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1. 发明申请

US20070185312A1 Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction 审中-公开
公开(公告)号：US20070185312A1
公开(公告)日：2007-08-09
申请号：US11218035
申请日：2005-08-31
申请人： Charles Zuker , Jon Adler , Juergen Lindemeier , Nick Ryba , Mark Hoon
发明人： Charles Zuker , Jon Adler , Juergen Lindemeier , Nick Ryba , Mark Hoon
IPC分类号： C07K14/705 , C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C12N5/06 , C12N5/08
CPC分类号： C07K14/705
摘要： The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.

2. 发明申请

US20080108088A1 T2R, a novel family of taste receptors 有权
标题翻译： T2R，一种新的味觉受体家族
公开(公告)号：US20080108088A1
公开(公告)日：2008-05-08
申请号：US11978088
申请日：2007-10-25
申请人： Charles Zuker , Jon Adler , Nick Ryba , Ken Mueller , Mark Hoon
发明人： Charles Zuker , Jon Adler , Nick Ryba , Ken Mueller , Mark Hoon
IPC分类号： G01N33/53
CPC分类号： G01N33/74 , C07K14/705 , C07K14/723 , C12Q1/025 , G01N33/5041 , G01N33/5044 , G01N33/68 , G01N2333/726
摘要： The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
摘要翻译：本发明提供了一种新的味道转导性G蛋白偶联受体家族的核酸和氨基酸序列，这种受体的抗体，检测此类核酸和受体的方法，以及筛选风味转导G蛋白偶联受体调节剂的方法。

3. 发明申请

US20050048586A1 T2R, a novel family of taste receptors 有权
标题翻译： T2R，一种新的味觉受体家族
公开(公告)号：US20050048586A1
公开(公告)日：2005-03-03
申请号：US10962365
申请日：2004-10-07
申请人： Charles Zuker , Jon Adler , Nick Ryba , Ken Mueller , Mark Hoon
发明人： Charles Zuker , Jon Adler , Nick Ryba , Ken Mueller , Mark Hoon
IPC分类号： G01N33/483 , C07K14/705 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/567
CPC分类号： G01N33/74 , C07K14/705 , C07K14/723 , C12Q1/025 , G01N33/5041 , G01N33/5044 , G01N33/68 , G01N2333/726
摘要： The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
摘要翻译：本发明提供了一种新的味道转导性G蛋白偶联受体家族的核酸和氨基酸序列，这种受体的抗体，检测此类核酸和受体的方法，以及筛选风味转导G蛋白偶联受体调节剂的方法。

4. 发明申请

US20060019275A1 Nucleic acids encoding proteins involved in sensory transduction 审中-公开
标题翻译：编码参与感觉转导的蛋白质的核酸
公开(公告)号：US20060019275A1
公开(公告)日：2006-01-26
申请号：US11130821
申请日：2005-05-16
申请人： Charles Zuker , Jon Adler , Juergen Lindemeier , David Cowan
发明人： Charles Zuker , Jon Adler , Juergen Lindemeier , David Cowan
IPC分类号： C07K14/705 , C12Q1/68 , C07H21/04 , C12P21/06 , C07K16/28
CPC分类号： C07K14/47
摘要： The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific polypeptides, antibodies to such polypeptides, methods of detecting such nucleic acids and polypeptides, and methods of screening for modulators of sensory cell specific polypeptides.
摘要翻译：本发明提供了分离的感觉细胞特异性多肽的核酸和氨基酸序列，对这些多肽的抗体，检测此类核酸和多肽的方法，以及筛选感觉细胞特异性多肽调节剂的方法。

