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1. 发明授权

US09808557B2 Tubular silk compositions and methods of use thereof 有权
公开(公告)号：US09808557B2
公开(公告)日：2017-11-07
申请号：US12672521
申请日：2008-08-11
申请人： Michael L. Lovett , Xianyan Wang , Christopher M. Cannizzaro , Gordana Vunjak-Novakovic , David L. Kaplan
发明人： Michael L. Lovett , Xianyan Wang , Christopher M. Cannizzaro , Gordana Vunjak-Novakovic , David L. Kaplan
IPC分类号： A61F2/06 , A61L27/36 , A61L27/22 , A61F2/08 , A61L27/26 , A61F2/07 , A61F2/82
CPC分类号： A61L27/227 , A61F2/07 , A61F2/08 , A61F2/82 , A61L27/26 , A61L27/3604 , D10B2211/22 , Y10T428/13 , C08L89/00
摘要： Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily be made in a range of inner diameters, can be derivatized with functional moieties, and can be produced in a range of permeabilities suitable for particularized uses. In one aspect, the tubular compositions can be used in the repair or replacement of damaged or diseased blood vessels, including, but not limited to vessels smaller than about 6 mm.

2. 发明申请

US20120123519A1 TUBULAR SILK COMPOSITIONS AND METHODS OF USE THEREOF 有权
标题翻译：管状丝素组合物及其使用方法
公开(公告)号：US20120123519A1
公开(公告)日：2012-05-17
申请号：US12672521
申请日：2008-08-11
申请人： Michael L. Lovett , Xianyan Wang , Christopher M. Cannizzaro , Gordana Vunjak-Novakovic , David L. Kaplan
发明人： Michael L. Lovett , Xianyan Wang , Christopher M. Cannizzaro , Gordana Vunjak-Novakovic , David L. Kaplan
IPC分类号： A61F2/82 , B29C41/14 , B32B1/08
CPC分类号： A61L27/227 , A61F2/07 , A61F2/08 , A61F2/82 , A61L27/26 , A61L27/3604 , D10B2211/22 , Y10T428/13 , C08L89/00
摘要： Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily be made in a range of inner diameters, can be derivatized with functional moieties, and can be produced in a range of permeabilities suitable for particularized uses. In one aspect, the tubular compositions can be used in the repair or replacement of damaged or diseased blood vessels, including, but not limited to vessels smaller than about 6 mm.
摘要翻译：描述的是管状丝素蛋白组合物及其制造和使用的方法。如本文所述的管状组合物可以在高爆裂强度的范围内制备，可以容易地在内径范围内制备，可以用官能部分衍生化，并且可以在适合于特定用途的渗透性范围内制备。在一个方面，管状组合物可用于修复或更换受损或患病的血管，包括但不限于小于约6mm的血管。

3. 发明申请

US20110076384A1 SYSTEM AND METHOD FOR MAKING BIOMATERIAL STRUCTURES 有权
标题翻译：制备生物体结构的系统和方法
公开(公告)号：US20110076384A1
公开(公告)日：2011-03-31
申请号：US12934666
申请日：2009-04-08
申请人： Christopher Cannizzaro , Michael L. Lovett , Gordana Vunjak-Novakovic , David L. Kaplan
发明人： Christopher Cannizzaro , Michael L. Lovett , Gordana Vunjak-Novakovic , David L. Kaplan
IPC分类号： B05C11/00 , A61L33/00
CPC分类号： D01F4/02 , D01D5/04 , D01D5/06 , D01D5/18 , D01D7/00
摘要： A system and method for making a biomaterial device includes a support structure providing a shape for a biomaterial device. At least one applicator has a supply of biomaterial solution and is positioned along the support structure. The at least one applicator forms a biomaterial fiber by applying shear force to the biomaterial solution and delivering the biomaterial fiber to the support structure. A controller causes relative movement between the support structure and the at least one applicator, and the biomaterial fiber is arranged on the support structure according to the relative movement to form the biomaterial device. The biomaterial may be silk fibroin which may be wound onto a reciprocating and rotating mandrel. Control over the properties of the biomaterial device is achieved through appropriate selection of material processing, winding strategy, and post-winding processing.
摘要翻译：用于制造生物材料装置的系统和方法包括为生物材料装置提供形状的支撑结构。至少一个施用器具有生物材料溶液的供应并且沿着支撑结构定位。所述至少一个施用器通过向所述生物材料溶液施加剪切力并将所述生物材料纤维递送到所述支撑结构来形成生物材料纤维。控制器引起支撑结构和至少一个施加器之间的相对运动，并且根据相对运动将生物材料纤维布置在支撑结构上以形成生物材料装置。生物材料可以是可以卷绕到往复和旋转的心轴上的丝素蛋白。通过适当选择材料加工，卷绕策略和后卷绕处理，可以控制生物材料装置的性能。

