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1. 发明申请

US20140179802A1 FIBER COMPRISING A BIODEGRADABLE POLYMER 审中-公开
标题翻译：包含可生物降解聚合物的纤维
公开(公告)号：US20140179802A1
公开(公告)日：2014-06-26
申请号：US14115146
申请日：2012-05-02
申请人： Astrid Franken , George Mihov , Jens Christoph Thies
发明人： Astrid Franken , George Mihov , Jens Christoph Thies
IPC分类号： A61K9/00 , A61K47/34
CPC分类号： A61K9/0051 , A61K9/0019 , A61K9/70 , A61K47/34 , C08G69/44 , D01F1/10 , D01F6/625 , D01F6/82 , D10B2331/02 , D10B2331/041 , D10B2401/12
摘要： The present invention relates to a fiber comprising a biodegradable polymer which undergoes dimensional change upon injection in the human or animal body wherein the dimensional change is a reduction of the surface area to volume ratio of a factor 2 to 10. The fiber is sized for injection via a pharmaceutical syringe needle having a bore of at least 25 Gauge. The biodegradable polymer is an amorphous biodegradable polymer selected from the group of poly-hexamethylene carbonates or polyesteramides. The amorphous biodegradable polymer is a preferably a polyesteramide comprising alpha-amino acids, diols and dicarboxylic acids as building blocks. The invention further relates to the use of the fiber for the manufacturing of a medicament for the treatment of ophthalmic diseases. The invention also relates to a process for the manufacturing of the fiber comprising the following process steps; a. extruding a biodegradable polymer into a fiber fitting in a needle of at least 25 Gauge b. which while under tension is cooled below its glass transition temperature such that the resultant fiber is amorphous.
摘要翻译：本发明涉及一种包含生物可降解聚合物的纤维，其在人或动物体内注射时经历尺寸变化，其中尺寸变化是因子2至10的表面积与体积比的降低。纤维的尺寸用于注射通过具有至少25度的孔的制药注射器针头。可生物降解的聚合物是选自聚六亚甲基碳酸酯或聚酯酰胺的无定形可生物降解的聚合物。无定形可生物降解聚合物优选为包含α-氨基酸，二醇和二羧酸作为结构单元的聚酯酰胺。本发明还涉及该纤维在制备用于治疗眼科疾病的药物中的用途。本发明还涉及一种用于制造纤维的方法，包括以下工艺步骤; 一个。将可生物降解的聚合物挤出到至少25巴的针中的纤维配合物中。其在张力下被冷却到其玻璃化转变温度以下，使得所得纤维是无定形的。

2. 发明申请

US20140105957A1 BIS-(ALPHA-AMINO-DIOL-DIESTER) CONTAINING POLYESTERAMIDE FOR OPHTAMOLOGY 审中-公开
标题翻译：含有聚酰胺酰胺的BIS-（ALPHA-AMINO-DIOL-DIESTER）
公开(公告)号：US20140105957A1
公开(公告)日：2014-04-17
申请号：US14113521
申请日：2012-05-02
申请人： Astrid Franken , George Mihov , Jens Christoph Thies
发明人： Astrid Franken , George Mihov , Jens Christoph Thies
IPC分类号： A61K47/34 , A61K9/00
CPC分类号： A61K47/34 , A61K9/0048 , A61K9/0051 , A61K31/4535 , A61K31/5575
摘要： The present invention relates to an ocular polymer delivery composition comprising at least one ophthalmologic agent dispersed in at least one biodegradable polymer, wherein the polymer comprises at least one of a poly (ester amide) (PEA) having a chemical formula described by structural formula (I).
摘要翻译：本发明涉及一种眼部聚合物递送组合物，其包含分散在至少一种可生物降解的聚合物中的至少一种眼科剂，其中所述聚合物包含具有结构式（Q）所描述的化学式的聚（酯酰胺）（PEA）一世）。

3. 发明授权

US09855219B2 Core-shell nanoparticles 有权
公开(公告)号：US09855219B2
公开(公告)日：2018-01-02
申请号：US12438596
申请日：2007-09-05
申请人： Nanning Joerg Arfsten , Steven Armes , Pascal Jozef Paul Buskens , Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven
发明人： Nanning Joerg Arfsten , Steven Armes , Pascal Jozef Paul Buskens , Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven
IPC分类号： G02B1/10 , C08K9/02 , A61K9/50 , C08K3/36 , C08K9/00 , C09D7/12 , G02B1/111 , C08L53/00
CPC分类号： A61K9/5089 , A61K9/501 , C08K3/36 , C08K9/00 , C08K9/02 , C08K9/10 , C08K9/12 , C08K2201/011 , C08K2201/013 , C08L53/00 , C08L2207/53 , C09D7/70 , G02B1/111 , Y10T428/254 , Y10T428/2998
摘要： The present invention relates to a composition suitable for forming an optical coating, the composition comprising core-shell nanoparticles, wherein said nanoparticles comprise: (a) core material comprising polymer; and (b) shell material comprising metal oxide.

