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1. 发明授权

US07154595B2 Cavity enhanced optical detector 有权
标题翻译：腔增强型光检测器
公开(公告)号：US07154595B2
公开(公告)日：2006-12-26
申请号：US10738599
申请日：2003-12-17
申请人： Barbara Paldus , Alexander Katchanov , Robert Provencal
发明人： Barbara Paldus , Alexander Katchanov , Robert Provencal
IPC分类号： G01N21/00
CPC分类号： G01N21/658 , G01J3/10 , G01J3/42 , G01J3/44 , G01N21/39 , G01N21/6402 , G01N2021/651 , G01N2021/655
摘要： A cavity enhanced optical detector comprising: i) a source of continuous wave laser light; ii) a high finesse resonant cavity comprising at least three spaced apart, high-reflectivity mirrors positioned to receive light from the laser light source; iii) at least one photo-detector for measuring the extinction coefficient of an analyte that is positioned in the resonant cavity; and iv) one or more additional photo-detectors for measuring the intensity of fluorescence emission and/or Raman scattering from the analyte.
摘要翻译：一种空腔增强型光学检测器，包括：i）连续波激光源; ii）高精细谐振腔，包括至少三个间隔开的高反射率反射镜，其被定位成接收来自激光光源的光; iii）至少一个光检测器，用于测量位于谐振腔中的分析物的消光系数; 和iv）一个或多个额外的光检测器，用于测量来自分析物的荧光发射强度和/或拉曼散射。

2. 发明申请

US20050134836A1 Cavity enhanced optical detector 有权
标题翻译：腔增强型光检测器
公开(公告)号：US20050134836A1
公开(公告)日：2005-06-23
申请号：US10738599
申请日：2003-12-17
申请人： Barbara Paldus , Robert Provencal , Alexander Katchanov
发明人： Barbara Paldus , Robert Provencal , Alexander Katchanov
IPC分类号： G01J3/42 , G01J3/44 , G01N21/39 , G01N21/64 , G01N21/00
CPC分类号： G01N21/658 , G01J3/10 , G01J3/42 , G01J3/44 , G01N21/39 , G01N21/6402 , G01N2021/651 , G01N2021/655
摘要： A cavity enhanced optical detector comprising: i) a source of continuous wave laser light; ii) a high finesse resonant cavity comprising at least three spaced apart, high-reflectivity mirrors positioned to receive light from the laser light source; iii) at least one photo-detector for measuring the extinction coefficient of an analyte that is positioned in the resonant cavity; and iv) one or more additional photo-detectors for measuring the intensity of fluorescence emission and/or Raman scattering from the analyte.
摘要翻译：一种空腔增强型光学检测器，包括：i）连续波激光源; ii）高精细谐振腔，包括至少三个间隔开的高反射率反射镜，其被定位成接收来自激光光源的光; iii）至少一个光检测器，用于测量位于谐振腔中的分析物的消光系数; 和iv）一个或多个额外的光检测器，用于测量来自分析物的荧光发射强度和/或拉曼散射。

3. 发明申请

US20050243884A1 Laser tuning by spectrally dependent spatial filtering 审中-公开
标题翻译：通过光谱依赖空间滤波进行激光调谐
公开(公告)号：US20050243884A1
公开(公告)日：2005-11-03
申请号：US11176059
申请日：2005-07-07
申请人： Barbara Paldus , Jinchun Xie , Robert Lodenkamper , David Adams , Eric Crosson , Alexander Katchanov , Grzegorz Pakulski , Chris Rella , Bruce Richman , Serguei Koulikov
发明人： Barbara Paldus , Jinchun Xie , Robert Lodenkamper , David Adams , Eric Crosson , Alexander Katchanov , Grzegorz Pakulski , Chris Rella , Bruce Richman , Serguei Koulikov
IPC分类号： H01S5/065 , H01S3/106 , H01S5/10 , H01S5/14 , H01S3/093
CPC分类号： H01S5/141 , H01S3/1068 , H01S5/101 , H01S5/1085 , H01S5/142
摘要： A laser tuning mechanism which embodies “spectrally dependent spatial filtering” (SDSF) and contemplates two key elements of the tuning mechanism. The first element of the SDSF tuning mechanism is a spectrally dependent beam distortion (i.e. alteration of the amplitude and/or phase profile of the beam) provided by an SDSF tuning element in a laser cavity. The second element of the SDSF tuning mechanism is an intracavity spatial filter which makes the round trip cavity loss a sensitive function of both beam distortion and cavity alignment. Such a laser can be aligned so that a specific beam distortion, which is provided by the SDSF tuning element at a tunable wavelength, is required to obtain minimum round trip cavity loss, thereby providing tunable laser emission. A preferred embodiment of the SDSF tuning mechanism is an external cavity semiconductor laser having a zeroth order acousto-optic tuning element.
摘要翻译：激光调谐机制体现了“光谱依赖空间滤波”（SDSF），并考虑了调谐机制的两个关键要素。 SDSF调谐机构的第一要素是由激光腔中的SDSF调谐元件提供的频谱依赖的光束失真（即光束的振幅和/或相位分布的改变）。 SDSF调谐机构的第二个元素是腔内空间滤波器，其使得往返腔体损耗具有波束失真和腔体对准的敏感功能。这样的激光器可以对齐，使得由SDSF调谐元件提供的可调谐波长的特定光束失真是需要的，以获得最小的往返腔损耗，从而提供可调谐的激光发射。 SDSF调谐机构的优选实施例是具有零级声光调谐元件的外腔半导体激光器。

