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1. 发明申请

US20140199764A1 MICROFLUIDIC MODULE AND USES THEREOF 审中-公开
标题翻译：微流控模块及其用途
公开(公告)号：US20140199764A1
公开(公告)日：2014-07-17
申请号：US14116481
申请日：2012-05-08
申请人： Karel Domansky , Daniel C. Leslie , Geraldine A. Hamilton , Anthony Bahinski , Donald E. Ingber
发明人： Karel Domansky , Daniel C. Leslie , Geraldine A. Hamilton , Anthony Bahinski , Donald E. Ingber
IPC分类号： C12N5/071 , B32B37/18
CPC分类号： C12N5/0602 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01J2219/0084 , B01J2219/0086 , B01J2219/00907 , B01L3/502707 , B01L2300/161 , B32B37/18 , G01N33/54393
摘要： Described herein are microfluidic modules and methods for making the same, wherein the microfluidic modules include a substrate comprising at least one ether-based, aliphatic polyurethane, and at least one fluidic element disposed therein. The ether-based aliphatic polyurethane can be either the substrate of the microfluidic modules or a coating of another substrate material, such that at least a portion of the ether-based, aliphatic polyurethane is in fluid communication. In one embodiment, the ether-based, aliphatic polyurethane includes dicyclohexylmethane-4,4′-diisocyanate. As the ether-based aliphatic polyurethane can decrease absorption of molecules, e.g., hydrophobic molecules, in such microfluidic modules, the microfluidic modules described herein can be used in various applications such as drug screening and fluorescent microscopy.
摘要翻译：本文描述的是微流体模块和用于制造其的方法，其中微流体模块包括包含至少一种醚基脂族聚氨酯和设置在其中的至少一个流体元件的基材。醚基脂肪族聚氨酯可以是微流体模块的基材或另一种基材的涂层，使得至少一部分醚基的脂族聚氨酯与流体连通。在一个实施方案中，醚基脂族聚氨酯包括二环己基甲烷-4,4'-二异氰酸酯。由于醚类脂族聚氨酯可以在这种微流体模块中减少分子（例如疏水性分子）的吸收，因此本文所述的微流体模块可用于各种应用，例如药物筛选和荧光显微镜。

2. 发明申请

US20130203045A1 METHOD FOR DETECTING NUCLEIC ACIDS BASED ON AGGREGATE FORMATION 审中-公开
标题翻译：基于聚集形成检测核酸的方法
公开(公告)号：US20130203045A1
公开(公告)日：2013-08-08
申请号：US13699983
申请日：2011-05-26
申请人： James P. Landers , Kimberly A. Kelly , Jingyi Li , Daniel C. Leslie
发明人： James P. Landers , Kimberly A. Kelly , Jingyi Li , Daniel C. Leslie
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/6888 , C12Q1/6816 , C12Q1/689 , C12Q1/70 , C12Q2565/113 , C12Q2563/143 , C12Q2537/125 , C12Q2563/149
摘要： The invention provides methods to detect or determine the presence or amount of a pathogen, such as a virus or bacterium, in a sample or the amount of cells based on the detection of their genomic DNA. The method employs magnetic substrates and subjects the sample and the magnetic substrate to forms of energy so as to induce aggregate formation and detects the aggregates.
摘要翻译：本发明提供了检测或确定样品中病原体如病毒或细菌的存在或数量或基于其基因组DNA检测的细胞数量的方法。该方法采用磁性底物，并使样品和磁性底物形成能量，以便诱导聚集体形成并检测聚集体。

3. 发明申请

US20120149587A1 METHOD FOR DETECTING NUCLEATED CELLS 审中-公开
标题翻译：检测核细胞的方法
公开(公告)号：US20120149587A1
公开(公告)日：2012-06-14
申请号：US13116659
申请日：2011-05-26
申请人： James P. Landers , Jingyi Li , Daniel C. Leslie
发明人： James P. Landers , Jingyi Li , Daniel C. Leslie
IPC分类号： C40B30/00 , C12Q1/68
CPC分类号： G01N33/54326 , B01J2219/005 , B01L3/502761 , G01N33/56966 , G01R33/1269
摘要： The invention provides methods to detect or quantify cells such as nucleated cells in a sample such as a physiological sample, which employ magnetic substrates and subjects the sample and the magnetic substrate to forms of energy so as to induce aggregate formation.
摘要翻译：本发明提供了检测或定量细胞的方法，例如样品例如生理样品中的有核细胞，其使用磁性底物并使样品和磁性底物受形成能量以诱导聚集体形成。