4. 发明申请

US20090215913A1 Highly porous polymeric materials comprising biologically active molecules via covalent grafting 审中-公开
标题翻译：通过共价接枝包含生物活性分子的高度多孔的聚合物材料
公开(公告)号：US20090215913A1
公开(公告)日：2009-08-27
申请号：US11918777
申请日：2006-04-21
申请人： Jens Christoph Thies , Sebastien Pierre , Neil Ronald Cameron
发明人： Jens Christoph Thies , Sebastien Pierre , Neil Ronald Cameron
IPC分类号： C08J9/36 , C08J9/00
CPC分类号： C12N11/06 , C12N11/08
摘要： The present invention relates to highly porous polymeric materials comprising covalently grafted biologically active species. The invention also relates to a process for the preparation of highly porous materials comprising functional monomers capable of grafting to a biologically active molecular species comprising the steps of: (a) preparing an emulsion composition comprising a droplet phase and a continuous phase and containing monomers, (b) curing the emulsion and (c) optionally removing the water/droplet phase. The invention further relates to a process for grafting biologically active species to such a highly porous polymeric material comprising the steps of: (i) exposing the highly porous material to a solution of the biologically active species in a suitable solvent medium, (ii) optionally adding an activating agent, (iii) optionally heating, and (iv) rinsing the porous material with solvent medium to remove non-grafted species. The highly porous polymeric materials comprising covalently grafted biologically active species can be used e.g. as a heterogeneous catalyst, in biosensors, for chromatography, in biomedical devices and in implants.
摘要翻译：本发明涉及包含共价接枝的生物活性物质的高度多孔的聚合物材料。本发明还涉及一种制备包含能够接枝到生物活性分子物质的官能单体的高度多孔材料的方法，包括以下步骤：（a）制备包含液滴相和连续相并含有单体的乳液组合物，（b）固化乳液和（c）任选地除去水/液滴相。本发明还涉及将生物活性物质接枝到这种高度多孔的聚合物材料的方法，包括以下步骤：（i）将高度多孔的材料暴露于生物活性物质在合适的溶剂介质中的溶液，（ii）任选地加入活化剂，（iii）任选地加热，和（iv）用溶剂介质漂洗多孔材料以除去未接枝的物质。包含共价接枝的生物活性物质的高度多孔的聚合物材料可以例如使用。作为非均相催化剂，生物传感器，色谱法，生物医学装置和植入物。

5. 发明申请

US20100230351A1 Hydrophilic Membrane 审中-公开
标题翻译：亲水膜
公开(公告)号：US20100230351A1
公开(公告)日：2010-09-16
申请号：US12670113
申请日：2008-07-24
申请人： Hendrik Derk Hoving , Jun Qiu , Jens Christoph Thies , Gijsbertus Hendrikus Maria Calis , Johannes Leonardus Maria Op Den Kamp
发明人： Hendrik Derk Hoving , Jun Qiu , Jens Christoph Thies , Gijsbertus Hendrikus Maria Calis , Johannes Leonardus Maria Op Den Kamp
IPC分类号： B01D67/00 , B01D61/00 , B01D61/36 , B01D61/42 , B01D61/02 , B01D61/14 , B01D71/70 , B01D71/52 , B01D71/02 , B05D3/06
CPC分类号： B01D69/02 , B01D71/024 , B01D71/025 , B01D71/027 , B01D71/52 , B01D71/70 , B01D2323/345 , B01D2325/36
摘要： The invention relates to an hydrophilic membrane comprising a membrane carrier and a hydrophilic coating with good properties. The coating may comprise covalently bound inorganic-organic hybrid material; or the coating may comprise ring-opening polymerized components like epoxy resins. The coating composition preferably is applied in a solvent, the solvent is evaporated, and the coating is cured with UV radiation. The hydrophilic membrane is very useful in water purification, and in other applications.
摘要翻译：本发明涉及包含膜载体和具有良好性能的亲水涂层的亲水膜。涂层可以包括共价结合的无机 - 有机杂化材料; 或涂层可以包括开环聚合的组分如环氧树脂。涂料组合物优选在溶剂中进行，蒸发溶剂，并用UV辐射固化涂层。亲水膜在水净化和其他应用中非常有用。

