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1. 发明申请

US20110027379A1 Oligo-Ethylene Glycol-Based Polymer Compositions and Methods of Use 审中-公开
标题翻译：低聚 - 乙二醇基聚合物组合物和使用方法
公开(公告)号：US20110027379A1
公开(公告)日：2011-02-03
申请号：US12746500
申请日：2008-12-04
申请人： Chih-Chang Chu , Ramaz Katsarava , Zaza D. Gomurashvili , William G. Turnell
发明人： Chih-Chang Chu , Ramaz Katsarava , Zaza D. Gomurashvili , William G. Turnell
IPC分类号： A61K9/14 , A61K47/34 , C08G63/685 , B32B5/00 , A61P35/00 , A61P29/00 , B82Y5/00
CPC分类号： A61K9/19 , A61K9/0024 , A61K9/006 , A61K9/10 , A61K9/1075 , A61K9/5146 , A61K9/7007 , A61K47/34 , A61K47/59 , A61K47/593 , A61K47/595 , C08G69/40 , C08G69/44 , C08L77/06 , C08L77/12 , Y10T428/2982
摘要： The invention provides biodegradable PEAs, PEURs and PEUs that are synthesized by solution polycondensation to include α-amino acids and oligo-ethylene ether segments in the polymer backbone. The polymers can be obtained by substituting oligo-ethylene glycol (OEG) for aliphatic di-acid and diols during their fabrication. Also provided are compositions in which bioactive agents are dispersed in the polymers. The compositions biodegrade by enzymatic action to release incorporated bioactive agents and oligo-ethylene glycol segments, which are fully biodegradable at a molecular weight less than 400 Da. Due to their comparatively rapid surface enzymatic hydrolysis, the compositions can be used to deliver bioactive agents in a controlled manner within a relatively rapid delivery time, such as about 18 to 24 hours.
摘要翻译：本发明提供通过溶液缩聚合成的可生物降解PEAs，PEUR和PEU，以在聚合物主链中包括α-氨基酸和低聚乙烯醚链段。聚合物可以通过在其制备过程中用低聚乙二醇（OEG）代替脂族二酸和二醇来获得。还提供了生物活性剂分散在聚合物中的组合物。组合物通过酶促作用生物降解以释放引入的生物活性剂和低聚乙二醇片段，其在分子量小于400Da时是完全可生物降解的。由于其相对快速的表面酶水解，组合物可用于以相对快速的递送时间（例如约18至24小时）以受控的方式递送生物活性剂。

2. 发明申请

US20090029937A1 BIODEGRADABLE CATIONIC POLYMER GENE TRANSFER COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：生物可降解阳离子聚合物基因转移组合物和使用方法
公开(公告)号：US20090029937A1
公开(公告)日：2009-01-29
申请号：US12177682
申请日：2008-07-22
申请人： Chih-Chang Chu , Martha A. Mutschler-Chu , Hua Song , Bo Liu , Zaza D. Gomurashvili
发明人： Chih-Chang Chu , Martha A. Mutschler-Chu , Hua Song , Bo Liu , Zaza D. Gomurashvili
IPC分类号： A61K48/00 , C12N15/11 , C12N15/87 , C12N5/06 , A61K47/34 , A61K31/7105
CPC分类号： C08L77/12 , C08G2230/00 , C08L75/06 , C12N15/87 , C12N15/88
摘要： The invention provides biodegradable, cationic compositions based on cationic α-amino acid-containing PEA, PEUR and PEU polymers for use in preparation of non-viral gene transfer compositions. In the invention gene transfer compositions a poly nucleic acid is condensed with the polymer to form a soluble unit wherein the electrical charge of the poly nucleic acid is neutralized by the polymers. The invention gene transfer compositions can be used to transfect target cells by contact with the target cells.
摘要翻译：本发明提供基于阳离子含α-氨基酸的PEA，PEUR和PEU聚合物的可生物降解阳离子组合物，用于制备非病毒基因转移组合物。在本发明的基因转移组合物中，聚核酸与聚合物缩合形成可溶性单元，其中多核酸的电荷被聚合物中和。本发明的基因转移组合物可用于通过与靶细胞接触来转染靶细胞。

