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1. 发明申请

US20080248014A1 Animal Medicament and Method of Manufacture 审中-公开
标题翻译：动物药品和制造方法
公开(公告)号：US20080248014A1
公开(公告)日：2008-10-09
申请号：US12065281
申请日：2006-08-30
申请人： Bruce William Donaldson , Douglas Lang
发明人： Bruce William Donaldson , Douglas Lang
IPC分类号： A61K38/43 , A61K47/42
CPC分类号： A61K38/012 , A23K10/26 , A23K20/147 , A23K20/158 , A23K20/189 , A61K9/0053 , A61K9/0056 , A61K9/10 , A61K9/19 , A61K31/00 , A61K36/185 , A61K47/40 , A61K47/42 , A61K2300/00
摘要： A medicament for administration to a non-human animal, wherein the medicament includes at Least partially hydrolysed protein and one or more pharmacologically active substances. In a preferred embodiment, the protein is derived from meat which is hydrolysed using a fruit-derived proteolytic enzyme such as actinidin from kiwifruit which enhances the palatability of the resulting hydrolysate. A method of manufacturing the medicament, and a method of medicating a non-human animal by administering to the animal a medicament are also disclosed.
摘要翻译：一种用于给予非人动物的药物，其中所述药物包括至少部分水解的蛋白质和一种或多种药理学活性物质。在一个优选的实施方案中，蛋白质衍生自使用水果衍生的蛋白水解酶例如来自猕猴桃的锕系元素水解的肉，其增强了所得水解产物的适口性。还公开了制备药物的方法，以及通过向动物施用药物来治疗非人动物的方法。

2. 发明申请

US20060073455A1 Virtual reality based prototyping system for medical devices 审中-公开
标题翻译：基于虚拟现实的医疗设备原型系统
公开(公告)号：US20060073455A1
公开(公告)日：2006-04-06
申请号：US10954448
申请日：2004-09-30
申请人： Hans Buyl , Hendrik Lambert , Douglas Lang
发明人： Hans Buyl , Hendrik Lambert , Douglas Lang
IPC分类号： G09B23/28
CPC分类号： G09B23/285
摘要： A system comprising a computer and a software module residing in computer memory, where the software module is operable to provide a virtual model of a medical device and to simulate a medical procedure involving the virtual model of the medical device. The virtual model of the medical device includes medical device design parameters. The system also includes a computer interface operable to change design parameters of the virtual model of the medical device in response to simulation of the virtual model in the medical procedure.
摘要翻译：一种包括驻留在计算机存储器中的计算机和软件模块的系统，其中软件模块可操作以提供医疗设备的虚拟模型并且模拟涉及医疗设备的虚拟模型的医疗过程。医疗设备的虚拟模型包括医疗设备设计参数。该系统还包括可操作以响应于医疗过程中的虚拟模型的模拟来改变医疗装置的虚拟模型的设计参数的计算机接口。

3. 发明授权

US08851127B2 Methods and systems for pharmaceutical compounding 有权
标题翻译：药物复方的方法和系统
公开(公告)号：US08851127B2
公开(公告)日：2014-10-07
申请号：US13099297
申请日：2011-05-02
申请人： Brian Marquis , Douglas Lang
发明人： Brian Marquis , Douglas Lang
IPC分类号： B65B3/04 , A61K31/57 , G05D11/13 , B65B3/00
CPC分类号： B65B3/003 , A61K31/57 , G05D11/132
摘要： Methods and systems for pharmaceutical compounding are described. In one embodiment a system comprises a solution of a pharmaceutical in an injection vehicle, the solution being contained in a vessel. The system also includes one or more tubes, a filter, and one or more valves. The system presents a sterile environment for compounding the solution.
摘要翻译：描述了药物复方的方法和系统。在一个实施方案中，系统包括药物在注射载体中的溶液，所述溶液包含在容器中。该系统还包括一个或多个管，过滤器和一个或多个阀。该系统提供了用于混合溶液的无菌环境。

