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1. 发明申请

US20100211140A1 METHODS AND DEVICES FOR NON-INVASIVE CEREBRAL AND SYSTEMIC COOLING 有权
标题翻译：非侵入性胚胎和系统冷却的方法和装置
公开(公告)号：US20100211140A1
公开(公告)日：2010-08-19
申请号：US12703425
申请日：2010-02-10
申请人： DENISE BARBUT , Allan Rozenberg , John K. Hoffman
发明人： DENISE BARBUT , Allan Rozenberg , John K. Hoffman
IPC分类号： A61F7/12
CPC分类号： A61F7/10 , A61F7/12 , A61F7/123 , A61F2007/0002 , A61F2007/0063 , A61F2007/0064 , A61F2007/0065 , A61F2007/0069 , A61K31/02 , A61M15/08 , A61M15/085 , A61M16/04 , A61M16/0409 , A61M16/0438 , A61M16/0454 , A61M16/0479 , A61M16/0486 , A61M16/107 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/007 , A61M25/1011 , A61M31/00 , A61M2025/0034 , A61M2025/0036 , A61M2025/0073
摘要： A method for providing and adjusting cerebral cooling in response to changes in a physiological parameter. A spray having a boiling point between 38-300° C. is delivered to the surface of a patient's nasal cavities. The spray causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis. A physiological parameter, such as cerebral temperature, changes in cerebral blood flow or brain oxygenation is monitored. The delivery rate of the spray is adjusted in response to the physiological parameter.
摘要翻译：一种用于响应于生理参数的变化来提供和调节脑冷却的方法。沸点在38-300℃之间的喷雾剂被输送到患者鼻腔的表面。喷雾通过直接通过鼻咽传播并通过颈动脉和威利斯圈造成血液冷却，导致冷却。监测生理参数，如脑温，脑血流量或脑氧合变化。响应于生理参数调节喷雾的输送速率。

2. 发明授权

US08308786B2 Methods and devices for non-invasive cerebral and systemic cooling via the nasal cavity 有权
标题翻译：通过鼻腔非侵入性脑和全身冷却的方法和装置
公开(公告)号：US08308786B2
公开(公告)日：2012-11-13
申请号：US12038720
申请日：2008-02-27
申请人： Allan Rozenberg , Denise Barbut , John K. Hoffman
发明人： Allan Rozenberg , Denise Barbut , John K. Hoffman
IPC分类号： A61F7/12 , A61F7/00 , A61B18/00 , A61M25/00 , A61M31/00
CPC分类号： A61F7/123 , A61F2007/0056
摘要： A method for cerebral and systemic cooling by circulating a cold liquid through a nasal catheter looped through the patient's nasal cavities and around the nasal septum. The nasal catheter is inserted into the patient's first nostril, advanced through the nasal cavity, around the nasal septum and out of the patient's second nostril. A cold fluid having a temperature between about −20° C. and about 37° C. is flowed though a lumen in the nasal catheter to cool the nasal cavity. The nasal catheter may have one or more flexible balloons mounted on the catheter such that when the catheter is looped around the nasal septum, the balloon(s) are positioned in a portion of the patient's first and second nasal cavities. When a cold liquid is circulated through the catheter lumen, the flexible balloons expand to a contact the inner walls of the nasal cavities and provide direct cooling of the nasal cavities.
摘要翻译：通过将冷液循环穿过患者鼻腔和鼻中隔周围的鼻导管进行脑和全身冷却的方法。将鼻导管插入患者的第一鼻孔，通过鼻腔，鼻中隔周围并从病人的第二鼻孔排出。温度在约-20℃和约37℃之间的冷流体通过鼻导管中的内腔流动以冷却鼻腔。鼻导管可以具有安装在导管上的一个或多个柔性气囊，使得当导管环绕鼻中隔环时，气囊被定位在患者的第一和第二鼻腔的一部分中。当冷液体通过导管腔循环时，柔性气囊膨胀成与鼻腔的内壁接触并提供对鼻腔的直接冷却。

