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    • 4. 发明授权
    • Method of making a biocompatible prosthesis
    • 制造生物相容假体的方法
    • US4994298A
    • 1991-02-19
    • US512543
    • 1990-04-18
    • Hirotsugu K. Yasuda
    • Hirotsugu K. Yasuda
    • A61L33/00B05D7/24
    • B05D1/62A61L33/0088Y10S623/901
    • A method of making a biocompatible hollow artifact with perforated walls made from a substrate of electro-conductive material whose surface is exposed to a biological environment, such as living animal tissue or blood, to impart to said material biocompatibility at the site of exposure, comprising:subjecting said exposed surface of the substrate to exposure to a plasma gas discharge in a plasma zone containing a plasma polymerizable monomeric gas to form a thin flexible coating on said substrate, said exposure being performed for a sufficient period of time and under relative movement between said plasma zone and said substrate, the volume of said plasma zone being capable of complete immersion of the substrate and being of such a magnitude in relation to the volume of the substrate as to enable the substrate to travel in or through the plasma zone under plasma polymerization without disturbing the plasma generation.
    • 一种制造具有多孔壁的生物相容性中空假象的方法,该多孔壁由其表面暴露于诸如活的动物组织或血液的生物环境的导电材料的基底制成,以赋予暴露部位的所述材料生物相容性,包括 :使所述衬底的所述暴露表面暴露于含有等离子体可聚合单体气体的等离子体气体中,以在所述衬底上形成薄的柔性涂层,所述曝光进行足够的时间并在相对运动之间进行 所述等离子体区域和所述衬底,所述等离子体区域的体积能够完全浸没衬底并且相对于衬底的体积具有如此大的量级,以使得衬底能够在等离子体中等离子体区域内或穿过等离子体区域 聚合而不影响等离子体产生。