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1. 发明申请

US20050136087A1 Stabilized formulation of ivermectin feed premix with an extended shelf life and method of making the same 有权
标题翻译：稳定的伊维菌素饲料预混物的制剂具有延长的保质期和制备它的方法
公开(公告)号：US20050136087A1
公开(公告)日：2005-06-23
申请号：US10790489
申请日：2004-03-01
申请人： Keith Freehauf
发明人： Keith Freehauf
IPC分类号： A01N25/00 , A01N25/02 , A01N25/08 , A01N25/12 , A01N37/02 , A01N43/04 , A23K1/00 , A23K1/14 , A23K1/16 , A23K1/165 , A23K1/17 , A23K1/18 , A61K47/00
CPC分类号： A23K50/30 , A23K20/121 , A23K50/20
摘要： The invention relates to a stabilized premix feed or feed-like formulation that has an extended shelf life due to a decrease of the degradates of the active ingredient by controlling the amount of an already existing stabilizer in the formulation. The feed premix is used in the treatment or prophylaxis of parasites in mammals, in particular swine and horses. The invention further relates to a method to extend the shelf life of a stable premix feed or feed-like formulation for the treatment or prophylaxis of parasite infestation in swine and horses comprising controlling the amount of an already existing antioxidant or stabilizer in the formulation to decrease or to prevent the formation of acid/base catalyzed decomposition of the active ingredient.
摘要翻译：本发明涉及稳定的预混合饲料或饲料状制剂，其通过控制制剂中已经存在的稳定剂的量，由于活性成分的降解而具有延长的保质期。饲料预混物用于治疗或预防哺乳动物，特别是猪和马的寄生虫。本发明还涉及一种延长稳定的预混合饲料或饲料样制剂的保质期的方法，用于治疗或预防猪和马中的寄生虫侵袭，包括控制制剂中已经存在的抗氧化剂或稳定剂的量减少或防止活性成分的酸/碱催化分解的形成。

2. 发明申请

US20130310372A1 PHARMACEUTICAL TRANSDERMAL COMPOSITIONS AND METHOD FOR TREATING INFLAMMATION IN CATTLE 审中-公开
标题翻译：药物过敏组合物和治疗烟草炎症的方法
公开(公告)号：US20130310372A1
公开(公告)日：2013-11-21
申请号：US13950735
申请日：2013-07-25
申请人： Keith Freehauf , Cheyney Meadows , John Gerard Sheehan
发明人： Keith Freehauf , Cheyney Meadows , John Gerard Sheehan
IPC分类号： A61K31/5415 , A61K31/192
CPC分类号： A61K31/5415 , A61K9/0014 , A61K9/08 , A61K31/192 , A61K31/196 , A61K45/06 , A61K47/10 , A61K47/24 , A61K2300/00
摘要： Novel transdermal preparations combining a non-steroidal anti-inflammatory drug (NSAID) selected from groups such as oxicams (for example, meloxicam), propionic acids (for example, ketoprofen) and anthranilic acids (for example, tolfenamic acid), are disclosed. Methods for using and administering such preparation in the treatment of inflammatory conditions in bovines are also disclosed.
摘要翻译：公开了结合非甾体抗炎药（NSAID）的新型透皮制剂，其选自诸如奥昔康胺（例如美洛昔康），丙酸（例如酮洛芬）和邻氨基苯甲酸（例如甲苯威酸）的组。还公开了在牛中治疗炎性病症中使用和施用该制剂的方法。

3. 发明申请

US20050176657A1 Anthelmintic oral homogeneous veterinary pastes 有权
标题翻译：驱虫药口服同类兽药
公开(公告)号：US20050176657A1
公开(公告)日：2005-08-11
申请号：US11107048
申请日：2005-04-15
申请人： Keith Freehauf , Maryam Moaddeb
发明人： Keith Freehauf , Maryam Moaddeb
IPC分类号： A61K9/06 , A61K9/00 , A61K31/498 , A61K31/7048 , A61K47/36 , A61K47/38 , A61K47/44 , A61K31/517
CPC分类号： A61K31/498 , A61K9/0056 , A61K31/7048 , A61K2300/00
摘要： This invention provides for, inter alia, oral homogeneous veterinary pastes for the treating, controlling and preventing of endo- and ectoparasite infections in warm-blooded animals or birds, such as horses and household pets. This invention further provides for a process of preparing these veterinary pastes and for a method for increasing the bioavailability of the anthelmintic agents contained in the paste in the warm-blooded animal or bird. The inventive oral homogeneous anthelmintic pastes comprise a first anthelmintic agent, for example, prazequantel and/or pyrantel, and at least one marcrolide anthelmintic compound, a solvent, which dissolves both the first anthelmintic agent and second the macrolide anthelmintic compound, and a thickening agent. The inventive oral homogeneous pastes achieve a better bioavailability of the two active anthelmintic agents than when the two actives are in suspension and not dissolved
摘要翻译：本发明特别提供了用于治疗，控制和预防温血动物或鸟类如马和家庭宠物中的内寄生虫和外寄生虫感染的口腔同质兽药。本发明进一步提供了制备这些兽用糊剂的方法和用于增加包含在温血动物或鸟类中的糊剂中的驱肠剂的生物利用度的方法。本发明的口腔均匀驱肠药膏包括第一驱肠虫剂，例如赞夸酮和/或吡柔比星，以及至少一种扑灭姜黄素的驱肠虫化合物，溶解第一驱肠虫剂和第二大环内酯类驱虫剂化合物的溶剂，以及增稠剂。与两种活性物质悬浮并不溶解时相比，本发明的口服均质膏实现了两种活性驱肠虫剂的更好的生物利用度