5. 发明申请

US20070042435A1 Assays for sensory modulators using a sensory cell specific G-protein beta subunit 审中-公开
标题翻译：使用感觉细胞特异性G蛋白β亚基的感觉调节剂的测定
公开(公告)号：US20070042435A1
公开(公告)日：2007-02-22
申请号：US11090764
申请日：2005-03-24
申请人： Charles Zuker , Jon Adler , Juergen Lindemeier
发明人： Charles Zuker , Jon Adler , Juergen Lindemeier
IPC分类号： G01N33/567
CPC分类号： G01N33/5058 , G01N33/5008 , G01N33/5041 , G01N33/566 , G01N2500/04
摘要： The invention identifies nucleic acid and amino acid sequences of sensory specific G-protein beta subunits that are specifically expressed in sensory cells, antibodies to such subunits, methods of detecting such nucleic acids and proteins, and methods of screening for modulators of sensory cell specific beta subunits.
摘要翻译：本发明鉴定了在感觉细胞中特异性表达的感觉特异性G蛋白β亚基的核酸和氨基酸序列，对这些亚基的抗体，检测此类核酸和蛋白的方法，以及筛选感觉细胞特异性β的调节剂的方法亚单位。

6. 发明授权

US08329885B2 Nucleic acid encoding a T2R taste receptor 有权
标题翻译：编码T2R味觉受体的核酸
公开(公告)号：US08329885B2
公开(公告)日：2012-12-11
申请号：US12966955
申请日：2010-12-13
申请人： Charles Zuker , Jon E. Adler , Nick Ryba , Ken Mueller , Mark Hoon
发明人： Charles Zuker , Jon E. Adler , Nick Ryba , Ken Mueller , Mark Hoon
IPC分类号： C07H21/04 , C12P21/06 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/02 , C12N15/74
CPC分类号： G01N33/74 , C07K14/705 , C07K14/723 , C12Q1/025 , G01N33/5041 , G01N33/5044 , G01N33/68 , G01N2333/726
摘要： The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
摘要翻译：本发明提供了一种新的味道转导性G蛋白偶联受体家族的核酸和氨基酸序列，这种受体的抗体，检测此类核酸和受体的方法，以及筛选风味转导G蛋白偶联受体调节剂的方法。

7. 发明授权

US07595166B2 Methods of screening modulators of T2R taste receptors 有权
标题翻译：筛选T2R味觉受体调节剂的方法
公开(公告)号：US07595166B2
公开(公告)日：2009-09-29
申请号：US11978088
申请日：2007-10-25
申请人： Charles Zuker , Jon E. Adler , Nick Ryba , Ken Mueller , Mark Hoon
发明人： Charles Zuker , Jon E. Adler , Nick Ryba , Ken Mueller , Mark Hoon
IPC分类号： G01N33/53 , G01N33/567 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： G01N33/74 , C07K14/705 , C07K14/723 , C12Q1/025 , G01N33/5041 , G01N33/5044 , G01N33/68 , G01N2333/726
摘要： The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
摘要翻译：本发明提供了一种新的味道转导性G蛋白偶联受体家族的核酸和氨基酸序列，这种受体的抗体，检测此类核酸和受体的方法，以及筛选风味转导G蛋白偶联受体调节剂的方法。

8. 发明申请

US20050260599A1 Mammalian sweet taste receptors 有权
标题翻译：哺乳动物甜味受体
公开(公告)号：US20050260599A1
公开(公告)日：2005-11-24
申请号：US10645441
申请日：2003-08-20
申请人： Nicholas Ryba , Mark Hoon , Charles Zuker , Gregory Nelson , Jayaram Chandrashekar , Yifeng Zhang
发明人： Nicholas Ryba , Mark Hoon , Charles Zuker , Gregory Nelson , Jayaram Chandrashekar , Yifeng Zhang
IPC分类号： G01N33/50 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/09 , C12Q1/68 , G01N33/15 , C07H21/04
CPC分类号： C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
摘要翻译：本发明提供了分离的甜味受体的核酸和氨基酸序列，其包含来自感官G蛋白偶联受体的T 1 R家族的两种异源G蛋白偶联受体多肽，对这种受体的抗体，检测此类核酸的方法和受体和筛选甜味受体调节剂的方法。

