , B01L2300/0825 , B01L2400/0406 , B01L2400/0487 , G01N33/525 , G01N33/558
摘要： Chromatographic strip is used in combination with a transmittance detecting system in a test to quantitate analytes in biological fluid. Chemical reagents or conjugate labels are simply absorbed on the passages' materials of the strip. The substrates, affinity reagents, or antibodies are immobilized on transparent beads in the detection cell of the strip. The biological fluid passes through the strip. The captured analytes are detected by transmittance detection for quantification. Uncaptured elements and interferences in the fluid are drained to the absorbent portion of the strip when the fluid passes the cell as a wash. This chromatographic strip with an analyte capture zone simplifies the procedures that a transmittance detecting system alone cannot overcome. Adjustable light path of the cells in the strip overcome the sensitivity limitation of reflectance detection.
摘要翻译：色谱条与透射检测系统结合使用，用于定量生物液体中的分析物。化学试剂或缀合物标签被简单地吸收在条带的通道材料上。底物，亲和试剂或抗体固定在条带检测细胞中的透明珠上。生物液体通过条带。通过透射检测来检测捕获的分析物进行定量。当流体作为洗涤物通过电池时，未吸收的元件和流体中的干扰被排出到条带的吸收部分。具有分析物捕获区的色谱条简化了透射率检测系统无法克服的程序。条中细胞的可调光路克服了反射率检测的灵敏度限制。

4. 发明申请

US20060003400A1 Methods and compositions for characterizing a redox reagent system enzyme 审中-公开
标题翻译：用于表征氧化还原试剂系统酶的方法和组合物
公开(公告)号：US20060003400A1
公开(公告)日：2006-01-05
申请号：US10883629
申请日：2004-06-30
申请人： Patricia Byrd , Suyue Qian , Thomas Hartz
发明人： Patricia Byrd , Suyue Qian , Thomas Hartz
IPC分类号： C12Q1/26 , C12Q1/32
CPC分类号： G01N33/558 , C12Q1/001 , C12Q1/004 , G01N33/521 , G01N33/5438
摘要： Methods and compositions for characterizing a redox reagent system enzyme are provided. In practicing the subject methods, a sample that includes a redox reagent system enzyme and a known amount of substrate is applied to an electrochemical cell that includes an enzyme-free reagent composition having a redox reagent system mediator. Also provided are electrochemical test strips that include the subject electrochemical cells, and systems and kits that include the same. The subject invention finds use in a variety of different applications, including redox reagent system characterization applications.
摘要翻译：提供了表征氧化还原试剂系统酶的方法和组合物。在实施本发明方法时，将包含氧化还原试剂系统酶和已知量的底物的样品应用于包括具有氧化还原试剂系统介体的无酶试剂组合物的电化学电池。还提供了包括目标电化学电池的电化学测试条，以及包括其的系统和试剂盒。本发明可用于各种不同的应用，包括氧化还原试剂系统表征应用。

5. 发明授权

US10327677B2 Analyte sensors with a sensing surface having small sensing spots 有权
公开(公告)号：US10327677B2
公开(公告)日：2019-06-25
申请号：US13315034
申请日：2011-12-08
申请人： Udo Hoss , Phu Le , Yi Wang , Frank David Fujimoto , Suyue Qian , Lam Tran
发明人： Udo Hoss , Phu Le , Yi Wang , Frank David Fujimoto , Suyue Qian , Lam Tran
IPC分类号： A61B5/05 , A61B5/145 , A61B5/1473 , C12Q1/00
摘要： Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

6. 发明申请

US20050255453A1 Multilayer reagent test strips and methods for using the same to quantify glycated protein in a physiological sample 审中-公开
标题翻译：多层试剂试纸和使用该试纸的方法用于定量生理样品中的糖化蛋白质
公开(公告)号：US20050255453A1
公开(公告)日：2005-11-17
申请号：US11185239
申请日：2005-07-19
申请人： Suyue Qian , Sherry Guo , Koon-wah Leong
发明人： Suyue Qian , Sherry Guo , Koon-wah Leong
IPC分类号： G01N33/48 , C12M1/34 , C12Q1/26 , C12Q1/28 , C12Q1/37 , G01N33/49 , G01N33/52 , G01N33/543 , G01N33/68 , C12Q1/00
CPC分类号： C12Q1/37 , C12Q1/26 , G01N33/526 , G01N33/54366
摘要： Multilayer reagent test strips for quantitating glycated protein in a fluid sample, as well as methods for using the same, are provided. The subject multilayer test strips include at least a filter layer, a proteinase layer and a ketoamine oxidase signal producing and fluid flow control system layer. In using the subject test strips, a fluid sample is applied to the test strip and a signal is generated that can be employed to quantitate the glycated protein level in the sample. The quantitated glycated protein level can then be employed to determine the amount of glycated protein in the fluid sample. Also provided are kits and systems that include the subject test strips and find use in practicing the subject methods. The subject compositions and methods find use in glycated protein monitoring applications, among other utilities.
摘要翻译：提供了用于定量流体样品中的糖化蛋白质的多层试剂试纸，以及使用它们的方法。主题多层测试条至少包括过滤层，蛋白酶层和酮胺氧化酶信号产生和流体流动控制系统层。在使用主题测试条时，将流体样品施加到测试条上，并产生可用于定量样品中糖基化蛋白质水平的信号。然后可以使用定量的糖基化蛋白水平来确定流体样品中糖化蛋白的量。还提供了包括主题测试条的试剂盒和系统，并用于实践主题方法。主题组合物和方法可用于糖化蛋白质监测应用以及其他实用工具。

