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1. 发明授权

US07273745B2 Pectate lyases 失效
标题翻译：果胶裂解酶
公开(公告)号：US07273745B2
公开(公告)日：2007-09-25
申请号：US11605148
申请日：2006-11-28
申请人： Lene Nonboe Andersen , Hanne Dela, legal representative , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schrøder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
发明人： Martin Schülein, deceased
IPC分类号： C12N9/88 , D06M16/00
CPC分类号： C12N9/2465 , A23K10/14 , A23K20/189 , C07K2319/20 , C11D3/386 , C12N9/88 , D06L4/40 , D06M16/003 , D21C5/005 , Y10T442/20
摘要： The present invention relates to pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) (amino acids 236-242 of SEQ ID NO: 2) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.
摘要翻译：本发明涉及属于多糖裂解酶家族1的氨基酸序列Asn Leu Asn Ser Arg Val Pro（NLNSRVP）（SEQ ID NO：2的氨基酸236-242）的果胶酸裂解酶在中性的工业过程中具有良好的性能或碱性条件如洗涤和纺织加工。果胶裂解酶可以衍生自芽孢杆菌属物种。

2. 发明授权

US06607902B2 Cell-wall degrading enzyme variants 有权
标题翻译：细胞壁降解酶变体
公开(公告)号：US06607902B2
公开(公告)日：2003-08-19
申请号：US09910505
申请日：2001-07-19
申请人： Sanne O Schrøder Glad , Carsten Andersen , Martin Schulein , Torben Peter Frandsen
发明人： Sanne O Schrøder Glad , Carsten Andersen , Martin Schulein , Torben Peter Frandsen
IPC分类号： C12N988
CPC分类号： C11D3/38636 , C12N9/88
摘要： A variant of a cell-wall degrading enzyme having a beta-helix structure, which variant holds at least one substituent in a position determined by identifying all residues potentially belonging to a stack; characterising the stack as interior or exterior; characterising the stack as polar, hydrophobic or aromatic/heteroaromatic based on the dominating characteristics of the parent or wild-type enzyme stack residues and/or its orientation relative to the beta-helix (interior or exterior); optimizing all stack positions of a stack either to hydrophobic aliphatic amino acids, hydrophobic aromatic or polar amino acids by allowing mutations within one or all positions to amino acids belonging to one of these groups; measuring thermostability of the variants by DSC or an application-related assay such as a Pad-Steam application test; and selecting the stabilized variants. Variant of a wild-type parent pectate lyase (EC 4.2.2.2) having the conserved amino acid residues D111, D141 or E141, D145, K165, R194 and R199 when aligned with the pectate lyase comprising the amino acid sequence of SEQ ID NO: 2 are preferred.
摘要翻译：具有β-螺旋结构的细胞壁降解酶的变体，该变体保持在通过鉴定潜在属于堆叠的所有残基而确定的位置中的至少一个取代基; 将堆栈表征为内部或外部; 基于母体或野生型酶堆残基的主导特征和/或其相对于β-螺旋（内部或外部）的取向，将所述叠层表征为极性，疏水性或芳族/杂芳族化合物; 通过在属于这些基团之一的氨基酸的一个或所有位置内允许突变将堆叠的所有堆叠位置优化为疏水性脂族氨基酸，疏水性芳族或极性氨基酸; 通过DSC测量变体的热稳定性或应用相关测定，例如Pad-Steam应用测试; 并选择稳定的变体。当与包含SEQ ID NO：1的氨基酸序列的果胶酸裂解酶比对时，具有保守氨基酸残基D111，D141或E141，D145，K165，R194和R199的野生型亲本果胶酸裂合酶（EC 4.2.2.2） 2是优选的。

3. 发明授权

US06368843B1 Pectate lyases 有权
标题翻译：果胶裂解酶
公开(公告)号：US06368843B1
公开(公告)日：2002-04-09
申请号：US09694531
申请日：2000-10-23
申请人： Lene Nonboe Andersen , Martin Schülein , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schrøder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
发明人： Lene Nonboe Andersen , Martin Schülein , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schrøder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
IPC分类号： C12N926
CPC分类号： C12N9/2465 , A23K10/14 , A23K20/189 , C07K2319/20 , C11D3/386 , C12N9/88 , D06L4/40 , D06M16/003 , D21C5/005 , Y10T442/20
摘要： A novel group of pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.
摘要翻译：属于多糖裂解酶1族的氨基酸序列Asn Leu Asn Ser Arg Val Pro（NLNSRVP）的新一组果胶酸裂解酶在中性或碱性条件例如洗涤和纺织加工中在工业过程中具有良好的性能。果胶裂解酶可以衍生自芽孢杆菌属物种。

4. 发明授权

US06187580B1 Pectate lyases 有权
标题翻译：果胶裂解酶
公开(公告)号：US06187580B1
公开(公告)日：2001-02-13
申请号：US09198955
申请日：1998-11-24
申请人： Lene Nonboe Andersen , Martin Schülein , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schrøder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
发明人： Lene Nonboe Andersen , Martin Schülein , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schrøder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
IPC分类号： C12N988
CPC分类号： C12N9/2465 , A23K10/14 , A23K20/189 , C07K2319/20 , C11D3/386 , C12N9/88 , D06L4/40 , D06M16/003 , D21C5/005 , Y10T442/20
摘要： A novel group of pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase are derivable from Bacillus species.
摘要翻译：属于多糖裂解酶1族的氨基酸序列Asn Leu Asn Ser Arg Val Pro（NLNSRVP）的新一组果胶酸裂解酶在中性或碱性条件例如洗涤和纺织加工中在工业过程中具有良好的性能。果胶裂解酶可从芽孢杆菌属物种衍生。

5. 发明授权

US07312062B2 Lipolytic enzyme variants 有权
标题翻译：脂解酶变体
公开(公告)号：US07312062B2
公开(公告)日：2007-12-25
申请号：US10779427
申请日：2004-11-22
申请人： Kirsten Bojsen , Allan Svendsen , Claus Crone Fuglsang , Shamkant Anant Patkar , Kim Borch , Jesper Vind , Andreas Petri , Sanne O. Schrøder Glad , Gitte Budolfsen
发明人： Kirsten Bojsen , Allan Svendsen , Claus Crone Fuglsang , Shamkant Anant Patkar , Kim Borch , Jesper Vind , Andreas Petri , Sanne O. Schrøder Glad , Gitte Budolfsen
IPC分类号： C12N9/16 , C12N9/18 , D06M16/00 , A21D10/00
CPC分类号： C12Y301/01003 , A21D8/042 , C11B3/003 , C11D3/38627 , C12N9/20 , C12P9/00
摘要： The substrate specificity of a lipolytic enzyme can be modified by making alterations to the amino acid sequence in a defined region of the lipolytic enzyme, so as to increase the level of a desired activity or to decrease the level of an undesired activity. Thus, the inventors have developed lipolytic enzyme variants with a modified amino acid sequence with a substrate specificity which can be tailored for specific uses.
摘要翻译：可以通过改变脂肪分解酶的限定区域中的氨基酸序列来修饰脂解酶的底物特异性，从而增加所需活性的水平或降低不需要的活性的水平。因此，本发明人已经开发了具有修饰的氨基酸序列的脂肪分解酶变体，其具有底物特异性，其可以针对特定用途进行定制。

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