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1. 发明申请

US20110237977A1 Device for Collecting First Pass Urine 审中-公开
标题翻译：首次通过尿液收集装置
公开(公告)号：US20110237977A1
公开(公告)日：2011-09-29
申请号：US13127432
申请日：2009-11-18
申请人： Jan Knight , Robert Knight
发明人： Jan Knight , Robert Knight
IPC分类号： A61B5/20
CPC分类号： A61B10/007
摘要： A device for collecting a sample of the first pass portion of urine voided by a donor isolated from the midstream portion of the urine comprises a first part (1) comprising an opening at its upper end (4) adapted to receive urine voided by a donor, a urine collection body (3) downstream of the upper end and a closable exit (6) located downstream of the urine collection body and at the lower end (5) of the first part, the exit providing a circular orifice (7), a second part (2) located downstream of the exit of the first part and comprising a collecting vessel (10) which is in communication with the exit of the first part, wherein the circular orifice provided by the exit of the first part defines an inlet into the collecting vessel and has a diameter which is smaller than the diameter of the collecting vessel at the upper end thereof, and wherein the collecting vessel contains a moveable closure member (13) for blocking the inlet into the collecting vessel which moveable closure member is capable of floating in urine and is adapted such that, in use, it blocks the inlet into the collecting vessel on the filling of the collecting vessel with urine so as to cause further voided urine to be collected in the urine collection body of the first part. By use of the device, a sample of first pass urine, undiluted by midstream urine, may be collected for medical analysis.
摘要翻译：用于收集由尿液的中游部分隔离的供体排出的尿液的第一通过部分的样品的装置包括第一部分（1），其在其上端（4）处包括适于接收由供体排出的尿的开口，在上端下游的尿液收集体（3）和位于尿液收集体下游的第一部分的下端（5）处的可封闭出口（6），所述出口提供圆形孔口（7），第二部分（2）位于第一部分的出口的下游，并且包括与第一部分的出口连通的收集容器（10），其中由第一部分的出口提供的圆形孔口限定入口进入收集容器并且其直径小于其上端处的收集容器的直径，并且其中收集容器包含用于阻挡进入收集容器的入口的可移动关闭构件（13），可移动闭合构件能够漂浮在尿液中，并且适于使得在使用中，在用尿液填充收集容器时阻止入口进入收集容器，以便使进一步排尿的尿液被收集在第一部分。通过使用该装置，可以采集未经中流尿液稀释的第一通尿样品进行医学分析。

2. 发明授权

US09884322B2 Stand for microplates 有权
公开(公告)号：US09884322B2
公开(公告)日：2018-02-06
申请号：US13884738
申请日：2011-11-11
申请人： Jan Knight , Robert Knight
发明人： Jan Knight , Robert Knight
IPC分类号： B01L9/00
CPC分类号： B01L9/523 , B01L2200/087
摘要： A laboratory stand for a microplate comprises a base (2), at least one post (3, 4) extending upwardly from the base, a shelf (5) located above the base and supported by the at least one post, and means for adjusting the height of the shelf in relation to the base. The shelf (5) comprises a rear portion (9) which is substantially horizontal and a front portion (10), which is inclined downwards away from the horizontal, which is adapted to retain at least one microplate. The laboratory stand improves pipetting ergonomics.

3. 发明授权

US5830359A Method of separating particles from a filter 失效
标题翻译：从过滤器中分离颗粒的方法
公开(公告)号：US5830359A
公开(公告)日：1998-11-03
申请号：US530221
申请日：1995-10-03
申请人： Jan Knight , Robert Knight
发明人： Jan Knight , Robert Knight
IPC分类号： G01N33/50 , B01D61/00
CPC分类号： G01N33/5094 , G01N33/5002 , Y10T436/255
摘要： Particles that move at low Reynolds numbers are separated from a filter material on which they are adsorbed by subjecting the filter material, in a liquid medium, to agitation of sufficient magnitude to create turbulence and shear forces acting on the filter material such that the particles become desorbed from the filter material and become suspended in the liquid medium. The method may be used to recover biological particles, such as leucocytes and blood platelets, from filter materials on which they are retained by adsorption. The recovered particles may then be used in diagnostic testing and analytical techniques.
摘要翻译： PCT No.PCT / GB94 / 00774 Sec。 371 1995年10月3日第 102（e）日期1995年10月3日PCT 1994年4月7日PCT PCT。第WO94 / 23296号公报日期：1994年10月13日以低雷诺数移动的颗粒物通过使过滤材料在液体介质中受到吸附的过滤材料与其过滤材料分离，以使搅拌足够大，以产生作用在过滤材料上的湍流和剪切力使得颗粒从过滤材料脱附并悬浮在液体介质中。该方法可用于从其通过吸附保留的过滤材料中回收生物颗粒，例如白细胞和血小板。然后将回收的颗粒用于诊断测试和分析技术。

