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1. 发明授权

US08565505B2 Automated sequential planning of MR scans 有权
标题翻译：自动顺序规划MR扫描
公开(公告)号：US08565505B2
公开(公告)日：2013-10-22
申请号：US13126274
申请日：2009-11-02
申请人： Cornelis Johannes Franciscus Maria Bergmans , Daniel Bystrov , Harald Sepp Heese , Marc Kouwenhoven , Johan Michiel Den Harder , Arjan Willem Simonetti , Wendy De Kok
发明人： Cornelis Johannes Franciscus Maria Bergmans , Daniel Bystrov , Harald Sepp Heese , Marc Kouwenhoven , Johan Michiel Den Harder , Arjan Willem Simonetti , Wendy De Kok
IPC分类号： G06K9/00
CPC分类号： G01R33/54 , G01R33/543 , G01R33/546 , G01R33/5608 , G01R33/56383
摘要： A method of acquiring at least one clinical MRI image of a subject comprising the following steps: acquiring a first survey image with a first field of view, the first survey image having a first spatial resolution,—locating a first region of interest and at least one anatomical landmarks in the first survey image, determining the position and the orientation of the first region of interest using the anatomical landmarks, the position and the orientation of the first region being used for—planning a second survey image,—acquiring the second survey image with a second field of view, the second survey image having a second spatial resolution, the second spatial resolution being higher than the first spatial resolution, generating a geometry planning for the anatomical region of interest using the second survey image,—acquiring a diagnostic image of the anatomical region of interest using the geometry planning.
摘要翻译：一种获取对象的至少一个临床MRI图像的方法，包括以下步骤：获取具有第一视场的第一测量图像，所述第一测量图像具有第一空间分辨率， - 定位第一感兴趣区域并且至少在第一调查图像中的一个解剖标记，使用解剖学标记确定第一感兴趣区域的位置和方向，第一区域的位置和取向用于计划第二调查图像， - 获取第二调查具有第二视场的图像，所述第二测量图像具有第二空间分辨率，所述第二空间分辨率高于所述第一空间分辨率，使用所述第二测量图像生成所述感兴趣解剖区域的几何规划， - 获取诊断使用几何规划的感兴趣解剖区域的图像。

2. 发明申请

US20110206260A1 AUTOMATED SEQUENTIAL PLANNING OF MR SCANS 有权
标题翻译：自动序列扫描的顺序规划
公开(公告)号：US20110206260A1
公开(公告)日：2011-08-25
申请号：US13126274
申请日：2009-11-02
申请人： Cornelis Johannes Franciscus Maria Bergmans , Daniel Bystrov , Harald Sepp Heese , Marc Kouwenhoven , Johan Michiel Den Harder , Arjan Willem Simonetti , Wendy De Kok
发明人： Cornelis Johannes Franciscus Maria Bergmans , Daniel Bystrov , Harald Sepp Heese , Marc Kouwenhoven , Johan Michiel Den Harder , Arjan Willem Simonetti , Wendy De Kok
IPC分类号： G06K9/00
CPC分类号： G01R33/54 , G01R33/543 , G01R33/546 , G01R33/5608 , G01R33/56383
摘要： A method of acquiring at least one clinical MRI image of a subject comprising the following steps: acquiring a first survey image with a first field of view, the first survey image having a first spatial resolution,—locating a first region of interest and at least one anatomical landmarks in the first survey image, determining the position and the orientation of the first region of interest using the anatomical landmarks, the position and the orientation of the first region being used for—planning a second survey image,—acquiring the second survey image with a second field of view, the second survey image having a second spatial resolution, the second spatial resolution being higher than the first spatial resolution, generating a geometry planning for the anatomical region of interest using the second survey image,—acquiring a diagnostic image of the anatomical region of interest using the geometry planning.
摘要翻译：一种获取对象的至少一个临床MRI图像的方法，包括以下步骤：获取具有第一视场的第一测量图像，所述第一测量图像具有第一空间分辨率， - 定位第一感兴趣区域并且至少在第一调查图像中的一个解剖标记，使用解剖学标记确定第一感兴趣区域的位置和方向，第一区域的位置和取向用于计划第二调查图像， - 获取第二调查具有第二视场的图像，所述第二测量图像具有第二空间分辨率，所述第二空间分辨率高于所述第一空间分辨率，使用所述第二测量图像生成所述感兴趣解剖区域的几何规划， - 获取诊断使用几何规划的感兴趣解剖区域的图像。

