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1. 发明授权

US06615075B2 QRST subtraction using an adaptive template for analysis of TU wave obscured atrial activity 有权
标题翻译： QRST减法使用自适应模板分析T波波模糊心房活动
公开(公告)号：US06615075B2
公开(公告)日：2003-09-02
申请号：US09809719
申请日：2001-03-14
申请人： Michael D. Mlynash , Arne Sippens Groenewegen , Michael D. Lesh
发明人： Michael D. Mlynash , Arne Sippens Groenewegen , Michael D. Lesh
IPC分类号： A61B50452
CPC分类号： A61B5/061 , A61B5/04085 , A61B5/04525 , A61B5/6831 , A61B5/7232 , A61B5/7264
摘要： The present invention provides a noninvasive localization, characterization and classification apparatus and method for cardiac arrhythmias. The invention enables discrete isolation of the intricate spatial and temporal detail in morphology of the atrial activity of interest from superimposed ventricular activity of a preceding heartbeat in a particular arrhythmia. An adaptive QRST subtraction template is used that is modulated for discrepancies in voltage and rate between the QRST template and arrhythmia signal. The QRST template modulation is accomplished by using one or more fiducial points and windows that are annotated in both the QRST template and the arrhythmia signal. The invention includes, but is not limited to, the isolation of atrial activity that are commonly known as: (1) P waves in case of focal atrial fibrillation, atrial tachycardia, and orthodromic AV reentrant tachycardia; (2) fibrillation waves in case of chronic atrial fibrillation; and (3) flutter waves in case of atrial flutter.
摘要翻译：本发明提供了用于心律失常的非侵入性定位，表征和分类装置和方法。本发明使得在特定心律不齐中的前一心跳的叠加心室活动的兴趣心房活动的形态学上的错综复杂的空间和时间细节的离散分离。使用自适应QRST减法模板，其被调制为QRST模板和心律失常信号之间的电压和速率的差异。 QRST模板调制是通过使用在QRST模板和心律失常信号中注释的一个或多个基准点和窗口来实现的。本发明包括但不限于通常所述的心房活动的分离：（1）在局灶性房颤，心房心动过速和正畸AV折返性心动过速的情况下的P波; （2）慢性心房颤动的原纤维颤动波; 和（3）在心房颤动的情况下的颤动波。

2. 发明申请

US20120035643A1 METHOD OF IMPLANTING AN ADJUSTABLE OCCLUSION DEVICE 有权
标题翻译：将可调节的装置装入的方法
公开(公告)号：US20120035643A1
公开(公告)日：2012-02-09
申请号：US13274380
申请日：2011-10-17
申请人： Alexander K. Khairkhahan , Andrew G.C. Frazier , Alan R. Klenk , Marc S. Kreidler , Stewart M. Kume , Darrell H. Ogi , Chad C. Roue , Erik J. van der Burg , Dino DeCicco , Michael D. Lesh
发明人： Alexander K. Khairkhahan , Andrew G.C. Frazier , Alan R. Klenk , Marc S. Kreidler , Stewart M. Kume , Darrell H. Ogi , Chad C. Roue , Erik J. van der Burg , Dino DeCicco , Michael D. Lesh
IPC分类号： A61M29/00
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B17/122 , A61B2017/00243 , A61B2017/00557 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00619 , A61B2017/00623 , A61B2017/081 , A61B2017/1205 , A61B2017/12095 , A61F2/01 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0071 , A61F2230/008 , A61M25/10 , A61M2025/1054 , A61M2210/125
摘要： Disclosed is an adjustable occlusion device for use in a body lumen such as the left atrial appendage. The occlusion device is removably carried by a deployment catheter. The device may be enlarged or reduced to facilitate optimal placement or removal. Methods are also disclosed.
摘要翻译：公开了一种用于体腔内的可调闭塞装置，例如左心耳。闭塞装置可移除地由展开导管携带。该装置可以被放大或缩小以便于最佳的放置或移除。还公开了方法。

3. 发明授权

US07988726B2 Percutaneous mitral annuloplasty with cardiac rhythm management 有权
标题翻译：经皮二尖瓣成形术与心律管理
公开(公告)号：US07988726B2
公开(公告)日：2011-08-02
申请号：US10715221
申请日：2003-11-17
申请人： Jonathan J. Langberg , Michael D. Lesh
发明人： Jonathan J. Langberg , Michael D. Lesh
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61F2/2466 , A61N2001/0585
摘要： An implantable device is positioned within the coronary sinus and tightened around the mitral annulus to reduce mitral valve regurgitation. The device carries at least one electrode, in electronic communication with a cardiac rhythm management device.
摘要翻译：植入式装置位于冠状窦内并且紧固在二尖瓣环周围以减少二尖瓣反流。该装置携带至少一个与心律管理装置电子通信的电极。

