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1. 发明授权

US5911456A Method and apparatus for mounting parts with pick-up mistake detection and storage of mistake rate 失效
标题翻译：安装零件的方法和装置带有错误检测和存储错误率
公开(公告)号：US5911456A
公开(公告)日：1999-06-15
申请号：US925746
申请日：1997-09-09
申请人： Yuzo Tsubouchi , Nobutaka Abe , Yuji Nakamura
发明人： Yuzo Tsubouchi , Nobutaka Abe , Yuji Nakamura
IPC分类号： F25D17/06 , F25D16/00 , F25D23/00 , H05K13/04 , H05K13/08 , H05K3/30 , B23P11/00 , B23P21/00
CPC分类号： H05K13/08 , H05K13/0413 , Y10T29/4913 , Y10T29/49131 , Y10T29/49133 , Y10T29/49769 , Y10T29/53061 , Y10T29/53091 , Y10T29/53191 , Y10T29/53261
摘要： There is disclosed an electronic parts mounting method in which it is possible to avoid a pick-up mistake for electronic parts (chips) in simultaneously picking up the chips respectively stored in juxtaposed parts feeders by a plurality of nozzles provided to a transfer head. Nozzle position data of first, second and third nozzles 9a, 9b and 9c are beforehand obtained by a first camera, and pick-up positions of the chips in parts feeders 4 are obtained by a second camera. After picking up respectively the chips in the parts feeders 4 by the nozzles 9a to 9c it is judged whether or not there would be caused the pick-up mistake. When it is judged there is caused no pick-up mistake, a transfer head is moved to a position above a board and each of the chips is mounted to the board. When it is judged there is caused any pick-up mistake, a pick-up mistake rate of any of the parts feeders in which the pick-up mistake occurs, is updated and each of the chips is picked up again by the nozzle which caused the pick-up mistake.
摘要翻译：公开了一种电子部件安装方法，其中可以避免电子部件（芯片）通过设置在转印头上的多个喷嘴同时拾取分离存储在并置部件进给器中的碎屑的拾取错误。通过第一照相机预先获得第一，第二和第三喷嘴9a，9b和9c的喷嘴位置数据，并且通过第二照相机获得部件供给器4中的芯片的拾取位置。在通过喷嘴9a至9c分别拾取部件进给器4中的切屑之后，判断是否会引起拾取错误。当判断为没有引起错误时，将转印头移动到板上方的位置，并将每个芯片安装到板上。当判断出有引起错误的情况下，发生拾取错误的任何零件进给器的拾取错误率被更新，并且通过喷嘴再次拾取每个切屑拿起错误。

2. 发明授权

US5840594A Method of and apparatus for mounting electronic parts on a board 失效
标题翻译：将电子部件安装在电路板上的方法和装置
公开(公告)号：US5840594A
公开(公告)日：1998-11-24
申请号：US929420
申请日：1997-09-15
申请人： Yuzo Tsubouchi , Nobutaka Abe , Yuji Nakamura
发明人： Yuzo Tsubouchi , Nobutaka Abe , Yuji Nakamura
IPC分类号： B23P21/00 , B25J15/00 , H01L21/00 , H05K13/04 , H05K13/08 , H01L21/66
CPC分类号： H01L21/67144
摘要： A first camera detects a positional relationship among first, second and third nozzles. A second camera detects pick-up positions of chips in parts feeders. Tolerance zones for the respective chips are determined, within which the nozzle can pick up the chip. When one of nozzles is placed in the corresponding pick-up position, it is judged whether or not other nozzles are located within the corresponding tolerance zones, respectively. If the judgment result is "YES", the nozzles pick up the chips simultaneously , and if this result is "NO", the nozzles pick up the chips separately.
摘要翻译：第一相机检测第一，第二和第三喷嘴之间的位置关系。第二台相机检测零件进给器中的芯片的拾取位置。确定各个芯片的公差区域，其中喷嘴可以拾取芯片。当其中一个喷嘴被放置在相应的拾取位置时，判断其他喷嘴是否分别位于相应的公差区域内。如果判断结果为“是”，则喷嘴同时拾取芯片，如果该结果为“否”，则喷嘴分别取出芯片。