3. 发明申请

US20120035463A1 AUTOMATED ANATOMY DELINEATION FOR IMAGE GUIDED THERAPY PLANNING 有权
标题翻译：自动化解剖图像指导治疗计划
公开(公告)号：US20120035463A1
公开(公告)日：2012-02-09
申请号：US13260735
申请日：2010-03-02
申请人： Vladimir Pekar , Daniel Bystrov
发明人： Vladimir Pekar , Daniel Bystrov
IPC分类号： A61B5/055 , A61N5/00 , A61N7/00 , A61B6/03
CPC分类号： A61N5/103 , G06F19/3481 , G16H20/40 , G16H30/20
摘要： When delineating anatomical structures in a medical image of a patient for radiotherapy planning, a processor (18) detects landmarks (24) in a low-resolution image (e.g., MRI or low-dose CT) and maps the detected landmarks to reference landmarks (28) in a reference contour of the anatomical structure. The mapped landmarks facilitate adjusting the reference contour to fit the anatomical structure. The adjusted reference contour data is transformed and applied to a second image using a thin-plate spline, and the adjusted high-resolution image is used for radiotherapy planning.
摘要翻译：当描绘用于放射治疗规划的患者的医学图像中的解剖结构时，处理器（18）以低分辨率图像（例如，MRI或低剂量CT）检测地标（24），并将检测到的地标映射到参考地标（ 28）在解剖结构的参考轮廓中。映射的标记有助于调整参考轮廓以适应解剖结构。使用薄板样条将调整后的参考轮廓数据变换并应用于第二图像，并且将调整后的高分辨率图像用于放射治疗计划。

4. 发明申请

US20110280461A1 GROUP-WISE IMAGE REGISTRATION BASED ON MOTION MODEL 有权
标题翻译：基于运动模型的集团愿景图像注册
公开(公告)号：US20110280461A1
公开(公告)日：2011-11-17
申请号：US13146661
申请日：2010-01-18
申请人： Daniel Bystrov , Heinrich Schulz , Torbjoern Vik , Stefan Matthias Florian Schmidt
发明人： Daniel Bystrov , Heinrich Schulz , Torbjoern Vik , Stefan Matthias Florian Schmidt
IPC分类号： G06K9/00
CPC分类号： G06T7/246 , G06T7/33 , G06T2207/10076 , G06T2207/30061
摘要： A method includes generating a set of group-wise registered images from a time sequence of images based on a region of interest of a subject or object identified in at least one of the images, the image sequence, and a motion model indicative of an estimate of a motion of the subject or object during which the image sequence is acquired.
摘要翻译：一种方法包括基于图像中的至少一个中识别的对象或对象的感兴趣区域，从图像的时间序列生成一组分组注册图像，图像序列和指示估计的运动模型获取图像序列的对象或物体的运动。

5. 发明授权

US08000508B2 User interface for motion analysis in kinematic MR studies 有权
标题翻译：用于运动学分析的用户界面
公开(公告)号：US08000508B2
公开(公告)日：2011-08-16
申请号：US11814406
申请日：2006-01-05
申请人： Daniel Bystrov , Vladimir Pekar , Kirsten Meetz , Thomas Netsch , Stewart Young
发明人： Daniel Bystrov , Vladimir Pekar , Kirsten Meetz , Thomas Netsch , Stewart Young
IPC分类号： G06K9/00
CPC分类号： G06T13/20 , G06T7/246 , G06T2207/10076 , G06T2207/10088 , G06T2207/30048
摘要： In a diagnostic imaging system (10), a user interface (82) facilitates viewing of 4D kinematic data sets. A set of reference points is selected in a first 3D image to designate an anatomical component. An algorithm (104) calculates a propagation of the selected reference points from the first 3D image into other 3D images. Transforms which describe the propagation of the reference points between 3D images are defined. An aligning algorithm (112) applies inverse of the transforms to the 3D images to define a series of frames for the video processor (120) to display, in which frames the designated anatomical component defined by the reference points in each of the 3D images remains fixed while the other portions of the anatomical region of interest move relative to the fixed designated anatomical component.
摘要翻译：在诊断成像系统（10）中，用户界面（82）便于观看4D运动数据集。在第一3D图像中选择一组参考点以指定解剖组件。算法（104）计算所选择的参考点从第一3D图像到其他3D图像的传播。定义描述3D图像之间参考点传播的变换。对准算法（112）将变换的逆向应用于3D图像以定义用于视频处理器（120）显示的一系列帧，其中由每个3D图像中的参考点定义的指定解剖组件保留固定，而感兴趣的解剖区域的其他部分相对于固定的指定解剖部件移动。

