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1. 外观设计

USD643530S1 Skin treatment handpiece 有权
标题翻译：皮肤处理手机
公开(公告)号：USD643530S1
公开(公告)日：2011-08-16
申请号：US29264446
申请日：2006-08-10
申请人： Paul O. Ramstad , Donna S. Levy , Alexis A. Mataban , Stephen Derek Smithson , Daniel K. Childs , Matthew William Tivnon
设计人： Paul O. Ramstad , Donna S. Levy , Alexis A. Mataban , Stephen Derek Smithson , Daniel K. Childs , Matthew William Tivnon

2. 发明申请

US20080119830A1 Disposable tip for laser handpiece 审中-公开
标题翻译：一次性激光手机提示
公开(公告)号：US20080119830A1
公开(公告)日：2008-05-22
申请号：US11589799
申请日：2006-10-31
申请人： Paul O. Ramstad , Albert C. Zakowski , Stephen Derek Smithson , Andrey Degtyaryov , Michael Robert Gluszczak , Raymond Gordon White , Ronald S. Bader , Daniel K. Childs
发明人： Paul O. Ramstad , Albert C. Zakowski , Stephen Derek Smithson , Andrey Degtyaryov , Michael Robert Gluszczak , Raymond Gordon White , Ronald S. Bader , Daniel K. Childs
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B2017/00477 , A61B2018/00291 , A61B2018/00452 , A61N5/0616 , A61N2005/0644
摘要： The present invention generally relates to a disposable insert for a laser handpiece providing a hygienic surface for applying monochromatic light to a patient. The disposable insert is configured for providing vacuum to a laser cavity and provides a measure of safety to the user by insuring that the laser will be inoperative in the absence of the insert.
摘要翻译：本发明总体上涉及一种用于激光手柄的一次性插入件，其提供用于向患者施加单色光的卫生表面。一次性插入件构造成用于向激光腔提供真空，并且通过确保激光在没有插入件的情况下不起作用而向使用者提供安全性的度量。

3. 发明授权

US4816513A Automated polypeptide synthesis process 失效
标题翻译：自动多肽合成过程
公开(公告)号：US4816513A
公开(公告)日：1989-03-28
申请号：US53324
申请日：1987-05-22
申请人： John Bridgham , Timothy G. Geiser , Michael W. Hunkapiller , Stephen B. H. Kent , Mark P. Marriott , Paul O. Ramstad , Eric S. Nordman
发明人： John Bridgham , Timothy G. Geiser , Michael W. Hunkapiller , Stephen B. H. Kent , Mark P. Marriott , Paul O. Ramstad , Eric S. Nordman
IPC分类号： C07K1/00 , B01J19/00 , C07K1/04 , C40B40/10 , C40B60/14 , C08L89/00 , C07C103/52
CPC分类号： C07K1/045 , B01J19/0046 , B01J2219/00286 , B01J2219/00389 , B01J2219/00484 , B01J2219/00488 , B01J2219/0049 , B01J2219/00495 , B01J2219/005 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/00725 , C40B40/10 , C40B60/14
摘要： An apparatus is provided for automatically constructing a polypeptide of high purity, up to 50 amino acids in length, using only single couplings. The apparatus includes an activation system for receiving protected amino acids, one kind at a time, having a common vessel (an activator vessel) in which to activate each of the amino acids. Also included is a reaction vessel for containing a resin used in solid-phase peptide synthesis for attaching a peptide chain thereto. A transfer system is also provided, which operates under control of a computer, to transfer the activated species from the activation system to the reaction vessel and to transfer amino acids, reagents, gases, and solvents from one part of the apparatus to another. The activator system also includes a temperature controlled concentrator vessel in which an activator solvent is replaced by a coupling solvent to enhance the coupling of the activated species to the peptide chain in the reaction vessel. Also included in the synthesizer system is a vortexer for affecting total washing of materials in the reaction vessel and the reaction vessel itself, an automated peptide resin sampling system, and an autodelivery system for providing individual containers of amino acid to the synthesizer in the order desired in the peptide sequence. A liquid sensor system is also included to monitor transitions between gases and liquids in specific tubes in the synthesizer in order to provide input signals to the computer system for control purposes. The computer system software which controls the operation of the synthesizer is organized according to a series of menus which allows the user of the system to select individual cycles of operation for each vessel in the synthesizer. In addition, an algorithm has been developed which provides for optimum efficiency in the production of a peptide for any given selection of cycles.
摘要翻译：提供了一种用于仅使用单个耦合自动构建高纯度多达50个氨基酸长度的多肽的装置。该装置包括用于一次接收受保护的氨基酸的激活系统，其具有在其中激活每个氨基酸的共同血管（活化剂容器）。还包括用于含有固相肽合成中用于连接肽链的树脂的反应容器。还提供了在计算机控制下操作的转移系统，以将活化物质从活化系统转移到反应容器中，并将氨基酸，试剂，气体和溶剂从设备的一部分转移到另一部分。活化剂体系还包括温度控制的浓缩容器，其中活化剂溶剂被偶联溶剂代替以增强活化物质与反应容器中的肽链的偶联。还包括在合成器系统中的是用于影响反应容器和反应容器本身中的材料的全部洗涤的涡流器，自动化肽树脂取样系统和用于按合适的顺序向合成器提供单个氨基酸容器的自动输送系统在肽序列中。还包括液体传感器系统以监测合成器中特定管中的气体和液体之间的转换，以便为控制目的向计算机系统提供输入信号。控制合成器操作的计算机系统软件根据一系列菜单进行组织，这些菜单允许系统的用户为合成器中的每个容器选择各个操作周期。此外，已经开发了一种算法，其提供用于任何给定选择周期的肽的生产的最佳效率。

