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1. 发明授权

US08237786B2 System and method for dense-stochastic-sampling imaging 有权
标题翻译：密集随机抽样成像的系统和方法
公开(公告)号：US08237786B2
公开(公告)日：2012-08-07
申请号：US12751816
申请日：2010-03-31
申请人： Gaudenz Danuser , Paul C. Goodwin
发明人： Gaudenz Danuser , Paul C. Goodwin
IPC分类号： H04N9/47 , H04N13/04
CPC分类号： G01N21/6428 , G01N21/636 , G01N21/6458 , G01N2021/6415 , G01N2021/6419 , G01N2201/126 , G02B21/365 , G02B21/367 , G06T3/4053
摘要： Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images.
摘要翻译：本发明的实施例涉及成像技术，特别涉及一种随时间检测相对较弱信号的成像系统，并且使用所检测的信号来确定信号发射器的位置。本发明的具体实施方案涉及用于成像荧光团标记的样品的方法和系统，以便以明显大于与光学显微镜相关联的衍射限制分辨率的分辨率产生样品的图像。本发明的实施例采用重叠 - 发射 - 图像消歧以允许从密集布置的发射器收集数据，这显着减少用于产生中间图像的数据收集时间以及计算构建高分辨率所需的中间图像的数量最终图像。本发明的另外的实施例采用分层图像处理技术来进一步解析和解释消歧图像。

2. 发明授权

US08830314B2 System and method for dense-stochastic-sampling imaging 有权
标题翻译：密集随机抽样成像的系统和方法
公开(公告)号：US08830314B2
公开(公告)日：2014-09-09
申请号：US13535468
申请日：2012-06-28
申请人： Gaudenz Danuser , Paul C. Goodwin
发明人： Gaudenz Danuser , Paul C. Goodwin
IPC分类号： H04N7/18 , G02B21/36 , G01N21/64
CPC分类号： G01N21/6428 , G01N21/636 , G01N21/6458 , G01N2021/6415 , G01N2021/6419 , G01N2201/126 , G02B21/365 , G02B21/367 , G06T3/4053
摘要： Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images.
摘要翻译：本发明的实施例涉及成像技术，特别涉及一种随时间检测相对较弱信号的成像系统，并且使用所检测的信号来确定信号发射器的位置。本发明的具体实施方案涉及用于成像荧光团标记的样品的方法和系统，以便以明显大于与光学显微镜相关联的衍射限制分辨率的分辨率产生样品的图像。本发明的实施例采用重叠 - 发射 - 图像消歧以允许从密集布置的发射器收集数据，这显着减少用于产生中间图像的数据收集时间以及计算构建高分辨率所需的中间图像的数量最终图像。本发明的另外的实施例采用分层图像处理技术来进一步解析和解释消歧图像。

3. 发明申请

US20110149097A1 SYSTEM AND METHOD FOR DENSE-STOCHASTIC-SAMPLING IMAGING 有权
标题翻译：用于渗透 - 采样成像的系统和方法
公开(公告)号：US20110149097A1
公开(公告)日：2011-06-23
申请号：US12751816
申请日：2010-03-31
申请人： Gaudenz Danuser , Paul C. Goodwin
发明人： Gaudenz Danuser , Paul C. Goodwin
IPC分类号： H04N5/228 , G01J1/58
CPC分类号： G01N21/6428 , G01N21/636 , G01N21/6458 , G01N2021/6415 , G01N2021/6419 , G01N2201/126 , G02B21/365 , G02B21/367 , G06T3/4053
摘要： Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images.
摘要翻译：本发明的实施例涉及成像技术，特别涉及一种随时间检测相对较弱信号的成像系统，并且使用所检测的信号来确定信号发射器的位置。本发明的具体实施方案涉及用于成像荧光团标记的样品的方法和系统，以便以明显大于与光学显微镜相关联的衍射限制分辨率的分辨率产生样品的图像。本发明的实施例采用重叠 - 发射 - 图像消歧以允许从密集布置的发射器收集数据，这显着减少用于产生中间图像的数据收集时间以及计算构建高分辨率所需的中间图像的数量最终图像。本发明的另外的实施例采用分层图像处理技术来进一步解析和解释消歧图像。

4. 发明授权

US08828928B2 Amphiphilic peptides and peptide particles 有权
标题翻译：两亲肽和肽颗粒
公开(公告)号：US08828928B2
公开(公告)日：2014-09-09
申请号：US13592733
申请日：2012-08-23
申请人： Christian Dittrich , Gaudenz Danuser
发明人： Christian Dittrich , Gaudenz Danuser
IPC分类号： A61K38/10 , C07K7/06 , A61K9/48 , C07K19/00 , A61K48/00 , C07K7/08 , C07K14/00
CPC分类号： C07K7/06 , A61K9/4825 , A61K9/5169 , A61K31/7105 , A61K31/711 , A61K31/713 , C07K7/08 , C07K14/001 , C07K19/00 , Y10T428/2982
摘要： The inventions provided herein relate to amphiphilic peptides and particles comprising the amphiphilic peptides. Such amphiphilic peptides and particles described herein can be used as a delivery system, e.g., for therapeutic or diagnostic purposes, or as cell penetration vehicles or cell transfection agents.
摘要翻译：本文提供的发明涉及两亲肽和包含两亲肽的颗粒。本文所述的这种两亲性肽和颗粒可用作递送系统，例如用于治疗或诊断目的，或用作细胞穿透载体或细胞转染剂。

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