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1. 发明授权

US06246710B1 Method and apparatus for replenishing dye solution in a dye laser 失效
标题翻译：用于在染料激光器中补充染料溶液的方法和装置
公开(公告)号：US06246710B1
公开(公告)日：2001-06-12
申请号：US08929883
申请日：1997-09-15
申请人： Horace W. Furumoto , Harry L. Ceccon , George E. S. Cho , Mark P. Hacker
发明人： Horace W. Furumoto , Harry L. Ceccon , George E. S. Cho , Mark P. Hacker
IPC分类号： H01S322
CPC分类号： H01S3/022 , H01S3/213
摘要： In a dye laser system, a porous bed filter is loaded with dye prior to operation of the system. With repeated firings, the dye solution is filtered by the porous bed filter to remove by-products of the laser process. Solute concentration is monitored and dye and additives removed by the filter are replenished by a metering pump. Precise temperature control assures consistent filtering of dye by the filter for more consistent color and energy output. To control the metering pump, the differential output of a two-channel absorption detector is digitized. The digitized signal is loaded into a counter which drives the metering pump. The useful lifetime of the dye solution is enhanced by incorporating pH buffers in the solution.
摘要翻译：在染料激光系统中，在系统操作之前，多孔床式过滤器装载有染料。随着反复点燃，染料溶液被多孔床过滤器过滤，以除去激光过程的副产物。监测溶质浓度，并通过计量泵补充由过滤器除去的染料和添加剂。精确的温度控制确保了滤色片对染料的一致过滤，从而获得更一致的色彩和能量输出。为了控制计量泵，双通道吸收检测器的差分输出被数字化。数字化信号被装载到驱动计量泵的计数器中。通过在溶液中加入pH缓冲液可以增强染料溶液的使用寿命。

2. 发明授权

US06570900B2 Method and apparatus for replenishing dye solution in a dye laser 失效
标题翻译：用于在染料激光器中补充染料溶液的方法和装置
公开(公告)号：US06570900B2
公开(公告)日：2003-05-27
申请号：US09877500
申请日：2001-06-08
申请人： Horace W. Furumoto , Harry L. Ceccon , George E. S. Cho , Mark P. Hacker
发明人： Horace W. Furumoto , Harry L. Ceccon , George E. S. Cho , Mark P. Hacker
IPC分类号： H01S320
CPC分类号： H01S3/022 , H01S3/213
摘要： In a dye laser system, a porous bed filter is loaded with dye prior to operation of the system. With repeated firings, the dye solution is filtered by the porous bed filter to remove by-products of the laser process. Solute concentration is monitored and dye and additives removed by the filter are replenished by a metering pump. Precise temperature control assures consistent filtering of dye by the filter for more consistent color and energy output. To control the metering pump, the differential output of a two-channel absorption detector is digitized. The digitized signal is loaded into a counter which drives the metering pump. The useful lifetime of the dye solution is enhanced by incorporating pH buffers in the solution.
摘要翻译：在染料激光系统中，在系统操作之前，多孔床式过滤器装载有染料。随着反复点燃，染料溶液被多孔床过滤器过滤，以除去激光过程的副产物。监测溶质浓度，并通过计量泵补充由过滤器除去的染料和添加剂。精确的温度控制确保了滤色片对染料的一致过滤，从而获得更一致的色彩和能量输出。为了控制计量泵，双通道吸收检测器的差分输出被数字化。数字化信号被装载到驱动计量泵的计数器中。通过在溶液中加入pH缓冲液来增强染料溶液的有效寿命。

3. 发明授权

US5672170A Laser transmyocardial revascularization arrangement 失效
标题翻译：激光经心肌血运重建安排
公开(公告)号：US5672170A
公开(公告)日：1997-09-30
申请号：US666251
申请日：1996-06-20
申请人： George E. S. Cho , Horace W. Furumoto
发明人： George E. S. Cho , Horace W. Furumoto
IPC分类号： A61B17/00 , A61B18/24 , A61B5/06 , A61B5/00 , A61N1/362
CPC分类号： A61B18/24 , A61B2017/00247 , A61B2017/00703 , A61B2018/00392
摘要： The present invention involves a system for transmyocardial revascularization of a beating heart, including a laser device for ablating wall tissue of the heart being treated, with a pacemaker connected to the heart being treated, to provide electrical signals to control the cardiac cycle of that heart, and a conditioning circuit connected to both the pacemaker and to the laser, to permit the controlled "safe period" firing of the laser. The laser includes an optic waveguide articulably arranged to irradiate the wall of the heart. The conditioning circuit is programmed to permit the firing of the laser upon the time of the cardiac cycle of the heart during a non-ventricular repolarization time period.
摘要翻译：本发明涉及一种用于搏动心脏的心肌心肌血运重建的系统，包括用于消除正在治疗的心脏的壁组织的激光装置，其中起搏器连接到被治疗的心脏，以提供电信号以控制该心脏的心动周期以及连接起搏器和激光两者的调节电路，以允许激光的受控的“安全期”的烧制。该激光器包括可枢转地布置成照射心脏壁的光波导。调理电路被编程为允许在非心室复极化时间段期间在心脏心脏周期时激光的激发。