4. 发明授权

US08679761B2 Method for detection of inflammation in the urinary tract or urethra 有权
标题翻译：检测尿道或尿道炎症的方法
公开(公告)号：US08679761B2
公开(公告)日：2014-03-25
申请号：US13634495
申请日：2011-03-15
申请人： Jan Knight , Robert Knight
发明人： Jan Knight , Robert Knight
IPC分类号： C12Q1/68
CPC分类号： C12Q1/04 , C12Q1/26 , G01N33/56972 , G01N33/571 , G01N33/582 , G01N2333/22 , G01N2333/295
摘要： A method for detecting inflammation in the urinary tract or urethra of a patient, especially urethritis, comprises a) contacting leucocytes obtained from a urine sample provided by the patient with a luminescence reagent which emits light on reaction with an oxidant; b) adding an activator to the mixture of leucocytes and luminescence reagent; c) continuously monitoring and/or measuring light emitted by the luminescence reagent over a predetermined time period commencing before and ending after the addition of the activator. The light emission is indicative of the presence or absence of inflammation in the urinary tract or urethra of the patient. The urine sample is preferably a sample of first pass urine. The method makes possible a diagnosis especially of urethritis and, in particular, urethral infections selected from Chlamydia trachomatis and Neisseria gonorrhoeae, which can be carried out quickly without invasive procedures. A diagnostic kit for carrying out the method, comprising a luminescence reagent which emits light on reaction with an oxidant, an activator and a library of standard signature light emission curves is also disclosed.
摘要翻译：一种用于检测患者尿道或尿道中尤其是尿道炎的炎症的方法，包括：a）将由患者提供的尿液样本获得的白细胞与发射与氧化剂反应的光的发光试剂接触; b）向白细胞和发光试剂的混合物中加入活化剂; c）在从激活剂加入之前和结束之后的预定时间段内连续地监测和/或测量由发光试剂发射的光。发光指示患者尿道或尿道中是否存在炎症。尿液样品优选为第一遍尿样品。该方法可以特别诊断尿道炎，特别是选自沙眼衣原体和淋病奈瑟氏球菌的尿道感染，其可以在没有侵入性手术的情况下快速进行。还公开了一种用于执行该方法的诊断试剂盒，其包括与氧化剂反应发光的发光试剂，活化剂和标准标记光发射曲线库。

5. 发明申请

US20130336853A1 Stand for Microplates 有权
标题翻译：代替微孔板
公开(公告)号：US20130336853A1
公开(公告)日：2013-12-19
申请号：US13884738
申请日：2011-11-11
申请人： Jan Knight , Robert Knight
发明人： Jan Knight , Robert Knight
IPC分类号： B01L9/00
CPC分类号： B01L9/523 , B01L2200/087
摘要： A laboratory stand for a microplate comprises a base (2), at least one post (3, 4) extending upwardly from the base, a shelf (5) located above the base and supported by the at least one post, and means for adjusting the height of the shelf in relation to the base. The shelf (5) comprises a rear portion (9) which is substantially horizontal and a front portion (10), which is inclined downwards away from the horizontal, which is adapted to retain at least one microplate. The laboratory stand improves pipetting ergonomics.
摘要翻译：用于微孔板的实验室支架包括基部（2），从基部向上延伸的至少一个柱（3,4），位于基部上方并由至少一个支柱支撑的搁架（5），以及用于调节货架相对于底座的高度。搁板（5）包括基本上水平的后部（9）和向前倾斜的前部（10），其适于保持至少一个微板。实验室支架可提高吸液人体工程学。