6. 发明授权

US07903852B2 Automatic determination of parameters of an imaging geometry 有权
标题翻译：自动确定成像几何参数
公开(公告)号：US07903852B2
公开(公告)日：2011-03-08
申请号：US11572710
申请日：2005-07-19
申请人： Rudolf Springorum , Kirsten Meetz , Frederik Visser , Daniel Bystrov
发明人： Rudolf Springorum , Kirsten Meetz , Frederik Visser , Daniel Bystrov
IPC分类号： G06K9/00
CPC分类号： G06T7/68 , G06T7/80 , G06T2207/30004
摘要： The apparatus comprises an input for receiving a suitable source image data of an object. The core of the apparatus is formed by a control unit 4 arranged to load image data from the input and determine a spatial position and orientation of a portion of the object and to automatically calculate actual parameters of the imaging geometry based on said position and orientation and using default parameters if the imaging geometry, selected by the control unit in accordance with the portion of the object. The apparatus according to the invention comprises a recognition module arranged to determine a spatial position and orientation of the portion of the object with respect to a coordinate system of an imaging apparatus conceived to use the actual parameters of the imaging geometry provided by the apparatus.
摘要翻译：该装置包括用于接收对象的合适的源图像数据的输入。该装置的核心由控制单元4形成，该控制单元4布置成从输入装载图像数据，并且确定对象的一部分的空间位置和方向，并且基于所述位置和方向自动计算成像几何的实际参数;以及使用默认参数，如果成像几何，由控制单元根据对象的部分选择。根据本发明的装置包括识别模块，该识别模块被布置成确定物体的该部分相对于使用由该装置提供的成像几何的实际参数构思的成像装置的坐标系的空间位置和取向。

7. 发明申请

US20090067696A1 AUTOMATED ROBUST LEARNING OF GEOMETRIES FOR MR-EXAMINATIONS 有权
标题翻译：自动化学习MR检查的几何
公开(公告)号：US20090067696A1
公开(公告)日：2009-03-12
申请号：US12279992
申请日：2007-02-12
申请人： Daniel Bystrov , Thomas Netsch , Stewart Young
发明人： Daniel Bystrov , Thomas Netsch , Stewart Young
IPC分类号： G06K9/00
CPC分类号： G01R33/543 , G01R33/5608
摘要： The present invention relates to a geometry planning software product for magnetic resonance system, comprising a database manager arranged to process an anatomical landmark set and a planning geometry of a current geometry planning session by forming a combination of both, and to add said combination to a database. The invention enables the learning of relevance of different anatomical structures for a specific planning geometry from user input. It also enables fully automated outlier detection.
摘要翻译：本发明涉及一种用于磁共振系统的几何规划软件产品，其包括数据库管理器，其被布置为通过形成两者的组合来处理解剖学标记集和当前几何规划会话的规划几何，并将所述组合添加到数据库。本发明使得能够从用户输入中学习不同解剖结构与特定规划几何的相关性。它还可以实现全自动异常值检测。

8. 发明授权

US09020234B2 Contour delineation for radiation therapy planning with real-time contour segment impact rendering 有权
标题翻译：用于具有实时轮廓段影响渲染的放射治疗计划的轮廓描绘
公开(公告)号：US09020234B2
公开(公告)日：2015-04-28
申请号：US13821572
申请日：2011-09-05
申请人： Thomas Netsch , Daniel Bystrov
发明人： Thomas Netsch , Daniel Bystrov
IPC分类号： G06T7/00 , A61N5/10
CPC分类号： G06T7/0012 , A61N5/103 , G06T7/12 , G06T2207/10072 , G06T2207/30096
摘要： A contouring module (22, 24) iteratively adjusts contours delineating a radiation target region and risk regions in a planning image. An intensity modulation optimization module (30) generates a radiation therapy plan conforming with dosage or dosage constraints (26) for the radiation target region and the risk regions delineated by the contours. A differential analysis module (40) is configured to invoke the intensity modulation optimization module (30) to estimate partial derivatives of an output of the intensity modulation optimization respective to the contours. The contouring module (22, 24) is configured to invoke the differential analysis module (40) after each iterative contour adjustment to estimate the partial derivatives respective to the contour segments and to render the contour segments on a display of the planning image with the contour segments coded based on the estimated partial derivatives to indicate impact of the contour segments on the intensity modulation optimization.
摘要翻译：轮廓模块（22,24）迭代地调整描绘辐射目标区域的轮廓并且在规划图像中风险区域。强度调制优化模块（30）产生符合用于辐射目标区域的剂量或剂量约束（26）和由轮廓描绘的风险区域的放射治疗计划。差分分析模块（40）被配置为调用强度调制优化模块（30）以估计相应于轮廓的强度调制优化的输出的偏导数。轮廓模块（22,24）被配置为在每次迭代轮廓调整之后调用差分分析模块（40）以估计相应于轮廓段的偏导数，并且使轮廓段在具有轮廓的规划图像的显示器上呈现基于估计的偏导数编码的段，以指示轮廓段对强度调制优化的影响。

