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1. 发明授权

US08301228B2 Real time radiation treatment planning system 有权
标题翻译：实时辐射治疗计划系统
公开(公告)号：US08301228B2
公开(公告)日：2012-10-30
申请号：US13013051
申请日：2011-01-25
申请人： Johann Kindlein , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
发明人： Johann Kindlein , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
IPC分类号： A61B6/00
CPC分类号： A61N5/1031 , A61N5/1001 , A61N5/1007 , A61N5/1039 , A61N2005/1012 , A61N2005/1032 , A61N2005/1074 , G06F19/00 , G06F19/3481
摘要： The invention relates to a real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body using hollow needles. According to embodiments of the invention, the system may include a processing means processing means-configured to perform a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm, with respect to one or more specific organs within the pre-selected anatomical portion and with respect to the needles, for converting the image data obtained with an imaging means into a three-dimensional image of the anatomical portion, using at least one single or multi-objective anatomy-based genetic optimization algorithm. For pre-planning or virtual simulation purposes, the processing means is arranged to determine in real time the optimal number and position of at least one of the needles, positions of energy emitting sources within the needles, and the dwell times of the energy emitting sources at the positions. For post-planning purposes, the processing means is arranged to determine, based on three-dimensional image information, in real time the real needle positions and the dwell times of the energy emitting sources for the positions.
摘要翻译：本发明涉及一种实时放射治疗计划系统，用于使用空心针对动物体的预先选择的解剖部分进行放射治疗。根据本发明的实施例，系统可以包括处理装置处理装置，其被配置为相对于预先选择的解剖部分内的一个或多个特定器官执行三维成像算法和三维图像分割算法并且相对于针，用于使用至少一个单目标或多目标基于解剖的遗传优化算法将用成像装置获得的图像数据转换成解剖部分的三维图像。对于预先规划或虚拟模拟目的，处理装置被布置成实时确定针中的至少一个针的最佳数量和位置，针内的能量发射源的位置以及能量发射源的停留时间在职位。为了规划后的目的，处理装置被布置成基于三维图像信息实时确定位置的能量发射源的实际针位置和停留时间。

2. 发明申请

US20110288361A1 REAL TIME RADIATION TREATMENT PLANNING SYSTEM 有权
标题翻译：实时放射治疗计划系统
公开(公告)号：US20110288361A1
公开(公告)日：2011-11-24
申请号：US13013051
申请日：2011-01-25
申请人： Johann KINDLEIN , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
发明人： Johann KINDLEIN , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
IPC分类号： A61M36/12
CPC分类号： A61N5/1031 , A61N5/1001 , A61N5/1007 , A61N5/1039 , A61N2005/1012 , A61N2005/1032 , A61N2005/1074 , G06F19/00 , G06F19/3481
摘要： The invention relates to a real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body using hollow needles. According to embodiments of the invention, the system may include a processing means processing means-configured to perform a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm, with respect to one or more specific organs within the pre-selected anatomical portion and with respect to the needles, for converting the image data obtained with an imaging means into a three-dimensional image of the anatomical portion, using at least one single or multi-objective anatomy-based genetic optimization algorithm. For pre-planning or virtual simulation purposes, the processing means is arranged to determine in real time the optimal number and position of at least one of the needles, positions of energy emitting sources within the needles, and the dwell times of the energy emitting sources at the positions. For post-planning purposes, the processing means is arranged to determine, based on three-dimensional image information, in real time the real needle positions and the dwell times of the energy emitting sources for the positions.
摘要翻译：本发明涉及一种实时放射治疗计划系统，用于使用空心针对动物体的预先选择的解剖部分进行放射治疗。根据本发明的实施例，系统可以包括处理装置处理装置，其被配置为相对于预先选择的解剖部分内的一个或多个特定器官执行三维成像算法和三维图像分割算法并且相对于针，用于使用至少一个单目标或多目标基于解剖的遗传优化算法将用成像装置获得的图像数据转换成解剖部分的三维图像。对于预先规划或虚拟模拟目的，处理装置被布置成实时确定针中的至少一个针的最佳数量和位置，针内的能量发射源的位置以及能量发射源的停留时间在职位。为了规划后的目的，处理装置被布置成基于三维图像信息实时确定位置的能量发射源的实际针位置和停留时间。