4. 发明申请

US20100142206A1 DEVICE AND SYSTEM FOR AN OPTICAL ELEMENT HOLDER 失效
标题翻译：光学元件的装置和系统
公开(公告)号：US20100142206A1
公开(公告)日：2010-06-10
申请号：US12646933
申请日：2009-12-23
申请人： Michael Robert Gluszczak , Paul O. Ramstad , Stephen Derek Smithson , George Phillips , Roy W. Lindahl
发明人： Michael Robert Gluszczak , Paul O. Ramstad , Stephen Derek Smithson , George Phillips , Roy W. Lindahl
IPC分类号： F21V17/06 , F21V29/00
CPC分类号： F21V29/83 , A61N5/0616 , A61N2005/005 , A61N2005/0654 , A61N2005/0667 , F21V29/02 , F21V29/67 , G02B6/0006 , G02B7/006 , G02B7/008
摘要： A supporting structure is disclosed for both securing optical elements for providing optimal cooling of the optical elements and the light source.
摘要翻译：公开了用于确保用于提供光学元件和光源的最佳冷却的光学元件的支撑结构。

5. 外观设计

USD608881S1 Disposable tip 有权
标题翻译：一次性提示
公开(公告)号：USD608881S1
公开(公告)日：2010-01-26
申请号：US29267974
申请日：2006-10-26
申请人： Paul O. Ramstad , Donna S. Levy , Alexis A. Mataban , Stephen Derek Smithson , Daniel K. Childs , Matthew William Tivnon
设计人： Paul O. Ramstad , Donna S. Levy , Alexis A. Mataban , Stephen Derek Smithson , Daniel K. Childs , Matthew William Tivnon

6. 发明授权

US07235163B2 Loading features for channel array 有权
标题翻译：加载通道阵列的功能
公开(公告)号：US07235163B2
公开(公告)日：2007-06-26
申请号：US10661231
申请日：2003-09-12
申请人： Paul O. Ramstad , Sean M. Desmond , Janice G. Shigeura, legal representative , Richard T. Reel , Richard Morris
发明人： John Shigeura, deceased
IPC分类号： G01N27/447 , G01N27/453 , G01N30/02 , B01L3/02
CPC分类号： G01N27/44743
摘要： Apparatus and method for loading a channel device for electrophoretic separation including cilia which can be deflected into wells of a multi-well tray.
摘要翻译：用于装载用于电泳分离的通道装置的装置和方法，包括可以偏转到多孔盘的孔中的纤毛。

7. 发明授权

US06833238B2 Petal-array support for use with microplates 失效
标题翻译：花瓣阵列支持与微孔板一起使用
公开(公告)号：US06833238B2
公开(公告)日：2004-12-21
申请号：US10413935
申请日：2003-04-14
申请人： Paul O. Ramstad , Michael P. Harrold , Kevin M. Hennessy , Aldrich N. K. Lau
发明人： Paul O. Ramstad , Michael P. Harrold , Kevin M. Hennessy , Aldrich N. K. Lau
IPC分类号： C12Q100
CPC分类号： G01N33/54313 , B01L3/50853 , B01L2300/046 , B01L2300/0609 , B01L2300/069 , B01L2300/0829 , G01N1/405 , Y10T436/255
摘要： Devices are provided which include supports upon which one or more ion-exchange materials can be disposed for purifying a sample. In various embodiments, the supports include a plurality of deformable members, for example, petal-shaped purification members, that provide binding sites for ion-exchange material and optionally biochemical species, chemicals, salts, or other materials. An apparatus and method are also provided for the insertion and removal of the purification members into respective wells of a multi-well microplate.
摘要翻译：提供了包括可以设置一种或多种离子交换材料用于纯化样品的载体的装置。在各种实施例中，支撑件包括多个可变形构件，例如花瓣形净化构件，其提供用于离子交换材料和任选的生化物质，化学物质，盐或其它材料的结合位点。还提供了一种用于将净化构件插入和移除到多孔微板的相应孔中的装置和方法。