4. 发明授权

US5668824A Method and apparatus for replenishing dye solution in a dye laser 失效
标题翻译：用于在染料激光器中补充染料溶液的方法和装置
公开(公告)号：US5668824A
公开(公告)日：1997-09-16
申请号：US165331
申请日：1993-12-10
申请人： Horace W. Furumoto , Harry L. Ceccon , George E. S. Cho , Mark P. Hacker
发明人： Horace W. Furumoto , Harry L. Ceccon , George E. S. Cho , Mark P. Hacker
IPC分类号： H01S3/131 , H01S3/02 , H01S3/213 , H01S3/20
CPC分类号： H01S3/022 , H01S3/213
摘要： In a dye laser system, a porous bed filter is loaded with dye prior to operation of the system. With repeated firings, the dye solution is filtered by the porous bed filter to remove by-products of the laser process. Solute concentration is monitored and dye and additives removed by the filter are replenished by a metering pump. Precise temperature control assures consistent filtering of dye by the filter for more consistent color and energy output. To control the metering pump, the differential output of a two-channel absorption detector is digitized. The digitized signal is loaded into a counter which drives the metering pump. The useful lifetime of the dye solution is enhanced by incorporating pH buffers in the solution.
摘要翻译：在染料激光系统中，在系统操作之前，多孔床式过滤器装载有染料。随着反复点燃，染料溶液被多孔床过滤器过滤，以除去激光过程的副产物。监测溶质浓度，并通过计量泵补充由过滤器除去的染料和添加剂。精确的温度控制确保了滤色片对染料的一致过滤，从而获得更一致的色彩和能量输出。为了控制计量泵，双通道吸收检测器的差分输出被数字化。数字化信号被装载到驱动计量泵的计数器中。通过在溶液中加入pH缓冲液可以增强染料溶液的使用寿命。

5. 发明授权

US06547781B1 Ultra-long flashlamp-excited pulse dye laser for therapy and method therefor 有权
公开(公告)号：US06547781B1
公开(公告)日：2003-04-15
申请号：US09501450
申请日：2000-02-10
申请人： Horace W. Furumoto
发明人： Horace W. Furumoto
IPC分类号： A61B1820
CPC分类号： H01S3/092 , A61B18/203 , A61B2017/00172 , A61B2017/22085 , A61B2018/00452 , A61B2018/00476 , H01S3/08072 , H01S3/1633 , H01S2301/08
摘要： A flashlamp-excited dye laser generating light pulses for therapy has a circulator which circulates a gain media through a dye cell. A controller coordinates operation by triggering flashlamps to excite the laser gain media while the circulator is circulating the gain media. This operation enables the effective generation of laser light pulses with a duration of at least one millisecond. The laser pulse is formed from many subpulses. If the flow velocity of dye solution is great enough such that the new solution enters the resonant cavity before the solutions in the cavity are substantially spent, subsequent subpulses are not quenched, enabling the generation of ultra-long effective pulses with high fluences. Specifically, longer effective pulses of up to 50 msec are attainable with energies of up to 50 Joules. These energies enable reasonable spot sizes, which makes the invention relevant to cutaneous as well as deep tissue therapy, for example.

