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1. 发明申请

US20050043795A1 Method for constructing reconstructed skin 有权
标题翻译：构造重建皮肤的方法
公开(公告)号：US20050043795A1
公开(公告)日：2005-02-24
申请号：US10847380
申请日：2004-05-18
申请人： Akira Hachiya , Eiko Kaiho
发明人： Akira Hachiya , Eiko Kaiho
IPC分类号： A01K67/027 , A61F2/10 , A61L27/00 , C12N5/06 , A61F2/02
CPC分类号： A61F2/105
摘要： The present invention relates to a method for constructing human skin tissue, in which human skin tissue is reconstructed on a body surface of a non-human animal, which includes: (a) burying a cell-injectable cylindrical chamber into a dorsal skin of an immunodeficient non-human animal, (b) injecting a cell suspension containing a cultured human fibroblast and a cultured human keratinocyte into the chamber, (c) cutting an upper bottom part of the chamber 7 or more days after grafting of the cell to fully open the cylinder part of the chamber, and then (d) eliminating the chamber. The present invention provides a reconstructed human skin which is excellent in terms of quantity and convenience for researching expression of genes and proteins of a human skin or evaluating medicines acting on a human skin, particularly melanocyte.
摘要翻译：本发明涉及一种构建人体皮肤组织的方法，其中人体皮肤组织被重建在非人类动物的身体表面上，其包括：（a）将细胞注射的圆柱形腔室埋入背部皮肤中免疫缺陷非人动物，（b）将含有培养的人成纤维细胞和培养的人角质形成细胞的细胞悬浮液注射到所述室中，（c）在将细胞移植到完全开放之后切割腔室7的上部底部或更多天腔室的气缸部分，然后（d）消除腔室。本发明提供了一种在人体皮肤基因和蛋白质表达的研究和评价药物特别是黑素细胞方面的数量和方便性方面优异的重建人体皮肤。

2. 发明授权

US07736894B2 Method for constructing reconstructed skin 有权
标题翻译：构造重建皮肤的方法
公开(公告)号：US07736894B2
公开(公告)日：2010-06-15
申请号：US10847380
申请日：2004-05-18
申请人： Akira Hachiya , Eiko Kaiho
发明人： Akira Hachiya , Eiko Kaiho
IPC分类号： C12N5/00
CPC分类号： A61F2/105
摘要： The present invention relates to a method for constructing human skin tissue, in which human skin tissue is reconstructed on a body surface of an immunodeficient non-human animal.
摘要翻译：本发明涉及一种构建人体皮肤组织的方法，其中人体皮肤组织在免疫缺陷型非人动物的身体表面上被重建。

3. 发明申请

US20090280088A1 Method of controlling hair shape 审中-公开
标题翻译：控制头发形状的方法
公开(公告)号：US20090280088A1
公开(公告)日：2009-11-12
申请号：US12149912
申请日：2008-05-09
申请人： Akira Hachiya , Penkanok Sriwiriyanont
发明人： Akira Hachiya , Penkanok Sriwiriyanont
IPC分类号： C12Q1/68 , A61K48/00 , G01N33/53 , A61K31/7088 , A61P17/00
CPC分类号： A61K31/7088 , A61K48/005 , C12Q1/6881 , C12Q2600/158 , G01N33/6863 , G01N2333/65
摘要： The present invention provides a method for determining or modulating hair morphology and properties of natural wavy and frizzy hair and a method for evaluating or selecting a hair morphology modulator. The present invention provides a method for modulating hair morphology, including controlling an expression of IGFBP-5 gene or IGFBP-5 protein in a human hair follicle.
摘要翻译：本发明提供了一种用于确定或调节天然波浪和卷曲毛发的头发形态和性质的方法以及用于评估或选择毛发形态调节剂的方法。本发明提供调节毛发形态的方法，包括控制人毛囊中IGFBP-5基因或IGFBP-5蛋白的表达。

4. 发明授权

US08771647B2 Human photoaged skin model 有权
标题翻译：人类皮肤皮肤模型
公开(公告)号：US08771647B2
公开(公告)日：2014-07-08
申请号：US11766522
申请日：2007-06-21
申请人： Akira Hachiya , Tsutomu Fujimura
发明人： Akira Hachiya , Tsutomu Fujimura
IPC分类号： A01K67/027
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/035
摘要： The present invention provides a human photoaged skin model and an animal model, and a method of making the same, for evaluating cosmetics and similar products in terms of their anti-aging or rejuvenating effect.
摘要翻译：本发明提供一种人类皮肤皮肤模型和动物模型及其制备方法，用于评估化妆品和类似产品的抗老化或恢复活力。