6. 发明申请

US20100167009A1 ARTICLES COMPRISING POROUS COATINGS 有权
标题翻译：包含多孔涂层的文章
公开(公告)号：US20100167009A1
公开(公告)日：2010-07-01
申请号：US12160644
申请日：2007-02-12
申请人： Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven , Hermanus Adrianus Langermans
发明人： Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven , Hermanus Adrianus Langermans
IPC分类号： B32B3/26 , B05D3/02 , B32B3/00 , B05D3/00
CPC分类号： G02B1/11 , A47G1/06 , B82Y20/00 , C03C17/007 , C03C2217/425 , C03C2217/45 , C03C2217/475 , C03C2217/732 , G02B1/10 , G02B1/111 , G02B1/118 , G02B2207/101 , Y10T428/24355 , Y10T428/24942 , Y10T428/249978 , Y10T428/24998 , Y10T428/25 , Y10T428/265 , Y10T428/31504 , Y10T428/31507 , Y10T428/31786 , Y10T428/31935
摘要： The invention relates to an article comprising a substrate and a nano-porous coating, wherein the reflectivity of the article is less then 2%, and whereby the amount of sodium measured in the coating by XPS is less then 1 wt %, and further to a method of making the article.
摘要翻译：本发明涉及一种包含基材和纳米多孔涂层的制品，其中制品的反射率小于2％，并且由此通过XPS在涂层中测量的钠的量小于1重量％，进而至制作文章的方法。

7. 发明申请

US20100015433A1 CORE-SHELL NANOPARTICLES 有权
标题翻译：核心纳米粒子
公开(公告)号：US20100015433A1
公开(公告)日：2010-01-21
申请号：US12438596
申请日：2007-09-05
申请人： Nanning Joerg Arfsten , Steven Armes , Pascal Jozef Paul Buskens , Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven
发明人： Nanning Joerg Arfsten , Steven Armes , Pascal Jozef Paul Buskens , Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven
IPC分类号： G02B1/10 , C08K9/02 , C08K3/18 , B32B5/16 , C08K3/36
CPC分类号： A61K9/5089 , A61K9/501 , C08K3/36 , C08K9/00 , C08K9/02 , C08K9/10 , C08K9/12 , C08K2201/011 , C08K2201/013 , C08L53/00 , C08L2207/53 , C09D7/70 , G02B1/111 , Y10T428/254 , Y10T428/2998
摘要： The present invention relates to a composition suitable for forming an optical coating, the composition comprising core-shell nanoparticles, wherein said nanoparticles comprise: (a) core material comprising polymer; and (b) shell material comprising metal oxide.
摘要翻译：本发明涉及一种适用于形成光学涂层的组合物，该组合物包含核 - 壳纳米颗粒，其中所述纳米颗粒包含：（a）包含聚合物的芯材; 和（b）包含金属氧化物的壳材料。

8. 发明申请

US20060275595A1 Nano-structured surface coating process, nano-structured coatings and articles comprising the coating 审中-公开
标题翻译：纳米结构表面涂层工艺，纳米结构涂层和包含该涂层的制品
公开(公告)号：US20060275595A1
公开(公告)日：2006-12-07
申请号：US10557243
申请日：2004-05-13
申请人： Jens Christoph Thies , Guido Meijers , Atze Nijenhuis , Edwin Currie , Christopher Tronche , John Southwell
发明人： Jens Christoph Thies , Guido Meijers , Atze Nijenhuis , Edwin Currie , Christopher Tronche , John Southwell
IPC分类号： B05D1/12 , C08F2/46 , B32B3/00
CPC分类号： C03C17/007 , C03C2217/425 , C04B41/009 , C04B41/4584 , C04B41/81 , C08K3/20 , C08K3/36 , C08K9/08 , C09D4/00 , C09D7/62 , G02B1/11 , C04B41/483 , C04B41/4842 , C04B35/14 , C08F220/10
摘要： The invention relates to a new process for the preparation of nano-structured and/or nano-porous surfaces, coatings having a nano-structured and/or nano-porous surface and articles comprising said coatings. The invention also relates to the use of coatings according to the invention, in particular as anti-reflective coatings. The process for the preparation of the surface nano-structured and/or nano-porous coatings is a process comprising the steps of: a) applying a mixture to a substrate which mixture comprises: i) reactive nano-particles; ii) at least one solvent; iii) optionally a compound having at least one polymerisable group, in an amount that results in an increase in the transmission of at least 0.5%, for at least part of the electromagnetic spectrum between 400 and 800 nm, after the mixture has been applied and cured on a transparent substrate, in comparison with the same substrate without a coating; b) inducing crosslinking and/or polymerisation in the mixture applied to the substrate.
摘要翻译：本发明涉及一种用于制备纳米结构和/或纳米多孔表面的新方法，具有纳米结构和/或纳米多孔表面的涂层和包含所述涂层的制品。本发明还涉及根据本发明的涂层的用途，特别是抗反射涂层。用于制备表面纳米结构和/或纳米多孔涂层的方法是包括以下步骤的方法：a）将混合物施加到基材上，该混合物包含：i）反应性纳米颗粒; ii）至少一种溶剂; iii）任选地具有至少一个可聚合基团的化合物，其量在使用混合物之后导致400至800nm之间的至少部分电磁谱的透射率至少为0.5％，并且与没有涂层的相同基板相比，在透明基板上固化; b）在施加到基底上的混合物中诱导交联和/或聚合。