6. 发明授权

US06228075B1 Alexandrite laser system for hair removal 有权
标题翻译： Alexandrite激光系统用于脱毛
公开(公告)号：US06228075B1
公开(公告)日：2001-05-08
申请号：US09270227
申请日：1999-03-15
申请人： Horace W. Furumoto
发明人： Horace W. Furumoto
IPC分类号： A61B1818
CPC分类号： H01S3/092 , A61B18/203 , A61B2017/00172 , A61B2017/22085 , A61B2018/00452 , A61B2018/00476 , H01S3/08072 , H01S3/1633 , H01S2301/08
摘要： A long pulse alexandrite laser hair removal system is disclosed using light pulses of greater than 1 msec and fluences between 10 and 50 J/cm2. The use of an alexandrite laser allows good penetration while still achieving an acceptable combination of hemoglobin and melanin absorption. The use of an index-matching application on the skin sections to be treated is also described. This substance will be absorbed into the epidermal layer to provide better coupling of the laser light into the skin. Also, and most advantageously, it will reduce reflections at the epidermal-dermal junction, which can lead to the damage of the skin. Also a topical thermal or photochromic indicator is suggested since skin irradiation in the near-infrared generally does not produce any characteristic skin color change as is found when using pulsed dye lasers, for example.
摘要翻译：公开了使用大于1毫秒的光脉冲和10至50J / cm 2之间的通量的长脉冲亚历山大激光脱毛系统。使用亚历山大雕刻激光器可以很好地渗透，同时仍能达到可接受的血红蛋白和黑色素吸收的组合。还描述了在待治疗的皮肤部分上使用指数匹配应用。该物质将被吸收到表皮层中以提供更好的激光与皮肤的耦合。此外，并且最有利地，它将减少表皮 - 皮肤接合处的反射，其可导致皮肤的损伤。建议使用局部热或光致变色指示剂，因为例如在使用脉冲染料激光时，近红外线中的皮肤辐射通常不会产生任何特征的肤色变化。

7. 发明授权

US5843072A Method for treatment of unwanted veins and device therefor 失效
标题翻译：治疗不需要的静脉的方法及其装置
公开(公告)号：US5843072A
公开(公告)日：1998-12-01
申请号：US745133
申请日：1996-11-07
申请人： Horace W. Furumoto , George Cho , David H. McDaniel
发明人： Horace W. Furumoto , George Cho , David H. McDaniel
IPC分类号： A61B17/00 , A61B17/22 , A61B18/20 , H01S3/08 , H01S3/092 , H01S3/16 , A61B17/36
CPC分类号： H01S3/092 , A61B18/203 , A61B2017/00172 , A61B2017/22085 , A61B2018/00452 , A61B2018/00476 , H01S2301/08 , H01S3/08072 , H01S3/1633
摘要： A combined sclerotherapy and light treatment method is described for the treatment of unwanted veins such as varicose and telangiectatic leg veins. Substantially increased success, in the range of 90-100%, has been achieved by implementing a dwell time of between 12 hours and 6 months between the light-based therapy and the sclerotherapy. Near infra-red wavelength light is preferably used in the light therapy due to its better depths of penetration through the skin to deeper lying, larger vessels such as varicose veins.
摘要翻译：描述了治疗不想要的静脉，例如静脉曲张和毛细血管扩张性腿静脉的组合的硬化疗法和光治疗方法。通过在光疗法和硬化疗法之间实施12个月至6个月之间的停留时间，已经实现了在90-100％范围内的显着增加的成功。近红外波长的光优选用于光疗法，因为其更好的穿透皮肤的深度到更深的躺卧，更大的血管如静脉曲张。

8. 发明授权

US06273883B1 Alexandrite laser system for treatment of dermatological specimens 失效
标题翻译：用于治疗皮肤病学标本的Alexandrite激光系统
公开(公告)号：US06273883B1
公开(公告)日：2001-08-14
申请号：US08835012
申请日：1997-04-08
申请人： Horace W. Furumoto
发明人： Horace W. Furumoto
IPC分类号： A61B1818
CPC分类号： H01S3/092 , A61B18/203 , A61B2017/00172 , A61B2017/22085 , A61B2018/00452 , A61B2018/00476 , H01S3/08072 , H01S3/1633 , H01S2301/08
摘要： A long pulse alexandrite laser system for treating dermatological specimens is disclosed. The use of alexandrite allows operation in the near-infrared, specifically in a 50 nm range surrounding 755. Infrared in this range allows good penetration while still achieving an acceptable ratio of hemoglobin to melanin absorption. In operation, the laser generates pulses; having a durations between 5 and 100 msec and fluences between 10 and 50 J/cm2. A light delivery system is provided that transmits the laser light output pulse to dermatological targets of a patient. The system is also directed to a hair removal. Here, it is desirable to use an index-matching application on the skin sections to be treated, and a visual indicator is thermo- or photo-responsive or otherwise responsive to the laser light pulse to generate a visible change. This provides the operator with a record of those parts of the skin that have already been treated. Finally, the system is directed to a combined sclerotherapy and light treatment method and kit for unwanted veins. Substantially increased success, in the range of 90-100% has been achieved by implementing a dwell time of between 12 hours and 6 months between the light-based therapy and the sclerotherapy. Preferably, the light-based therapy is performed before the sclerotherapy. Success can be achieved by performing the sclerotherapy followed by the light-based therapy after the dwell time, however.
摘要翻译：公开了用于治疗皮肤病学标本的长脉冲亚历山大镭射系统。使用alexandrite可以在近红外线中进行操作，特别是在围绕755的50nm范围内。在该范围内的红外线允许良好的穿透，同时仍然达到可接受的血红蛋白与黑色素吸收比。在操作中，激光产生脉冲; 持续时间在5和100毫秒之间，注量在10和50J / cm2之间。提供了一种光传输系统，其将激光输出脉冲传送到患者的皮肤病学靶标。该系统还针对脱毛。这里，期望在要处理的皮肤部分上使用折射率匹配应用，并且视觉指示器是热敏或光敏响应的，或以其他方式响应于激光脉冲以产生可见变化。这为操作者提供已经被处理的皮肤部分的记录。最后，该系统针对组合的硬化疗法和光治疗方法和用于不想要的静脉的试剂盒。在光疗和硬化治疗之间，通过实施12个月至6个月的停留时间，在90-100％的范围内大大提高了成功率。优选地，光硬化治疗在硬化治疗之前进行。然而，通过在停留时间之后进行硬化治疗，然后进行基于光的治疗，可以实现成功。