6. 发明申请

US20130143252A1 Method for Detection of Inflammation in the Urinary Tract or Urethra 有权
标题翻译：检测尿道或尿道炎症的方法
公开(公告)号：US20130143252A1
公开(公告)日：2013-06-06
申请号：US13634495
申请日：2011-03-15
申请人： Jan Knight , Robert Knight
发明人： Jan Knight , Robert Knight
IPC分类号： C12Q1/04 , C12Q1/26
CPC分类号： C12Q1/04 , C12Q1/26 , G01N33/56972 , G01N33/571 , G01N33/582 , G01N2333/22 , G01N2333/295
摘要： A method for detecting inflammation in the urinary tract or urethra of a patient, especially urethritis, comprises a) contacting leucocytes obtained from a urine sample provided by the patient with a luminescence reagent which emits light on reaction with an oxidant; b) adding an activator to the mixture of leucocytes and luminescence reagent; c) continuously monitoring and/or measuring light emitted by the luminescence reagent over a predetermined time period commencing before and ending after the addition of the activator. The light emission is indicative of the presence or absence of inflammation in the urinary tract or urethra of the patient. The urine sample is preferably a sample of first pass urine. The method makes possible a diagnosis especially of urethritis and, in particular, urethral infections selected from Chlamydia trachomatis and Neisseria gonorrhoeae, which can be carried out quickly without invasive procedures. A diagnostic kit for carrying out the method, comprising a luminescence reagent which emits light on reaction with an oxidant, an activator and a library of standard signature light emission curves is also disclosed.
摘要翻译：一种用于检测患者尿道或尿道中尤其是尿道炎的炎症的方法，包括：a）将由患者提供的尿样获得的白细胞与发出与氧化剂反应的光的发光试剂接触; b）向白细胞和发光试剂的混合物中加入活化剂; c）在从激活剂加入之前和结束之后的预定时间段内连续地监测和/或测量由发光试剂发射的光。发光指示患者尿道或尿道中是否存在炎症。尿液样品优选为第一遍尿样品。该方法可以特别诊断尿道炎，特别是选自沙眼衣原体和淋病奈瑟氏球菌的尿道感染，其可以在没有侵入性手术的情况下快速进行。还公开了一种用于执行该方法的诊断试剂盒，其包括与氧化剂反应发光的发光试剂，活化剂和标准标记光发射曲线库。

7. 发明申请

US20130059323A1 Detection of Overtraining Syndrome in an Individual 审中-公开
标题翻译：检测个体超调综合征
公开(公告)号：US20130059323A1
公开(公告)日：2013-03-07
申请号：US13634493
申请日：2011-03-15
申请人： Jan Knight
发明人： Jan Knight
IPC分类号： G01N21/76
CPC分类号： G01N33/56972 , G01N2800/306
摘要： The onset of or the existence of overtraining syndrome in an individual is detected by a method which comprises a) contacting leucocytes in, or obtained from, a blood sample provided by the individual with a luminescence reagent which emits light on reaction with an oxidant; b) adding an activator to the mixture of leucocytes and the luminescence reagent; c) continuously monitoring and/or measuring light emitted by the luminescence reagent over a predetermined time period commencing before and ending after the addition of the activator; and d) assessing the light emission. The individual may be a human, for example an elite athlete, or a non-human mammal, for example a racehorse. A diagnostic kit, for carrying out the method, comprising a luminescence reagent which emits light on reaction with an oxidant, an activator and a library of standard signature light emission curves is also disclosed.
摘要翻译：通过一种方法检测个体中过度训练综合征的发生或存在，其包括：a）使由个体提供的血液样品中的白细胞与发出与氧化剂反应的光的发光试剂接触; b）向白细胞和发光试剂的混合物中加入活化剂; c）在从所述激活剂添加之前和结束之后的预定时间段内连续地监测和/或测量由所述发光试剂发射的光; 和d）评估光发射。个体可以是人，例如精英运动员，或非人哺乳动物，例如赛马。还公开了一种用于实施该方法的诊断试剂盒，其包含与氧化剂反应发光的发光试剂，活化剂和标准标记光发射曲线的文库。

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