4. 发明申请

US20050219366A1 Digital audio-video differential delay and channel analyzer 审中-公开
标题翻译：数字音视频差分延时和通道分析仪
公开(公告)号：US20050219366A1
公开(公告)日：2005-10-06
申请号：US10813814
申请日：2004-03-31
申请人： Richard Hollowbush , Kenneth Altschuler , Ed Brosz , Carl Cochrane , David Guerrero , Douglas Lang
发明人： Richard Hollowbush , Kenneth Altschuler , Ed Brosz , Carl Cochrane , David Guerrero , Douglas Lang
IPC分类号： H04N5/04 , H04N17/00 , H04N17/02
CPC分类号： H04N17/004 , H04N5/04
摘要： A testing device and method for a digital video processing system is coupleable to an input and output of the processing system, and inserts video and audio marking information into the input to test system operation. The test device inserts a video marker and an audio marker data code for a single audio channel, preferably in the same digital input frame. The device then monitors the same audio channel and also all the other audio channels at the output, while monitoring for the video marker. The device indicates the occurrence and timing of results that appear at the outputs, the relative timing of the output audio mark(s) versus the video mark, an alarm in the event that an output mark is not found or found on an unexpected channel, etc. The test device successively exercises the audio and video portions of the processing system while also providing numeric timing measurements that are useful for proper setup and operation.
摘要翻译：用于数字视频处理系统的测试装置和方法可耦合到处理系统的输入和输出，并将视频和音频标记信息插入输入以测试系统操作。测试设备插入用于单个音频通道的视频标记和音频标记数据代码，优选地在相同的数字输入帧中。然后，设备监视相同的音频通道以及输出端的所有其他音频通道，同时监视视频标记。该设备指示出现在输出处的结果的出现和定时，输出音频标记相对于视频标记的相对定时，在意外通道上未找到或找到输出标记的情况下的报警，测试设备连续地对处理系统的音频和视频部分进行操作，同时还提供对正确的设置和操作有用的数字定时测量。

5. 发明申请

US20060265019A1 RATE-ADAPTIVE THERAPY WITH SENSOR CROSS-CHECKING 有权
标题翻译：具有传感器交叉检查的速率自适应治疗
公开(公告)号：US20060265019A1
公开(公告)日：2006-11-23
申请号：US11461632
申请日：2006-08-01
申请人： Weimin Sun , Bruce Jones , Douglas Lang
发明人： Weimin Sun , Bruce Jones , Douglas Lang
IPC分类号： A61N1/365
CPC分类号： A61N1/36585
摘要： A method and system for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker in which maximum exertion levels attained by the patient are measured at periodic intervals and stored in order to compute or update a maximum exercise capacity. The slope of the rate-response curve is then adjusted to map an exertion level corresponding to the updated maximum exercise capacity to a maximum allowable pacing rate. In accordance with the invention, a maximum exercise capacity is determined by cross-checking periodic maximum exertion level sensor values with a motion-level sensor value.
摘要翻译：一种用于自动调整速率自适应心脏起搏器的操作参数的方法和系统，其中以周期性间隔测量由患者获得的最大消耗水平并存储以便计算或更新最大运动能力。然后调整速率 - 响应曲线的斜率以将对应于更新的最大运动能力的运动水平映射到最大允许起搏速率。根据本发明，通过用运动水平传感器值交叉检查周期性最大消耗水平传感器值来确定最大运动能力。