3. 发明授权

US07824436B2 Methods and devices for non-invasive cerebral and systemic cooling 有权
公开(公告)号：US07824436B2
公开(公告)日：2010-11-02
申请号：US11432285
申请日：2006-05-10
申请人： Denise Barbut , Allan Rozenberg , John K. Hoffman
发明人： Denise Barbut , Allan Rozenberg , John K. Hoffman
IPC分类号： A61F7/00 , A61F7/12
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/0065 , A61K31/02 , A61M11/02 , A61M11/06 , A61M15/08 , A61M15/085 , A61M16/04 , A61M16/0409 , A61M16/0438 , A61M16/0443 , A61M16/0459 , A61M16/0461 , A61M16/0479 , A61M16/0486 , A61M16/06 , A61M16/107 , A61M16/209 , A61M19/00 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/007 , A61M25/1011 , A61M31/00 , A61M2016/0027 , A61M2025/0034 , A61M2025/0036 , A61M2025/0073 , A61M2202/0275 , A61M2205/3606
摘要： A method for cerebral and systemic cooling by providing a nebulized liquid having a boiling point of 38-300° C. The nebulized liquid is delivered as a mist or a spray via the nasal and/or oral cavities of a patient. The mist causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis. Compositions and medical devices for cerebral and systemic cooling are also provided. Cooling assemblies, and methods of use, are also provided that include flexible balloon assemblies that are inserted to various locations in a patient's body. The flexible balloons are then infused with a liquid having a temperature between about −20° C. and about 37° C. The flexible balloon assemblies can be inserted into the nasal cavity, oral cavity, throat, stomach, and other locations to effect cerebral cooling.

4. 发明授权

US08480723B2 Methods and devices for non-invasive cerebral and systemic cooling 有权
标题翻译：非侵入性脑系统冷却的方法和装置
公开(公告)号：US08480723B2
公开(公告)日：2013-07-09
申请号：US12101933
申请日：2008-04-11
申请人： Denise Barbut , Allan Rozenberg , John K. Hoffman
发明人： Denise Barbut , Allan Rozenberg , John K. Hoffman
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/0065 , A61K31/02 , A61M11/02 , A61M11/06 , A61M15/08 , A61M15/085 , A61M16/04 , A61M16/0409 , A61M16/0438 , A61M16/0443 , A61M16/0459 , A61M16/0461 , A61M16/0479 , A61M16/0486 , A61M16/06 , A61M16/107 , A61M16/209 , A61M19/00 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/007 , A61M25/1011 , A61M31/00 , A61M2016/0027 , A61M2025/0034 , A61M2025/0036 , A61M2025/0073 , A61M2202/0275 , A61M2205/3606
摘要： A method for cerebral and systemic cooling by providing a nebulized liquid having a boiling point of 38-300° C. The nebulized liquid is delivered as a mist or a spray via the nasal and/or oral cavities of a patient. The mist causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis. Compositions and medical devices for cerebral and systemic cooling are also provided. Cooling assemblies, and methods of use, are also provided that include flexible balloon assemblies that are inserted to various locations in a patient's body. The flexible balloons are then infused with a liquid having a temperature between about −20° C. and about 37° C. The flexible balloon assemblies can be inserted into the nasal cavity, oral cavity, throat, stomach, and other locations to effect cerebral cooling.
摘要翻译：通过提供沸点为38-300℃的雾化液体来进行脑和全身冷却的方法。雾化的液体以雾或喷雾的形式通过患者的鼻腔和/或口腔腔输送。雾气通过颈部直接热传导通过鼻咽和血液冷却通过颈动脉和威利斯圈引起冷却。还提供了用于脑和全身冷却的组合物和医疗装置。还提供了冷却组件和使用方法，其包括插入患者体内各个位置的柔性气囊组件。然后将柔性气囊注入温度在约-20℃和约37℃之间的液体。柔性气囊组件可以插入鼻腔，口腔，咽喉，胃和其他位置以影响脑冷却。

