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1. 发明申请

US20120022246A1 Magnetic Pigment 审中-公开
标题翻译：磁性颜料
公开(公告)号：US20120022246A1
公开(公告)日：2012-01-26
申请号：US13269195
申请日：2011-10-07
申请人： Jorg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jorg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
IPC分类号： C07H21/04
CPC分类号： C23C30/00 , C12Q1/6806 , Y10S428/90 , Y10S435/814 , Y10T428/12042 , Y10T428/2996 , C12Q2563/149 , C12Q2563/143
摘要： Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.
摘要翻译：具有基本上无孔隙或具有小于10nm直径的孔的外部玻璃表面的磁性颗粒以及具有玻璃表面的铁磁颗粒优选用于从样品中分离生物材料。它们提供快速可靠的净化。

2. 发明申请

US20050266429A1 Magnetic pigment 有权
标题翻译：磁性颜料
公开(公告)号：US20050266429A1
公开(公告)日：2005-12-01
申请号：US11041750
申请日：2005-01-24
申请人： Jorg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jorg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
IPC分类号： C03C14/00 , C12Q1/68 , C23C30/00
CPC分类号： C23C30/00 , C12Q1/6806 , Y10S428/90 , Y10S435/814 , Y10T428/12042 , Y10T428/2996 , C12Q2563/149 , C12Q2563/143
摘要： Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.
摘要翻译：具有基本上无孔隙或具有小于10nm直径的孔的外部玻璃表面的磁性颗粒以及具有玻璃表面的铁磁颗粒优选用于从样品中分离生物材料。它们提供快速可靠的净化。

3. 发明申请

US20070082360A1 Magnetic pigment 审中-公开
标题翻译：磁性颜料
公开(公告)号：US20070082360A1
公开(公告)日：2007-04-12
申请号：US11638289
申请日：2006-12-12
申请人： Jorg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jorg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
IPC分类号： C12Q1/68 , B22F3/10 , C07H21/04
CPC分类号： C23C30/00 , C12Q1/6806 , Y10S428/90 , Y10S435/814 , Y10T428/12042 , Y10T428/2996 , C12Q2563/149 , C12Q2563/143
摘要： Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.
摘要翻译：具有基本上无孔隙或具有小于10nm直径的孔的外部玻璃表面的磁性颗粒以及具有玻璃表面的铁磁颗粒优选用于从样品中分离生物材料。它们提供快速可靠的净化。

4. 发明授权

US06870047B2 Magnetic pigment 失效
标题翻译：磁性颜料
公开(公告)号：US06870047B2
公开(公告)日：2005-03-22
申请号：US09756743
申请日：2001-01-10
申请人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
IPC分类号： G01N33/552 , B01J20/28 , B03C20060101 , B03C1/01 , C07H20060101 , C07H1/08 , C07H21/00 , C12N20060101 , C12N15/09 , C12N15/10 , C12N15/11 , C12Q20060101 , C12Q1/68 , G01N33/553 , H01F1/00 , H01F1/11 , H01F1/36 , C12N15/00 , C12N13/00 , C12P19/34
CPC分类号： C03C3/111 , B03C1/01 , B82Y25/00 , C03C3/078 , C03C3/083 , C03C3/085 , C03C3/087 , C03C3/089 , C03C3/091 , C03C3/102 , C03C3/105 , C03C3/108 , C07H21/00 , C12N15/1013 , C12Q1/6804 , C12Q1/6806 , C12Q1/6834 , H01F1/0063 , H01F1/112 , H01F1/36 , Y10S428/90 , Y10S435/814 , Y10T428/2996
摘要： Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free class surface or having pores with a diameter offices than 10 nm. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing the particles is by forming a mixture of magnetic cores with a sol formed from an alcohol and a metal alkoxide, spray-drying the mixture to coat the cores with a layer of gelled sol, and heating the coated cores to obtain the magnetic glass particles. Preferably, the particles have an average particle size of less than 100 μm. The magnetic core may be a composite material containing a mica core and magnetite particles immobilized on the mica core, and the glass layer may contain boron oxide. Magnetic core materials include magnetite (Fe3O4) and Fe2O3.
摘要翻译：制备磁性颗粒，其包含涂覆有具有基本上无孔的等级表面或具有直径为10nm以上的孔的玻璃层的磁芯。颗粒用于分离生物材料如核酸。制备颗粒的优选方法是通过用由醇和金属醇盐形成的溶胶形成磁芯的混合物，喷雾干燥混合物以用一层凝胶溶胶涂覆芯，并加热涂覆的芯以获得磁性玻璃颗粒。优选地，颗粒的平均粒度小于100μm。磁芯可以是包含固定在云母芯上的云母芯和磁铁矿颗粒的复合材料，并且玻璃层可以含有氧化硼。磁芯材料包括磁铁矿（Fe3O4）和Fe2O3。