3. 发明授权

US07304122B2 Elastomeric functional biodegradable copolyester amides and copolyester urethanes 有权
标题翻译：弹性功能生物降解共聚酯酰胺和共聚酯氨基甲酸酯
公开(公告)号：US07304122B2
公开(公告)日：2007-12-04
申请号：US10362848
申请日：2001-08-30
申请人： Chih-Chang Chu , Ramaz Katsarava
发明人： Chih-Chang Chu , Ramaz Katsarava
IPC分类号： C08G63/02 , C08G18/80 , A61K9/16
CPC分类号： A61L27/18 , C08G69/44 , C08G71/04 , C08G2230/00 , C08L77/12
摘要： The present invention provides elastomeric copolyester amides, elastomeric copolyester urethanes, and methods for making the same. The polymers that are based on α-amino acids and possess suitable physical, chemical and biodegradation properties. The polymers are useful as carriers of drugs or other bioactive substances. The polymers can be linked, intermixed, or a combination thereof, to one or more drugs.
摘要翻译：本发明提供弹性体共聚酯酰胺，弹性体共聚酯聚氨酯，及其制备方法。基于α-氨基酸并具有合适的物理，化学和生物降解性质的聚合物。聚合物可用作药物或其他生物活性物质的载体。聚合物可以与一种或多种药物连接，混合或其组合。

4. 发明授权

US07408018B2 Elastomeric functional biodegradable copolyester amides and copolyester urethanes 有权
标题翻译：弹性功能生物降解共聚酯酰胺和共聚酯氨基甲酸酯
公开(公告)号：US07408018B2
公开(公告)日：2008-08-05
申请号：US11543321
申请日：2006-10-05
申请人： Chih-Chang Chu , Ramaz Katsarava
发明人： Chih-Chang Chu , Ramaz Katsarava
IPC分类号： A61K9/16 , C08G69/26
CPC分类号： A61L27/18 , C08G69/44 , C08G71/04 , C08G2230/00 , C08L77/12
摘要： The invention provides elastomeric copolyester amides, elastomeric copolyester urethanes, and methods for making the same. The polymers are based on α-amino acids and possess physical, chemical and biodegradation properties that render them suitable for use in the human body. The polymers are useful as carriers of drugs or other bioactive substances. The polymers can also be linked, intermixed, or a combination thereof, to one or more drugs. Additionally, the polymers can be used to coat stents, for example, to suppress restenosis. Furthermore, the biodegradation of the copolyester amides and copolyester urethanes allows for the delivery of essential α-amino acids to sites in the body, for example, to facilitate wound repair of injured tissues.
摘要翻译：本发明提供了弹性体共聚酯酰胺，弹性体共聚酯聚氨酯和其制备方法。聚合物基于α-氨基酸，并具有物理，化学和生物降解性质，使其适用于人体。聚合物可用作药物或其他生物活性物质的载体。聚合物也可以与一种或多种药物连接，混合或其组合。此外，聚合物可用于包衣支架，例如抑制再狭窄。此外，共聚酯酰胺和共聚酯氨基甲酸酯的生物降解允许将必需的α-氨基酸递送到体内的部位，例如以便于受伤组织的伤口修复。

5. 发明申请

US20070167605A1 Unsaturated poly(ester-amide) biomaterials 有权
标题翻译：不饱和聚（酯 - 酰胺）生物材料
公开(公告)号：US20070167605A1
公开(公告)日：2007-07-19
申请号：US11587530
申请日：2005-05-31
申请人： Chih-Chang Chu , Ramaz Katsarava , Kai Guo
发明人： Chih-Chang Chu , Ramaz Katsarava , Kai Guo
IPC分类号： C08G69/08
CPC分类号： C08G69/44 , A61K47/593 , A61K47/595 , C08L2201/06
摘要： Biodegradable poly(ester-amides) are synthesized from amino acids, diols and dicarboxylic acids where one or both of the diols and dicarboxylic acids contain unsaturation; e.g., from di-p-nitrophenyl dicarboxylates and p-toluenesulfonic acid salts of bis(alpha-amino acid) disesters of diols where one or both of the dicarboxylate and diol moieties contain unsaturation or from di-p-nitrophenyl dicarboxylates, and p-toluene-sulfonic acid salts of bis(alpha-amino acid) diesters of diols and p-toluenesulfonic acid salt of lysine ester where one or both of the dicarboxylate and diol moieties contain unsaturation. The polymers are useful as biodegradable carriers for drugs of other bioactive agents.
摘要翻译：由氨基酸，二醇和二羧酸合成可生物降解的聚（酯 - 酰胺），其中二醇和二羧酸之一或二者均含有不饱和键; 例如二羧酸二酯和二羧酸二酯部分含有不饱和键的双（α-氨基酸）二酯的双对硝基苯基二羧酸酯和对甲苯磺酸盐，或二羧酸二对硝基苯酯，二元醇的双（α-氨基酸）二酯和赖氨酸酯的对甲苯磺酸盐的甲苯磺酸盐，其中二羧酸酯和二醇部分中的一个或两个都含有不饱和键。聚合物可用作其他生物活性剂药物的可生物降解载体。