4. 发明申请

US20090221996A1 CIRCUMFERENTIAL ABLATION DEVICE ASSEMBLY 有权
标题翻译：循环消除装置组件
公开(公告)号：US20090221996A1
公开(公告)日：2009-09-03
申请号：US12464473
申请日：2009-05-12
申请人： Michael D. Lesh
发明人： Michael D. Lesh
IPC分类号： A61B18/18 , A61B18/14 , A61B18/04 , A61N7/00
CPC分类号： A61B18/1492 , A61B18/00 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/0016 , A61B2018/00214 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00369 , A61B2018/00375 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2218/002 , A61N7/02
摘要： This invention is a circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein. The assembly includes a circumferential ablation element which is adapted to ablate a circumferential region of tissue along a pulmonary vein wall which circumscribes the pulmonary vein lumen, thereby transecting the electrical conductivity of the pulmonary vein against conduction along its longitudinal axis and into the left atrium. The circumferential ablation element includes an expandable member with a working length that is adjustable from a radially collapsed position to a radially expanded position. An equatorial band circumscribes the outer surface of the working length and is adapted to ablate tissue adjacent thereto when actuated by an ablation actuator. The equatorial band has a length relative to the longitudinal axis of the expandable member that is narrow relative to the working length, and is also substantially shorter than its circumference when the working length is in the radially expanded position. A pattern of insulators may be included over an ablation element which otherwise spans the working length in order to form the equatorial band described. The expandable member is also adapted to conform to the pulmonary vein in the region of its ostium, such as by providing a great deal of radial compliance or by providing a taper along the working length which has a distally reducing outer diameter. A linear ablation element is provided adjacent to the circumferential ablation element in a combination assembly which is adapted for use in a less-invasive “maze”-type procedure in the region of the pulmonary vein ostia in the left ventricle.
摘要翻译：本发明是适于在肺静脉中形成圆周传导阻滞的周缘消融装置组件。该组件包括圆周消融元件，其适于沿着围绕肺静脉管腔的肺静脉壁消融组织的周缘区域，从而横切肺静脉的导电性，以抵抗沿着其纵向轴线并进入左心房的传导。周向消融元件包括可膨胀构件，其具有可从径向收缩位置到径向扩张位置的可调节的工作长度。赤道带包围工作长度的外表面，并且适于在由消融致动器致动时消融邻近的组织。赤道带相对于可扩展构件的纵向轴线具有相对于工作长度窄的长度，并且当工作长度处于径向扩张位置时也比其圆周短得多。绝缘体的图案可以包括在消融元件上，否则将跨越工作长度以形成所描述的赤道带。可膨胀构件还适于在其口部的区域中符合肺静脉，例如通过提供大量径向顺应性或通过沿具有远端减小外径的工作长度提供锥形。在组合组件中邻近周缘消融元件提供线性消融元件，该组合组件适用于在左心室的肺静脉口区域中的侵入性较小的“迷宫”型手术。

5. 发明申请

US20090198331A1 IMPLANTABLE PROSTHESIS WITH OPEN CELL FLOW REGULATION 审中-公开
标题翻译：具有开放细胞流调节的可植入性
公开(公告)号：US20090198331A1
公开(公告)日：2009-08-06
申请号：US12024846
申请日：2008-02-01
申请人： Randy J. Kesten , Michael D. Lesh
发明人： Randy J. Kesten , Michael D. Lesh
IPC分类号： A61F2/12
CPC分类号： A61F2/12
摘要： An implantable prosthesis is provided having a membrane which holds a flowable substance. The membrane is separated into a first chamber and a second chamber with the first and second chambers being fluidly coupled via an orifice. The orifice has a size which may be adjusted by the user after implanting the prosthesis into the patient.
摘要翻译：提供具有保持可流动物质的膜的可植入假体。膜被分离成第一室和第二室，其中第一和第二室通过孔流体耦合。孔口具有在将假体植入病人之后可由使用者调节的尺寸。

6. 发明申请

US20090198328A1 BREAST IMPLANT WITH ADJUSTABLE COMPRESSION RESPONSE 审中-公开
标题翻译：乳房植入物可调节压力响应
公开(公告)号：US20090198328A1
公开(公告)日：2009-08-06
申请号：US12024826
申请日：2008-02-01
申请人： Randy J. Kesten , Michael D. Lesh
发明人： Randy J. Kesten , Michael D. Lesh
IPC分类号： A61F2/12
CPC分类号： A61F2/12
摘要： An implantable prosthesis is provided having a membrane which holds a flowable substance. The membrane is separated into a first chamber and a second chamber with the first and second chambers being fluidly coupled via an orifice. The orifice has a size which may be adjusted by the user after implanting the prosthesis into the patient.
摘要翻译：提供具有保持可流动物质的膜的可植入假体。膜被分离成第一室和第二室，其中第一和第二室通过孔流体耦合。孔口具有在将假体植入病人之后可由使用者调节的尺寸。