5. 发明授权

US06255477B1 Particles having a magnetic core and outer glass layer for separating biological material 失效
标题翻译：具有用于分离生物材料的磁芯和外部玻璃层的颗粒
公开(公告)号：US06255477B1
公开(公告)日：2001-07-03
申请号：US08952969
申请日：1998-03-11
申请人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
IPC分类号： C12N1500
CPC分类号： C03C3/111 , B03C1/01 , B82Y25/00 , C03C3/078 , C03C3/083 , C03C3/085 , C03C3/087 , C03C3/089 , C03C3/091 , C03C3/102 , C03C3/105 , C03C3/108 , C07H21/00 , C12N15/1013 , C12Q1/6804 , C12Q1/6806 , C12Q1/6834 , H01F1/0063 , H01F1/112 , H01F1/36 , Y10S428/90 , Y10S435/814 , Y10T428/2996
摘要： Magnetic glass particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing the particles is by forming a mixture of magnetic cores with a sol formed from an alcohol and a metal alkoxide, spray-drying the mixture to coat the cores with a layer of gelled sol, and heating the coated cores to obtain the magnetic glass particles. Preferably, the particles have an average particle size of less than 100 &mgr;m and any pores of the glass surface have a diameter of less than 10 nm. The magnetic core may be a composite material containing a mica core and magnetite particles immobilized on the mica core, and the glass layer may contain boron oxide. Magnetic core materials include magnetite (Fe3O4) and Fe2O3. In using the magnetic glass particles to separate a biological material, the particles are contacted with a fluid containing the biological material such that the biological material binds to the glass surface, and the bound biological material is separated from the fluid such as by using a magnetic field. Before applying a magnetic field, the magnetic particles may sediment when contacted with the biological material.
摘要翻译：制备磁性玻璃颗粒，其包含涂覆有具有基本无孔玻璃表面的玻璃层的磁芯。颗粒用于分离生物材料如核酸。制备颗粒的优选方法是通过用由醇和金属醇盐形成的溶胶形成磁芯的混合物，喷雾干燥混合物以用一层凝胶溶胶涂覆芯，并加热涂覆的芯以获得磁性玻璃颗粒。优选地，颗粒的平均粒度小于100μm，并且玻璃表面的任何孔具有小于10nm的直径。磁芯可以是包含固定在云母芯上的云母芯和磁铁矿颗粒的复合材料，并且玻璃层可以含有氧化硼。磁芯材料包括磁铁矿（Fe3O4）和Fe2O3。在使用磁性玻璃颗粒分离生物材料时，颗粒与包含生物材料的流体接触，使得生物材料结合到玻璃表面，并且结合的生物材料与流体分离，例如通过使用磁性领域。在施加磁场之前，当与生物材料接触时，磁性颗粒可能沉淀。

