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1. 发明授权

US07629467B2 Diphenyl substituted cycloalkanes, compositions containing such compounds and methods of use 失效
标题翻译：二苯基取代的环烷烃，含这些化合物的组合物和使用方法
公开(公告)号：US07629467B2
公开(公告)日：2009-12-08
申请号：US10565604
申请日：2004-07-20
申请人： Lin Chu , Mark T. Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John H. Hutchinson
发明人： Lin Chu , Mark T. Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John H. Hutchinson
IPC分类号： C07D215/06 , C07D215/12 , C07D215/16 , A61K31/4375
CPC分类号： C07D215/14 , C07D215/12 , C07D237/28 , C07D277/64 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/02
摘要： The instant invention provides compounds of formula: (I) which are 5-lipoxygenase activating protein inhibitors: formula (I). Compounds of formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cyto-protective agents.
摘要翻译：本发明提供了式（I）化合物，其为5-脂氧合酶活化蛋白抑制剂：式（I）。式（I）化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。

2. 发明申请

US20100152185A1 DIPHENYL SUBSTITUTED CYCLOALKANES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：二苯基取代的环己烷，包含这些化合物的组合物和使用方法
公开(公告)号：US20100152185A1
公开(公告)日：2010-06-17
申请号：US12632286
申请日：2009-12-07
申请人： Lin Chu , Mark T. Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight MacDonald , John H. Hutchinson
发明人： Lin Chu , Mark T. Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight MacDonald , John H. Hutchinson
IPC分类号： A61K31/4709 , C07D215/14 , C07D401/12 , C07D413/12 , C07D417/12 , C07D277/64 , A61K31/47 , A61K31/5377 , A61K31/4439 , A61K31/428
CPC分类号： C07D215/14 , C07D215/12 , C07D237/28 , C07D277/64 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/02
摘要： The instant invention provides compounds of formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译：本发明提供了作为5-脂氧合酶活化蛋白抑制剂的式I化合物。式I的化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。

3. 发明申请

US20060211677A1 Diphenyl substituted cycloalkanes, compositions containing such compounds and methods of use 失效
公开(公告)号：US20060211677A1
公开(公告)日：2006-09-21
申请号：US10565604
申请日：2004-07-20
申请人： Lin Chu , Mark Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John Hutchinson
发明人： Lin Chu , Mark Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John Hutchinson
IPC分类号： C07D471/02 , C07D215/12 , C07D237/28 , A61K31/50 , A61K31/4965 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/4164 , A61K31/4745 , A61K31/433 , A61K31/4245
CPC分类号： C07D215/14 , C07D215/12 , C07D237/28 , C07D277/64 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/02
摘要： The instant invention provides compounds of formula: (I) which are 5-lipoxygenase activating protein inhibitors: formula (I). Compounds of formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cyto-protective agents.

4. 发明申请

US20070105914A1 Substituted sulfonamides 审中-公开
标题翻译：取代磺酰胺
公开(公告)号：US20070105914A1
公开(公告)日：2007-05-10
申请号：US10571842
申请日：2004-09-14
申请人： Helen Armstrong , Linda Chang , Ravindra Guthikonda , William Hagmann , Linus Lin , Shrenik Shah
发明人： Helen Armstrong , Linda Chang , Ravindra Guthikonda , William Hagmann , Linus Lin , Shrenik Shah
IPC分类号： A61K31/44 , A61K31/277 , A61K31/18
CPC分类号： C07C311/06 , A61K31/18 , A61K31/277 , A61K31/44 , C07C311/03 , C07C311/13 , C07C311/16 , C07C311/17 , C07C311/19 , C07C311/29 , C07D209/08
摘要： The substituted sulfonamides of the invention are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
摘要翻译：本发明的取代磺酰胺是大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，可用于治疗，预防和抑制由CB1受体介导的疾病。本发明的化合物可用作治疗精神病，记忆缺陷，认知障碍，偏头痛，神经病，包括多发性硬化和神经 - 巴利综合征的神经炎症性疾病以及病毒性脑炎的炎症性后遗症，脑血管事故和头部创伤，焦虑症，压力，癫痫，帕金森病，运动障碍和精神分裂症。该化合物还可用于治疗药物滥用障碍，治疗肥胖或进食障碍，以及治疗哮喘，便秘，慢性肠假性梗阻和肝硬化。

5. 发明授权

US6090841A Substituted pyrrole derivatives as cell adhesion inhibitors 失效
标题翻译：取代的吡咯衍生物作为细胞粘附抑制剂
公开(公告)号：US6090841A
公开(公告)日：2000-07-18
申请号：US189008
申请日：1998-11-09
申请人： Linda Chang , Malcolm MacCoss , William K. Hagmann
发明人： Linda Chang , Malcolm MacCoss , William K. Hagmann
IPC分类号： C07D207/34 , A01N43/36 , C07D207/32 , C07F9/32
CPC分类号： C07D207/34
摘要： Substituted pyrrole derivatives of Formula I are antagonists of VLA-4 and/or .alpha..sub.4 .beta..sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.
摘要翻译：式I的取代的吡咯衍生物是VLA-4和/或α4β7的拮抗剂，因此可用于抑制或预防细胞粘附和细胞粘附介导的病理学。这些化合物可以配制成药物组合物，并且适用于治疗哮喘，过敏，炎症，多发性硬化以及其它炎性和自身免疫性疾病。

