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1. 发明授权

US07394542B2 Method and apparatus for chemical imaging in a microfluidic circuit 有权
公开(公告)号：US07394542B2
公开(公告)日：2008-07-01
申请号：US10920320
申请日：2004-08-18
申请人： Thomas Voigt , David Tuschel
发明人： Thomas Voigt , David Tuschel
IPC分类号： G01J3/51 , G01N21/25 , G01N21/62 , G01N21/64 , G01N21/65
CPC分类号： G01N21/05 , B01L3/5027 , G01J3/0227 , G01J3/4406 , G01N21/03 , G01N21/31 , G01N21/3577 , G01N21/64 , G01N21/65 , G01N2021/0325 , G01N2021/0346 , G01N2021/651
摘要： The disclosure generally relates to a system for detecting a change in an attribute of a substance. The system may include a photon source for producing a first of a plurality of photons which interact with the substance while an attribute of the substance changes to produce a second plurality of photons. The system may also include a filter for receiving the collected photons and providing filtered photons; a photon detector for receiving the filtered photons and obtaining therefrom a spectrum of the substance; and a processor for detecting an aspect of the filtered photons wherein the aspect of the filtered photons is the function of the attribute of the substance.

2. 发明申请

US20070258089A1 Method and apparatus for chemical imaging in a microfluidic circuit 有权
标题翻译：用于在微流体电路中进行化学成像的方法和装置
公开(公告)号：US20070258089A1
公开(公告)日：2007-11-08
申请号：US11824878
申请日：2007-07-03
申请人： David Tuschel , Thomas Voigt
发明人： David Tuschel , Thomas Voigt
IPC分类号： G01J3/30
CPC分类号： G01N21/05 , B01L3/5027 , G01J3/0227 , G01J3/4406 , G01N21/03 , G01N21/31 , G01N21/3577 , G01N21/64 , G01N21/65 , G01N2021/0325 , G01N2021/0346 , G01N2021/651
摘要： The disclosure generally relates to a system for detecting a change in an attribute of a substance. The system may include a photon source for producing a first of a plurality of photons which interact with the substance while an attribute of the substance changes to produce a second plurality of photons. The system may also include a filter for receiving the collected photons and providing filtered photons; a photon detector for receiving the filtered photons and obtaining therefrom a spectrum of the substance; and a processor for detecting an aspect of the filtered photons wherein the aspect of the filtered photons is the function of the attribute of the substance.
摘要翻译：本发明一般涉及用于检测物质属性变化的系统。该系统可以包括用于产生与物质相互作用的多个光子中的第一个的光子源，同时物质的属性改变以产生第二多个光子。该系统还可以包括用于接收所收集的光子并提供经滤光的光子的滤光器; 光子检测器，用于接收经滤光的光子并从中获得物质的光谱; 以及用于检测滤光光子的方面的处理器，其中滤光光子的方面是物质属性的函数。

3. 发明申请

US20070221732A1 Method and apparatus for counterfeiting protection 审中-公开
公开(公告)号：US20070221732A1
公开(公告)日：2007-09-27
申请号：US11641666
申请日：2006-12-20
申请人： David Tuschel , Wesley Hutchison , Thomas Voigt
发明人： David Tuschel , Wesley Hutchison , Thomas Voigt
IPC分类号： G06K7/10 , B41M3/14 , B44F1/12
CPC分类号： G06K19/10 , G06K19/06037 , G09C5/00 , H04K1/00 , H04L9/321 , H04L9/3231 , H04L2209/60
摘要： The disclosure relates generally to methods and apparatus for protecting against counterfeit products and for methods and apparatus for providing counterfeiting protection for an object. In one embodiment, the method includes the steps of: (a) accessing an object including an identifying mark having a first portion and a second portion wherein said second portion includes an encrypted feature; (b) reading the first portion to thereby obtain a first set of information; (c) transmitting the first set of information to a remote location; (d) receiving from the remote location a second set of information; and (e) reading the second portion using the second set of information to thereby determine the authenticity of the object.

