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1. 发明授权

US5656485A Eimeria antigenic composition which elicits antibodies against avian coccidiosis 失效
公开(公告)号：US5656485A
公开(公告)日：1997-08-12
申请号：US691454
申请日：1996-08-02
申请人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan Lee Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
发明人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan Lee Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20 , C12N15/30 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/012
CPC分类号： C12N15/70 , C07K14/455 , C07K16/20 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , Y10S530/822
摘要： This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.

2. 发明授权

US5597571A Eimeria antigenic composition which elicits antibodies against avian coccidiosis 失效
标题翻译：引起针对禽类球虫病抗体的艾美球虫抗原组合物
公开(公告)号：US5597571A
公开(公告)日：1997-01-28
申请号：US484387
申请日：1995-06-07
申请人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
发明人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20 , C12N15/30 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/012
CPC分类号： C12N15/70 , C07K14/455 , C07K16/20 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , Y10S530/822
摘要： This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.
摘要翻译：本发明涉及禽类球虫病的新型重组抗原蛋白及其含有抗原决定簇的片段，以及编码抗原肽的基因。本发明还涉及使用禽类球虫病的新型抗原蛋白质制备的疫苗以及针对禽类球虫免疫鸡的方法。

3. 发明授权

US5482709A Eimeria antigenic composition which elicits antibodies against avian coccidiosis 失效
标题翻译：引起针对禽类球虫病抗体的艾美球虫抗原组合物
公开(公告)号：US5482709A
公开(公告)日：1996-01-09
申请号：US148432
申请日：1993-11-08
申请人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
发明人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20 , C12N15/30 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/012
CPC分类号： C12N15/70 , C07K14/455 , C07K16/20 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , Y10S530/822
摘要： This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.
摘要翻译：本发明涉及禽类球虫病的新型重组抗原蛋白及其含有抗原决定簇的片段，以及编码抗原肽的基因。本发明还涉及使用禽类球虫病的新型抗原蛋白质制备的疫苗以及针对禽类球虫免疫鸡的方法。

4. 发明授权

US5273901A Genetically engineered coccidiosis sporozoite 21.5 Kb antigen, ac-6b 失效
标题翻译：基因工程球孢子虫子孢子21.5 Kb抗原，ac-6b
公开(公告)号：US5273901A
公开(公告)日：1993-12-28
申请号：US581693
申请日：1990-09-12
申请人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
发明人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20 , C12N15/30 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/12 , C07K15/04
CPC分类号： C12N15/70 , C07K14/455 , C07K16/20 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , Y10S530/822
摘要： This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.
摘要翻译：本发明涉及禽类球虫病的新型重组抗原蛋白及其含有抗原决定簇的片段，以及编码抗原肽的基因。本发明还涉及使用禽类球虫病的新型抗原蛋白质制备的疫苗以及针对禽类球虫免疫鸡的方法。

5. 发明授权

US5709862A Isolated protein from Eimeria useful as a cross species vaccine 失效
标题翻译：来自艾美球虫的分离的蛋白质可用作交叉疫苗
公开(公告)号：US5709862A
公开(公告)日：1998-01-20
申请号：US148279
申请日：1993-11-08
申请人： David M. Anderson , Russell J. McCandliss , Susan Lee Strausberg , Robert L. Strausberg , Michael D. Ruff , Harry D. Danforth , Patricia C. Augustine
发明人： David M. Anderson , Russell J. McCandliss , Susan Lee Strausberg , Robert L. Strausberg , Michael D. Ruff , Harry D. Danforth , Patricia C. Augustine
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/002 , A61K39/012
CPC分类号： C07K14/455 , C12N15/70 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , C12N2830/002 , C12N2830/15 , Y10S530/822
摘要： A cloned gene or fragment thereof encodes antigenic proteins that bind with a monoclonal or polyvalent antibody that is directed against an antigenic protein of avian coccidia.
摘要翻译：克隆的基因或其片段编码与针对禽类球虫抗原蛋白的单克隆或多价抗体结合的抗原蛋白。

