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1. 发明申请

US20140138538A1 RESOLUTION AND MASS RANGE PERFORMANCE IN DISTANCE-OF-FLIGHT MASS SPECTROMETRY WITH A MULTICHANNEL FOCAL-PLANE CAMERA DETECTOR 审中-公开
标题翻译：使用多通道光学平面相机检测器的距离飞行质谱分辨率和质谱范围性能
公开(公告)号：US20140138538A1
公开(公告)日：2014-05-22
申请号：US14110998
申请日：2012-04-16
申请人： Gary M. Hieftje , Christie George Enke , Alexander W. Graham , Steven J. Ray , Elise Dennis , Charles J. Barinaga , David W. Koppenaal
发明人： Gary M. Hieftje , Christie George Enke , Alexander W. Graham , Steven J. Ray , Elise Dennis , Charles J. Barinaga , David W. Koppenaal
IPC分类号： H01J49/34
CPC分类号： H01J49/34 , H01J49/40
摘要： A distance-of-flight mass spectrometer (DOFMS) includes an ion source, a field-free region, an extraction region in which ions are accelerated, and a spatially-selective detector for spatially selectively detecting ions extracted by the extraction region. A method for operating a distance-of-flight mass spectrometer DOFMS comprises controlling a detection time in such a way as to permit ions with progressively greater mass-to-charge (m/z) ratios to enter the extraction region of the DOFMS at positions which will permit the ions with progressively greater m/z ratios to enter the detector of the DOFMS, generating a component mass spectrum at each selected value of detection time, and then assembling a composite mass spectrum by shifting the distance-of-flight axis of each component mass spectrum by a distance corresponding to the change in detection time.
摘要翻译：飞行时间质谱仪（DOFMS）包括离子源，无场区域，其中离子被加速的提取区域和用于空间选择性地检测由提取区域提取的离子的空间选择性检测器。用于操作飞行时间质谱仪DOFMS的方法包括以这样的方式控制检测时间，使得允许具有逐渐更大的质荷比（m / z）比的离子在位置处进入DOFMS的提取区域这将允许具有逐渐更大的m / z比的离子进入DOFMS的检测器，在检测时间的每个选定值处产生组分质谱，然后通过将飞行时间轴的位移每个组分质谱与检测时间的变化相对应。

2. 发明授权

US08604423B2 Method for enhancement of mass resolution over a limited mass range for time-of-flight spectrometry 有权
标题翻译：用于在飞行时间范围内有限质量范围内提高质量分辨率的方法
公开(公告)号：US08604423B2
公开(公告)日：2013-12-10
申请号：US13639257
申请日：2011-04-05
申请人： Christie G. Enke , Steven J. Ray , Alexander W. Graham , Gary M. Hieftje , Elise Dennis , Charles J. Barinaga , David W. Koppenaal
发明人： Christie G. Enke , Steven J. Ray , Alexander W. Graham , Gary M. Hieftje , Elise Dennis , Charles J. Barinaga , David W. Koppenaal
IPC分类号： H01J49/26 , H01J49/40 , B01D59/44
CPC分类号： H01J49/40 , H01J49/0031
摘要： Novel methods and instrumentation for mass spectrometry are described. Zoom-time of flight mass spectrometry (Zoom-TOF) allows increased mass resolution over a pre-determined specific range of masses. Methods for retrofitting traditional time-of-flight (TOF) and distance of flight (DOF) mass spectrometers are described, as well as novel instruments capable of performing Zoom-TOF analyses.
摘要翻译：描述了用于质谱的新方法和仪器。飞行时间缩放质谱（Zoom-TOF）允许在预定的特定质量范围内提高质量分辨率。描述了改进传统飞行时间（TOF）和飞行距离（DOF）质谱仪的方法，以及能够执行缩放TOF分析的新型仪器。

3. 发明申请

US20130020482A1 METHOD FOR ENHANCEMENT OF MASS RESOLUTION OVER A LIMITED MASS RANGE FOR TIME-OF-FLIGHT SPECTROMETRY 有权
标题翻译：用于增加飞行时间光谱的有限质量范围内的质量分辨率的方法
公开(公告)号：US20130020482A1
公开(公告)日：2013-01-24
申请号：US13639257
申请日：2011-04-05
申请人： Christie G. Enke , Steven J. Ray , Alexander W. Graham , Gary M. Hieftje , Elise Dennis , Charles J. Barinaga , David W. Koppenaal
发明人： Christie G. Enke , Steven J. Ray , Alexander W. Graham , Gary M. Hieftje , Elise Dennis , Charles J. Barinaga , David W. Koppenaal
IPC分类号： H01J49/26 , H01J49/02
CPC分类号： H01J49/40 , H01J49/0031
摘要： Novel methods and instrumentation for mass spectrometry are described. Zoom-time of flight mass spectrometry (Zoom-TOF) allows increased mass resolution over a pre-determined specific range of masses. Methods for retrofitting traditional time-of-flight (TOF) and distance of flight (DOF) mass spectrometers are described, as well as novel instruments capable of performing Zoom-TOF analyses.
摘要翻译：描述了用于质谱的新方法和仪器。飞行时间缩放质谱（Zoom-TOF）允许在预定的特定质量范围内提高质量分辨率。描述了改进传统飞行时间（TOF）和飞行距离（DOF）质谱仪的方法，以及能够执行缩放TOF分析的新型仪器。

