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1. 发明授权

US5955107A Pharmaceutical suspension tablet compositions 失效
标题翻译：药物悬浮液片剂组合物
公开(公告)号：US5955107A
公开(公告)日：1999-09-21
申请号：US989787
申请日：1997-12-12
申请人： Michael Augello , Sheila M. Dell , George A. Agyilirah , George E. Reier
发明人： Michael Augello , Sheila M. Dell , George A. Agyilirah , George E. Reier
IPC分类号： A61K9/00 , A61K9/20
CPC分类号： A61K9/0095 , A61K9/0056
摘要： Rapidly disintegrating and readily suspendible tablets and their method of preparation are disclosed in which there is a therapeutic amount of a pharmacologically active ingredient, 1 to 6 percent croscarmellose sodium, 10 to 50 percent microcrystalline cellulose, and 10 to 50 percent of a coprocessed additive consisting essentially of 75 to 95 percent microcrystalline cellulose and 5 to 25 percent calcium, sodium alginate complex. The tablets are suitable for oral administration of measured-dose suspensions of either water soluble or water insoluble pharmaceuticals.
摘要翻译：公开了快速崩解和容易悬浮的片剂及其制备方法，其中存在治疗量的药理活性成分，1至6％交联羧甲基纤维素钠，10至50％微晶纤维素和10至50％的协同加工添加剂，基本上为75至95％的微晶纤维素和5至25％的钙，藻酸钠复合物。片剂适合于口服施用水溶性或水不溶性药物的测量剂量悬浮液。

2. 发明授权

US6099865A Croscarmellose taste masking 失效
标题翻译：交联巧克力味掩味
公开(公告)号：US6099865A
公开(公告)日：2000-08-08
申请号：US330445
申请日：1999-06-11
申请人： Michael Augello , Sheila M. Dell , George E. Reier , Howard J. Stamato , Lynn M. DiMemmo
发明人： Michael Augello , Sheila M. Dell , George E. Reier , Howard J. Stamato , Lynn M. DiMemmo
IPC分类号： A61K9/00 , A61K9/16 , A61K9/20 , A61K9/50 , A61K9/62
CPC分类号： A61K9/1652 , A61K9/0056 , A61K9/5047 , A61K9/2054 , A61K9/2077 , A61K9/2081
摘要： The present invention describes the use of croscarmellose sodium to coat bitter-tasting active agents in a manner that will mask the bitter taste of these materials, taste masked pharmaceutical compositions in which the particles of pharmaceutically active agent are coated with croscarmellose sodium, taste masked pharmaceutical tablets made therefrom, in which the rapid disintegration of tablets that is imparted by croscarmellose sodium is preserved, and to a method for preparing such coated particles by preparing them in a fluidized bed coating process.
摘要翻译：本发明描述了使用交联羧甲基纤维素钠以掩蔽这些材料的苦味的方式涂上苦味活性剂，其中药物活性剂颗粒用交联羧甲纤维素钠涂覆的掩味药物组合物，掩味药剂由其制备的片剂，其中保存了由交联羧甲基纤维素钠赋予的片剂的快速崩解，以及通过在流化床包衣方法中制备这些包衣颗粒的方法。

3. 发明授权

US5985323A Microcrystalline cellulose/alginate wet granulation excipient/binder 失效
标题翻译：微晶纤维素/藻酸盐湿法造粒赋形剂/粘合剂
公开(公告)号：US5985323A
公开(公告)日：1999-11-16
申请号：US46359
申请日：1998-03-23
申请人： Michael Augello , George E. Reier
发明人： Michael Augello , George E. Reier
IPC分类号： A61K9/16 , A61K9/20
CPC分类号： A61K9/205 , A61K9/1652 , A61K9/2054
摘要： The present invention discloses an improved excipient composition for use as an excipient/binder for wet granulation of pharmaceuticals, a process for preparing the excipient composition, its use in granular pharmaceutical compositions, and compressed pharmaceutical tablets made from the granular pharmaceutical compositions. The excipient composition comprises a dried aqueous slurry of microcrystalline cellulose wetcake and a low viscosity alginate.
摘要翻译：本发明公开了一种用作药物湿法制粒的赋形剂/粘合剂的改进的赋形剂组合物，制备赋形剂组合物的方法，其在粒状药物组合物中的用途，以及由颗粒状药物组合物制成的压缩药片。赋形剂组合物包含微晶纤维素湿饼和低粘度藻酸盐的干燥水性浆液。

