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1. 发明授权

US4193998A 1,2,3,4,6,7-Hexahydro-11B.alpha.H-benzo[a]quinolizine-derivatives 失效
标题翻译： 1,2,3,4,6,7-六氢-11BαH-苯并[a]喹嗪衍生物
公开(公告)号：US4193998A
公开(公告)日：1980-03-18
申请号：US915379
申请日：1978-06-14
申请人： Csaba Szantay , Lajos Szabo , Istvan Toth , Erzsebet Kanyo , Gyula Sebestyen , Sandor Virag
发明人： Csaba Szantay , Lajos Szabo , Istvan Toth , Erzsebet Kanyo , Gyula Sebestyen , Sandor Virag
IPC分类号： C07D221/02 , A61K31/47 , A61K31/4745 , A61P1/04 , A61P25/04 , A61P29/00 , C07D455/03 , C07D455/06 , C07D491/147
CPC分类号： C07D455/00 , C07D455/06
摘要： There are provided new compounds of the formula I ##STR1## wherein both R.sup.1 moieties stand for an alkyl group having 1 to 4 carbon atoms or form together a methylene bridge,R.sup.2 is cyano or an alkoxycarbonyl group having 1 to 4 carbon atoms in the alkoxy position,R.sup.3 is hydroxy or alkanoyloxy having 1 to 4 carbon atoms in the alkoxy position in .alpha.-position or .beta.-steric position,and acid addition salts thereof. There is also provided a process for the preparation of the compounds of the formula I.
摘要翻译：提供了新的式I化合物，其中两个R 1部分代表具有1至4个碳原子的烷基或一起形成亚甲基桥，R 2是氰基或具有1至4个碳原子的烷氧基羰基，烷氧基的位置，R3是羟基或在α位或β-位的烷氧基位置具有1至4个碳原子的烷酰氧基及其酸加成盐。还提供了制备式I化合物的方法。

2. 发明授权

US4102886A Process for the preparation of benzo(a)quinolizidine derivatives 失效
标题翻译：苯并（a）喹嗪衍生物的制备方法
公开(公告)号：US4102886A
公开(公告)日：1978-07-25
申请号：US624470
申请日：1975-10-21
申请人： Csaba Szantay , Lajos Szabo , Laszlo Toke , Istvan Toth , Sandor Virag , Erzsebet Kanyo , Agoston David
发明人： Csaba Szantay , Lajos Szabo , Laszlo Toke , Istvan Toth , Sandor Virag , Erzsebet Kanyo , Agoston David
IPC分类号： C07D455/06 , C07D491/056 , C07D491/14
CPC分类号： C07D491/14 , C07D455/06
摘要： A process for the preparation of a compound of the formula I or a salt thereof ##STR1## wherein R.sup.1 and R.sup.2 each represent hydrogen or a C.sub.1-4 alkoxy group, or together form a methylenedioxy group;R.sup.3, r.sup.4, r.sup.5 and R.sup.6 are the same or different and are hydrogen or a group of the formula --CH.sub.2 --(CH.sub.2).sub.n --R.sup.7 with the proviso that at least one of the members R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is other than hydrogen; R.sup.7 is carboxyl or a carboxylic acid derivative group;N = 0.1 or 2 which comprises reacting a compound of the formula II ##STR2## with an organic secondary amine and reacting the N-amine of the formula III ##STR3## thus obtained wherein R.sup.8 and R.sup.9 each represent a C.sub.1-5 alkyl group, or together with the adjacent nitrogen atom form a 5- or 6-membered heterocyclic ring which can contain a further heteroatom, with a compound of the formula IVch.sub.2 .dbd. ch -- (ch.sub.2).sub.n -- R.sup.10 (IV)wherein R.sup.10 is a cyano or alkoxycarbonyl group.
摘要翻译：一种制备式I化合物或其盐的方法，其中R 1和R 2各自代表氢或C 1-4烷氧基，或一起形成亚甲二氧基; R 3，R 4，R 5和R 6相同或不同，为氢或式-CH 2 - （CH 2）n -R 7的基团，条件是至少有一个R 3，R 4，R 5和R 6不是氢; R7是羧基或羧酸衍生物基团; N = 0.1或2，其包含用有机仲胺反应式II化合物，并使由此得到的式III的N-胺反应，其中R 8和R 9各自表示C 1-5烷基，或者与相邻的氮原子一起形成可以含有另外的杂原子的5或6元杂环与式IV的化合物CH2 = CH-（CH2）n-R10（IV），其中R10是氰基或烷氧基羰基。