3. 发明申请

US20120202773A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF DISEASES ASSOCIATED WITH DECREASE IN BONE MASS COMPRISING EP4 AGONIST AS ACTIVE INGREDIENT 审中-公开
标题翻译：用于治疗与包含EP4激动剂作为主动成分的骨质疏松相关的疾病的药物组合物
公开(公告)号：US20120202773A1
公开(公告)日：2012-08-09
申请号：US13453434
申请日：2012-04-23
申请人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
发明人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
IPC分类号： A61K31/4015 , C08B37/16 , A61K31/724 , C07D409/06 , C07D405/10 , C07D405/06 , C07D417/12 , C07D413/12 , C07D417/14 , C07D263/24 , C07D403/12 , C07D409/12 , C07D409/14 , C07D401/12 , A61P19/08 , C07D413/14 , C07D207/26 , B82Y99/00 , B82Y5/00
CPC分类号： C07C405/0033 , A61K9/0019 , A61K9/1647 , A61K9/19 , A61K9/2054 , A61K31/4015 , A61K31/41 , A61K31/5575 , A61K31/559
摘要： A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).
摘要翻译：用于预防和/或治疗与包含EP4激动剂作为活性成分的骨量减少相关的疾病的局部施用的药物组合物。包含具有前列腺素骨架的化合物作为代表的EP4激动剂具有促进骨形成的作用，因此可用于预防和/或治疗与骨质量减少有关的疾病（骨疾病如原发性骨质疏松症，继发性骨质疏松症骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失和骨坏死，术后成骨，骨移植的替代疗法）。

4. 发明申请

US20120127200A1 MEDICAL IMAGE DISPLAY DEVICE AND MEDICAL IMAGE DISPLAY METHOD 有权
标题翻译：医学图像显示装置和医学图像显示方法
公开(公告)号：US20120127200A1
公开(公告)日：2012-05-24
申请号：US13383759
申请日：2010-07-21
申请人： Ryota Kohara , Hiroto Kokubun , Nobutaka Abe , Takashi Shirahata , Tetsuo Nakazawa
发明人： Ryota Kohara , Hiroto Kokubun , Nobutaka Abe , Takashi Shirahata , Tetsuo Nakazawa
IPC分类号： G09G5/00
CPC分类号： G06T19/00 , G06T15/08 , G06T19/006 , G06T2210/41
摘要： The medical image display device is provided with a medical image reading unit configured to read a medical image obtained by a medical image diagnostic apparatus, a projected image creating unit configured to project the medical image onto a projection plane to created the projected image, and a projected image display unit configured to display the projected image, wherein the projected image creating unit has a virtual liquid generating unit configured to generate virtual liquid, the light transmittance of which is not zero and a virtual liquid adding unit configured to add the virtual liquid to the surface of an organ within the medical image, and creates a projected image of the medical image to which the virtual liquid has been added.
摘要翻译：该医用图像显示装置设置有：医疗图像读取单元，被配置为读取由医用图像诊断装置获得的医学图像;投影图像生成单元，被配置为将医学图像投影到投影平面上，以生成投影图像;以及投影图像显示单元，被配置为显示投影图像，其中投影图像创建单元具有虚拟液体生成单元，该虚拟液体生成单元被配置为产生其透光率不为零的虚拟液体;虚拟液体添加单元，被配置为将虚拟液体添加到医疗图像内的器官的表面，并且创建已经添加了虚拟液体的医学图像的投影图像。