4. 发明授权

US5747067A Co-processed products 失效
标题翻译：加工产品
公开(公告)号：US5747067A
公开(公告)日：1998-05-05
申请号：US761582
申请日：1996-12-06
申请人： Michael Auguello , Thomas A. Ruszkay , George E. Reier
发明人： Michael Auguello , Thomas A. Ruszkay , George E. Reier
IPC分类号： A61K9/20 , A61K9/14 , A61K9/26 , A61K33/10
CPC分类号： A61K9/2009 , A61K9/2054
摘要： Particulate pharmaceutical tablet excipient compositions comprising co-processed microcrystalline cellulose and particulate USP calcium carbonate having a particle size distribution of 7 to 22 .mu.m wherein the range of calcium carbonate to microcrystalline cellulose is 70:30 to 90:10.
摘要翻译：包含协同处理的微晶纤维素和粒径分布为7至22μm的颗粒状USP碳酸钙的颗粒状药物片剂赋形剂组合物，其中碳酸钙至微晶纤维素的范围为70:30至90:10。

5. 发明授权

US4756911A Controlled release formulation 失效
标题翻译：控释制剂
公开(公告)号：US4756911A
公开(公告)日：1988-07-12
申请号：US852681
申请日：1986-04-16
申请人： Joseph D. Drost , George E. Reier , Nemichand B. Jain
发明人： Joseph D. Drost , George E. Reier , Nemichand B. Jain
IPC分类号： A61K9/20 , A61K9/22 , A61K9/28
CPC分类号： A61K9/2866 , A61K9/2054
摘要： A controlled release pharmaceutical formulation which undergoes substantially or approaches zero order release of active drug is provided, preferably in the form of a coated tablet, containing a core portion from which medicament, such as procainamide hydrochloride, is slowly released over a controlled length of time. The core also includes one or more primary hydrocolloid gelling agents which is a hydropropylmethyl cellulose having a viscosity of within the range of from about 1,000 to about 6,000 centipoises in 2% solution at 20.degree. C., and a methoxyl content of 28-30%, optionally a secondary hydrocarbon gelling agent, such as hydroxypropyl cellulose and/or methyl cellulose, one or more non-swellable binders and/or wax binders (where the medicament and/or hydrocolloid gelling agents are non-compressible), one or more inert fillers or excipients, one or more lubricants, and optionally one or more anti-adherents such as silicon dioxide and water. The above-described core is coated with a pharmaceutical coating composition containing a hydrophobic polymer and a hydrophilic polymer.
摘要翻译：提供基本上或接近零级释放活性药物的控释药物制剂，优选为包衣芯片形式的包衣片剂形式，其中药物如盐酸普鲁卡因酰胺在受控的时间内缓慢释放。核心还包括一种或多种主要的水胶体胶凝剂，其是在20℃在2％溶液中具有约1,000至约6,000厘泊的粘度的羟丙基甲基纤维素，以及甲氧基含量为28-30％，任选的第二烃胶凝剂，例如羟丙基纤维素和/或甲基纤维素，一种或多种不溶胀粘合剂和/或蜡粘合剂（其中药物和/或水胶体胶凝剂是不可压缩的），一种或多种惰性填充剂或赋形剂，一种或多种润滑剂，以及任选的一种或多种抗粘附剂，例如二氧化硅和水。上述核心涂覆有含有疏水性聚合物和亲水性聚合物的药物涂料组合物。

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