4. 发明申请

US20050094158A1 Flow cell for optical detection having reduced sensitivity to refractive index variation 有权
$Flow cell for optical detection having reduced sensitivity to refractive index variation$
标题翻译：用于光学检测的流动池具有降低的对折射率变化的敏感性
公开(公告)号：US20050094158A1
公开(公告)日：2005-05-05
申请号：US10700947
申请日：2003-10-31
申请人： Barbara Paldus , Alexander Katchanov , Robert Lodenkamper
发明人： Barbara Paldus , Alexander Katchanov , Robert Lodenkamper
IPC分类号： G01N21/39 , G01B9/02
CPC分类号： G01N21/39
摘要： An apparatus for cavity enhanced optical detection comprising: a) a source of optical radiation b) a resonant optical cavity which provides a round trip path for said optical radiation the cavity comprising: i) a plurality of mirrors, the first mirror being an input mirror which receives the optical radiation and inputs it into the cavity; ii) a flow cell positioned within said cavity, said flow cell comprising at least a first analysis channel which accommodates a flow of analyte fluid there through, iii) a second mirror, which second mirror receives the radiation from the optical source after its passage through both said input mirror and said analysis channel and reflects said received radiation. The resonant optical cavity provides a round trip path for analyte fluid having at least two different refractive index values and the location of the point at which said reflected radiation impinges on said input mirror remains substantially the same as the point from which said first mirror inputs said radiation into said cavity notwithstanding changes in the refractive index of the analyte fluid or the wavelength of the optical radiation.
摘要翻译：一种用于空腔增强光学检测的装置，包括：a）光辐射源; b）谐振光学腔，其为所述光辐射提供所述光辐射的往返路径，所述光腔包括：i）多个反射镜，所述第一反射镜是输入镜其接收光辐射并将其输入到腔中; ii）位于所述空腔内的流动池，所述流动池包括至少第一分析通道，其容纳其中通过的分析物流体流，iii）第二反射镜，所述第二反射镜在其通过之后接收来自光源的辐射所述输入反射镜和所述分析通道都反映所述接收的辐射。谐振光学腔提供具有至少两个不同折射率值的分析物流体的往返路径，并且所述反射辐射照射在所述输入反射镜上的点的位置保持与所述第一反射镜从其输入所述输入反射镜的点大致相同尽管分析物流体的折射率或光辐射的波长发生变化，但是辐射进入所述腔。

5. 发明授权

US06970484B2 Laser tuning by spectrally dependent spatial filtering 失效
公开(公告)号：US06970484B2
公开(公告)日：2005-11-29
申请号：US11106000
申请日：2005-04-13
申请人： Barbara Paldus , Jinchun Xie , Robert Lodenkamper , David M. Adams , Eric Crosson , Alexander Katchanov , Grzegorz Pakulski , Chris W. Rella , Bruce A. Richman
发明人： Barbara Paldus , Jinchun Xie , Robert Lodenkamper , David M. Adams , Eric Crosson , Alexander Katchanov , Grzegorz Pakulski , Chris W. Rella , Bruce A. Richman
IPC分类号： H01S5/065 , H01S3/106 , H01S5/10 , H01S5/14 , H01S3/10
CPC分类号： H01S5/141 , H01S3/1068 , H01S5/101 , H01S5/1085 , H01S5/142
摘要： A tunable laser and laser tuning method, based on the interaction of a spectrally dependent beam distortion and a spatial filter within a laser cavity. One embodiment of this laser is an external cavity semiconductor laser in which broad tunability is obtained by the insertion of an acousto-optic tunable filter (AOTF) into the laser cavity such that the intra-cavity laser beam passes through the AOTF in zeroth order.

