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    • 2. 发明申请
    • METHOD AND DEVICE FOR PRODUCING OPTIMIZED LIPID-BASED MICRO/NANO-BUBBLES
    • 用于生产优化的基于脂质的微孔/纳米泡沫的方法和装置
    • US20140328767A1
    • 2014-11-06
    • US14248338
    • 2014-04-09
    • Trust Bio-sonics Inc.
    • Chung-Hsin Wang
    • A61K49/22B01F11/02B01F15/06B01F3/04
    • A61K49/223A61K41/0028A61K49/22B01F3/04099B01F11/0266B01F15/06B01F2015/062B01F2215/0034B01F2215/0404
    • A method of producing lipid-based micro/nano bubbles includes steps of (a) preparing a lipid mixture including one or more first lipids with different phase transition temperature, and a second lipid bonding with a hydrophilic polymer moiety or molecules capable of getting across a lipid membrane and decreasing van der Waals forces between lipid bilayers; (b) emulsifying the lipid mixture with a solvent, to form a transparent lipid carrier solution; (c) placing the transparent lipid carrier solution in a closed vessel with halo-substituted hydrocarbon; (d) manipulating temperature of the transparent lipid carrier solution to be close to a main phase transition temperature thereof; and (e) agitating in a mechanical manner the vessel containing the transparent lipid carrier solution to form micro/nano bubbles within the closed vessel. This method contributes to form micro/nano bubbles with desired diameters in a way of optimal material utilization efficiency.
    • 制备基于脂质的微/纳米气泡的方法包括以下步骤:(a)制备包含一种或多种具有不同相变温度的第一种脂质的脂质混合物,以及与亲水性聚合物部分或能够穿过 脂质膜和减少脂双层之间的范德华力; (b)用溶剂乳化脂质混合物,形成透明的脂质载体溶液; (c)将透明的脂质载体溶液置于具有卤代烃的密闭容器中; (d)将所述透明脂质载体溶液的温度控制在接近其主相变温度的温度; 和(e)以机械方式搅拌含有透明脂质载体溶液的容器,以在封闭容器内形成微/纳米气泡。 该方法有助于以最佳材料利用效率的方式形成具有所需直径的微/纳米气泡。