6. 发明申请

US20070027293A1 Elastomeric functional biodegradable copolyester amides and copolyester urethanes 有权
公开(公告)号：US20070027293A1
公开(公告)日：2007-02-01
申请号：US11543321
申请日：2006-10-05
申请人： Chih-Chang Chu , Ramaz Katsarava
发明人： Chih-Chang Chu , Ramaz Katsarava
IPC分类号： C08G63/02
CPC分类号： A61L27/18 , C08G69/44 , C08G71/04 , C08G2230/00 , C08L77/12
摘要： The present invention provides elastomeric copolyester amides, elastomeric copolyester urethanes, and methods for making the same. The polymers that are based on α-amino acids and possess suitable physical, chemical and biodegradation properties. The polymers are useful as carriers of drugs or other bioactive substances. The polymers can be linked, intermixed, or a combination thereof, to one or more drugs.

7. 发明授权

US06503538B1 Elastomeric functional biodegradable copolyester amides and copolyester urethanes 有权
标题翻译：弹性功能生物降解共聚酯酰胺和共聚酯氨基甲酸酯
公开(公告)号：US06503538B1
公开(公告)日：2003-01-07
申请号：US09651338
申请日：2000-08-30
申请人： Chih-Chang Chu , Ramaz Katsarava
发明人： Chih-Chang Chu , Ramaz Katsarava
IPC分类号： A61K916
CPC分类号： C08G69/44 , A61K47/59 , A61K47/593 , A61K47/595 , C08G71/00
摘要： The present invention provides elastomeric copolyester amides, elastomeric copolyester urethanes, and methods for making the same. The polymers that are based on &agr;-amino acids and possess suitable physical, chemical and biodegradation properties. The polymers are useful as carriers of drugs or other bioactive substances.
摘要翻译：本发明提供弹性体共聚酯酰胺，弹性体共聚酯聚氨酯，及其制备方法。基于α-氨基酸并具有合适的物理，化学和生物降解性质的聚合物。聚合物可用作药物或其他生物活性物质的载体。

8. 发明授权

US07863406B2 Unsaturated poly(ester-amide) biomaterials 有权
标题翻译：不饱和聚（酯 - 酰胺）生物材料
公开(公告)号：US07863406B2
公开(公告)日：2011-01-04
申请号：US11587530
申请日：2005-05-31
申请人： Chih-Chang Chu , Ramaz Katsarava , Kai Guo
发明人： Chih-Chang Chu , Ramaz Katsarava , Kai Guo
IPC分类号： C08G69/10 , C08G69/44 , C08L77/04 , C08L77/12
CPC分类号： C08G69/44 , A61K47/593 , A61K47/595 , C08L2201/06
摘要： Biodegradable poly(ester-amides) are synthesized from amino acids, diols and dicarboxylic acids where one or both of the diols and dicarboxylic acids contain unsaturation; e.g., from di-p-nitrophenyl dicarboxylates and p-toluenesulfonic acid salts of bis(alpha-amino acid) disesters of diols where one or both of the dicarboxylate and diol moieties contain unsaturation or from di-p-nitrophenyl dicarboxylates, and p-toluene-sulfonic acid salts of bis(alpha-amino acid) diesters of diols and p-toluenesulfonic acid salt of lysine ester where one or both of the dicarboxylate and diol moieties contain unsaturation. The polymers are useful as biodegradable carriers for drugs of other bioactive agents.
摘要翻译：由氨基酸，二醇和二羧酸合成可生物降解的聚（酯 - 酰胺），其中二醇和二羧酸之一或二者均含有不饱和键; 例如二羧酸二酯和二羧酸二酯部分含有不饱和键的双（α-氨基酸）二酯的双对硝基苯基二羧酸酯和对甲苯磺酸盐，或二羧酸二对硝基苯酯，二元醇的双（α-氨基酸）二酯和赖氨酸酯的对甲苯磺酸盐的甲苯磺酸盐，其中二羧酸酯和二醇部分中的一个或两个都含有不饱和键。聚合物可用作其他生物活性剂药物的可生物降解载体。