7. 发明授权

US07824879B2 Device and method for measuring LDL-associated cholesterol 有权
标题翻译：用于测量LDL相关胆固醇的装置和方法
公开(公告)号：US07824879B2
公开(公告)日：2010-11-02
申请号：US12008394
申请日：2008-01-09
申请人： Shireen Khan , Suyue Qian , Jeff Shindelman , George E. Withers, III , Eileen Gee , William H. Chapman, Jr. , Greg Bennett , Thomas D. Schaal
发明人： Shireen Khan , Suyue Qian , Jeff Shindelman , George E. Withers, III , Eileen Gee , William H. Chapman, Jr. , Greg Bennett , Thomas D. Schaal
IPC分类号： C12Q1/60
CPC分类号： G01N33/526 , C12Q1/60 , G01N33/92
摘要： An assay device and method for determining the concentration of low density lipoprotein (LDL)-associated cholesterol (LDL-C) in a body-fluid sample, such as a blood sample is described.
摘要翻译：描述了用于测定体液样品如血液样品中的低密度脂蛋白（LDL）相关胆固醇（LDL-C）的浓度的测定装置和方法。

8. 发明申请

US20080166745A1 Device and method for measuring LDL-associated cholesterol 有权
标题翻译：用于测量LDL相关胆固醇的装置和方法
公开(公告)号：US20080166745A1
公开(公告)日：2008-07-10
申请号：US12008394
申请日：2008-01-09
申请人： Shireen Khan , Suyue Qian , Jeff Shindelman , George E. Withers , Eileen Gee , William H. Chapman , Greg Bennett , Thomas D. Schaal
发明人： Shireen Khan , Suyue Qian , Jeff Shindelman , George E. Withers , Eileen Gee , William H. Chapman , Greg Bennett , Thomas D. Schaal
IPC分类号： C12Q1/60 , C12M1/34
CPC分类号： G01N33/526 , C12Q1/60 , G01N33/92
摘要： An assay device and method for determining the concentration of low density lipoprotein (LDL)-associated cholesterol (LDL-C) in a body-fluid sample, such as a blood sample is described.
摘要翻译：描述了用于测定体液样品如血液样品中的低密度脂蛋白（LDL）相关胆固醇（LDL-C）的浓度的测定装置和方法。

9. 发明申请

US20050026302A1 Combining transmittance detection and chromatographic strip techniques providing a simple, easy, sensitive, accurate, fast and inexpensive way to quantitate analytes in biological fluid 失效
标题翻译：结合透射率检测和色谱条技术，提供简单，容易，灵敏，准确，快速和廉价的方法来定量生物流体中的分析物
公开(公告)号：US20050026302A1
公开(公告)日：2005-02-03
申请号：US10628670
申请日：2003-07-28
申请人： Suyue Qian
发明人： Suyue Qian
IPC分类号： B01L3/00 , G01N21/86 , G01N33/52 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/558
CPC分类号： G01N21/8483 , B01L3/502 , B01L2300/0654 , B01L2300/0825 , B01L2400/0406 , B01L2400/0487 , G01N33/525 , G01N33/558
摘要： Chromatographic strip is used in combination with a transmittance detecting system in a test to quantitate analytes in biological fluid. Chemical reagents or conjugate labels are simply absorbed on the passages' materials of the strip. The substrates, affinity reagents, or antibodies are immobilized on transparent beads in the detection cell of the strip. The biological fluid passes through the strip. The captured analytes are detected by transmittance detection for quantification. Uncaptured elements and interferences in the fluid are drained to the absorbent portion of the strip when the fluid passes the cell as a wash. This chromatographic strip with an analyte capture zone simplifies the. procedures that a transmittance detecting system alone cannot overcome. Adjustable light path of the cells in the strip overcome the sensitivity limitation of reflectance detection.
摘要翻译：色谱条与透射检测系统结合使用，用于定量生物液体中的分析物。化学试剂或缀合物标签被简单地吸收在条带的通道材料上。底物，亲和试剂或抗体固定在条带检测细胞中的透明珠上。生物液体通过条带。通过透射检测来检测捕获的分析物进行定量。当流体作为洗涤物通过电池时，未吸收的元件和流体中的干扰被排出到条带的吸收部分。具有分析物捕获区的此色谱条简化了。无法克服透射率检测系统的程序。条中细胞的可调光路克服了反射率检测的灵敏度限制。

10. 发明申请

US20120150005A1 Analyte Sensors with a Sensing Surface Having Small Sensing Spots 审中-公开
标题翻译：具有感应表面的分析物传感器具有小的感测点
公开(公告)号：US20120150005A1
公开(公告)日：2012-06-14
申请号：US13315034
申请日：2011-12-08
申请人： Udo Hoss , Phu Le , Yi Wang , Frank David Fujimoto , Suyue Qian , Lam Tran
发明人： Udo Hoss , Phu Le , Yi Wang , Frank David Fujimoto , Suyue Qian , Lam Tran
IPC分类号： A61B5/1473 , A61B5/1468 , C12Q1/54
CPC分类号： A61B5/14532 , A61B5/1473 , C12Q1/001 , C12Q1/006
摘要： Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
摘要翻译：本公开的实施例涉及具有感测表面的分析物确定方法和装置（例如，电化学分析物监测系统），该感测表面包括彼此横向设置的两个或更多个感测元件，其中感测表面位于体内的工作电极和/或体外分析物传感器，例如使用分析物传感器和/或测试条的连续和/或自动体内监测。还提供在分析物监测中使用例如电化学分析物传感器的系统和方法。

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