3. 发明授权

US07899517B2 Real time radiation treament planning system 有权
标题翻译：实时辐射处理规划系统
公开(公告)号：US07899517B2
公开(公告)日：2011-03-01
申请号：US10448311
申请日：2003-05-30
申请人： Johann Kindlein , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
发明人： Johann Kindlein , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
IPC分类号： A61B5/05
CPC分类号： A61N5/1031 , A61N5/1001 , A61N5/1007 , A61N5/1039 , A61N2005/1012 , A61N2005/1032 , A61N2005/1074 , G06F19/00 , G06F19/3481
摘要： A real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body. A processor is provided with a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm for at least the specific organs within the anatomical portion and the needles. The processor converts the image data into a three-dimensional image of the anatomical portion using at least one single or multi-objective anatomy based genetic optimization algorithm. The processor determines in real time the optimal number and position of the hollow needles, the position of the energy emitting source within each hollow needle and the dwell times of the energy emitting source at each position. For post planning purposes, the processor determines, based on three-dimensional image information in real time, the real needle positions and the dwell times of the energy emitting source for each position.
摘要翻译：一种实时放射治疗计划系统，用于对动物体的预先选择的解剖部分进行放射治疗。为处理器提供三维成像算法和至少在解剖部分和针内的特定器官的三维图像分割算法。处理器使用至少一个基于单目标或多目标解剖学的遗传优化算法将图像数据转换成解剖部分的三维图像。处理器实时确定中空针的最佳数量和位置，能量发射源在每个中空针内的位置以及在每个位置处的能量发射源的驻留时间。对于后期规划目的，处理器基于实时的三维图像信息确定每个位置的能量发射源的实际针位置和停留时间。

4. 发明申请

US20070083117A1 REGISTERING ULTRASOUND IMAGE DATA AND SECOND IMAGE DATA OF AN OBJECT 有权
标题翻译：注册超声图像数据和对象的第二图像数据
公开(公告)号：US20070083117A1
公开(公告)日：2007-04-12
申请号：US11539318
申请日：2006-10-06
申请人： Georgios Sakas , Marcus Grimm
发明人： Georgios Sakas , Marcus Grimm
IPC分类号： A61B8/00
CPC分类号： G06T3/0068 , A61B8/4254 , G01S7/5205
摘要： The invention relates to a method of registering ultrasound image data of an object and second image data of the object, wherein the second image data are three-dimensional (3-D) image data. Sets (first sets IUS) of the ultrasound image data are obtained, wherein each set of ultrasound image data consists of ultrasound image data of locations within a single plane of a coordinate system of the ultrasound image data. Sets (second sets IEX) of 2-D image data from the second image data are extracted, wherein each set of 2-D image data consists of image data of locations within a single cut plane of a coordinate system of the second image data (unit 41). One of the first sets (IUS) is compared with one of the second sets (IEX) and a measure of similarity between the first set (IUS) and the second set (IEX) is automatically generated (unit 42). The similarity is optimised by varying the first set (IUS) and/or the second set (IEX) to be compared (unit 43).
摘要翻译：本发明涉及一种记录物体的超声图像数据和物体的第二图像数据的方法，其中第二图像数据是三维（3-D）图像数据。获得超声图像数据的集合（第一集IUS），其中每组超声图像数据由超声图像数据的坐标系的单个平面内的位置的超声图像数据组成。提取来自第二图像数据的2-D图像数据的集合（第二集合IEX），其中每组2-D图像数据由第二图像数据的坐标系的单个切割平面内的位置的图像数据组成单元41）。将第一组（IUS）中的一个与第二组（IEX）中的一个进行比较，并且自动生成第一组（IUS）和第二组（IEX）之间的相似性度量（单元42）。通过改变要比较的第一组（IUS）和/或第二组（IEX）（单元43）来优化相似度。