9. 发明申请

US20110015367A1 UNSATURATED POLY(ESTER-AMIDE) AND POLY(ETHER ESTER AMIDE) BIOMATERIALS 审中-公开
标题翻译：不饱和多糖（酯化酰胺）和聚（醚类）生物体
公开(公告)号：US20110015367A1
公开(公告)日：2011-01-20
申请号：US12591488
申请日：2009-11-20
申请人： Chih-Chang Chu , Ramaz Katsarava , Kai Guo
发明人： Chih-Chang Chu , Ramaz Katsarava , Kai Guo
IPC分类号： C08G69/44
CPC分类号： C08G69/44 , A61K47/59 , A61K47/593 , A61K47/595 , C08B37/0072 , C08G69/42 , C08L2201/06
摘要： Functionalized poly(ester-amides) and poly(ether ester amides) polymers having the structural formula: wherein R1 is (C2-C28)alkylene, or (C2-C28)alkylene substituted with a side chain selected from the group consisting of (2-carboxyethyl)thio, (2-hydroxethyl)thio, (2-aminoethyl)thio and (2-aminoethyl)thio hydrochloride salt; R3 is selected from the group consisting of hydrogen, (C1-C6)alkyl, and (C6-C10)aryl (C1-C6)alkyl; and R4 is selected from the group consisting of (C2-C28)alkyloxy, (C2-C28)alkylene substituted with a side chain selected from the group consisting of (2-carboxyethyl)thio, (2-hydroxethyl) thio, (2-aminoethyl)thio and (2-aminoethyl)thio hydrochloride salt, and —C2H4(OC2H4)x; x ranges from 2-4; n ranges from 5 to 150; and wherein at least one of R1 and R4 attaches a functional group.
摘要翻译：具有以下结构式的官能化聚（酯 - 酰胺）和聚（醚酯酰胺）聚合物：其中R1是（C2-C28）亚烷基，或被选自（2）的侧链的侧链取代的（C 2 -C 28）（2-羟基乙基）硫基，（2-氨基乙基）硫基和（2-氨基乙基）硫代盐酸盐; R3选自氢，（C1-C6）烷基和（C6-C10）芳基（C1-C6）烷基; 并且R 4选自（C 2 -C 28）烷氧基，被选自（2-羧乙基）硫代，（2-羟乙基）硫基，（2-羟基乙基）硫基，（2-羟基乙基）氨基乙基）硫代和（2-氨基乙基）硫代盐酸盐和-C2H4（OC2H4）x; x范围从2-4; n范围从5到150; 并且其中R1和R4中的至少一个连接官能团。

10. 发明授权

US08841440B2 Organo-soluble chitosan salts and chitosan-derived biomaterials prepared thereof 有权
标题翻译：由其制备的有机溶解的壳聚糖盐和壳聚糖衍生的生物材料
公开(公告)号：US08841440B2
公开(公告)日：2014-09-23
申请号：US12935660
申请日：2009-04-01
申请人： Chih-Chang Chu , Chao Zhong
发明人： Chih-Chang Chu , Chao Zhong
IPC分类号： C07B37/08 , C08B37/08
CPC分类号： C08B37/003 , A01N43/16 , A61L26/0023 , A61L27/20 , A61L27/60 , C08L5/08 , A01N59/16 , A01N2300/00
摘要： Organo-soluble chitosan salts, method for preparing organo-soluble salts, chitosan-derived materials prepared with organo-soluble chitosan salts, and methods for preparing chitosan-derived materials are disclosed.
摘要翻译：公开了有机溶解性壳聚糖盐，有机可溶性盐的制备方法，由有机可溶性壳聚糖盐制备的壳聚糖衍生物质，以及制备壳聚糖衍生物质的方法。

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