4. 发明授权

US09068282B2 System and method for making biomaterial structures 有权
标题翻译：制造生物材料结构的系统和方法
公开(公告)号：US09068282B2
公开(公告)日：2015-06-30
申请号：US12934666
申请日：2009-04-08
申请人： Christopher Cannizzaro , Michael L. Lovett , Gordana Vunjak-Novakovic , David L. Kaplan
发明人： Christopher Cannizzaro , Michael L. Lovett , Gordana Vunjak-Novakovic , David L. Kaplan
IPC分类号： D01D10/00 , D01F4/02 , D01D5/06 , D01D5/18 , D01D7/00 , D01D5/04
CPC分类号： D01F4/02 , D01D5/04 , D01D5/06 , D01D5/18 , D01D7/00
摘要： A system and method for making a biomaterial device includes a support structure providing a shape for a biomaterial device. At least one applicator has a supply of biomaterial solution and is positioned along the support structure. The at least one applicator forms a biomaterial fiber by applying shear force to the biomaterial solution and delivering the biomaterial fiber to the support structure. A controller causes relative movement between the support structure and the at least one applicator, and the biomaterial fiber is arranged on the support structure according to the relative movement to form the biomaterial device. The biomaterial may be silk fibroin which may be wound onto a reciprocating and rotating mandrel. Control over the properties of the biomaterial device is achieved through appropriate selection of material processing, winding strategy, and post-winding processing.
摘要翻译：用于制造生物材料装置的系统和方法包括为生物材料装置提供形状的支撑结构。至少一个施用器具有生物材料溶液的供应并且沿着支撑结构定位。所述至少一个施用器通过向所述生物材料溶液施加剪切力并将所述生物材料纤维递送到所述支撑结构来形成生物材料纤维。控制器引起支撑结构和至少一个施加器之间的相对运动，并且根据相对运动将生物材料纤维布置在支撑结构上以形成生物材料装置。生物材料可以是可以卷绕到往复和旋转的心轴上的丝素蛋白。通过适当选择材料加工，卷绕策略和后卷绕处理，可以控制生物材料装置的性能。

5. 发明授权

US07842780B2 Silk fibroin materials and use thereof 有权
标题翻译：丝素蛋白材料及其用途
公开(公告)号：US07842780B2
公开(公告)日：2010-11-30
申请号：US10541182
申请日：2004-01-07
申请人： David L. Kaplan , Rina Nazarov , Gordana Vunjak-Novakovic , Lorenz Meinel
发明人： David L. Kaplan , Rina Nazarov , Gordana Vunjak-Novakovic , Lorenz Meinel
IPC分类号： A23J7/00 , A61K38/08 , A61K38/39 , C07K7/06 , C07K7/08
CPC分类号： A61K38/1825 , A61K38/1841 , A61K47/42 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/56 , D01D5/00 , D01F4/02 , Y10T428/29 , C08L89/00
摘要： The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
摘要翻译：本发明提供生产多孔丝素蛋白支架材料的方法。多孔丝素蛋白支架可用于组织工程。可以调节本文所述的丝素蛋白支架的孔隙率以模拟在天然组织中发现的密度梯度。因此，用于三维组织工程的方法，例如，还提供使用丝素蛋白骨架材料的骨和软骨。

6. 发明申请

US20140094410A1 SILK FIBROIN MATERIALS AND USE THEREOF 有权
标题翻译：丝绸纤维材料及其用途
公开(公告)号：US20140094410A1
公开(公告)日：2014-04-03
申请号：US13680570
申请日：2012-11-19
申请人： David L. Kaplan , Rina Nazarov , Gordana Vunjak-Novakovic , Lorenz Meinel
发明人： David L. Kaplan , Rina Nazarov , Gordana Vunjak-Novakovic , Lorenz Meinel
IPC分类号： A61K47/42 , A61K38/18
CPC分类号： A61K38/1825 , A61K38/1841 , A61K47/42 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/56 , D01D5/00 , D01F4/02 , Y10T428/29 , C08L89/00
摘要： The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
摘要翻译：本发明提供生产多孔丝素蛋白支架材料的方法。多孔丝素蛋白支架可用于组织工程。可以调节本文所述的丝素蛋白支架的孔隙率以模拟在天然组织中发现的密度梯度。因此，用于三维组织工程的方法，例如，还提供使用丝素蛋白骨架材料的骨和软骨。

7. 发明授权

US08361617B2 Silk fibroin materials and use thereof 有权
标题翻译：丝素蛋白材料及其用途
公开(公告)号：US08361617B2
公开(公告)日：2013-01-29
申请号：US12836692
申请日：2010-07-15
申请人： David L. Kaplan , Rina Nazarov , Gordana Vunjak-Novakovic , Lorenz Meinel
发明人： David L. Kaplan , Rina Nazarov , Gordana Vunjak-Novakovic , Lorenz Meinel
IPC分类号： B32B9/02 , A23J7/00 , A61K38/08 , A61K38/39
CPC分类号： A61K38/1825 , A61K38/1841 , A61K47/42 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/56 , D01D5/00 , D01F4/02 , Y10T428/29 , C08L89/00
摘要： The present application provides a composition comprising porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffold described herein can be adjusted to mimic the gradient of densities found in natural tissue.
摘要翻译：本申请提供了包含多孔丝素蛋白支架材料的组合物。多孔丝素蛋白支架可用于组织工程。可以调节本文所述的丝素蛋白支架的孔隙率，以模拟在天然组织中发现的密度梯度。