9. 发明申请

US20110033678A1 COATING SYSTEM 审中-公开
标题翻译：涂装系统
公开(公告)号：US20110033678A1
公开(公告)日：2011-02-10
申请号：US12160564
申请日：2007-02-12
申请人： Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven , Nanning Joerg Arfsten , Hermanus Adrianus Langermans , Alice Lançon Delcourt
发明人： Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven , Nanning Joerg Arfsten , Hermanus Adrianus Langermans , Alice Lançon Delcourt
IPC分类号： B32B7/02 , B32B27/36 , B32B9/00
CPC分类号： G02B1/11 , A47G1/06 , B82Y20/00 , C03C17/007 , C03C2217/425 , C03C2217/45 , C03C2217/475 , C03C2217/732 , G02B1/10 , G02B1/111 , G02B1/118 , G02B2207/101 , Y10T428/24355 , Y10T428/24942 , Y10T428/249978 , Y10T428/24998 , Y10T428/25 , Y10T428/265 , Y10T428/31504 , Y10T428/31507 , Y10T428/31786 , Y10T428/31935
摘要： The present invention provides a coating system comprising an antireflective functionality and UV absorbing functionality. The present invention further provides methods, uses, and articles comprising such a system.
摘要翻译：本发明提供一种包含抗反射功能和UV吸收功能的涂层体系。本发明还提供包括这种系统的方法，用途和制品。

10. 发明申请

US20110021335A1 SOL-GEL PROCESS WITH A PROTECTED CATALYST 审中-公开
标题翻译：具有保护催化剂的溶胶凝胶工艺
公开(公告)号：US20110021335A1
公开(公告)日：2011-01-27
申请号：US12747975
申请日：2008-12-15
申请人： Pascal Jozef Paul Buskens , Jens Christoph Thies , Nanning Joerg Arfsten
发明人： Pascal Jozef Paul Buskens , Jens Christoph Thies , Nanning Joerg Arfsten
IPC分类号： C04B35/00 , C09D1/00 , B05D3/02
CPC分类号： C04B41/4537 , C03C1/008 , C03C17/009 , C03C23/0005 , C03C2218/111 , C03C2218/113 , C04B41/009 , C04B41/81 , C08K3/22 , C08K5/0008 , C09D7/61 , C09D7/63 , C04B35/00
摘要： The invention provides a sol-gel process for preparing a mixture of metal-oxide-metal compounds wherein at least one metal oxide precursor is subjected to a hydrolysis treatment to obtain one or more corresponding metal oxide hydroxides, the metal oxide hydroxides so obtained are subjected to a condensation treatment to form the metal-oxide-metal compounds, which process is carried out in the presence of a catalyst which comprises a labile protecting group (P9) and a base (B) which are covalently linked, whereby the covalent link between the protecting group and the base is cleavable by exposure to an external stimulus, and wherein the base released after exposure to such external stimulus is capable of catalyzing the condensation of the metal-hydroxide groups that are present in the metal oxide hydroxides so obtained.
摘要翻译：本发明提供了一种用于制备金属氧化物 - 金属化合物的混合物的溶胶 - 凝胶法，其中至少一种金属氧化物前体进行水解处理以获得一种或多种相应的金属氧化物氢氧化物，所得到的金属氧化物氢氧化物进行缩合处理以形成金属氧化物 - 金属化合物，该方法在包含不稳定保护基（P9）和共价连接的碱（B）的催化剂的存在下进行，由此共价连接保护基和碱可以通过暴露于外部刺激而被切割，并且其中在暴露于这种外部刺激之后释放的碱能够催化如此获得的金属氧化物氢氧化物中存在的金属氢氧根的缩合。

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