9. 发明授权

US4636287A Frequency swept laser system for isotope excitation 失效
标题翻译：频率扫描激光系统用于同位素激发
公开(公告)号：US4636287A
公开(公告)日：1987-01-13
申请号：US546633
申请日：1983-10-28
申请人： Charles T. Pike , Horace W. Furumoto , Lawrence A. Levin
发明人： Charles T. Pike , Horace W. Furumoto , Lawrence A. Levin
IPC分类号： B01D59/50 , H01S3/106 , H01S3/107 , H01S3/23 , B01D59/00
CPC分类号： H01S3/2383 , B01D59/50 , H01S3/1066 , H01S3/107
摘要： Method and apparatus for exciting particles in an environment in which a selected isotope, of broadened spectral absorption bandwidth, is exposed to laser radiation having a frequency bandwidth substantially narrower than the spectral width. The laser radiation is frequency swept entirely across the broadened spectral width of the absorption band of the selected isotope type particles to provide spectral matching with substantially all of these particles. A laser system is provided having the capability of sweeping a narrow spectral emission entirely across a broadened spectral absorption band.
摘要翻译：用于在环境中激发颗粒的方法和装置，其中所选择的同位素扩展的光谱吸收带宽暴露于具有基本上窄于光谱宽度的频率带宽的激光辐射。激光辐射被全部扫过所选择的同位素型粒子的吸收带宽的光谱宽度，以提供基本上所有这些粒子的光谱匹配。提供的激光系统具有完全跨越加宽的光谱吸收带扫掠窄光谱发射的能力。

10. 再颁专利

USRE40403E1 Method for non-invasive wrinkle removal and skin treatment 有权
标题翻译：非侵入性除皱和皮肤治疗方法
公开(公告)号：USRE40403E1
公开(公告)日：2008-06-24
申请号：US10176394
申请日：2002-06-19
申请人： George Cho , Horace W. Furumoto , Brian D. Zelickson
发明人： George Cho , Horace W. Furumoto , Brian D. Zelickson
IPC分类号： A61N5/67 , A61B18/20
CPC分类号： A61B18/203 , A61B2018/00452 , A61B2018/0047
摘要： A method for the treatment of wrinkles on human skin, by stimulating collagen growth beneath the epidermis layer, comprising the steps of: arranging a pulsed dye laser generator in light communication with a pulsed dye laser delivery device. The pulsed dye laser delivery device is applied against tissue having wrinkles. The pulsed dye laser generator generates a pulsed dye laser light. A pulsed dye laser light from the pulsed dye laser delivery device is directed onto the tissue, to reach hemoglobin in a collagen layer up to about 1.2 mm. beneath the surface of the tissue to effect growth changes therein.
摘要翻译：一种通过刺激表皮层下面的胶原生长来治疗人皮肤皱纹的方法，包括以下步骤：将脉冲染料激光发生器与脉冲染料激光输送装置进行光连通。将脉冲染料激光输送装置施加到具有皱纹的组织上。脉冲染料激光发生器产生脉冲染料激光。来自脉冲染料激光输送装置的脉冲染料激光被引导到组织上，以达到高达约1.2mm的胶原层中的血红蛋白。在组织的表面下方以实现其中的生长变化。

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