5. 发明授权

US08088570B2 Method for screening an agent for preventing or ameliorating wrinkles 有权
标题翻译：用于筛选用于预防或改善皱纹的药剂的方法
公开(公告)号：US08088570B2
公开(公告)日：2012-01-03
申请号：US11405471
申请日：2006-04-18
申请人： Tsutomu Fujimura , Takuji Kume , Akira Hachiya
发明人： Tsutomu Fujimura , Takuji Kume , Akira Hachiya
IPC分类号： C12Q1/00
CPC分类号： G01N33/5044 , G01N33/5082 , G01N2333/4742
摘要： There is provided a screening method which can select a photoaging-preventing or improving agent or a wrinkle-preventing or improving agent with efficiency and reliability. The screening method for a photoaging- or wrinkle-preventing or improving agent selects, as a candidate, a substance inhibiting the expression of keratin 6 and/or keratin 16 genes or keratin 6 and/or keratin 16 proteins in a skin tissue or cell.
摘要翻译：提供了一种筛选方法，其可以有效地和可靠地选择光老化防止或改善剂或防皱或改善剂。光老化或防皱或改善剂的筛选方法选择抑制角蛋白6和/或角蛋白16基因或角蛋白6和/或角蛋白16蛋白在皮肤组织或细胞中表达的物质作为候选物质。

6. 发明授权

US07973211B2 Animal model for hyperpigmentation 有权
标题翻译：用于色素沉着过度的动物模型
公开(公告)号：US07973211B2
公开(公告)日：2011-07-05
申请号：US12073869
申请日：2008-03-11
申请人： Akira Hachiya , Penkanok Sriwiriyanont , Shinya Kasamatsu
发明人： Akira Hachiya , Penkanok Sriwiriyanont , Shinya Kasamatsu
IPC分类号： A01K67/00
CPC分类号： A01K67/0271 , A01K2267/03
摘要： An animal model for hyperpigmentations in which the formation of hyperpigmentations in human skin is faithfully simulated is provided. An animal model for hyperpigmentations, wherein a black person's skin is grafted onto a non-human animal, is provided.
摘要翻译：提供了一种用于色素沉着过度的动物模型，其中人皮肤中色素沉着过度的形成被真实地模拟。提供了一种用于色素沉着的动物模型，其中将黑人的皮肤移植到非人动物上。

7. 发明申请

US20080263686A1 ANIMAL MODEL FOR PIGMENT SPOTS 有权
标题翻译：动物模型用于颜色搭配
公开(公告)号：US20080263686A1
公开(公告)日：2008-10-23
申请号：US11785549
申请日：2007-04-18
申请人： Akira Hachiya , Penkanok Sriwiriyanont
发明人： Akira Hachiya , Penkanok Sriwiriyanont
IPC分类号： A01K67/00 , A61K49/00 , C12N5/06
CPC分类号： A61K49/0006 , A01K67/0271 , A61K49/0008
摘要： An animal model for pigment spots in which the formation of pigment spots in human skin is faithfully simulated is provided. An animal model for pigment spots, wherein a black person's skin is grafted onto a non-human animal, is provided.
摘要翻译：提供了一种用于颜色斑点的动物模型，其中人类皮肤中颜料斑点的形成被真实地模拟。提供了将黑人皮肤移植到非人动物上的颜料斑点的动物模型。