6. 发明申请

US20050175045A1 Laser tuning by spectrally dependent spatial filtering 失效
标题翻译：通过光谱依赖空间滤波进行激光调谐
公开(公告)号：US20050175045A1
公开(公告)日：2005-08-11
申请号：US11106000
申请日：2005-04-13
申请人： Barbara Paldus , Jinchun Xie , Robert Lodenkamper , David Adams , Eric Crosson , Alexander Katchanov , Grzegorz Pakulski , Chris Rella , Bruce Richman
发明人： Barbara Paldus , Jinchun Xie , Robert Lodenkamper , David Adams , Eric Crosson , Alexander Katchanov , Grzegorz Pakulski , Chris Rella , Bruce Richman
IPC分类号： H01S5/065 , H01S3/106 , H01S5/10 , H01S5/14 , H01S3/10
CPC分类号： H01S5/141 , H01S3/1068 , H01S5/101 , H01S5/1085 , H01S5/142
摘要： A tunable laser and laser tuning method, based on the interaction of a spectrally dependent beam distortion and a spatial filter within a laser cavity. One embodiment of this laser is an external cavity semiconductor laser in which broad tunability is obtained by the insertion of an acousto-optic tunable filter (AOTF) into the laser cavity such that the intra-cavity laser beam passes through the AOTF in zeroth order.
摘要翻译：基于频谱依赖的波束失真和激光腔内的空间滤波器的相互作用的可调激光和激光调谐方法。该激光器的一个实施例是外腔半导体激光器，其中通过将声光可调滤波器（AOTF）插入到激光腔中获得宽可调性，使得腔内激光束以零级顺序通过AOTF。

7. 发明授权

US06959024B2 Laser Tuning by spectrally dependent spatial filtering 有权
标题翻译：激光通过光谱依赖空间滤波进行调谐
公开(公告)号：US06959024B2
公开(公告)日：2005-10-25
申请号：US10308541
申请日：2002-12-02
申请人： Barbara Paldus , Jinchun Xie , Robert Lodenkamper , David M. Adams , Eric Crosson , Alexander Katchanov , Grzegorz Pakulski , Chris W. Rella , Bruce A. Richman , Serguei Koulikov
发明人： Barbara Paldus , Jinchun Xie , Robert Lodenkamper , David M. Adams , Eric Crosson , Alexander Katchanov , Grzegorz Pakulski , Chris W. Rella , Bruce A. Richman , Serguei Koulikov
IPC分类号： H01S5/065 , H01S3/106 , H01S5/10 , H01S5/14 , H01S3/10
CPC分类号： H01S5/141 , H01S3/1068 , H01S5/101 , H01S5/1085 , H01S5/142
摘要： A laser tuning mechanism which embodies “spectrally dependent spatial filtering” (SDSF) and contemplates two key elements of the tuning mechanism. The first element of the SDSF tuning mechanism is a spectrally dependent beam distortion (i.e. alteration of the amplitude and/or phase profile of the beam) provided by an SDSF tuning element in a laser cavity. The second element of the SDSF tuning mechanism is an intracavity spatial filter which makes the round trip cavity loss a sensitive function of both beam distortion and cavity alignment. Such a laser can be aligned so that a specific beam distortion, which is provided by the SDSF tuning element at a tunable wavelength, is required to obtain minimum round trip cavity loss, thereby providing tunable laser emission. A preferred embodiment of the SDSF tuning mechanism is an external cavity semiconductor laser having a zeroth order acousto-optic tuning element.
摘要翻译：激光调谐机制体现了“光谱依赖空间滤波”（SDSF），并考虑了调谐机制的两个关键要素。 SDSF调谐机构的第一要素是由激光腔中的SDSF调谐元件提供的频谱依赖的光束失真（即光束的振幅和/或相位分布的改变）。 SDSF调谐机构的第二个元素是腔内空间滤波器，其使得往返腔体损耗具有波束失真和腔体对准的敏感功能。这样的激光器可以对齐，使得由SDSF调谐元件提供的可调谐波长的特定光束失真是需要的，以获得最小的往返腔损耗，从而提供可调谐的激光发射。 SDSF调谐机构的优选实施例是具有零级声光调谐元件的外腔半导体激光器。