4. 发明授权

US10656146B2 Detection of polymeric analytes 有权
公开(公告)号：US10656146B2
公开(公告)日：2020-05-19
申请号：US12879810
申请日：2010-09-10
申请人： James P. Landers , Daniel C. Leslie
发明人： James P. Landers , Daniel C. Leslie
IPC分类号： G01N33/543 , G01R33/12
摘要： The present invention relates to methods for detecting polymeric analytes, especially biopolymers, and sensors for detecting the polymeric analytes. The present invention uses magnetic beads in a rotating magnetic field to provide a visual detection of the presence of a polymeric analyte, such as nucleic acids, lipids, polysaccharides, proteins, etc. When a polymeric analyte binds to the magnetic beads, application of a rotating magnetic field to the beads results in unique pinwheel formations. Without the presence of the polymeric analyte, the movement of the magnetic beads induced by the rotating magnetic field differs significantly from the pinwheel formations. The pinwheel, therefore, is used to detect the presence of polymeric analytes.

5. 发明申请

US20110229898A1 DNA analyzer 有权
公开(公告)号：US20110229898A1
公开(公告)日：2011-09-22
申请号：US13064094
申请日：2011-03-04
申请人： H. Randall Bell , Joan M. Bienvenue , John W. Pettit , James P. Landers , Jessica V. Norris , Orion N. Scott , Daniel J. Marchiarullo , Daniel C. Leslie
发明人： H. Randall Bell , Joan M. Bienvenue , John W. Pettit , James P. Landers , Jessica V. Norris , Orion N. Scott , Daniel J. Marchiarullo , Daniel C. Leslie
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/502753 , B01L7/525 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , G01N27/44791 , G01N29/32 , G01N2021/4186
摘要： Aspects of the disclosure provide a microfluidic chip to facilitate DNA analysis. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, a dilution domain coupled to the first domain to dilute a PCR mixture received from the first domain, and a second domain that is coupled to the dilution domain so as to receive the amplified DNA fragments. The second domain includes a separation channel that is configured to perform electrophoretic separation of the amplified DNA fragments. In addition, the disclosure provides a DNA analyzer to act on the microfluidic chip to perform an integrated single chip DNA analysis.

6. 发明申请

US20110070660A1 DETECTION OF POLYMERIC ANALYTES 审中-公开
标题翻译：检测聚合物分析仪
公开(公告)号：US20110070660A1
公开(公告)日：2011-03-24
申请号：US12879810
申请日：2010-09-10
申请人： James P. Landers , Daniel C. Leslie
发明人： James P. Landers , Daniel C. Leslie
IPC分类号： G01N33/53 , G01N33/92 , G01N33/68 , G01N30/00
CPC分类号： G01N33/54326 , B01J2219/005 , G01R33/1269
摘要： The present invention relates to methods for detecting polymeric analytes, especially biopolymers, and sensors for detecting the polymeric analytes. The present invention uses magnetic beads in a rotating magnetic field to provide a visual detection of the presence of a polymeric analyte, such as nucleic acids, lipids, polysaccharides, proteins, etc. When a polymeric analyte binds to the magnetic beads, application of a rotating magnetic field to the beads results in unique pinwheel formations. Without the presence of the polymeric analyte, the movement of the magnetic beads induced by the rotating magnetic field differs significantly from the pinwheel formations. The pinwheel, therefore, is used to detect the presence of polymeric analytes.
摘要翻译：本发明涉及用于检测聚合物分析物，特别是生物聚合物的方法和用于检测聚合物分析物的传感器。本发明使用旋转磁场中的磁珠来提供聚合物分析物（例如核酸，脂质，多糖，蛋白质等）的存在的目视检测。当聚合物分析物结合磁珠时，应用旋转磁场到珠子产生独特的风车形成。在不存在聚合物分析物的情况下，由旋转磁场引起的磁珠的运动与风车地层显着不同。因此，风车用于检测聚合物分析物的存在。

7. 发明申请

US20130084565A1 VERSATILE, VISIBLE METHOD FOR DETECTING POLYMERIC ANALYTES 审中-公开
标题翻译：用于检测聚合物分析仪的多种可见方法
公开(公告)号：US20130084565A1
公开(公告)日：2013-04-04
申请号：US13505406
申请日：2010-11-03
申请人： James P. Landers , Daniel C. Leslie , Briony Catherine Strachan , Jingvi Li
发明人： James P. Landers , Daniel C. Leslie , Briony Catherine Strachan , Jingvi Li
IPC分类号： G01N21/75
CPC分类号： G01N21/75 , C12Q1/6816 , C12Q2565/102 , C12Q2563/143 , C12Q2537/125
摘要： The invention provides methods to detect or determine the presence or amount of a polymeric analyte in a sample, which employ magnetic substrates and subjects the sample and the magnetic substrate to forms of energy so as to induce aggregate formation.
摘要翻译：本发明提供了检测或确定样品中聚合物分析物的存在或量的方法，该样品使用磁性底物并使样品和磁性底物受形成能量以诱导聚集体形成。

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