8. 发明申请

US20070243520A1 Method for screening an agent for preventing or ameliorating wrinkles 有权
标题翻译：用于筛选用于预防或改善皱纹的药剂的方法
公开(公告)号：US20070243520A1
公开(公告)日：2007-10-18
申请号：US11405471
申请日：2006-04-18
申请人： Tsutomu Fujimura , Takuji Kume , Akira Hachiya
发明人： Tsutomu Fujimura , Takuji Kume , Akira Hachiya
IPC分类号： C12Q1/00
CPC分类号： G01N33/5044 , G01N33/5082 , G01N2333/4742
摘要： There is provided a screening method which can select a photoaging-preventing or improving agent or a wrinkle-preventing or improving agent with efficiency and reliability. The screening method for a photoaging- or wrinkle-preventing or improving agent selects, as a candidate, a substance inhibiting the expression of keratin 6 and/or keratin 16 genes or keratin 6 and/or keratin 16 proteins in a skin tissue or cell.
摘要翻译：提供了一种筛选方法，其可以有效地和可靠地选择光老化防止或改善剂或防皱或改善剂。光老化或防皱或改善剂的筛选方法选择抑制角蛋白6和/或角蛋白16基因或角蛋白6和/或角蛋白16蛋白在皮肤组织或细胞中表达的物质作为候选物质。

9. 发明授权

US08187841B2 Method for evaluating or selecting agent for preventing or curing photodamage of skin 有权
标题翻译：评估或选择预防或治愈皮肤光损伤的药剂的方法
公开(公告)号：US08187841B2
公开(公告)日：2012-05-29
申请号：US12487080
申请日：2009-06-18
申请人： Urara Yokose , Akira Hachiya , Tsutomu Fujimura
发明人： Urara Yokose , Akira Hachiya , Tsutomu Fujimura
IPC分类号： C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： A method for evaluating or selecting a substance capable of preventing or curing photodamage of skin is provided. Provided is a method for evaluating or selecting an agent for preventing or curing photodamage of skin, the method including: (A) contacting cells that are capable of expressing TIMP-1 gene or TIMP-1 protein, with a test substance; (B) measuring the expression level of the TIMP-1 gene or the TIMP-1 protein in the cells; (C) comparing the expression level obtained in (B), with the expression level of TIMP-1 gene or TIMP-1 protein in a control group in which the cells capable of expressing TIMP-1 gene or TIMP-1 protein have not been contacted with the test substance; and (D) evaluating or selecting the test substance which increases the expression level of TIMP-1 gene or TIMP-1 protein, as an agent for preventing or curing photodamage of skin, based on the results of (C).
摘要翻译：提供了一种评估或选择能够预防或治愈皮肤光损伤的物质的方法。本发明提供一种评价或选择用于预防或治疗皮肤光损伤的药剂的方法，所述方法包括：（A）使能够表达TIMP-1基因或TIMP-1蛋白质的细胞与测试物质接触; （B）测定细胞中TIMP-1基因或TIMP-1蛋白的表达水平; （C）比较（B）中获得的表达水平与其中能够表达TIMP-1基因或TIMP-1蛋白的细胞未被发现的对照组中TIMP-1基因或TIMP-1蛋白的表达水平与测试物质接触; （D）根据（C）的结果，评价或选择提高TIMP-1基因或TIMP-1蛋白表达水平的试验物质，作为预防或治愈皮肤光损伤的药剂。

10. 发明授权

US07468421B2 Depilatories and agents for external use 失效
标题翻译：脱毛剂和外用药剂
公开(公告)号：US07468421B2
公开(公告)日：2008-12-23
申请号：US11026090
申请日：2005-01-03
申请人： Atsushi Ohuchi , Akemi Kobayashi , Akira Hachiya
发明人： Atsushi Ohuchi , Akemi Kobayashi , Akira Hachiya
IPC分类号： C07K7/00
CPC分类号： A61Q9/04 , A61K8/046 , A61K8/64 , A61K38/1703 , A61K38/2285 , A61Q7/02
摘要： This invention relates to depilatories and external preparations, each of which contains endothelin or its agonist, and also to a depilating method characterized by administering endothelin or its agonist.As the depilatories and external preparations according to the present invention inhibit growth of hair in mammalian skin, their application to the human body as drugs or cosmetics permits safe and effective removal of hair from the body. These depilatories and external preparations are also usable as wool harvesting preparations.
摘要翻译：本发明涉及脱毛剂和外用制剂，其各自含有内皮缩血管肽或其激动剂，还涉及以给药内皮素或其激动剂为特征的脱毛方法。由于根据本发明的脱毛剂和外用制剂抑制哺乳动物皮肤中的毛发生长，因此将其作为药物或化妆品施用于人体允许从身体安全有效地去除毛发。这些脱毛剂和外用制剂也可用作羊毛收获制剂。

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