9. 发明申请

US20050250113A1 Mammalian magnesium/manganese sensing G protein coupled receptor 审中-公开
标题翻译：哺乳动物镁/锰感应G蛋白偶联受体
公开(公告)号：US20050250113A1
公开(公告)日：2005-11-10
申请号：US10841129
申请日：2004-05-07
申请人： Charles Zuker , Isolda Erlenbach , Mark Hoon , Nicholas Ryba , Yifeng Zhang
发明人： Charles Zuker , Isolda Erlenbach , Mark Hoon , Nicholas Ryba , Yifeng Zhang
IPC分类号： A61K38/00 , C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/567
CPC分类号： G01N33/566 , A61K38/00 , G01N2333/726 , G01N2500/04
摘要： The present invention provides isolated nucleic acid and amino acid sequences of magnesium and manganese-sensing G-protein coupled receptor polypeptides from the C family of G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of magnesium and manganese metabolism.
摘要翻译：本发明提供了来自C族G蛋白偶联受体的镁和锰感应G-蛋白偶联受体多肽的分离的核酸和氨基酸序列，这些受体的抗体，检测此类核酸和受体的方法，以及方法筛选镁和锰代谢调节剂。

10. 发明申请

US20070150970A1 Compositions and methods for identifying modulators of transducisomes, a new class of therapeutic targets 审中-公开
标题翻译：用于鉴定转导体调节剂的组合物和方法，一类新的治疗靶点
公开(公告)号：US20070150970A1
公开(公告)日：2007-06-28
申请号：US11501473
申请日：2006-08-08
申请人： Charles Zuker , John Mendlein , Yumei Sun , Susan Tsunoda , Jimena Sierralta
发明人： Charles Zuker , John Mendlein , Yumei Sun , Susan Tsunoda , Jimena Sierralta
IPC分类号： A01K67/033 , C07H21/04 , C12N5/06 , C07K14/705 , C12N9/12 , C12N9/16
CPC分类号： G01N33/5041 , G01N2333/726 , G01N2333/912 , G01N2333/916
摘要： The invention provides cells and methods for identifying modulators of signal transduction, based on transducisome proteins that coordinate and assemble many types of signal transduction proteins. A transducisome is a PDZ domain containing protein that binds at least one signal transduction protein or a PDZ domain containing protein with at least one signal transduction protein bound. Examples of transducisome proteins include INAD, GRIP and other recently identified multi-PDZ domain proteins. Examples of signal transduction proteins include GPCRs, tyrosine kinase receptors, tyrosine phosphatase receptors, ion channels, phospholipases, adenylate cyclases, kinases and G-proteins. Also provided are methods for identifying modulators of signal transduction, proteins (and polynucleotides encoding the same) corresponding to transducisomes, modified transducisomes or defective transducisomes to use in assays of signal transduction, and a screening assay system for detecting protein-protein interactions.
摘要翻译：本发明提供用于鉴定信号转导调节剂的细胞和方法，其基于协调和组合许多类型的信号转导蛋白的传导蛋白。传导蛋白是含有蛋白质的PDZ结构域，其结合至少一个信号转导蛋白或含有至少一个信号转导蛋白结合的含有PDZ结构域的蛋白质。传导蛋白的实例包括INAD，GRIP和其他最近鉴定的多PDZ结构域蛋白。信号转导蛋白的实例包括GPCR，酪氨酸激酶受体，酪氨酸磷酸酶受体，离子通道，磷脂酶，腺苷酸环化酶，激酶和G蛋白。还提供了用于鉴定信号转导调节剂的方法，对应于用于信号转导测定的传导蛋白，修饰的传导蛋白或有缺陷的传导蛋白的蛋白质（和编码它们的多核苷酸）的方法，以及用于检测蛋白质 - 蛋白质相互作用的筛选测定系统。

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