5. 发明申请

US20160074012A1 Apparatus and method of ultrasound image acquisition, generation and display 审中-公开
标题翻译：超声图像采集，生成和显示的装置和方法
公开(公告)号：US20160074012A1
公开(公告)日：2016-03-17
申请号：US14669830
申请日：2015-03-26
申请人： Leonardo Forzoni , Stefano De Beni , Velizar Kolev , Georgios Sakas
发明人： Leonardo Forzoni , Stefano De Beni , Velizar Kolev , Georgios Sakas
IPC分类号： A61B8/08 , A61B8/00
CPC分类号： A61B8/5207 , A61B8/0825 , A61B8/4245 , A61B8/463 , A61B8/466 , A61B8/5238
摘要： A method of ultrasound image acquisition, generation and display includes the steps of: acquiring ultrasound image data corresponding to an anatomic region being examined using an ultrasound probe; generating an ultrasound image based on the image data; displaying the image on a display; generating a map of the outer surface of the anatomic region; detecting the position of the probe during image data acquisition; identifying on the map the point corresponding to the detected position of the probe; and displaying the map in which such point is marked, at the same time as the ultrasound image is displayed.
摘要翻译：一种超声波图像获取，生成和显示的方法包括以下步骤：使用超声探头获取对应于正在检查的解剖区域的超声图像数据; 基于所述图像数据生成超声图像; 在显示器上显示图像; 产生解剖区域的外表面的图; 在图像数据采集期间检测探头的位置; 在地图上识别与探测器的检测位置相对应的点; 并且与显示超声波图像同时显示标记了该点的地图。

6. 发明授权

US07639895B2 Registering ultrasound image data and second image data of an object 有权
标题翻译：注册物体的超声图像数据和第二图像数据
公开(公告)号：US07639895B2
公开(公告)日：2009-12-29
申请号：US11539318
申请日：2006-10-06
申请人： Georgios Sakas , Marcus Grimm
发明人： Georgios Sakas , Marcus Grimm
IPC分类号： G06K9/36
CPC分类号： G06T3/0068 , A61B8/4254 , G01S7/5205
摘要： The invention relates to a method of registering ultrasound image data of an object and second image data of the object, wherein the second image data are three-dimensional (3-D) image data. Sets (first sets IUS) of the ultrasound image data are obtained, wherein each set of ultrasound image data consists of ultrasound image data of locations within a single plane of a coordinate system of the ultrasound image data. Sets (second sets IEX) of 2-D image data from the second image data are extracted, wherein each set of 2-D image data consists of image data of locations within a single cut plane of a coordinate system of the second image data (unit 41). One of the first sets (IUS) is compared with one of the second sets (IEX) and a measure of similarity between the first set (IUS) and the second set (IEX) is automatically generated (unit 42). The similarity is optimised by varying the first set (IUS) and/or the second set (IEX) to be compared (unit 43).
摘要翻译：本发明涉及一种记录物体的超声图像数据和物体的第二图像数据的方法，其中第二图像数据是三维（3-D）图像数据。获得超声图像数据的集合（第一集IUS），其中每组超声图像数据由超声图像数据的坐标系的单个平面内的位置的超声图像数据组成。提取来自第二图像数据的2-D图像数据的集合（第二集合IEX），其中每组2-D图像数据由第二图像数据的坐标系的单个切割平面内的位置的图像数据组成单元41）。将第一组（IUS）中的一个与第二组（IEX）中的一个进行比较，并且自动生成第一组（IUS）和第二组（IEX）之间的相似度的度量（单元42）。通过改变要比较的第一组（IUS）和/或第二组（IEX）（单元43）来优化相似度。

7. 发明授权

US07412086B2 Setting a relative position of a radiation device and a patient 有权
标题翻译：设置辐射装置和患者的相对位置
公开(公告)号：US07412086B2
公开(公告)日：2008-08-12
申请号：US11206116
申请日：2005-08-18
申请人： Georgios Sakas , Boris Peter Selby , Stefan Otmar Walter , Rolf Kussäther
发明人： Georgios Sakas , Boris Peter Selby , Stefan Otmar Walter , Rolf Kussäther
IPC分类号： G06K9/00 , A61N5/10
CPC分类号： A61N5/1049 , A61N5/1069 , A61N2005/1061
摘要： A method and arrangement for setting a relative position of a radiation device and a patient. The invention relates to the use of radiation therapy for the targeted, selective destruction of tumors.
摘要翻译：一种用于设置辐射装置和患者的相对位置的方法和装置。本发明涉及放射治疗用于靶向，选择性破坏肿瘤的用途。