5. 发明申请

US20080249188A1 METHODS AND DEVICES FOR NON-INVASIVE CEREBRAL AND SYSTEMIC COOLING 有权
标题翻译：非侵入性胚胎和系统冷却的方法和装置
公开(公告)号：US20080249188A1
公开(公告)日：2008-10-09
申请号：US12101933
申请日：2008-04-11
申请人： Denise Barbut , Allan Rozenberg , John K. Hoffman
发明人： Denise Barbut , Allan Rozenberg , John K. Hoffman
IPC分类号： A61K31/02 , A61P43/00
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/0065 , A61K31/02 , A61M11/02 , A61M11/06 , A61M15/08 , A61M15/085 , A61M16/04 , A61M16/0409 , A61M16/0438 , A61M16/0443 , A61M16/0459 , A61M16/0461 , A61M16/0479 , A61M16/0486 , A61M16/06 , A61M16/107 , A61M16/209 , A61M19/00 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/007 , A61M25/1011 , A61M31/00 , A61M2016/0027 , A61M2025/0034 , A61M2025/0036 , A61M2025/0073 , A61M2202/0275 , A61M2205/3606
摘要： A method for cerebral and systemic cooling by providing a nebulized liquid having a boiling point of 38-300° C. The nebulized liquid is delivered as a mist or a spray via the nasal and/or oral cavities of a patient. The mist causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis. Compositions and medical devices for cerebral and systemic cooling are also provided. Cooling assemblies, and methods of use, are also provided that include flexible balloon assemblies that are inserted to various locations in a patient's body. The flexible balloons are then infused with a liquid having a temperature between about −20° C. and about 37° C. The flexible balloon assemblies can be inserted into the nasal cavity, oral cavity, throat, stomach, and other locations to effect cerebral cooling.
摘要翻译：通过提供沸点为38-300℃的雾化液体来进行脑和全身冷却的方法。雾化的液体以雾或喷雾的形式通过患者的鼻腔和/或口腔腔输送。雾气通过颈部直接热传导通过鼻咽和血液冷却通过颈动脉和威利斯圈引起冷却。还提供了用于脑和全身冷却的组合物和医疗装置。还提供了冷却组件和使用方法，其包括插入患者体内各个位置的柔性气囊组件。然后将柔性气囊注入温度在约-20℃和约37℃之间的液体。柔性气囊组件可以插入鼻腔，口腔，咽喉，胃和其他位置以实现脑冷却。

6. 发明申请

US20080215002A1 METHODS AND DEVICES FOR NON-INVASIVE CEREBRAL AND SYSTEMIC COOLING 有权
标题翻译：非侵入性胚胎和系统冷却的方法和装置
公开(公告)号：US20080215002A1
公开(公告)日：2008-09-04
申请号：US12038720
申请日：2008-02-27
申请人： Allan Rozenberg , Denise Barbut , John K. Hoffman
发明人： Allan Rozenberg , Denise Barbut , John K. Hoffman
IPC分类号： A61F7/12 , A61M29/00 , A61B17/00 , A61M31/00
CPC分类号： A61F7/123 , A61F2007/0056
摘要： A method for cerebral and systemic cooling by circulating a cold liquid through a nasal catheter looped through the patient's nasal cavities and around the nasal septum. The nasal catheter is inserted into the patient's first nostril, advanced through the nasal cavity, around the nasal septum and out of the patient's second nostril. A cold fluid having a temperature between about −20° C. and about 37° C. is flowed though a lumen in the nasal catheter to cool the nasal cavity. The nasal catheter may have one or more flexible balloons mounted on the catheter such that when the catheter is looped around the nasal septum, the balloon(s) are positioned in a portion of the patient's first and second nasal cavities. When a cold liquid is circulated through the catheter lumen, the flexible balloons expand to a contact the inner walls of the nasal cavities and provide direct cooling of the nasal cavities.
摘要翻译：通过将冷液循环穿过患者鼻腔和鼻中隔周围的鼻导管进行脑和全身冷却的方法。将鼻导管插入患者的第一鼻孔，通过鼻腔，鼻中隔周围并从病人的第二鼻孔排出。温度在约-20℃和约37℃之间的冷流体通过鼻导管中的内腔流动以冷却鼻腔。鼻导管可以具有安装在导管上的一个或多个柔性气囊，使得当导管环绕鼻中隔环时，气囊被定位在患者的第一和第二鼻腔的一部分中。当冷液体通过导管腔循环时，柔性气囊膨胀成与鼻腔的内壁接触并提供对鼻腔的直接冷却。