7. 发明授权

US07025756B2 Method of securing tissue 有权
标题翻译：固定组织的方法
公开(公告)号：US07025756B2
公开(公告)日：2006-04-11
申请号：US10861691
申请日：2004-06-04
申请人： Andrew G. C. Frazier , Michael D. Lesh , Chad C. Roue , Erik J. van der Burg
发明人： Andrew G. C. Frazier , Michael D. Lesh , Chad C. Roue , Erik J. van der Burg
IPC分类号： A61M31/00
CPC分类号： A61B17/0057 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0644 , A61B17/12122 , A61B2017/00243 , A61B2017/00292 , A61B2017/00575 , A61B2017/00579 , A61B2017/00632 , A61B2017/00668 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0417 , A61B2017/042 , A61B2017/0437 , A61B2017/0445 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0472 , A61B2017/0477 , A61B2017/048 , A61B2017/0488 , A61B2017/0645 , A61B2017/0647 , A61F2/24 , A61F2/2427 , A61F2/2487 , Y10S606/907
摘要： Disclosed is an anastomosis catheter, for achieving a tissue to tissue or synthetic graft to tissue attachment. The catheter includes a plurality of deployable tissue anchors, which may be laterally deployed into surrounding tissue. The anchors may be used to achieve end to end or end to side anastomoses. Methods are also disclosed.
摘要翻译：公开了一种用于实现组织到组织或合成移植物到组织附着的吻合导管。导管包括多个可展开的组织锚，其可以横向地布置到周围组织中。锚可以用于实现端对端或端到端吻合。还公开了方法。

8. 发明授权

US06997925B2 Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall 有权
公开(公告)号：US06997925B2
公开(公告)日：2006-02-14
申请号：US10274729
申请日：2002-10-21
申请人： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
发明人： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/00 , A61B18/08 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/00065 , A61B2018/00101 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/00232 , A61B2018/00238 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00369 , A61B2018/00375 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2018/143 , A61B2018/1432 , A61B2218/002 , A61M25/1002 , A61N7/02
摘要： This invention is related to a tissue ablation system and method that treats atrial arrhythmia by ablating a circumferential region of tissue at a location where a pulmonary vein extends from an atrium. The system includes a circumferential ablation member with an ablation element and also includes a delivery assembly for delivering the ablation member to the location. The circumferential ablation member is generally adjustable between different configurations to allow both the delivery through a delivery sheath into the atrium and the ablative coupling between the ablation element and the circumferential region of tissue.

9. 发明授权

US06855144B2 Tissue ablation device and method of use 有权
公开(公告)号：US06855144B2
公开(公告)日：2005-02-15
申请号：US10233264
申请日：2002-08-30
申请人： Michael D. Lesh
发明人： Michael D. Lesh
IPC分类号： A61B18/12 , A61B17/00 , A61B17/22 , A61B18/14 , A61B18/18
CPC分类号： A61B18/1492 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/0016 , A61B2018/00214 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00369 , A61B2018/00375 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2218/002
摘要： A tissue ablation device creates long linear lesions along a body space wall of an animal, and primarily between adjacent pulmonary vein ostia in a left atrial wall. An ablation element includes first and second ends that are bordered by first and second anchors. The anchors are adapted to secure the ablation element ends at predetermined first and second locations along the body space wall such that the ablation element is adapted to ablate an elongate region of tissue between those locations. The anchors may be guidewire tracking members, each including a bore adapted to receive and track over a guidewire, and may anchor within adjacent pulmonary vein ostia when the engaged guidewires are positioned within the respective veins. Stop members may be provided on the guidewires and may be adapted for positioning the relative anchors or for forcing the anchors to fit snugly within the vein ostia. A conduit passageway through the catheter houses a stiffening stylet which may be advanced into the region of the ablation element in order to impart a shape to that element to conform it to a predetermined region of anatomy, or to stiffen the underlying catheter in order to advance the assembly into remote anatomy.

10. 发明授权

US06810882B2 Transluminal mitral annuloplasty 有权
标题翻译：二尖瓣成形术
公开(公告)号：US06810882B2
公开(公告)日：2004-11-02
申请号：US09909101
申请日：2001-07-19
申请人： Jonathan J. Langberg , Michael D. Lesh , Erik van der Burg
发明人： Jonathan J. Langberg , Michael D. Lesh , Erik van der Burg
IPC分类号： A61B1900
CPC分类号： A61F2/2451 , A61F2/2466
摘要： A mitral annuloplasty and left ventricle restriction device is designed to be transvenously advanced and deployed within the coronary sinus and in some embodiments other coronary veins. The device places tension on adjacent structures, reducing the diameter and/or limiting expansion of the mitral annulus and/or limiting diastolic expansion of the left ventricle. These effects may be beneficial for patients with dilated cardiomyopathy.
摘要翻译：二尖瓣成形术和左心室限制装置被设计成在冠状窦内部和在一些实施例中是其他冠状静脉中经过递送和部署。该装置在相邻结构上施加张力，减小二尖瓣环的直径和/或限制扩张和/或限制左心室的舒张期扩张。这些影响可能对扩张型心肌病患者有益。

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