6. 发明授权

US5311874A Method for tachycardia discrimination 失效
标题翻译：心动过速辨别方法
公开(公告)号：US5311874A
公开(公告)日：1994-05-17
申请号：US884770
申请日：1992-05-18
申请人： Lawrence S. Baumann , David K. Swanson , Douglas Lang
发明人： Lawrence S. Baumann , David K. Swanson , Douglas Lang
IPC分类号： A61B5/0245 , A61B5/0452 , G06F17/00 , G06Q50/00 , A61B5/0464
CPC分类号： A61B5/0464 , A61B5/7239
摘要： A cardiac discrimination method in which feature values of a heart related signal (e.g., cardiac biopotentials) determined to be non-baseline are compared with feature values of a heart related signal determined to be normal baseline. The feature values are extracted on an event-basis (a periodically), for obtaining feature values of a complex. For each complex, the feature values form a sequence with the value having the largest absolute value for the sequence given special identity as a fiducial point. The normal baseline complexes' characteristic sequence and a non-baseline complex's sequence are aligned according to the fiducial points, and unoccupied positions on the ends of the sequences resulting from the alignment are filled with zeros to create normal baseline and non-baseline vectors. The similarity value and dissimilarity value of the normalized non-baseline vector with respect to the normalized normal baseline vector are determined. The type of tachycardia (VT or non-VT) and consequently the selection of appropriate therapy are determined by the location in a discrimination plane of a discrimination point, the coordinates of which are equal to the similarity and dissimilarity values. In addition, the location of a similarly generated hemodynamic discrimination point can be used to discriminate hemodynamically stable and unstable tachycardias based on the features derived from events in hemodynamic related signals. Furthermore, physiological indicators may be processed in a similar manner to determine an ideal rate at which the heart should be paced by a pacemaker.
摘要翻译：确定将心脏相关信号（例如，心脏生物电位）确定为非基线的特征值与确定为正常基线的心脏相关信号的特征值进行比较的心脏辨别方法。以事件为基础（周期性地）提取特征值，以获得复合体的特征值。对于每个复合体，特征值形成具有给定特殊身份的序列作为基准点的序列具有最大绝对值的序列。正态基线复合物的特征序列和非基线复合物的序列根据基准点进行比对，并且由比对产生的序列末端的空闲位置用零填充以产生正常的基线和非基线载体。确定归一化非基线矢量相对于归一化正态基线矢量的相似度值和不相似度值。心动过速的类型（VT或非VT）以及因此选择合适的治疗由鉴别点的坐标位置等于相似度和相似性值的位置确定。此外，基于从血液动力相关信号中的事件导出的特征，类似地产生的血液动力学辨别点的位置可以用于区分血液动力学稳定和不稳定的心动过速。此外，可以以类似的方式处理生理指标，以确定心脏应由起搏器起搏的理想速率。

7. 发明申请

US20060247704A1 SELF-CALIBRATING RATE-ADAPTIVE PACEMAKER 失效
公开(公告)号：US20060247704A1
公开(公告)日：2006-11-02
申请号：US11457382
申请日：2006-07-13
申请人： Weimin Sun , Bruce Jones , Douglas Lang , Donald Hopper
发明人： Weimin Sun , Bruce Jones , Douglas Lang , Donald Hopper
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/36585
摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.