7. 发明申请

US20140343641A1 METHODS AND DEVICES FOR NON-INVASIVE CEREBRAL AND SYSTEMIC COOLING 有权
标题翻译：非侵入性胚胎和系统冷却的方法和装置
公开(公告)号：US20140343641A1
公开(公告)日：2014-11-20
申请号：US14266600
申请日：2014-04-30
申请人： Denise Barbut , Alan Rozenberg , John K. Hoffman
发明人： Denise Barbut , Alan Rozenberg , John K. Hoffman
IPC分类号： A61F7/10
CPC分类号： A61F7/10 , A61F7/12 , A61F7/123 , A61F2007/0002 , A61F2007/0063 , A61F2007/0064 , A61F2007/0065 , A61F2007/0069 , A61K31/02 , A61M15/08 , A61M15/085 , A61M16/04 , A61M16/0409 , A61M16/0438 , A61M16/0454 , A61M16/0479 , A61M16/0486 , A61M16/107 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/007 , A61M25/1011 , A61M31/00 , A61M2025/0034 , A61M2025/0036 , A61M2025/0073
摘要： Methods for cerebral cooling are described. Cooling assemblies include elongate tubular members, a reservoir containing a pressurized fluid, and a manifold connecting the reservoir and elongate tubular members. After insertion of the elongate tubular members into the patient's nostrils, a pressurized fluid is delivered onto a surface of the patient's nasal cavity through a plurality of ports in the elongate tubular members. The delivery of the fluid causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis.
摘要翻译：描述脑冷却的方法。冷却组件包括细长的管状构件，容纳加压流体的储存器，以及连接贮存器和细长管状构件的歧管。在将细长管状构件插入患者的鼻孔之后，加压流体通过细长管状构件中的多个端口被输送到患者鼻腔的表面上。流体的输送通过直接通过鼻咽的传热和通过颈动脉和威利斯圈的血液冷却引起冷却。

8. 发明申请

US20120197362A1 DEVICES FOR COOLING THE NASAL CAVITY 有权
标题翻译：用于冷却NASAL CAVITY的装置
公开(公告)号：US20120197362A1
公开(公告)日：2012-08-02
申请号：US13439772
申请日：2012-04-04
申请人： ALLAN ROZENBERG , John K. Hoffman , James Savage
发明人： ALLAN ROZENBERG , John K. Hoffman , James Savage
IPC分类号： A61F7/12
CPC分类号： A61F7/123 , A61F7/12 , A61F2007/0006 , A61F2007/0068 , A61F2007/0214 , A61F2007/0247 , A61M3/025 , A61M3/0295 , A61M13/003 , A61M16/0409 , A61M16/045 , A61M16/0461 , A61M16/0479 , A61M16/0486 , A61M16/208 , A61M16/209 , A61M25/10 , A61M2025/1052 , A61M2205/3606 , A61M2210/0618
摘要： A cerebral cooling device that uses a pressurized source to deliver a fluid that evaporates in the nasal cavity to provide cooling and has a balloon on the distal end that inflates from some of the pressure front the pressurized source. The device includes a nasal catheter having delivery ports located in the distal region and a balloon on the distal end. The proximal end of the catheter is in fluid communication with a pressurized source of a low boiling point fluid. A manifold located between the pressurized source and the catheter distributes the fluid and pressure from the pressurized source to a first lumen of the catheter to inflate the balloon and to a second lumen of the catheter through the delivery ports to cool the nasal cavity. A check valve in the manifold ensures that the fluid and pressure are first delivered to the balloon.
摘要翻译：一种脑冷却装置，其使用加压源来输送在鼻腔中蒸发的流体以提供冷却，并且在远端上具有从加压源前面的一些压力膨胀的气囊。该装置包括鼻导管，其具有位于远侧区域中的输送口和远端上的气囊。导管的近端与低沸点流体的加压源流体连通。位于加压源和导管之间的歧管将来自加压源的流体和压力分配到导管的第一腔，以通过输送端口将球囊和导管的第二腔膨胀以冷却鼻腔。歧管中的止回阀确保首先将流体和压力传送到气囊。