3. 发明授权

US4342871A Benzo(a)quinolizidine derivatives 失效
标题翻译：苯并（a）喹嗪啶衍生物
公开(公告)号：US4342871A
公开(公告)日：1982-08-03
申请号：US744608
申请日：1976-11-24
申请人： Csaba Szantay , Lajos Szabo , Laszlo Toke , Istvan Toth , Sandor Virag , Erzsebet Kanyo , Agoston David
发明人： Csaba Szantay , Lajos Szabo , Laszlo Toke , Istvan Toth , Sandor Virag , Erzsebet Kanyo , Agoston David
IPC分类号： C07D455/06 , C07D491/056 , C07D491/14 , C07D455/03 , A61K31/47
CPC分类号： C07D491/14 , C07D455/06
摘要： An antiphlogistic compound of the formula (I) ##STR1## or a pharmaceutically effective salt thereof wherein R.sup.1 and R.sup.2 are hydrogen or C.sub.1-4 alkoxy or together form a methylenedioxy group;R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are hydrogen or a group of the formula --CH.sub.2 --(CH.sub.2).sub.n -R.sup.7 with the proviso that at least one of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is other than hydrogen;R.sup.7 is a carboxylic group or a carboxylic acid derivative group; n=0, 1 or 2, provided that if R.sup.3, R.sup.4 and R.sup.5 are hydrogen and R.sup.7 in the group R.sup.6 is cyano or alkoxycarbonyl, and n=1, then R.sup.1 and R.sup.2 are hydrogen, C.sub.2-4 alkoxy, or together form a methylenedioxy group.
摘要翻译：式（I）的消炎化合物（I）或其药学上有效的盐，其中R 1和R 2是氢或C 1-4烷氧基或一起形成亚甲二氧基; R3，R4，R5和R6是氢或式-CH2-（CH2）n-R7的基团，条件是R3，R4，R5和R6中的至少一个不是氢; R7是羧基或羧酸衍生物基团; n = 0,1或2，条件是如果R3，R4和R5是氢，R6中的R7是氰基或烷氧基羰基，n = 1，则R1和R2是氢，C2-4烷氧基或一起形成亚甲二氧基。

4. 发明授权

US4210650A Antiphlogistic method of treatment 失效
标题翻译：消炎治疗方法
公开(公告)号：US4210650A
公开(公告)日：1980-07-01
申请号：US13271
申请日：1979-02-21
申请人： Csaba Szantay , Lajos Szabo , Laszlo Toke , Istvan Toth , Sandor Virag , Erzsebet Kanyo , Agoston David
发明人： Csaba Szantay , Lajos Szabo , Laszlo Toke , Istvan Toth , Sandor Virag , Erzsebet Kanyo , Agoston David
IPC分类号： C07D455/06 , A61K31/47
CPC分类号： C07D455/06
摘要： 2-oxo-3-(.beta.-cyanoethyl)-9,10-methylenedioxy-1,2,3,4,6,7-hexahydro-11bH-benzo(a)quinolizidine (SC-118) especially and the corresponding 9,10-diethoxy compound are superior antiphlogistics which are used in effective amounts in antiphlogistic therapy.
摘要翻译：特别是2-氧代-3-（β-氰基乙基）-9,10-亚甲二氧基-1,2,3,4,6,7-六氢-11H-苯并（a）喹唑啶（SC-118）和相应的9 ，10-二乙氧基化合物是有效量用于消炎治疗的优良消炎药。

5. 发明授权

US4851416A Berban derivatives as .alpha..sub.2 -adrenergic antagonists 失效
标题翻译： Berban衍生物作为α2-肾上腺素能拮抗剂
公开(公告)号：US4851416A
公开(公告)日：1989-07-25
申请号：US867323
申请日：1986-05-23
申请人： Szilveszter Vizi , Csaba Szantai , Lajos Szabo , Istvan Toth , Gabor Kovacs , Jeno Marton , Laszlo Harsing , Gyorgy Somogyi , Jozsef Gaal
发明人： Szilveszter Vizi , Csaba Szantai , Lajos Szabo , Istvan Toth , Gabor Kovacs , Jeno Marton , Laszlo Harsing , Gyorgy Somogyi , Jozsef Gaal
IPC分类号： C07D453/00 , A61K31/47 , A61P25/02 , A61P25/24 , A61P25/26 , C07D455/03 , C07D471/04
CPC分类号： C07D455/00
摘要： The invention relates to novel racemic or optically active berban derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent independently from the other a hydroxyl, straight or branched chain alkoxy group 1 to 6 carbon atoms or R.sup.1 and R.sup.2 together represent a C.sub.1-3 alkylenedioxy group;R.sup.3 and R.sup.4 represent independently from the other hydrogen, straight or branched chain alkyl group, having 1 to 6 carbon atoms and optionally substituted by hydroxyl group, or a C.sub.2-6 alkoxycarbonyl or cyano group; andR.sup.5 represents hydrogen, straight or branched chain alkyl group having 1 to 6 carbon atoms, C.sub.1-7 aliphatic or aromatic acyl group or C.sub.1-7 alkylsulphonyl or arylsulphonyl group, anda salt thereof, to pharmaceutical compositions containing them, to the use as well as to process for preparing the novel compounds. The compounds of the formula (I) are selective .alpha..sub.2 -adrenergic receptor-blocking substances and thus, they may be used for the treament of depressive illnesses.
摘要翻译：本发明涉及式（I）的新型外消旋或光学活性伯类衍生物，其中R 1和R 2彼此独立地表示1至6个碳原子的羟基，直链或支链烷氧基或R1和R2 一起代表C1-3亚烷基二氧基; R3和R4独立地表示独立于具有1-6个碳原子并且任选被羟基取代的另一个氢，直链或支链烷基或C 2-6烷氧羰基或氰基; 并且R 5表示氢，具有1〜6个碳原子的直链或支链烷基，C 1-7脂族或芳族酰基或C 1-7烷基磺酰基或芳基磺酰基及其盐与含有它们的药物组合物以及用于制备新化合物的方法。式（I）化合物是选择性α2-肾上腺素能受体阻断物质，因此可用于抑郁症的治疗。