4. 发明授权

US08648295B2 Combined distance-of-flight and time-of-flight mass spectrometer 有权
标题翻译：组合的飞行距离和飞行时间质谱仪
公开(公告)号：US08648295B2
公开(公告)日：2014-02-11
申请号：US13695675
申请日：2011-05-03
申请人： Christie G. Enke , Steven J. Ray , Alexander W. Graham , Gary M. Hieftje , Charles J. Barinaga , David W. Koppenaal
发明人： Christie G. Enke , Steven J. Ray , Alexander W. Graham , Gary M. Hieftje , Charles J. Barinaga , David W. Koppenaal
IPC分类号： H01J49/40 , H01J49/34
CPC分类号： H01J49/26 , B01D59/44 , H01J49/34 , H01J49/40
摘要： A combined distance-of-flight mass spectrometry (DOFMS) and time-of-flight mass spectrometry (TOFMS) instrument includes an ion source configured to produce ions having varying mass-to-charge ratios, a first detector configured to determine when each of the ions travels a predetermined distance, a second detector configured to determine how far each of the ions travels in a predetermined time, and a detector extraction region operable to direct portions of the ions either to the first detector or to the second detector.
摘要翻译：组合的飞行距离质谱（DOFMS）和飞行时间质谱（TOFMS）仪器包括被配置为产生具有不同质荷比的离子的离子源，第一检测器，被配置为确定每个离子传播预定距离，第二检测器被配置为确定每个离子在预定时间内行进的距离;以及检测器提取区域，其可操作以将部分离子引导到第一检测器或第二检测器。

5. 发明申请

US20130092832A1 COMBINED DISTANCE-OF-FLIGHT AND TIME-OF-FLIGHT MASS SPECTROMETER 有权
标题翻译：组合的飞行距离和飞行时间质谱仪
公开(公告)号：US20130092832A1
公开(公告)日：2013-04-18
申请号：US13695675
申请日：2011-05-03
申请人： Christie G. Enke , Steven J. Ray , Alexander W. Graham , Gary M. Hieftje , Charles J. Barinaga , David W. Koppenaal
发明人： Christie G. Enke , Steven J. Ray , Alexander W. Graham , Gary M. Hieftje , Charles J. Barinaga , David W. Koppenaal
IPC分类号： H01J49/26
CPC分类号： H01J49/26 , B01D59/44 , H01J49/34 , H01J49/40
摘要： A combined distance-of-flight mass spectrometry (DOFMS) and time-of-flight mass spectrometry (TOFMS) instrument includes an ion source configured to produce ions having varying mass-to-charge ratios, a first detector configured to determine when each of the ions travels a predetermined distance, a second detector configured to determine how far each of the ions travels in a predetermined time, and a detector extraction region operable to direct portions of the ions either to the first detector or to the second detector.
摘要翻译：组合的飞行距离质谱（DOFMS）和飞行时间质谱（TOFMS）仪器包括被配置为产生具有不同质荷比的离子的离子源，第一检测器，被配置为确定每个离子传播预定距离，第二检测器被配置为确定每个离子在预定时间内行进的距离;以及检测器提取区域，其可操作以将部分离子引导到第一检测器或第二检测器。

6. 发明申请

US20080202915A1 Methods and apparatus for ionization and desorption using a glow discharge 有权
标题翻译：使用辉光放电的电离和解吸的方法和装置
公开(公告)号：US20080202915A1
公开(公告)日：2008-08-28
申请号：US11980843
申请日：2007-10-31
申请人： Gary M. Hieftje , Steven J. Ray , Francisco J. Andrade , William C. Wetzel , Michael R. Webb , Gerardo Gamez
发明人： Gary M. Hieftje , Steven J. Ray , Francisco J. Andrade , William C. Wetzel , Michael R. Webb , Gerardo Gamez
IPC分类号： H05F3/00
CPC分类号： G01N27/62
摘要： A method for ionizing and desorbing a sample for analysis includes energizing a first and second electrode to produce a glow discharge at atmospheric pressure. The method further includes supplying a carrier gas to at least a portion of the glow discharge to create effluents thereof. The method further includes conducting the effluents of the glow discharge to the sample to ionize and desorb the sample for analysis. An associated apparatus is also disclosed.
摘要翻译：用于电离和解吸用于分析的样品的方法包括激励第一和第二电极以在大气压下产生辉光放电。该方法还包括将载气供应至辉光放电的至少一部分以产生其流出物。该方法还包括将辉光放电的流出物导入样品中以离子化和解吸样品进行分析。还公开了一种相关装置。