4. 发明授权

US07411672B2 Method and apparatus for chemical imaging in a microfluidic circuit 有权
标题翻译：用于在微流体电路中进行化学成像的方法和装置
公开(公告)号：US07411672B2
公开(公告)日：2008-08-12
申请号：US11824878
申请日：2007-07-03
申请人： David Tuschel , Thomas Voigt
发明人： David Tuschel , Thomas Voigt
IPC分类号： G01J3/44 , G01N21/64 , G01N21/65
CPC分类号： G01N21/05 , B01L3/5027 , G01J3/0227 , G01J3/4406 , G01N21/03 , G01N21/31 , G01N21/3577 , G01N21/64 , G01N21/65 , G01N2021/0325 , G01N2021/0346 , G01N2021/651
摘要： The disclosure generally relates to a system for detecting a change in an attribute of a substance. The system may include a photon source for producing a first of a plurality of photons which interact with the substance while an attribute of the substance changes to produce a second plurality of photons. The system may also include a filter for receiving the collected photons and providing filtered photons; a photon detector for receiving the filtered photons and obtaining therefrom a spectrum of the substance; and a processor for detecting an aspect of the filtered photons wherein the aspect of the filtered photons is the function of the attribute of the substance.
摘要翻译：本发明一般涉及用于检测物质属性变化的系统。该系统可以包括用于产生与物质相互作用的多个光子中的第一个的光子源，同时物质的属性改变以产生第二多个光子。该系统还可以包括用于接收所收集的光子并提供经滤光的光子的滤光器; 光子检测器，用于接收经滤光的光子并从中获得物质的光谱; 以及用于检测滤光光子的方面的处理器，其中滤光光子的方面是物质属性的函数。

5. 发明申请

US20060170922A1 Method and apparatus for a microscope image selector 有权
标题翻译：显微镜图像选择器的方法和装置
公开(公告)号：US20060170922A1
公开(公告)日：2006-08-03
申请号：US11045080
申请日：2005-01-31
申请人： Xinghua Wang , Thomas Voigt , David Tuschel , Chenhui Wang , Patrick Treado
发明人： Xinghua Wang , Thomas Voigt , David Tuschel , Chenhui Wang , Patrick Treado
IPC分类号： G01N21/64 , G01N21/65
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0291 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/59 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/656
摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.
摘要翻译：本公开总体上涉及用于同时获得样本的多个波长鉴别光谱图像的多模式成像装置。在一个实施例中，该装置包括具有旋转器组件的图像选择器，旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导到样本，图像选择器，适于接收与样本相互作用的照明光子，并选择性地将所述相互作用的光子引导到多个检测源之一; 显微镜转台，其容纳第二多个部件，所述显微镜转台适于接收具有第二波长并且将所述光子引导到所述样品的照明光子; 适于接收与样品相互作用的照明光子并且选择性地将所述相互作用的光子引导到多个检测源中的一个的微观炮塔; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

6. 发明授权

US07268330B2 Apparatus and method for defining illumination parameters of a sample 有权
标题翻译：用于定义样品的照明参数的装置和方法
公开(公告)号：US07268330B2
公开(公告)日：2007-09-11
申请号：US11451621
申请日：2006-06-13
申请人： David Tuschel , Thomas Voigt , Chenhui Wang
发明人： David Tuschel , Thomas Voigt , Chenhui Wang
IPC分类号： G01J1/32
CPC分类号： G01N21/6428 , G01J3/02 , G01J3/027 , G01J3/10 , G01N21/65 , G01N2021/6417 , G01N2021/6471 , G01N2201/067
摘要： In one embodiment, the disclosure relates to a method for determining illumination parameters for a sample, the method may include obtaining an absorption band of the sample; obtaining an emission band of the sample and determining the illumination parameters for the sample as a function of the absorption band and the emission band of the sample.
摘要翻译：在一个实施例中，本公开涉及一种用于确定样品的照明参数的方法，所述方法可以包括获得样品的吸收带; 获得样品的发射带，并根据样品的吸收带和发射带确定样品的照射参数。

7. 发明申请

US20060268267A1 System and method for dynamic chemical imaging 有权
标题翻译：动态化学成像系统和方法
公开(公告)号：US20060268267A1
公开(公告)日：2006-11-30
申请号：US11399032
申请日：2006-04-06
申请人： Thomas Voigt , David Tuschel , John Maier
发明人： Thomas Voigt , David Tuschel , John Maier
IPC分类号： G01J3/44
CPC分类号： G01N21/6456 , G01J3/12 , G01J3/1256 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/1269 , G01N21/3563 , G01N21/3577 , G01N21/65
摘要： A system and method for detecting dynamic changes that occur in a sample between a first time interval and a second time interval using a series of at least first and second sequential chemical images of the sample. During the first time interval: (i) the sample is illuminated with a plurality of photons to thereby produce photons scattered or emitted by the sample; (ii) a two-dimensional array of detection elements is used to simultaneously detect scattered or emitted photons in a first predetermined wavelength band from different locations on or within the sample; and (iii) the two-dimensional array of detection elements is thereafter used one or more further times to simultaneously detect scattered or emitted photons in one or more further predetermined wavelength band(s) from different locations on or within the sample. The outputs of the two-dimensional array of detection elements during the first time interval are then combined to generate the first chemical image of the sample. The process is repeated during the second time interval to generate the second chemical image of the sample. Dynamic changes occurring in the sample between the first time interval and the second time interval are detected based on one or more differences between the first and second chemical images.
摘要翻译：一种系统和方法，用于使用所述样本的至少第一和第二顺序化学图像的一系列来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。在第一时间间隔期间：（i）样品用多个光子照射，从而产生样品散射或发射的光子; （ii）检测元件的二维阵列用于同时从样品上或样品内的不同位置检测来自第一预定波长带的散射或发射的光子; 然后，（iii）检测元件的二维阵列此后再被使用一次或多次，以同时检测来自样品上或样品内的不同位置的一个或多个另外的预定波长带中的散射或发射的光子。然后组合在第一时间间隔期间检测元件的二维阵列的输出以产生样本的第一化学图像。该过程在第二时间间隔期间重复以产生样品的第二化学图像。基于第一和第二化学图像之间的一个或多个差异来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。