6. 发明授权

US5279960A 25 KD coccidial antigen of eimeria tenella 失效
标题翻译：艾美球虫的25 KD球虫抗原
公开(公告)号：US5279960A
公开(公告)日：1994-01-18
申请号：US879137
申请日：1992-05-05
申请人： David M. Anderson , Russell J. McCandliss , Susan L. Strausberg , Robert L. Strausberg , Michael D. Ruff , Harry D. Danforth , Patricia C. Augustine
发明人： David M. Anderson , Russell J. McCandliss , Susan L. Strausberg , Robert L. Strausberg , Michael D. Ruff , Harry D. Danforth , Patricia C. Augustine
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/012 , C07K15/04 , C12N15/30 , C12N15/67
CPC分类号： C07K14/455 , C12N15/70 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , C12N2830/002 , C12N2830/15 , Y10S530/822
摘要： A cloned gene or fragment thereof encodes antigenic proteins that bind with a monoclonal or polyvalent antibody that is directed against an antigenic protein of avian coccidia.
摘要翻译：克隆的基因或其片段编码与针对禽类球虫抗原蛋白的单克隆或多价抗体结合的抗原蛋白。

7. 发明授权

US5013652A Composite yeast vectors 失效
标题翻译：复合酵母载体
公开(公告)号：US5013652A
公开(公告)日：1991-05-07
申请号：US918147
申请日：1986-10-14
申请人： Robert L. Strausberg , Susan L. Strausberg
发明人： Robert L. Strausberg , Susan L. Strausberg
IPC分类号： C07K14/39 , C07K14/81 , C12N15/62 , C12N15/81
CPC分类号： C07K14/8128 , C07K14/39 , C12N15/625 , C12N15/81 , C07K2319/036 , C07K2319/81
摘要： A DNA sequence comprising:(a) a hybrid first yeast promoter comprising the functional segment of the DNA sequence encoding the upstream activation site of a gene selected from the group consisting of GAL1, GAL7 and GAL10, operably linked to the functional segment of the transcription initiation site of MF-.alpha.-1;(b) the functional segment of a signal sequence substantially comprising preferred yeast codons;(c) the functional segment of the DNA sequence comprising a Saccharomyces GAPDH transcription terminator;(d) the functional segment of the Saccharomyces 2.mu. circle replication origin; and(e) the functional segment of the yeast LEU2-d selectable marker. The DNA sequence may further comprise, inserted in phase between the signal sequence and transcription terminator, the functional segment of a DNA sequence encoding a heterologous target peptide. DNA expression vectors comprising these sequences, DNA expression systems comprising these vectors and further comprising a source of the peptide encoded by the DNA sequence of the GAL4 structural gene, yeast hosts transformed with said expression vectors or expression systems, methods of producing heterologous target peptides in yeast hosts employing the sequences, vectors and systems of the invention, and heterologous target peptides produced according to these methods are disclosed. By means of the present invention, ultrahigh (greater than 1 gram/liter, or at least 10% of total yeast cell protein) expression of heterologous peptides may be effected.
摘要翻译：一种DNA序列，其包含：（a）混合的第一酵母启动子，其包含编码选自GAL1，GAL7和GAL10的基因的上游激活位点的DNA序列的功能区段，其可操作地连接到转录的功能区段 MF-α-1的起始位点; （b）基本上包含优选的酵母密码子的信号序列的功能片段; （c）包含酵母GAPDH转录终止子的DNA序列的功能区段; （d）酵母菌2亩复制起源的功能区段; 和（e）酵母LEU2-d选择标记的功能区段。 DNA序列可以进一步包含在信号序列和转录终止子之间的相位插入编码异源靶肽的DNA序列的功能区段。包含这些序列的DNA表达载体，包含这些载体的DNA表达系统，并且还包含由所述GAL4结构基因的DNA序列编码的肽的来源，用所述表达载体或表达系统转化的酵母宿主，在所述DNA表达系统中产生异源靶肽的方法公开了使用本发明的序列，载体和系统的酵母宿主，以及根据这些方法生产的异源靶肽。通过本发明，可以实现异源肽的超高（大于1克/升，或总酵母细胞蛋白的至少10％）的表达。

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