6. 发明申请

US20050234061A1 Substituted amides 审中-公开
公开(公告)号：US20050234061A1
公开(公告)日：2005-10-20
申请号：US11109076
申请日：2005-04-19
申请人： William Hagmann , Linus Lin , Shrenik Shah , Ravindra Guthikonda , Hongbo Qi , Linda Chang , Ping Liu , Helen Armstrong , James Jewell , Thomas Lanza
发明人： William Hagmann , Linus Lin , Shrenik Shah , Ravindra Guthikonda , Hongbo Qi , Linda Chang , Ping Liu , Helen Armstrong , James Jewell , Thomas Lanza
IPC分类号： A61K31/165 , A61K31/27 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/405 , A61K31/415 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4402 , A61K31/4409 , A61K31/4436 , A61K31/445 , A61K31/4453 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/5377 , A61K31/553 , A61P1/04 , A61P1/10 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/24 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/10 , A61P17/00 , A61P19/02 , A61P19/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , C07C233/12 , C07C233/13 , C07C235/06 , C07C235/18 , C07C235/20 , C07C235/34 , C07C235/74 , C07C235/78 , C07C237/06 , C07C255/55 , C07C255/60 , C07C271/14 , C07C271/22 , C07C275/30 , C07C311/03 , C07C323/41 , C07D207/27 , C07D209/08 , C07D209/34 , C07D209/52 , C07D209/94 , C07D211/34 , C07D213/36 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/89 , C07D215/06 , C07D231/12 , C07D233/36 , C07D233/70 , C07D233/80 , C07D237/14 , C07D237/28 , C07D237/32 , C07D239/34 , C07D249/04 , C07D249/08 , C07D249/12 , C07D249/18 , C07D261/08 , C07D261/20 , C07D263/58 , C07D267/14 , C07D277/20 , C07D277/30 , C07D277/36 , C07D277/64 , C07D277/74 , C07D295/12 , C07D295/13 , C07D295/14 , C07D295/15 , C07D401/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D513/04 , C07D521/00 , A61K31/502 , A61K31/401
CPC分类号： C07D213/64 , C07C233/13 , C07C235/06 , C07C235/20 , C07C235/34 , C07C235/74 , C07C235/78 , C07C237/06 , C07C255/55 , C07C255/60 , C07C271/14 , C07C271/22 , C07C275/30 , C07C311/03 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D209/34 , C07D209/94 , C07D211/34 , C07D213/65 , C07D213/68 , C07D215/06 , C07D231/12 , C07D233/56 , C07D233/70 , C07D237/28 , C07D237/32 , C07D239/34 , C07D249/04 , C07D249/08 , C07D249/12 , C07D263/58 , C07D267/14 , C07D277/30 , C07D277/36 , C07D295/13 , C07D295/15 , C07D513/04
摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.

7. 发明授权

US06271252B1 Cyclic amino acid derivatives as cell adhesion inhibitors 失效
标题翻译：环状氨基酸衍生物作为细胞粘附抑制剂
公开(公告)号：US06271252B1
公开(公告)日：2001-08-07
申请号：US09554989
申请日：2000-05-23
申请人： Linda Chang , William K. Hagmann , Malcolm MacCoss
发明人： Linda Chang , William K. Hagmann , Malcolm MacCoss
IPC分类号： A61K31401
CPC分类号： C07D493/08 , C07C311/19 , C07C311/20 , C07C2601/14 , C07D207/16
摘要： Cyclic amino acid derivatives of Formula I are antagonists of VLA-4 and/or &agr;4&bgr;7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.
摘要翻译：式I的环状氨基酸衍生物是VLA-4和/或α4β7的拮抗剂，因此可用于抑制或预防细胞粘附和细胞粘附介导的病理学。这些化合物可以配制成药物组合物，并且适用于治疗哮喘，过敏，炎症，多发性硬化以及其它炎性和自身免疫性疾病。

8. 发明授权

US06195409B1 Automatic scan prescription for tomographic imaging 有权
标题翻译：自动扫描处方用于断层成像
公开(公告)号：US06195409B1
公开(公告)日：2001-02-27
申请号：US09272436
申请日：1999-03-19
申请人： Linda Chang , Thomas M. Ernst , Laurent Itti
发明人： Linda Chang , Thomas M. Ernst , Laurent Itti
IPC分类号： A61B603
CPC分类号： A61B6/032 , A61B5/055 , A61B6/545 , G06F19/00 , Y10S378/901
摘要： The system and method for automatic scan prescription involves initially performing at least one localizer scan for the object being imaged. The localizer images are analyzed to extract important structural information about the object of interest, and of subobjects of interest, yielding an abstract, schematic description of the object of interest. Optimal spatial locations and scanning parameters are then determined for subsequent scans from the information about the object, possible subobjects, and their relationship to a template. The locations for a particular scan included in a set of protocols selected by the operator are then communicated to the scanner in order to automatically drive the scanner. In a presently preferred embodiment, all of the analysis, matching, and scan prescription operations are preferably carried out by a microprocessor based microcomputer. Subsequent detailed and radiologically relevant scans can then be performed using optimal scanning parameters for the patient.
摘要翻译：用于自动扫描处方的系统和方法包括最初对被成像对象执行至少一个定位器扫描。分析定位器图像以提取关于感兴趣对象的重要结构信息以及感兴趣的子对象，从而产生一个抽象的，关注对象的示意图。然后，从关于对象的信息，可能的子对象以及它们与模板的关系确定随后的扫描的最佳空间位置和扫描参数。包括在由操作员选择的一组协议中的特定扫描的位置然后被传送到扫描仪，以便自动驱动扫描仪。在目前的优选实施例中，所有分析，匹配和扫描处方操作优选地由基于微处理器的微计算机执行。然后可以使用用于患者的最佳扫描参数来执行随后的详细和放射学相关的扫描。

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