8. 发明申请

US20080123342A1 Device and system for an optical element holder 失效
标题翻译：用于光学元件支架的装置和系统
公开(公告)号：US20080123342A1
公开(公告)日：2008-05-29
申请号：US11594193
申请日：2006-11-08
申请人： Michael Robert Gluszczak , Paul O. Ramstad , Stephen Derek Smithson , George Phillips , Roy W. Lindahl
发明人： Michael Robert Gluszczak , Paul O. Ramstad , Stephen Derek Smithson , George Phillips , Roy W. Lindahl
IPC分类号： F21V7/00 , G02B7/00
CPC分类号： F21V29/83 , A61N5/0616 , A61N2005/005 , A61N2005/0654 , A61N2005/0667 , F21V29/02 , F21V29/67 , G02B6/0006 , G02B7/006 , G02B7/008
摘要： A supporting structure is disclosed for both securing optical elements and for providing optimal cooling of the optical elements and the light source.
摘要翻译：公开了一种用于固定光学元件并用于提供光学元件和光源的最佳冷却的支撑结构。

9. 发明授权

US5653259A Valve block 失效
标题翻译：阀块
公开(公告)号：US5653259A
公开(公告)日：1997-08-05
申请号：US539496
申请日：1995-10-06
申请人： Paul O. Ramstad
发明人： Paul O. Ramstad
IPC分类号： B01J4/02 , B01J19/00 , C40B60/14 , F16K7/14 , F16K27/00 , F16K31/06 , F16K7/12
CPC分类号： F16K31/06 , B01J19/0046 , B01J4/02 , F16K27/003 , F16K7/14 , B01J2219/00389 , B01J2219/00412 , C40B60/14 , Y10T137/4259 , Y10T137/87684 , Y10T137/87885
摘要： A manifold block and valving system using the manifold block are provided, which are used for conducting chemical reagents, solvents, and other fluids. The manifold block includes a "straight-through" common passage in fluid connection with several entry ports, including also a number of projections in the common passage in the vicinity of the entry ports. These projections partially obstruct the fluid flow, causing a turbulence that provides a washing action in those port regions. The manifold may be constructed of a photosensitive glass ceramic such as Fotoceram.TM. which consists of a number of layers which have been processed to form the manifold block, or of other suitable materials such as silicon.
摘要翻译：提供使用歧管块的歧管块和阀门系统，用于导入化学试剂，溶剂和其它流体。歧管块包括与多个入口端口流体连接的“直通”公共通道，包括在入口端口附近的公共通道中的多个突起。这些突起部分地阻碍流体流动，导致在这些端口区域中提供洗涤动作的湍流。歧管可以由诸如Fotoceram TM的感光玻璃陶瓷构成，其由已经被处理以形成歧管块的多个层或其它合适的材料例如硅组成。

10. 发明授权

US4668476A Automated polypeptide synthesis apparatus 失效
标题翻译：自动多肽合成仪
公开(公告)号：US4668476A
公开(公告)日：1987-05-26
申请号：US592638
申请日：1984-03-23
申请人： John Bridgham , Timothy G. Geiser , Michael W. Hunkapiller , Stephen B. H. Kent , Mark P. Marriott , Paul O. Ramstad , Eric S. Nordman
发明人： John Bridgham , Timothy G. Geiser , Michael W. Hunkapiller , Stephen B. H. Kent , Mark P. Marriott , Paul O. Ramstad , Eric S. Nordman
IPC分类号： C07K1/00 , B01J19/00 , C07K1/04 , C40B40/10 , C40B60/14 , C07K1/08
CPC分类号： C07K1/045 , B01J19/0046 , B01J2219/00286 , B01J2219/00389 , B01J2219/00484 , B01J2219/00488 , B01J2219/0049 , B01J2219/00495 , B01J2219/005 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/00725 , C40B40/10 , C40B60/14
摘要： An apparatus is provided for automatically constructing a polypeptide of high purity, up to 50 amino acids in length, using only single couplings. The apparatus includes an activation system for receiving protected amino acids, one kind at a time, having a common vessel (an activator vessel) in which to activate each of the amino acids. Also included is a reaction vessel for containing a resin used in solid-phase peptide synthesis for attaching a peptide chain thereto. A transfer system is also provided, which operates under control of a computer, to transfer the activated species from the activation system to the reaction vessel and to transfer amino acids, reagents, gases, and solvents from one part of the apparatus to another.

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