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    • 6. 发明申请
    • APPLICATION OF ENERGY IN MEDICAL TREATMENTS
    • 能源在医疗治疗中的应用
    • US20130190737A1
    • 2013-07-25
    • US13738675
    • 2013-01-10
    • David MullerJohn Marshall
    • David MullerJohn Marshall
    • A61F9/007
    • A61F9/0079A61F9/00736A61F9/008A61F2009/0087A61F2009/00887A61N5/062A61N2005/0661
    • Embodiments apply light energy in medical treatments. To enhance or control the effect of the light energy, embodiments apply the light energy after tissue has been treated, e.g., with a photosensitizing agent. For example, embodiments may treat target tissue with riboflavin before exposure to ultraviolet light. For example, a system for cataract surgery includes a removal system configured to remove a first lens from an eye, wherein a capsular bag remains in the eye after removal of the first lens. The system includes an application system configured to treat lenticular epithelial cells in the capsular bag with the photosensitizing agent. The system includes a delivery system with a light source and an optical device. The optical device delivers light to the treated lenticular epithelial cells. Energy from the light destroys the lenticular epithelial cells in the capsular bag to reduce the growth of epithelial cells that cause posterior capsule opacification.
    • 实施例在光疗中应用光能。 为了增强或控制光能的效果,实施例在组织被处理后例如用光敏剂施加光能。 例如,实施方案可以在暴露于紫外线之前用核黄素治疗靶组织。 例如,用于白内障手术的系统包括被配置为从眼睛去除第一透镜的去除系统,其中在移除第一透镜之后,囊袋保留在眼睛中。 该系统包括被配置成用光敏剂治疗囊袋中的透镜上皮细胞的应用系统。 该系统包括具有光源和光学装置的传送系统。 光学器件将光递送到经处理的透镜上皮细胞。 来自光的能量破坏囊袋中的透镜上皮细胞以减少导致后囊不透明的上皮细胞的生长。
    • 7. 发明授权
    • Method for making structural changes in corneal fibrils
    • 角膜原纤维结构变化的方法
    • US08366689B2
    • 2013-02-05
    • US12570959
    • 2009-09-30
    • John MarshallAli HusseinDavid Muller
    • John MarshallAli HusseinDavid Muller
    • A61M35/00A61B18/18
    • A61F9/008A61F9/0079A61F9/009A61F2009/00853A61F2009/00872
    • In a system for stabilizing a pattern of structural changes in corneal fibrils, an eye treatment system causes corneal fibrils of a cornea of an eye to transition from a first structure to a second structure. An application device applies a cross-linking element to the corneal fibrils. An activating device applies an initiating element to the corneal fibrils and activates the cross-linking element. The cross-linking element causes cross-linking in the corneal fibrils to preserve the second structure of the corneal fibrils. Another application device may apply a cross-linking breaker to the corneal fibrils. The cross-linking breaker halts or reverses at least partially the cross-linking in the corneal fibrils. Another activating device applies an initiating element to the corneal fibrils and activates the cross-linking breaker. Advantageously, the cross-linking breaker provides greater control over the amount and progress of cross-linking that occurs in the corneal fibrils.
    • 在用于稳定角膜原纤维结构变化的模式的系统中,眼睛治疗系统使眼睛角膜的角膜原纤维从第一结构转变到第二结构。 应用装置将交联元件应用于角膜原纤维。 激活装置将起始元件施加到角膜原纤维并激活交联元件。 交联元件引起角膜原纤维中的交联以保留角膜原纤维的第二结构。 另一应用装置可以将交联断路器应用于角膜原纤维。 交联断路器至少部分地停止或逆转角膜原纤维中的交联。 另一激活装置将起始元件施加到角膜原纤维并激活交联断路器。 有利地,交联断路器对角膜原纤维中发生的交联的量和进展提供更大的控制。