4. 发明申请

US20080027011A1 Homogeneous paste and gel formulations 审中-公开
标题翻译：均匀糊剂和凝胶配方
公开(公告)号：US20080027011A1
公开(公告)日：2008-01-31
申请号：US11713881
申请日：2007-03-05
申请人： Hassan Nached , Keith Freehauf , Peter Hanson
发明人： Hassan Nached , Keith Freehauf , Peter Hanson
IPC分类号： A61K31/341 , A61K31/18 , A61K31/351 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/44 , A61K31/501 , A61K31/7048 , A61K47/02 , A61P31/00
CPC分类号： A61K9/0095 , A61K9/006
摘要： This invention provides for a pharmaceutical or veterinary paste or gel formulation which may comprise an effective amount of a therapeutic agent; optionally an absorbent or a viscosity modifier; optionally a hydrophilic carrier, a colorant, stabilizer, surfactant, or preservative and optionally an antioxidant, solvent, flavoring, buffering system or thickener and methods of preparing these formulations. This invention also provides for, inter alia, oral homogeneous veterinary pastes or gels for the treating, controlling and preventing of endo- and ectoparasite infections in warm-blooded animals, such as birds, horses and household pets.
摘要翻译：本发明提供了可以包含有效量的治疗剂的药物或兽用糊剂或凝胶制剂; 任选的吸收剂或粘度调节剂; 任选的亲水载体，着色剂，稳定剂，表面活性剂或防腐剂以及任选的抗氧化剂，溶剂，调味剂，缓冲体系或增稠剂以及制备这些制剂的方法。本发明还特别提供用于治疗，控制和预防温血动物如鸟，马和家庭宠物中的内寄生虫和外寄生虫感染的口腔同质兽用糊剂或凝胶。

5. 发明授权

US06316481B1 Pharmaceutical composition containing proton pump inhibitors 有权
标题翻译：含有质子泵抑制剂的药物组合物
公开(公告)号：US06316481B1
公开(公告)日：2001-11-13
申请号：US09510312
申请日：2000-02-22
申请人： Keith Freehauf
发明人： Keith Freehauf
IPC分类号： A61K31415
CPC分类号： A61K31/4439 , A61K9/0095 , A61K47/12 , A61K47/14 , A61K47/44
摘要： The present invention is concerned with an oral pharmaceutical formulation containing a proton pump inhibitor (PPI) which is suitable for the treatment of gastric acid related diseases in man and animals. More specifically, the composition is a paste, and is particularly suitable for delivery of a proton pump inhibitor to horses.
摘要翻译：本发明涉及含有质子泵抑制剂（PPI）的口服药物制剂，其适用于治疗人和动物中的胃酸相关疾病。更具体地，组合物是糊状物，特别适用于向马输送质子泵抑制剂。

6. 发明申请

US20110105480A1 PHARMACEUTICAL TRANSDERMAL COMPOSITIONS AND METHOD FOR TREATING INFLAMMATION IN CATTLE 审中-公开
标题翻译：药物过敏组合物和治疗烟草炎症的方法
公开(公告)号：US20110105480A1
公开(公告)日：2011-05-05
申请号：US13000508
申请日：2009-06-23
申请人： Keith Freehauf , Cheyney Meadows , John Gerard Sheehan
发明人： Keith Freehauf , Cheyney Meadows , John Gerard Sheehan
IPC分类号： A61K31/5415 , A61K31/19 , A61K31/195 , A61P29/00
CPC分类号： A61K31/5415 , A61K9/0014 , A61K9/08 , A61K31/192 , A61K31/196 , A61K45/06 , A61K47/10 , A61K47/24 , A61K2300/00
摘要： Novel transdermal preparations combining a non-steroidal anti-inflammatory drug (NSAID) selected from groups such as oxicams (for example, meloxicam), propionic acids (for example, ketoprofen) and anthranilic acids (for example, tolfenamic acid), are disclosed. Methods for using and administering such preparation in the treatment of inflammatory conditions in bovines are also disclosed.
摘要翻译：公开了结合非甾体抗炎药（NSAID）的新型透皮制剂，其选自诸如奥昔康胺（例如美洛昔康），丙酸（例如酮洛芬）和邻氨基苯甲酸（例如甲苯威酸）的组。还公开了在牛中治疗炎性病症中使用和施用该制剂的方法。

