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    • 1. 发明申请
    • Method of preparing mixed formulation of sustained release microspheres by continuous one-step process
    • 通过连续一步法制备缓释微球混合制剂的方法
    • US20070059363A1
    • 2007-03-15
    • US10562379
    • 2004-06-25
    • Hee LeeSung KimJung KimJi LeeYoung JungJun KimYun SeoHo-Il ChoiSeung ChangKee Park
    • Hee LeeSung KimJung KimJi LeeYoung JungJun KimYun SeoHo-Il ChoiSeung ChangKee Park
    • A61K38/17A61K9/22
    • A61K9/1694A61K9/1647A61K9/5084A61K38/24
    • Disclosed is a method for preparing a mixed formulation of sustained release microspheres with various compositions by a continuous one-step process. The present method is characterized by preparing the mixed formulation of sustained release microspheres with different compositions by a continuous one-step process by continuously introducing the mixed fluids into a dryer from the two or more different fluids for preparation of sustained release microspheres containing a biodegradable polymer, a drug, an additive and a solvent with different types of contents or both of the components, by controlling the mixing ratios of the fluids according to the time, unlike a conventional method including spray-drying a mixture of microspheres containing a biodegradable polymer, a drug, an additive and a solvent with a single composition. The present method can achieve a desired drug release, which is difficult to be obtained by conventional microspheres with a single composition, by preparing microspheres by a continuous one-step process, and can simplify the conventional complex process of separately preparing several microsphere formulations and then mixing the formulations at a proper ratio to achieve a desired drug release.
    • 公开了通过连续一步法制备具有各种组成的缓释微球混合制剂的方法。 本发明的方法的特征在于通过连续一步法制备具有不同组成的缓释微球的混合制剂,通过从两种或更多种不同的流体连续引入混合流体到干燥器中,用于制备含有可生物降解聚合物的缓释微球 ,药物,添加剂和具有不同类型含量的溶剂或两种组分的溶剂通过控制流体的混合比而不同于常规方法,包括喷雾干燥含有可生物降解的聚合物的微球体的混合物, 药物,添加剂和具有单一组成的溶剂。 本发明方法可以通过连续一步法制备微球,实现通过具有单一组成的常规微球难以获得的所需药物释放,并且可以简化分别制备几种微球制剂的常规复合方法,然后 以适当的比例混合制剂以实现期望的药物释放。