9. 发明申请

US20100324483A1 DEVICES FOR COOLING THE NASAL CAVITY 有权
标题翻译：用于冷却NASAL CAVITY的装置
公开(公告)号：US20100324483A1
公开(公告)日：2010-12-23
申请号：US12819116
申请日：2010-06-18
申请人： ALLAN ROZENBERG , John K. Hoffman , James Savage
发明人： ALLAN ROZENBERG , John K. Hoffman , James Savage
IPC分类号： A61F7/12 , A61M25/10 , A61M1/00
CPC分类号： A61F7/123 , A61F7/12 , A61F2007/0006 , A61F2007/0068 , A61F2007/0214 , A61F2007/0247 , A61M3/025 , A61M3/0295 , A61M13/003 , A61M16/0409 , A61M16/045 , A61M16/0461 , A61M16/0479 , A61M16/0486 , A61M16/208 , A61M16/209 , A61M25/10 , A61M2025/1052 , A61M2205/3606 , A61M2210/0618
摘要： A cerebral cooling device that uses a pressurized source to deliver a fluid that evaporates in the nasal cavity to provide cooling and has a balloon on the distal end that inflates from some of the pressure from the pressurized source. The device includes a nasal catheter having delivery ports located in the distal region and a balloon on the distal end. The proximal end of the catheter is in fluid communication with a pressurized source of a low boiling point fluid. A manifold located between the pressurized source and the catheter distributes the fluid and pressure from the pressurized source to a first lumen of the catheter to inflate the balloon and to a second lumen of the catheter through the delivery ports to cool the nasal cavity. A check valve in the manifold ensures that the fluid and pressure are first delivered to the balloon.
摘要翻译：一种脑冷却装置，其使用加压源来输送在鼻腔中蒸发的流体以提供冷却，并且在远端上具有从加压源的一些压力膨胀的气囊。该装置包括鼻导管，其具有位于远侧区域中的输送口和远端上的气囊。导管的近端与低沸点流体的加压源流体连通。位于加压源和导管之间的歧管将来自加压源的流体和压力分配到导管的第一腔，以通过输送端口将球囊和导管的第二腔膨胀以冷却鼻腔。歧管中的止回阀确保首先将流体和压力传送到气囊。

10. 发明授权

US6116235A Vapor retention assembly 失效
标题翻译：蒸汽保持组件
公开(公告)号：US6116235A
公开(公告)日：2000-09-12
申请号：US884598
申请日：1997-06-27
申请人： Mark A. Walters , Ernest G. Schutt , John K. Hoffman , Mark H. Wyzgala , W. Dean Kirkland
发明人： Mark A. Walters , Ernest G. Schutt , John K. Hoffman , Mark H. Wyzgala , W. Dean Kirkland
IPC分类号： A61M16/00 , A61M16/16 , A61M15/00
CPC分类号： A61M16/009 , A61M16/0093 , Y10S128/913
摘要： Methods and apparatus for the conservation of respiratory promoters following their pulmonary introduction are disclosed. In preferred embodiments the present invention provides methods and apparatus for reducing the loss of respiratory promoter, and particularly fluorochemcials, during medical procedures such as liquid ventilation. The disclosed methods comprise the use of vapor retention assemblies, which may be conventional heat and moisture exchangers, to passively retain the respiratory promoter and return it to the lungs in subsequent breaths. Novel vapor retention assemblies comprising fluorophilic exchange elements are also disclosed.
摘要翻译：公开了在肺部引入后保护呼吸促进剂的方法和装置。在优选的实施方案中，本发明提供了用于在诸如液体通气的医疗过程期间减少呼吸促进剂，特别是氟化合物的损失的方法和装置。所公开的方法包括使用可以是常规热和湿交换器的蒸汽保持组件来被动地保持呼吸促进剂并在随后的呼吸中将其返回到肺。还公开了包含氟亲口交换元件的新型蒸气保留组件。

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