7. 发明授权

US07563773B2 Anthelmintic oral homogeneous veterinary pastes 有权
标题翻译：驱虫药口服同类兽药
公开(公告)号：US07563773B2
公开(公告)日：2009-07-21
申请号：US11107048
申请日：2005-04-15
申请人： Keith Freehauf , Maryam Moaddeb
发明人： Keith Freehauf , Maryam Moaddeb
IPC分类号： A01N43/04 , A61K31/70 , A61K31/495
CPC分类号： A61K31/498 , A61K9/0056 , A61K31/7048 , A61K2300/00
摘要： This invention provides for, inter alia, oral homogeneous veterinary pastes for the treating, controlling and preventing of endo- and ectoparasite infections in warm-blooded animals or birds, such as horses and household pets. This invention further provides for a process of preparing these veterinary pastes and for a method for increasing the bioavailability of the anthelmintic agents contained in the paste in the warm-blooded animal or bird. The inventive oral homogeneous anthelmintic pastes comprise a first anthelmintic agent, for example, prazequantel and/or pyrantel, and at least one marcrolide anthelmintic compound, a solvent, which dissolves both the first anthelmintic agent and second the macrolide anthelmintic compound, and a thickening agent. The inventive oral homogeneous pastes achieve a better bioavailability of the two active anthelmintic agents than when the two actives are in suspension and not dissolved
摘要翻译：本发明特别提供了用于治疗，控制和预防温血动物或鸟类如马和家庭宠物中的内寄生虫和外寄生虫感染的口腔同质兽药。本发明进一步提供了制备这些兽用糊剂的方法和用于增加包含在温血动物或鸟类中的糊剂中的驱肠剂的生物利用度的方法。本发明的口腔均匀驱肠药膏包括第一驱肠虫剂，例如赞夸酮和/或吡柔比星，以及至少一种扑灭姜黄素的驱肠虫化合物，溶解第一驱肠虫剂和第二大环内酯类驱虫剂化合物的溶剂，以及增稠剂。与两种活性物质悬浮并不溶解时相比，本发明的口服均质膏实现了两种活性驱肠虫剂的更好的生物利用度

8. 发明申请

US20060205681A1 Homogenous paste formulations 审中-公开
标题翻译：均匀糊剂配方
公开(公告)号：US20060205681A1
公开(公告)日：2006-09-14
申请号：US11314387
申请日：2005-12-20
申请人： Maryam Moaddeb , Keith Freehauf
发明人： Maryam Moaddeb , Keith Freehauf
IPC分类号： A01N43/58 , A01N43/60 , A01N43/04
CPC分类号： A61K47/02 , A61K9/0056 , A61K47/10
摘要： This invention provides for a pharmaceutical or veterinary paste formulation comprising: an effective amount of a therapeutic agent; fumed silica; an absorbent and a viscosity modifier; optionally a hydrophilic carrier and optionally, a colorant, stabilizer, surfactant, or preservative and methods of preparing these formulations. This invention also provides for, inter alia, oral homogeneous veterinary pastes for the treating, controlling and preventing of endo- and ectoparasite infections in warm-blooded animals, such as birds, horses and household pets.
摘要翻译：本发明提供了一种药物或兽用糊剂制剂，其包含：有效量的治疗剂; 气相二氧化硅; 吸收剂和粘度调节剂; 任选的亲水载体和任选的着色剂，稳定剂，表面活性剂或防腐剂以及制备这些制剂的方法。本发明还特别提供用于治疗，控制和预防温血动物如鸟，马和家养宠物中的内寄生虫和外寄生虫感染的口服同类兽药。

9. 发明授权

US07001889B2 Anthelmintic oral homogeneous veterinary pastes 有权
公开(公告)号：US07001889B2
公开(公告)日：2006-02-21
申请号：US10177822
申请日：2002-06-21
申请人： Keith Freehauf , Maryam Moaddeb
发明人： Keith Freehauf , Maryam Moaddeb
IPC分类号： A01N43/04 , A01N43/58 , A61K31/70 , A61K31/495
CPC分类号： A61K31/498 , A61K9/0056 , A61K31/7048 , A61K2300/00
摘要： This invention provides for, inter alia, oral homogeneous veterinary pastes for the treating, controlling and preventing of endo- and ectoparasite infections in warm-blooded animals or birds, such as horses and household pets. This invention further provides for a process of preparing these veterinary pastes and for a method for increasing the bioavailability of the anthelmintic agent contained in the paste in the warm-blooded animal or bird. The inventive oral homogeneous anthelmintic pastes comprise a first anthelmintic agent, for example, prazequantel and/or pyrantel, and at least one marcrolide anthelmintic compound, a solvent, which dissolves both the first anthelmintic agent and second the macrolide anthelmintic compound, and a thickening agent. The inventive oral homogeneous pastes achieve a better bioavailability of the two active anthelmintic agents than when the two actives are in suspension and not dissolved

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