8. 发明申请

US20100279112A1 SILK FIBROIN MATERIALS AND USE THEREOF 有权
标题翻译：丝绸纤维材料及其用途
公开(公告)号：US20100279112A1
公开(公告)日：2010-11-04
申请号：US12836692
申请日：2010-07-15
申请人： David L. Kaplan , Rina Nazarov , Gordana Vunjak-Novakovic , Lorenz Meinel
发明人： David L. Kaplan , Rina Nazarov , Gordana Vunjak-Novakovic , Lorenz Meinel
IPC分类号： B32B9/02
CPC分类号： A61K38/1825 , A61K38/1841 , A61K47/42 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/56 , D01D5/00 , D01F4/02 , Y10T428/29 , C08L89/00
摘要： The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
摘要翻译：本发明提供生产多孔丝素蛋白支架材料的方法。多孔丝素蛋白支架可用于组织工程。可以调节本文所述的丝素蛋白支架的孔隙率以模拟在天然组织中发现的密度梯度。因此，用于三维组织工程的方法，例如，还提供使用丝素蛋白骨架材料的骨和软骨。

9. 发明授权

US09290579B2 Covalently immobilized protein gradients in three-dimensional porous scaffolds 有权
标题翻译：在三维多孔支架中共价固定的蛋白质梯度
公开(公告)号：US09290579B2
公开(公告)日：2016-03-22
申请号：US11407373
申请日：2006-04-19
申请人： Charu Vepari , David L. Kaplan , Gordana Vunjak-Novakovic
发明人： Charu Vepari , David L. Kaplan , Gordana Vunjak-Novakovic
IPC分类号： C07K17/02 , C12N11/02 , C07K17/04 , C12N11/04 , C12N11/06 , C12N11/10
CPC分类号： C07K17/02 , C07K17/04 , C12N11/02 , C12N11/04 , C12N11/06 , C12N11/10
摘要： The invention provides a method for forming an immobilized agent gradient within a 3-dimensional porous scaffold. A 3-dimensional scaffold formed from a biocompatible material is provided. The surface of the scaffold and/or the agent is activated so as to allow binding of the agent to the scaffold. The activated scaffold is contacted with a solution containing the agent. Contact with the solution is maintained for a sufficient period of time to allow diffusion of the solution through a portion of the scaffold, thereby forming a desired gradient of the agent through the 3-dimensional scaffold.
摘要翻译：本发明提供了在三维多孔支架内形成固定化剂梯度的方法。提供由生物相容性材料形成的3维支架。支架和/或试剂的表面被活化，以允许试剂与支架结合。活化的支架与含有该试剂的溶液接触。保持与溶液接触足够的时间以允许溶液扩散通过支架的一部分，从而通过3维支架形成所需试剂的梯度。

10. 发明申请

US20080274157A1 Cartilage implant plug with fibrin glue and method for implantation 审中-公开
标题翻译：具有纤维蛋白胶的软骨植入物塞和植入方法
公开(公告)号：US20080274157A1
公开(公告)日：2008-11-06
申请号：US12079629
申请日：2008-03-26
申请人： Gordana Vunjak-Novakovic , Katherine G. Truncale , Moon Hae Sunwoo , Arthur A. Gertzman
发明人： Gordana Vunjak-Novakovic , Katherine G. Truncale , Moon Hae Sunwoo , Arthur A. Gertzman
IPC分类号： A61K35/32 , A61F2/00 , A61P19/00
CPC分类号： A61K35/32 , A61B17/00491 , A61F2/30744 , A61F2/30756 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/2867 , A61F2002/30062 , A61F2002/30224 , A61F2002/30225 , A61F2002/30759 , A61F2210/0004 , A61F2230/0069 , A61F2310/00365 , A61F2310/00383 , A61K38/00 , A61K38/363 , A61K38/4833 , A61L24/0005 , A61L24/0015 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/3687 , A61L27/38 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/43 , A61L2300/64 , A61L2430/06 , A61K2300/00
摘要： The invention is directed toward a cartilage repair assembly comprising a shaped structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that said shaped bone and cartilage cap when centered in the bore does not engage the side wall of the bore and is positioned from the side wall of the bone a distance ranging from 10 microns to 1000 microns and is surrounded by milled cartilage and a fibrin thrombin glue. A method for inserting the assembly into a cartilage defect area is disclosed.
摘要翻译：本发明涉及一种软骨修复组件，其包括具有整体上覆软骨帽的软骨下骨的成形结构，其被处理以除去生物可吸收载体中的细胞碎片和蛋白聚糖和研磨的软骨。该成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得当在孔中心定位时所述成形的骨和软骨帽不接合孔的侧壁并且从骨的侧壁定位一定距离范围从10微米到1000微米，被碾磨的软骨和纤维蛋白凝血酶胶包围。公开了一种将组件插入软骨缺损区域的方法。

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