7. 发明授权

US08207494B2 Laser ablation flowing atmospheric-pressure afterglow for ambient mass spectrometry 有权
标题翻译：激光消融流动大气压余辉用于环境质谱
公开(公告)号：US08207494B2
公开(公告)日：2012-06-26
申请号：US12387348
申请日：2009-05-01
申请人： Gary M. Hieftje , Francisco J. Andrade , Steven J. Ray , Jacob T. Shelley
发明人： Gary M. Hieftje , Francisco J. Andrade , Steven J. Ray , Jacob T. Shelley
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0463 , H01J49/0004
摘要： Disclosed is an apparatus for performing mass spectrometry and a method of analyzing a sample through mass spectrometry. In particular, the disclosure relates to an apparatus capable of ambient mass spectrometry and mass spectral imaging and a method for the same. The apparatus couples laser ablation, flowing atmospheric-pressure afterglow ionization, and a mass spectrometer.
摘要翻译：公开了一种用于进行质谱分析的装置和通过质谱分析样品的方法。特别地，本公开涉及能够进行环境质谱和质谱成像的装置及其方法。该装置耦合激光烧蚀，大气压余辉电离和质谱仪。

8. 发明授权

US07294830B2 Simultaneous acquisition of chemical information 有权
标题翻译：同时获取化学信息
公开(公告)号：US07294830B2
公开(公告)日：2007-11-13
申请号：US10500685
申请日：2003-01-02
申请人： Gary M. Hieftje , Steven J. Ray
发明人： Gary M. Hieftje , Steven J. Ray
IPC分类号： B01D59/44
CPC分类号： H01J49/107
摘要： A method and apparatus for operating a mass spectrometer include providing at least two different ion sources, and coupling ion streams simultaneously from the at least two different ion sources to the spectrometer. Another method of operating a spectrometer includes a first coupling an ion stream from a first one of the ion sources into the spectrometer, next coupling an ion stream from a second one of the ion sources into the spectrometer, next coupling an ion stream from the second one of the ion sources into the spectrometer, and next coupling an ion stream from the first one of the ion sources into the spectrometer.
摘要翻译：用于操作质谱仪的方法和装置包括提供至少两种不同的离子源，并且将离子流同时从至少两种不同的离子源耦合到光谱仪。操作光谱仪的另一种方法包括将离子流中的第一离子源的离子流首先耦合到光谱仪中，然后将来自第二离子源的离子流耦合到光谱仪中，然后将离子流从第二离子流离子源中的一个进入光谱仪，然后将来自第一个离子源的离子流耦合到光谱仪中。

9. 发明授权

US07893408B2 Methods and apparatus for ionization and desorption using a glow discharge 有权
标题翻译：使用辉光放电的电离和解吸的方法和装置
公开(公告)号：US07893408B2
公开(公告)日：2011-02-22
申请号：US11980843
申请日：2007-10-31
申请人： Gary M. Hieftje , Steven J. Ray , Francisco J. Andrade , William C. Wetzel , Michael R. Webb , Gerardo Gamez , Jacob T. Shelley
发明人： Gary M. Hieftje , Steven J. Ray , Francisco J. Andrade , William C. Wetzel , Michael R. Webb , Gerardo Gamez , Jacob T. Shelley
IPC分类号： H05H1/26
CPC分类号： G01N27/62
摘要： A method for ionizing and desorbing a sample for analysis includes energizing a first and second electrode to produce a glow discharge at atmospheric pressure. The method further includes supplying a carrier gas to at least a portion of the glow discharge to create effluents thereof. The method further includes conducting the effluents of the glow discharge to the sample to ionize and desorb the sample for analysis. An associated apparatus is also disclosed.
摘要翻译：用于电离和解吸用于分析的样品的方法包括激励第一和第二电极以在大气压下产生辉光放电。该方法还包括将载气供应至辉光放电的至少一部分以产生其流出物。该方法还包括将辉光放电的流出物导入样品中以离子化和解吸样品进行分析。还公开了一种相关装置。

10. 发明申请

US20090272893A1 Laser ablation flowing atmospheric-pressure afterglow for ambient mass spectrometry 有权
标题翻译：激光消融流动大气压余辉用于环境质谱
公开(公告)号：US20090272893A1
公开(公告)日：2009-11-05
申请号：US12387348
申请日：2009-05-01
申请人： Gary M. Hieftje , Francisco J. Andrade , Steven J. Ray , Jacob T. Shelley
发明人： Gary M. Hieftje , Francisco J. Andrade , Steven J. Ray , Jacob T. Shelley
IPC分类号： H01J49/26 , H01J49/40
CPC分类号： H01J49/0463 , H01J49/0004
摘要： Disclosed is an apparatus for performing mass spectrometry and a method of analyzing a sample through mass spectrometry. In particular, the disclosure relates to an apparatus capable of ambient mass spectrometry and mass spectral imaging and a method for the same. The apparatus couples laser ablation, flowing atmospheric-pressure afterglow ionization, and a mass spectrometer.
摘要翻译：公开了一种用于进行质谱分析的装置和通过质谱分析样品的方法。特别地，本公开涉及能够进行环境质谱和质谱成像的装置及其方法。该装置耦合激光烧蚀，大气压余辉电离和质谱仪。

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