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1. 发明授权

US3692835A Pharmacologically active amino-ethyl oximes 失效
标题翻译：药理学活性氨基乙氧基
公开(公告)号：US3692835A
公开(公告)日：1972-09-19
申请号：US3692835D
申请日：1968-03-25
申请人： DIJK JAN VAN , JENKIN ERIC DAVIES
发明人： DIJK JAN VAN , DAVIES JENKIN ERIC
IPC分类号： A61K31/00 , C07C271/16 , C07D20060101 , C07D215/12 , C07D317/58 , C07D319/18 , C07D327/08 , C07C131/00
CPC分类号： C07C271/16 , C07C2603/18 , C07D215/12 , C07D317/58 , C07D319/18 , C07D327/08
摘要： Certain substituted amino-ethyl oximes such as 0-(2-aminoethyl)-4''-methoxy acetophenone oxime and 0-2(amino-ethyl)2''chlorohexano-phenone oxime have been found to exhibit antidepressive activity. The invention relates to new compounds of formula I and salts thereof with pharmaceutically acceptable acids, in which formula all the substituents may be hydrogen, while R1 and R2 may furthermore be a methyl group, R3 an alkyl group, an alkoxy-alkylene group, an alkylthioalkylene group, an alkylsulphoxyalkylene group or an alkylsulphonalkylene group having up to eight carbon atoms or a benzyl group, and R4, R5 and R6 a halogen atom, an alkyl group, an alkoxy group or an alkylthio group having up to six carbon atoms, a benzyloxy group, -OH, -NH2, a mono- or dialkylamino group, in which the alkyl group(s) contain(s) one or two carbon atoms, -CN or -CF3, and two of the substitutents R4, R5 and R6 may each represent a metanitro group or together a trimethylene group, a tetramethylene group, a methylene dioxy group, an ethylene dioxy group, a benzo group, a pyridino group, an indeno-1,2-, a 1,4-benzthiazino-2,3 group or a 1,4-benzoxthino-2,3 group, with the exception of the HCl salt of the compound in which R5 and R6 each represent an orthochlorine atom and R1, R2, R3 and R4 each represent hydrogen.
摘要翻译：已经发现某些取代的氨基乙基肟如O-（2-氨基 - 乙基）-4'-甲氧基苯乙酮肟和0-2（氨基 - 乙基）-2'-氯代己酮肟表现出抗抑郁活性。

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