8. 发明授权

US5788645A Method and apparatus for event processing in biological application 失效
标题翻译：生物应用中事件处理的方法和装置
公开(公告)号：US5788645A
公开(公告)日：1998-08-04
申请号：US657389
申请日：1996-06-03
申请人： David K. Swanson , Graydon Beatty , Douglas Lang
发明人： David K. Swanson , Graydon Beatty , Douglas Lang
IPC分类号： A61N1/36 , A61N1/362 , A61N1/365 , A61N1/39 , G06F159/00
CPC分类号： A61N1/36507 , A61N1/3622
摘要： A method and apparatus for processing biological signals on an event basis. An event low pass filter (LPF) is provided which passes variations in event features below an event cut-off value, which is analogous to the time-based cutoff frequency. An event high pass filter (HPF) is provided which passes variations in event features that are above an event-rate cutoff. An event variability detector is provided which determines the variation of a discrete variable from values at prior events. An event discriminator is provided for filtering out contributions of unrelated events that are superimposed on a discrete periodic measurement of interest. In all of these techniques, sampling of a biological signal is performed in coincidence with a biological event which does not occur at a constant frequency. In accordance with another aspect, an algorithm is provided using event-based techniques for discriminating abnormal rhythms from normal sinus rhythm on the basis of atrial rate, ventricular rate, and A-V intervals. An interval conditioning stage is provided for processing intervals of atrial beats, ventricular beats, and atrial to ventricular beats and classifying intervals for each according to an adaptive triple-bin technique. The three bins are defined as "current", "fast" and "slow" and each comprises memory space for storing the count of intervals stored into the particular bin and the average value of those intervals.
摘要翻译：一种用于在事件基础上处理生物信号的方法和装置。提供事件低通滤波器（LPF），其将事件特征的变化传递到事件截止值以下，其类似于基于时间的截止频率。提供了一种事件高通滤波器（HPF），其传递高于事件率截止值的事件特征的变化。提供了事件变异性检测器，其确定离散变量与先前事件的值的变化。提供事件鉴别器用于滤除叠加在感兴趣的离散周期测量上的不相关事件的贡献。在所有这些技术中，生物信号的采样与不以恒定频率发生的生物事件一致地进行。根据另一方面，提供一种使用基于事件的技术的算法，其基于心房率，心室率和A-V间隔来区分来自正常窦性心律的异常节律。提供间隔调节阶段，用于根据自适应三仓技术处理心房搏动，心室搏动和心房至心室搏动的间隔和分类间隔。三个箱被定义为“当前”，“快速”和“慢”，并且每个包含用于存储存储到特定仓中的间隔的计数的存储空间和那些间隔的平均值。

9. 发明申请

US20120282143A1 METHODS AND SYSTEMS FOR PHARMACEUTICAL COMPOUNDING 有权
标题翻译：药物化学方法与系统
公开(公告)号：US20120282143A1
公开(公告)日：2012-11-08
申请号：US13099297
申请日：2011-05-02
申请人： Brian Marquis , Douglas Lang
发明人： Brian Marquis , Douglas Lang
IPC分类号： G05D9/00
CPC分类号： B65B3/003 , A61K31/57 , G05D11/132
摘要： Methods and systems for pharmaceutical compounding are described. In one embodiment a system comprises a solution of a pharmaceutical in an injection vehicle, the solution being contained in a vessel. The system also includes one or more tubes, a filter, and one or more valves. The system presents a sterile environment for compounding the solution.
摘要翻译：描述了药物复方的方法和系统。在一个实施方案中，系统包括药物在注射载体中的溶液，所述溶液包含在容器中。该系统还包括一个或多个管，过滤器和一个或多个阀。该系统提供了用于混合溶液的无菌环境。

10. 发明申请

US20060195147A1 SYSTEM AND METHOD FOR DETECTION ENHANCEMENT PROGRAMMING 有权
标题翻译：用于检测增强编程的系统和方法
公开(公告)号：US20060195147A1
公开(公告)日：2006-08-31
申请号：US11379742
申请日：2006-04-21
申请人： James Gilkerson , Vickie Conley , Scott Stubbs , Douglas Lang
发明人： James Gilkerson , Vickie Conley , Scott Stubbs , Douglas Lang
IPC分类号： A61N1/39
CPC分类号： A61N1/3987 , A61N1/37247 , A61N1/37252 , A61N1/3925
摘要： A system and method of enabling detection enhancements selected from a plurality of detection enhancements. In a system having a plurality of clinical rhythms, including a first clinical rhythm, where each of the detection enhancements is associated with the clinical rhythms, the first clinical rhythm is selected. The first clinical rhythm is associated with first and second detection enhancements. When the first clinical rhythm is selected, parameters of the first and second detection enhancements are set automatically. A determination is made as to whether changes are to be made to the parameters. If so, one or more of the parameters are modified under user control.
摘要翻译：一种启用从多个检测增强中选择的检测增强的系统和方法。在具有多个临床节律的系统中，包括第一临床节律，其中每个检测增强与临床节律相关联，选择第一临床节律。第一种临床节律与第一和第二检测增强有关。当选择第一临床节律时，自动设置第一和第二检测增强的参数。确定是否对参数进行改变。如果是这样，则在用户控制下修改一个或多个参数。

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