8. 发明申请

US20060072808A1 Registration of first and second image data of an object 审中-公开
标题翻译：对象的第一和第二图像数据的注册
公开(公告)号：US20060072808A1
公开(公告)日：2006-04-06
申请号：US11227074
申请日：2005-09-16
申请人： Marcus Grimm , Georgios Sakas
发明人： Marcus Grimm , Georgios Sakas
IPC分类号： G06K9/00
CPC分类号： A61B8/4254 , G06T7/33 , G06T2207/10072 , G06T2207/10132 , G06T2207/30004
摘要： The invention relates to the registration of ultrasound image data of an object and of three-dimensional second image data of the object. It is proposed to support a manual registration by an automatic process. Reference information defining a reference location in the ultrasound image are used, wherein the reference location is located on a surface of the object or is located at a defined distance to the surface of the object when the ultrasound detector generates the ultrasound image data. At least one surface point on the surface of the object or at a defined distance to the surface is identified in the second image. The ultrasound image data and the second image data are aligned with respect to one registration direction using the reference information and using information concerning a location of the surface point in the second image.
摘要翻译：本发明涉及对象的超声图像数据的登记和对象的三维第二图像数据的登记。建议通过自动过程支持手动注册。使用在超声波图像中定义参考位置的参考信息，其中当超声波检测器产生超声图像数据时，参考位置位于物体的表面上，或位于物体表面的限定距离处。在第二个图像中识别出物体表面上至少一个表面点或距离表面的一定距离。超声图像数据和第二图像数据使用参考信息相对于一个登记方向对准，并且使用关于第二图像中的表面点的位置的信息。

9. 发明授权

US08131345B2 Combining first and second image data of an object 有权
标题翻译：组合对象的第一和第二图像数据
公开(公告)号：US08131345B2
公开(公告)日：2012-03-06
申请号：US11858279
申请日：2007-09-20
申请人： Georgios Sakas , Marcus Grimm
发明人： Georgios Sakas , Marcus Grimm
IPC分类号： A61B5/00
CPC分类号： A61B8/5238 , A61B8/00 , A61B8/4254 , A61B8/483 , G06T7/33 , G06T7/38 , G06T2207/10072 , G06T2207/10132 , G06T2207/30004 , G06T2207/30108
摘要： A system and method are provided for displaying images of first and second image data in which geometry data is transferred from an ultrasound imaging detector to an image combination device in addition to first image data to reduce the need for calibration and registration.
摘要翻译：提供了一种系统和方法，用于除了第一图像数据之外还显示几何数据从超声成像检测器传送到图像组合装置的第一和第二图像数据的图像，以减少对校准和配准的需要。

10. 发明申请

US20080009699A1 Combining first and second image data of an object 有权
标题翻译：组合对象的第一和第二图像数据
公开(公告)号：US20080009699A1
公开(公告)日：2008-01-10
申请号：US11858279
申请日：2007-09-20
申请人： Georgios Sakas , Marcus Grimm
发明人： Georgios Sakas , Marcus Grimm
IPC分类号： A61B5/05
CPC分类号： A61B8/5238 , A61B8/00 , A61B8/4254 , A61B8/483 , G06T7/33 , G06T7/38 , G06T2207/10072 , G06T2207/10132 , G06T2207/30004 , G06T2207/30108
摘要： The invention relates to a method of combining first and second image data of an object (3), wherein the first image data of the object (3) are repeatedly generated by an ultrasound detector (1), wherein the second image data of the object (3) are generated separately, for example the second image data have been recorded earlier by a computer tomography, a magnetic resonance or a positron emission tomography imaging device, wherein the first image data are transferred from the ultrasound detector (1) to a combination device (5) and wherein the combination device (5) is adapted to combine the first and second image data of the object (3). Geometry data is transferred in addition to the first image data from the ultrasound detector (1) to the combination device (5), wherein the geometry data comprise information for establishing a link between the geometry of the first image data and the geometry of the second image data.
摘要翻译：本发明涉及一种组合对象（3）的第一和第二图像数据的方法，其中由超声波检测器（1）重复地生成对象（3）的第一图像数据，其中对象的第二图像数据（3）分开产生，例如通过计算机断层摄影，磁共振或正电子发射断层成像装置较早地记录了第二图像数据，其中第一图像数据从超声波检测器（1）传送到组合装置（5），并且其中组合装置（5）适于组合对象（3）的第一和第二图像数据。几何数据除了从超声检测器（1）到组合装置（5）的第一图像数据之外被传送，其中几何数据包括用于建立第一图像数据的几何形状和第二图像的几何形状之间的链接的信息图像数据。

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