6. 发明授权

US06723843B2 Oligosaccharide synthesis 失效
标题翻译：寡糖合成
公开(公告)号：US06723843B2
公开(公告)日：2004-04-20
申请号：US10231909
申请日：2002-08-30
申请人： Istvan Toth , Gyula Dekany , Barry Kellam
发明人： Istvan Toth , Gyula Dekany , Barry Kellam
IPC分类号： C07H1520
CPC分类号： C07H15/18 , C07C59/90 , C07C69/738 , C07H3/06
摘要： The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.
摘要翻译：本发明提供了一种用于寡糖固相合成的系统，基于以下发现：通式（I）的2-取代-1,3-二氧环烷基连接基团可用于偶联O-糖苷和 N-糖苷型至聚合物载体。本发明提供用于固相寡糖合成的试剂，试剂盒和方法。

7. 发明授权

US06573337B1 Oligosaccharide synthesis 失效
标题翻译：寡糖合成
公开(公告)号：US06573337B1
公开(公告)日：2003-06-03
申请号：US09242816
申请日：1999-09-02
申请人： Istvan Toth , Gyula Dekany , Barry Kellam
发明人： Istvan Toth , Gyula Dekany , Barry Kellam
IPC分类号： C08F21208
CPC分类号： C07H15/18 , C07C59/90 , C07C69/738 , C07H3/06
摘要： The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.
摘要翻译：本发明提供了一种用于寡糖固相合成的系统，基于以下发现：通式（I）的2-取代-1,3-二氧环烷基连接基团可用于偶联O-糖苷和 N-糖苷型至聚合物载体。本发明提供用于固相寡糖合成的试剂，试剂盒和方法。

8. 发明授权

US07559409B2 Procedure and apparatus for the installation of an elevator 有权
标题翻译：安装电梯的步骤和设备
公开(公告)号：US07559409B2
公开(公告)日：2009-07-14
申请号：US10053578
申请日：2002-01-24
申请人： Håkan Bärneman , Gert Van Der Meijden , Istvan Toth
发明人： Håkan Bärneman , Gert Van Der Meijden , Istvan Toth
IPC分类号： B66B7/00 , B66B9/00
CPC分类号： B66B19/002 , B66B5/04 , B66B5/046 , B66B7/02 , B66B9/00 , B66B11/00 , Y10S187/90
摘要： An apparatus for the installation of an elevator includes at least one suspension element fixed to the upper part of the elevator shaft, to which element is fitted a suspension device used to support shaft equipment during installation. The suspension device is mounted on the suspension element using a mounting tool from top floor landing.
摘要翻译：一种用于安装升降机的装置包括至少一个固定到电梯井的上部的悬挂元件，该元件装配有用于在安装期间支撑轴设备的悬挂装置。悬挂装置使用顶层着陆的安装工具安装在悬挂元件上。