9. 发明授权

US08781254B2 Method, an apparatus and a computer program for data processing 有权
标题翻译：用于数据处理的方法，装置和计算机程序
公开(公告)号：US08781254B2
公开(公告)日：2014-07-15
申请号：US12516357
申请日：2007-11-26
申请人： Stewart Young , Daniel Bystrov , Thomas Netsch , Michael Kaus , Vladimir Pekar
发明人： Stewart Young , Daniel Bystrov , Thomas Netsch , Michael Kaus , Vladimir Pekar
IPC分类号： G06K9/36
CPC分类号： G06T7/149 , G06T7/12 , G06T7/70 , G06T2207/30016
摘要： A method of data processing is provided for estimating a position of an object in an image from a position of a reference object in a reference image. The method includes learning the position of the reference object in the reference image and its relation to a set of reference landmarks in the reference image, accessing the image, accessing the relation between the position of the reference object and the set of the reference landmarks, identifying a set of landmarks in the image corresponding to the set of the reference landmarks, and applying the relation to the set of landmarks in the image for estimating the position of the object in the image.
摘要翻译：提供一种数据处理方法，用于从参考图像中的参考对象的位置估计图像中的对象的位置。该方法包括：在参考图像中学习参考对象的位置及其与参考图像中的一组参考地标的关系，访问图像，访问参考对象的位置与参考地标集合之间的关系，识别对应于所述参考地标集合的图像中的一组地标，以及将所述关系应用于所述图像中的所述地标集合，以估计所述图像中的对象的位置。

10. 发明申请

US20100295848A1 INTERACTIVE IMAGE SEGMENTATION 有权
标题翻译：互动图像分割
公开(公告)号：US20100295848A1
公开(公告)日：2010-11-25
申请号：US12863462
申请日：2009-01-07
申请人： Ruediger Grewer , Sebastian Dries , Daniel Bystrov , Vladimir Pekar , Torbjoern Vik , Heinrich Schulz , Michael Kaus
发明人： Ruediger Grewer , Sebastian Dries , Daniel Bystrov , Vladimir Pekar , Torbjoern Vik , Heinrich Schulz , Michael Kaus
IPC分类号： G06K9/34 , G06T17/00
CPC分类号： G06T7/11 , G06T2207/20101 , G06T2207/20128 , G06T2207/30004
摘要： When adapting models of anatomical structures in a patient for diagnosis or therapeutic planning, an atlas (26) of predesigned anatomical structure models or image volumes can be accessed, and a segmentation of one or more such structures can be selected and overlaid on an a 3D image of corresponding structure(s) in a clinical image (52) of a patient. A user can click on an initially unapproved segmentation 5 landmark (72) on the patient image (52), reposition the unapproved landmark, and approve the repositioned landmark. Remaining unapproved landmarks (72) are then repositioned as a function of the position of the approved landmark (92) using one or more interpolation techniques to adapt the model to the patient image on the fly.
摘要翻译：当适应用于诊断或治疗计划的患者中的解剖结构的模型时，可以访问预先设计的解剖结构模型或图像体积的图集（26），并且可以选择并覆盖在3D上的一个或多个这样的结构的分割在患者的临床图像（52）中的相应结构的图像。用户可以点击患者图像（52）上的最初未被批准的细分5地标（72），重新定位未经批准的地标，并批准重新定位的地标。然后通过使用一种或多种内插技术将剩余的未经批准的地标（72）重新定位为批准的地标（92）的位置的函数，以便将模型随时适应患者图像。

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