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    • 9. 发明授权
    • pH sensitive block copolymer and polymeric micelle using the same
    • pH敏感嵌段共聚物和使用其的聚合物胶束
    • US08318204B2
    • 2012-11-27
    • US11573858
    • 2005-12-27
    • Doo Sung LeeMin Sang Kim
    • Doo Sung LeeMin Sang Kim
    • A61K9/14A61K47/00
    • C08F299/024
    • Disclosed is a pH-sensitive block copolymer obtained by copolymerization of: (a) a polyethylene glycol compound (A); and (b) at least one poly(amino acid) compound selected from the group consisting of a poly(β-amino ester) and poly(amido amine) or a copolymer thereof (B). A method for preparing the same block copolymer, and a polymer micelle type drug composition comprising the pH-sensitive block copolymer and a physiologically active substance that can be encapsulated with the block copolymer are also disclosed. The pH-sensitive block copolymer is obtained by polymerization of a hydrophilic polyethylene glycol compound with a pH-sensitive biodegradable poly(amino acid) compound. Therefore, the pH-sensitive block copolymer can form a micelle structure due to its amphiphilicity and ionization characteristics depending on pH variations, and thus can be used as drug carrier for target-directed drug delivery depending on pH variations in the body.
    • 公开了通过以下方法获得的pH敏感性嵌段共聚物:(a)聚乙二醇化合物(A); 和(b)至少一种选自聚(亚氨基酯)和聚(酰氨基胺)或其共聚物(B)的聚(氨基酸)化合物。 还公开了制备相同嵌段共聚物的方法,以及包含该pH敏感性嵌段共聚物的聚合物胶束型药物组合物和可以用嵌段共聚物包封的生理活性物质。 通过亲水性聚乙二醇化合物与pH敏感的可生物降解的聚(氨基酸)化合物的聚合获得pH敏感性嵌段共聚物。 因此,pH敏感性嵌段共聚物由于其两亲性和离子化特性而根据pH变化而形成胶束结构,因此可以根据体内的pH变化用作靶向药物递送的药物载体。