6. 发明申请

US20110117561A1 Magnetic Pigment 审中-公开
标题翻译：磁性颜料
公开(公告)号：US20110117561A1
公开(公告)日：2011-05-19
申请号：US12957157
申请日：2010-11-30
申请人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C23C30/00 , C12Q1/6806 , Y10S428/90 , Y10S435/814 , Y10T428/12042 , Y10T428/2996 , C12Q2563/149 , C12Q2563/143
摘要： Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.
摘要翻译：具有基本上无孔隙或具有小于10nm直径的孔的外部玻璃表面的磁性颗粒以及具有玻璃表面的铁磁颗粒优选用于从样品中分离生物材料。它们提供快速可靠的净化。

7. 发明授权

US07371830B2 Method for separating biological material from a fluid using magnetic particles 有权
标题翻译：使用磁性颗粒从流体中分离生物材料的方法
公开(公告)号：US07371830B2
公开(公告)日：2008-05-13
申请号：US11041750
申请日：2005-01-24
申请人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christop Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christop Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
IPC分类号： C07K1/22 , C12N13/00 , C12N1/02 , C12P19/34 , C12P1/00 , C07H21/00
CPC分类号： C23C30/00 , C12Q1/6806 , Y10S428/90 , Y10S435/814 , Y10T428/12042 , Y10T428/2996 , C12Q2563/149 , C12Q2563/143
摘要： Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface or having pores with a diameter of less than 10 nm. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing the particles is by forming a mixture of magnetic cores with a sol formed from an alcohol and a metal alkoxide, spray-drying the mixture to coat the cores with a layer of gelled sol, and heating the coated cores to obtain the magnetic glass particles. Preferably, the particles have an average particle size of less than 100 μm. The magnetic core may be a composite material containing a mica core and magnetite particles immobilized on the mica core, and the glass layer may contain boron oxide. Magnetic core materials include magnetite (Fe3O4) and Fe2O3.
摘要翻译：制备磁性颗粒，其包含涂覆有具有基本无孔玻璃表面或具有小于10nm直径的孔的玻璃层的磁芯。颗粒用于分离生物材料如核酸。制备颗粒的优选方法是通过用由醇和金属醇盐形成的溶胶形成磁芯的混合物，喷雾干燥混合物以用一层凝胶溶胶涂覆芯，并加热涂覆的芯以获得磁性玻璃颗粒。优选地，颗粒的平均粒度小于100μm。磁芯可以是包含固定在云母芯上的云母芯和磁铁矿颗粒的复合材料，并且玻璃层可以含有氧化硼。磁芯材料包括磁铁矿（Fe 3 O 4 O 4）和Fe 2 O 3 O 3。

8. 发明授权

US06919444B2 Magnetic particles for purifying nucleic acids 有权
标题翻译：用于纯化核酸的磁性颗粒
公开(公告)号：US06919444B2
公开(公告)日：2005-07-19
申请号：US10371375
申请日：2003-02-20
申请人： Herbert Harttig , Michael Riedling , Martin Mennig , Helmut Schmidt
发明人： Herbert Harttig , Michael Riedling , Martin Mennig , Helmut Schmidt
IPC分类号： C12N15/00 , B01D15/08 , B01J2/00 , B03C1/00 , B03C1/01 , B22F1/02 , C03B8/02 , C03C3/091 , C03C3/093 , C04B35/653 , C12M1/00 , C12N15/09 , C12N15/10 , C12Q1/68 , H01F1/00 , H01F1/11 , H01F1/24 , C07H21/04
CPC分类号： B82Y25/00 , B03C1/01 , C12N15/1006 , C12N15/1013 , C12Q1/6806 , H01F1/11 , H01F1/112 , Y10T428/2989 , Y10T428/2993 , Y10T428/2996
摘要： Preparations of particles having a glass surface, wherein more than 75% by weight of these particles have a particle size between 0.5 μm and 15 μm and a glass surface which contains between 2 and 6 mole % zinc oxide, have proven to be particularly advantageous in processes for the purification of nucleic acids. This in particular results in an increased nucleic acid yield.
摘要翻译：具有玻璃表面的颗粒的制备，其中大于75重量％的这些颗粒具有0.5μm和15μm之间的粒度和含有2至6摩尔％氧化锌的玻璃表面，已被证明是特别有利的核酸纯化方法。这特别导致增加的核酸产量。