9. 发明授权

US4877893A Process for the preparation of 2-(O-alkyl)-2-thio-1,3,2-oxathiophospholanes 失效
标题翻译： 2-（O-烷基）-2-硫代-1,3,2-氧硫代磷脂的制备方法
公开(公告)号：US4877893A
公开(公告)日：1989-10-31
申请号：US181778
申请日：1988-04-15
申请人： Neu Jozsef , Imre Csatlos , Andras Varga , Robert Suranyi , Zoltan Ilovai , Sandor Gaal , Jozsef Karsai , Endre Sebestyen , Eva Gardi , Karoly Siki , Istvan Toth , Guszt/e,acu/a/ v Gal , Zsolt Dombay , Mrs. Erzsebet Grega nee Toth , Csaba Pavliscsak , Gyula Tarpai , Peter Bonnyay , Pal Santha
发明人： Neu Jozsef , Imre Csatlos , Andras Varga , Robert Suranyi , Zoltan Ilovai , Sandor Gaal , Jozsef Karsai , Endre Sebestyen , Eva Gardi , Karoly Siki , Istvan Toth , Guszt/e,acu/a/ v Gal , Zsolt Dombay , Mrs. Erzsebet Grega nee Toth , Csaba Pavliscsak , Gyula Tarpai , Peter Bonnyay , Pal Santha
IPC分类号： A01N57/10 , A01N57/36 , C07F9/6578
CPC分类号： A01N57/36 , C07F9/6578
摘要： A fungicidal composition comprising as active ingredient a 2-(O-[substituted]alkyl)-2-thio-1,3,2-oxathiophospholane of the Formula I ##STR1## wherein R.sub.1,R.sub.2, R.sub.3 and R.sub.4 independently from each other stand for hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkynyl andX represents halogen, hydrogen, C.sub.1-6 alkyl or mercapto. The process for the preparation of the compounds of the Formula I involves phosphorous pentasulfide, alcohols and pyridine. The compositions are wide spectrum fungicides, particularly useful in combating Sclerotinia sp., Penicillium sp., Alternaria sp., Fusarium sp., Phytophthora infestans and powdery mildew.
摘要翻译：一种杀真菌组合物，其包含作为活性成分的式I（I）的2-（O- [取代的]烷基）-2-硫代-1,3,2-氧硫代磷脂，其中R1，R2，R3和R4独立地为氢原子，C 1-6烷基，C 2-6炔基，X代表卤素，氢，C 1-6烷基或巯基。制备式I化合物的方法包括五硫化二磷，醇和吡啶。组合物是广谱杀真菌剂，特别可用于防治核盘菌属，青霉属，链格孢属，镰刀菌属，致病疫霉属和白粉菌。

10. 发明授权

US4511736A Process for the preparation of substituted chloroacetanilides 失效
标题翻译：制备取代氯乙酰苯胺的方法
公开(公告)号：US4511736A
公开(公告)日：1985-04-16
申请号：US456383
申请日：1983-01-07
申请人： Ferenc Mogyorodi , Eniko Koppany , Tibor Bodi , Karoly Balogh , Istvan Toth , Rezso Bognar , Sandor Makleit , Gyorgy Litkei , Miklos Rakosi , Zoltan Dinya
发明人： Ferenc Mogyorodi , Eniko Koppany , Tibor Bodi , Karoly Balogh , Istvan Toth , Rezso Bognar , Sandor Makleit , Gyorgy Litkei , Miklos Rakosi , Zoltan Dinya
IPC分类号： C07C233/07 , A01N20060101 , A01N37/28 , C07C20060101 , C07C102/00 , C07C102/06
CPC分类号： C07C231/02 , A01N37/22
摘要： The invention relates to a novel process for preparing chloroacetanilides of the formula ##STR1## wherein: R.sub.1 and R.sub.2 represent independently from each other a hydrogen atom or a C.sub.1-8 alkyl or C.sub.1-8 alkoxy group; andR.sub.3 stands for a straight chained or branched C.sub.1-8 alkoxy group.Said process is characterized by chloroacetylating a 2,6-dialkylaniline of the formula ##STR2## wherein R.sub.1 and R.sub.2 are as defined above, at a temperature of 10.degree. to 120.degree. C., optionally in a solvent medium in the presence of an acid binding agent, then reacting a thus-obtained intermediate with chloromethyl chloroformiate or, alternatively, reacting a compound of the formula (II) first with chloromethyl chloroformiate and subjecting then to chloroacetylation, thereafter reacting a thus-obtained intermediate with an alcohol of the formulaR.sub.3 --OH (III),wherein R.sub.3 is as defined above, optionally in a solvent medium in the presence of an acid binding agent, and recovering a product of the formula (I) in a known manner.The process of the invention enables the more simple and economic preparation of the compounds of formula (I) of improved purity.
摘要翻译：本发明涉及一种制备式（I）的氯乙酰苯胺的新方法，其中：R1和R2彼此独立地表示氢原子或C1-8烷基或C1-8烷氧基; R3代表直链或支链C 1-8烷氧基。所述方法的特征在于在10℃至120℃的温度下，任选在存在的溶剂介质中氯代乙酰化式（II）的2,6-二烷基苯胺，其中R 1和R 2如上定义然后使由此获得的中间体与氯甲基氯甲酸酯反应，或者使式（II）的化合物首先与氯甲酸氯甲酯反应，然后进行氯乙酰化，然后使由此得到的中间体与醇的醇反应任选地在酸性结合剂存在下在溶剂介质中，以已知方式回收式（I）的产物，其中R3如上所定义的式R3-OH（III）。本发明的方法使得可以更简单和经济地制备具有改进纯度的式（I）化合物。

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