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    • 2. 发明授权
      US06423966B1 Method and apparatus for maldi analysis 有权
    • Method and apparatus for maldi analysis
    • US06423966B1
    • 2002-07-23
    • US09483629
    • 2000-01-14
    • Franz Hillenkamp , David M. Lough , G. Scott Higgins , Dirk Reuter
    • Franz Hillenkamp , David M. Lough , G. Scott Higgins , Dirk Reuter
    • H01J4904
    • Matrix assisted laser desorption/ionization is performed,in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpening the spectral peaks. In one embodiment the light is delivered to a matrix or sample holder having a cover, baffle or compartment. The baffle or compartment impedes or contains a plume of desorbed material and the analyte undergoes collisions to lower its mean velocity and directionality. Thus “thermalized” the analyte ions are passed to a mass analysis instrument. In a preferred embodiment an optical fiber butts up against a thin transparent plate on which the specimen resides, with the matrix side in a vacuum acceleration chamber. A mechanical stage moves the specimen in both the x- and y-directions to select a point on the specimen which is to receive the radiation. The use of a fiber optic illuminator allows the entire stage assembly to be subsumed essentially within the dimensions of a conventional stage. In other embodiments, a thermalizing compartment is provided in a capillary tube about the end of the illumination fiber and the sample matrix is deposited along the inner cylindrical wall of the tube, so the capillary forms a migration path to the outlet for thermalization of the desorbed analyte. In other embodiments microstructures having the shape of a small lean-to, overhang or perforated cover plate, or providing a high aspect surface texture, provide the necessary containment to promote thermalization of the released analyte. A thin layer or cover of fibrous or permeable material may also be used to thermalize the analyte before mass analysis, and in other embodiment this material may also act as the substrate. An automated instrument may include a fixed array of illumination fibers which are illuminated at different times to eject samples from a corresponding array of points on the specimen.
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
    • 6. 发明授权
      US6111251A Method and apparatus for MALDI analysis 失效
    • Method and apparatus for MALDI analysis
    • US6111251A
    • 2000-08-29
    • US934455
    • 1997-09-19
    • Franz Hillenkamp
    • Franz Hillenkamp
    • G01N27/62 , B01D59/44 , C40B60/14 , G01N27/64 , H01J49/00 , H01J49/04 , H01J49/10 , H01J49/16
    • H01J49/164 , H01J49/0418 , B01J2219/00387 , C40B60/14
    • Matrix assisted laser desorption/ionization is performed in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpening the spectral peaks. In one embodiment the light is delivered to a matrix or sample holder having a cover, baffle or compartment. The baffle or compartment impedes or contains a plume of desorbed material and the analyte undergoes collisions to lower its mean velocity and directionality. Thus "thermalized" the analyte ions are passed to a mass analysis instrument. In a preferred embodiment an optical fiber butts up against a thin transparent plate on which the specimen resides, with the matrix side in a vacuum acceleration chamber. A mechanical stage moves the specimen in both the x- and y-directions to select a point on the specimen which is to receive the radiation. The use of a fiber optic illuminator allows the entire stage assembly to be subsumed essentially within the dimensions of a conventional stage. In other embodiments, a thermalizing compartment is provided in a capillary tube about the end of the illumination fiber and the sample matrix is deposited along the inner cylindrical wall of the tube, so the capillary forms a migration path to the outlet for thermalization of the desorbed analyte. In other embodiments microstructures having the shape of a small lean-to, overhang or perforated cover plate, or providing a high aspect surface texture, provide the necessary containment to promote thermalization of the released analyte. A thin layer or cover of fibrous or permeable material may also be used to thermalize the analyte before mass analysis, and in another embodiment this material may also act as the substrate. An automated instrument may include a fixed array of illumination fibers which are illuminated at different times to eject samples from a corresponding array of points on the specimen.
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 7. 发明申请
      US20110001043A1 DETECTOR DEVICE FOR HIGH MASS ION DETECTION, A METHOD FOR ANALYZING IONS OF HIGH MASS AND A DEVICE FOR SELECTION BETWEEN ION DETECTORS 有权
    • DETECTOR DEVICE FOR HIGH MASS ION DETECTION, A METHOD FOR ANALYZING IONS OF HIGH MASS AND A DEVICE FOR SELECTION BETWEEN ION DETECTORS
    • 用于高质量离子检测的检测器装置，用于分析高质量离子的方法和用于在离子检测器之间选择的装置
    • US20110001043A1
    • 2011-01-06
    • US12811484
    • 2008-01-04
    • Ryan Wenzel , Ulrich Rohling , Alexis Nazabal , Franz Hillenkamp
    • Ryan Wenzel , Ulrich Rohling , Alexis Nazabal , Franz Hillenkamp
    • H01J49/40 , B01D59/44
    • H01J49/025 , H01J43/22
    • Described here is a detector for measuring heavy mass ions with high sensitivity and low saturation for time-of-flight mass spectrometry and a detector housing for selecting between multiple detectors. It relates to sensitive measuring methods of large masses in the range of about ten thousand to a few million atomic mass units. Specifically it relates to a conversion dynode in a specifically insolated geometry followed by a discrete dynode secondary electron multiplier specifically modified to decrease electron saturation and electronic ringing. Conversion dynode detectors have been used before for time-of-flight mass spectrometry and compared to direct detection with electron multipliers they exhibit superior sensitivity for high-mass, slow-moving macromolecular ions. Using a conversion dynode specifically insolated to a common ground plane has the added capabilities of allowing an increased voltage to be applied to the conversion dynode while maintaining a minimum distance between the conversion dynode and the front of the electron multiplier. This creates faster ion flight time for the secondary ions produced within the detector allowing for higher time resolution and sensitivity from the detector. Also, by adding capacitance as charge buffers to the last few electrodes of a discrete dynode electron multiplier used as a secondary electron multiplier, saturation can be greatly reduced or avoided, which is often a major problem when measuring samples with ions covering a broad mass range. The detector housing described allows multiple detectors to be selected without breaking the vacuum. By keeping all moving mechanical parts inside the vacuum, a more simple, robust and cost effective design can be realized which provides a platform for measuring ions using different detector designs.
    • 这里描述的是用于测量用于飞行时间质谱的高灵敏度和低饱和度的重质量离子的检测器，以及用于在多个检测器之间进行选择的检测器壳体。 它涉及在大约一万到几百万原子质量单位范围内的大质量的敏感测量方法。 具体地说，它涉及一种具有特殊绝缘几何形状的转换倍增极，后面是一个特别修改为减少电子饱和度和电子振铃的离散倍增电极二次电子倍增器。 已经使用转换倍增电极检测器进行飞行时间质谱分析，与使用电子倍增器的直接检测相比，它们对高质量，慢速移动的大分子离子具有优异的灵敏度。 使用专用于公共接地层的转换倍增电极具有增加的功能，允许将增加的电压施加到转换倍增电极，同时保持转换倍增极与电子倍增器的前端之间的最小距离。 这为检测器内产生的二次离子产生更快的离子飞行时间，从而能够从检测器获得较高的时间分辨率和灵敏度。 此外，通过将电容作为电荷缓冲器添加到用作二​​次电子倍增器的离散倍增电子倍增器的最后几个电极中，可以大大降低或避免饱和度，这通常是当测量具有宽质量范围的离子的样品时的主要问题 。 所述检测器壳体允许选择多个检测器而不破坏真空。 通过将所有移动的机械部件保持在真空中，可以实现更简单，鲁棒和成本有效的设计，其提供了使用不同检测器设计来测量离子的平台。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
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