9. 发明授权

US06545143B1 Magnetic particles for purifying nucleic acids 有权
标题翻译：用于纯化核酸的磁性颗粒
公开(公告)号：US06545143B1
公开(公告)日：2003-04-08
申请号：US09856737
申请日：2002-01-09
申请人： Herbert Harttig , Michael Riedling , Martin Mennig , Helmut Schmidt
发明人： Herbert Harttig , Michael Riedling , Martin Mennig , Helmut Schmidt
IPC分类号： C07H2104
CPC分类号： B82Y25/00 , B03C1/01 , C12N15/1006 , C12N15/1013 , C12Q1/6806 , H01F1/11 , H01F1/112 , Y10T428/2989 , Y10T428/2993 , Y10T428/2996
摘要： Preparations of particles having a glass surface, wherein more than 75% by weight of these particles have a particle size between 0.5 &mgr;m and 15 &mgr;m and a glass surface which contains between 2 and 6 mole % zinc oxide, have proven to be particularly advantageous in processes for the purification of nucleic acids. This in particular results in an increased nucleic acid yield.
摘要翻译：具有玻璃表面的颗粒的制备，其中大于75重量％的这些颗粒具有0.5μm和15μm之间的粒度和含有2至6摩尔％氧化锌的玻璃表面，已被证明是特别有利的核酸纯化方法。这特别导致增加的核酸产量。

10. 发明授权

US06979466B2 Nanoscale particles having an iron oxide-containing core enveloped by at least two shells 失效
标题翻译：具有包含至少两个壳的含氧化铁芯的纳米级颗粒
公开(公告)号：US06979466B2
公开(公告)日：2005-12-27
申请号：US10391356
申请日：2003-03-17
申请人： Christoph Lesniak , Thomas Schiestel , Helmut Schmidt , Andreas Jordan
发明人： Christoph Lesniak , Thomas Schiestel , Helmut Schmidt , Andreas Jordan
IPC分类号： A61K9/16 , A61K41/00 , A61P35/00 , A61K9/51
CPC分类号： A61K41/0052
摘要： The invention relates to nanoscale particles suited especially for use in tumor therapy by hyperthermia. Said particles comprise a (preferably superparamagnetic) iron oxide-containing core and at least two shells surrounding said core. The (innermost) shell adjoining the core is an envelope which comprises groups capable of forming cationic groups and is broken down by human or animal tissue at such a slow rate as to allow for association of the core surrounded by said envelope with the surface of cells and/or for absorption of said core into the inside of cells. The outer shell(s) consist(s) of species having neutral and/or anionic groups which allow the nanoscale particles to appear to the outside as having a neutral or negative charge and which are broken down by human or animal tissue more rapidly than the innermost shell—and in so doing uncover the shells underneath—but still sufficiently slowly so as to ensure that the nanoscale particles are adequately distributed in a tissue infiltrated with same particles in a particular point.
摘要翻译：本发明涉及特别适用于通过高热治疗肿瘤治疗的纳米级颗粒。所述颗粒包含（优选超顺磁性）含氧化铁的芯和围绕所述芯的至少两个壳。与核心相邻的（最内侧）壳是包含能够形成阳离子基团并且以如此慢的速率被人或动物组织分解以允许由所述包膜包围的核与细胞表面缔合的基团和/或用于将所述核吸收到细胞内部。外壳由具有中性和/或阴离子基团的物质组成，其允许纳米级颗粒以外面的形式出现在外部，具有中性或负电荷，并且比人或动物组织更快地分解最内层的壳体，并且在其中露出壳下面，但是仍然足够缓慢，以便确保纳米级颗粒在特定的点上适当地分布在渗透有相同颗粒的组织中。

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