8. 发明申请

US20060001870A1 System and method for dynamic chemical imaging 有权
公开(公告)号：US20060001870A1
公开(公告)日：2006-01-05
申请号：US10882082
申请日：2004-06-30
申请人： Thomas Voigt , David Tuschel , John Maier
发明人： Thomas Voigt , David Tuschel , John Maier
IPC分类号： G01J3/44
CPC分类号： G01N21/6456 , G01J3/12 , G01J3/1256 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/1269 , G01N21/3563 , G01N21/3577 , G01N21/65
摘要： A system and method for detecting dynamic changes that occur in a sample between a first time interval and a second time interval using a series of at least first and second sequential chemical images of the sample. During the first time interval: (i) the sample is illuminated with a plurality of photons to thereby produce photons scattered or emitted by the sample; (ii) a two-dimensional array of detection elements is used to simultaneously detect scattered or emitted photons in a first predetermined wavelength band from different locations on or within the sample; and (iii) the two-dimensional array of detection elements is thereafter used one or more further times to simultaneously detect scattered or emitted photons in one or more further predetermined wavelength band(s) from different locations on or within the sample. The outputs of the two-dimensional array of detection elements during the first time interval are then combined to generate the first chemical image of the sample. The process is repeated during the second time interval to generate the second chemical image of the sample. Dynamic changes occurring in the sample between the first time interval and the second time interval are detected based on one or more differences between the first and second chemical images.

9. 发明授权

US07414725B2 Method and apparatus for a microscope image selector 有权
标题翻译：显微镜图像选择器的方法和装置
公开(公告)号：US07414725B2
公开(公告)日：2008-08-19
申请号：US11902874
申请日：2007-09-26
申请人： Xinghua Wang , Thomas Voigt , David Tuschel , Chenhui Wang , Patrick Treado
发明人： Xinghua Wang , Thomas Voigt , David Tuschel , Chenhui Wang , Patrick Treado
IPC分类号： G01N21/25 , G02B21/00
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0291 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/59 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/656
摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.
摘要翻译：本公开总体上涉及用于同时获得样本的多个波长鉴别光谱图像的多模式成像装置。在一个实施例中，该装置包括具有旋转器组件的图像选择器，旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导到样本，图像选择器，适于接收与样本相互作用的照明光子，并选择性地将所述相互作用的光子引导到多个检测源之一; 显微镜转台，其容纳第二多个部件，所述显微镜转台适于接收具有第二波长并且将所述光子引导到所述样品的照明光子; 适于接收与样品相互作用的照明光子并且选择性地将所述相互作用的光子引导到多个检测源中的一个的微观炮塔; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

10. 发明申请

US20070241177A1 Method and apparatus for counterfeiting protection 有权
标题翻译：防伪方法及装置
公开(公告)号：US20070241177A1
公开(公告)日：2007-10-18
申请号：US11641671
申请日：2006-12-20
申请人： David Tuschel , Wesley Hutchison , Thomas Voigt
发明人： David Tuschel , Wesley Hutchison , Thomas Voigt
IPC分类号： G06F17/00 , G06K7/10
CPC分类号： G06K15/00 , G06K19/06028 , G06K19/10 , G06K2017/0064
摘要： The disclosure relates generally to methods and apparatus for protecting against counterfeit products and for methods and apparatus for providing counterfeiting protection for an object. In one embodiment, the method includes the steps of: (a) accessing an object including an identifying mark having a first portion and a second portion wherein said second portion includes an encrypted feature; (b) reading the first portion to thereby obtain a first set of information; (c) transmitting the first set of information to a remote location; (d) receiving from the remote location a second set of information; and (e) reading the second portion using the second set of information to thereby determine the authenticity of the object.
摘要翻译：本公开总体上涉及用于防止假冒产品的方法和装置以及用于为对象提供假冒保护的方法和装置。在一个实施例中，该方法包括以下步骤：（a）访问包括具有第一部分和第二部分的识别标记的对象，其中所述第二部分包括加密特征; （b）读取第一部分，从而获得第一组信息; （c）将第一组信息发送到远程位置; （d）从远程位置接收第二组信息; 和（e）使用第二组信息读取第二部分，从而确定对象的真实性。

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