8. 发明授权

US09267100B2 Composite sensor assemblies for single use bioreactors 有权
标题翻译：用于单次生物反应器的复合传感器组件
公开(公告)号：US09267100B2
公开(公告)日：2016-02-23
申请号：US13385100
申请日：2012-02-02
申请人： Mark Selker , Timothy Johnston , Barbara Paldus
发明人： Mark Selker , Timothy Johnston , Barbara Paldus
IPC分类号： C12M1/00 , G01N21/359 , G01N21/552 , G01N21/65 , G01N21/85
CPC分类号： C12M27/14 , C12M23/00 , C12M29/00 , C12M29/06 , G01N21/359 , G01N21/552 , G01N21/65 , G01N21/8507
摘要： A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises: i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, the base plate portion being fusibly sealable to the bioreactor vessel at a hole in the wall thereof; ii) a generally opaque polymeric monitoring sensor assembly including electrical, and/or optical measurement components. The sensor assembly fits inside the bore of the hollow tubular portion of the port, and is adhesively retained therein.
摘要翻译：一种用于监测适用于聚合物生物过程容器或与下游设备的生物过程的复合传感器组件，包括：i）包含具有中空管状部分和底板部分的高表面张力热塑性塑料的端口，板部分在其壁的孔处易于密封到生物反应器容器; ii）包括电和/或光学测量部件的通常不透明的聚合物监测传感器组件。传感器组件装配在端口的中空管状部分的孔内，并且粘合地保持在其中。

9. 发明申请

US20080282026A1 Bioprocess data management 审中-公开
标题翻译：生物过程数据管理
公开(公告)号：US20080282026A1
公开(公告)日：2008-11-13
申请号：US12150806
申请日：2008-05-01
申请人： Mark Selker , Barbara Paldus , Charles Kamas
发明人： Mark Selker , Barbara Paldus , Charles Kamas
IPC分类号： G06F12/00
CPC分类号： G11C11/22 , A61L2/0035 , A61L2/24 , G16B15/30
摘要： A data management system for a biological process, comprising: a. a single-use component, b. a tag assembly, including a non-volatile memory storage component, that is associated with the single-use component, c. the memory storage component including a unique identification and a memory, and at least one data element that describes a key performance or control parameter of the single-use component d. a memory reader useable to obtain the identification from the memory storage component
摘要翻译：一种用于生物过程的数据管理系统，包括：a。一次性使用的组件，b。与单次使用组件相关联的标签组件，包括非易失性存储器存储组件，c。所述存储器存储组件包括唯一标识和存储器，以及描述所述一次性组件d的关键性能或控制参数的至少一个数据元素。可用于从存储器存储组件获得标识的存储器读取器

10. 发明申请

US20080171383A1 Optical interface for disposable bioreactors 有权
标题翻译：一次性生物反应器的光学接口
公开(公告)号：US20080171383A1
公开(公告)日：2008-07-17
申请号：US11725255
申请日：2007-03-17
申请人： Mark Selker , Benjamin Blizard , Timothy Johnston , Barbara Paldus
发明人： Mark Selker , Benjamin Blizard , Timothy Johnston , Barbara Paldus
IPC分类号： C12M1/34
CPC分类号： C12M23/14 , C12M29/00 , C12M41/26 , C12M41/32 , C12M41/34
摘要： A port assembly for use with a polymeric bioreactor bag said assembly comprising: i) a hollow port member comprised at least in part of a material suitable to be fusibly affixed to the wall surface of said bioreactor bag; ii) at least one fluorophore spot positioned on said port member; iii) conduit means for conveying excitation light from an optical source to said fluorophore, said conduit means being an assembly comprising at least one of a lens, an optic fiber, a curved parabolic collimator, a shaped reflector or a wave guide; iv) conduit means for conveying fluorescent emission light from said fluorophore to a photo-detector, said conduit means being an assembly comprising at least one of a lens, an optic fiber, a curved parabolic collimator, a shaped reflector or a wave guide.
摘要翻译：一种与聚合物生物反应器袋一起使用的端口组件，所述组件包括：i）中空端口构件，其至少部分地包括适于被柔性地固定到所述生物反应器袋的壁表面的材料; ii）位于所述端口构件上的至少一个荧光团斑点; iii）用于将来自光源的激发光传送到所述荧光团的导管装置，所述导管装置是包括透镜，光纤，弯曲抛物线准直器，成形反射器或波导中的至少一个的组件; iv）用于将来自所述荧光团的荧光发射光传送到光检测器的导管装置，所述导管装置是包括透镜，光纤，弯曲抛物线准直仪，成形反射器或波导中的至少一个的组件。

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