5. 发明申请

US20080026067A1 Method for Increasing Specific Surface Area of Slightly Soluble Drug 审中-公开
标题翻译：增加微溶性药物比表面积的方法
公开(公告)号：US20080026067A1
公开(公告)日：2008-01-31
申请号：US11587158
申请日：2005-04-19
申请人： Shin-itsu Kuwabe , Hideo Masaoka , Nobutaka Abe
发明人： Shin-itsu Kuwabe , Hideo Masaoka , Nobutaka Abe
IPC分类号： A61K31/421 , A61K9/14 , A61P3/10 , C07D263/32
CPC分类号： C07D263/32 , A61K31/421
摘要： The preparation method of the powder of which dissolution rate improves is characterized by including of the process that slightly soluble drug having acidic group (e.g., 3-(5-{2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy}-3,4-dihydronaphthalen-1-yl)propanoic acid etc.) is made to metal salt solution and is neutralized to precipitate. By the method of the present invention, since a powder of which specific surface area increases and dissolution rate improves can be obtained, it is excellent as a preparation method of drug bulk.
摘要翻译：溶解速率提高的粉末的制备方法的特征在于包括具有酸性基团的微溶药物（例如3-（5- {2- [5-甲基-2-（4-甲基苯基）-1 ，3-恶唑-4-基]乙氧基} -3,4-二氢萘-1-基）丙酸等）制成金属盐溶液并中和沉淀。通过本发明的方法，由于可以获得比表面积增加，溶解速度提高的粉末，作为药物的制备方法是优异的。

6. 发明授权

US5996203A Electronic component mounting apparatus and nozzle replacement method 有权
标题翻译：电子元件安装装置和喷嘴更换方法
公开(公告)号：US5996203A
公开(公告)日：1999-12-07
申请号：US130309
申请日：1998-08-07
申请人： Nobutaka Abe , Akira Nishimura
发明人： Nobutaka Abe , Akira Nishimura
IPC分类号： B23P21/00 , B23Q3/155 , B23Q13/00 , B23Q17/22 , B23Q17/24 , B25J15/04 , H05K13/02 , H05K13/04 , B23Q17/00
CPC分类号： H05K13/0408 , B23Q13/00 , B23Q17/22 , B23Q17/24 , B23Q3/15546 , H05K13/0413 , Y10T29/49131 , Y10T29/4978 , Y10T29/53091 , Y10T29/53178 , Y10T29/53191 , Y10T483/14 , Y10T483/18
摘要： An electronic component mounting apparatus for determining whether or not a nozzle replacement operation is successfully performed. A horizontal array of nozzles are accommodated in the holder in a nozzle stocker, and a light emitting device and a light receiving device are arranged so that the light path between both runs above the nozzles. The nozzle stocker is arranged in a travel path of a feeding head. The nozzle mount of the feeding head returns a used nozzle into the holder or mounts a new nozzle thereon. When any nozzle remains lifted from the holder intercepting the light path, a returning operation of the used nozzle is determined to be a failure. When a nozzle replacement is performed, its success or failure is reliably determined by detecting a intercepting height of light and release height of light by the nozzle and nozzle mount, respectively.
摘要翻译：一种用于确定是否成功执行喷嘴更换操作的电子部件安装装置。水平排列的喷嘴容纳在保持器中的喷嘴贮存器中，并且布置发光装置和光接收装置，使得两者之间的光路在喷嘴上方延伸。喷嘴储料器布置在进料头的行进路径中。进料头的喷嘴安装件将使用过的喷嘴返回到保持器中或在其上安装新的喷嘴。当任何喷嘴保持从夹持光路的保持器提升时，所使用的喷嘴的返回操作被确定为失败。当进行喷嘴更换时，通过分别检测光的遮断高度和通过喷嘴和喷嘴座分别释放光的高度，可靠地确定其成功或失败。

7. 发明授权

US08207223B2 Pharmaceutical composition for treatment of diseases associated with decrease in bone mass comprising EP4 agonist as active ingredient 有权
标题翻译：用于治疗与包含EP4激动剂作为活性成分的骨质量减少相关的疾病的药物组合物
公开(公告)号：US08207223B2
公开(公告)日：2012-06-26
申请号：US12549136
申请日：2009-08-27
申请人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
发明人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
IPC分类号： A01N37/08 , A01N53/00 , A61K31/215 , A61K31/19 , A61K31/557
CPC分类号： C07C405/0033 , A61K9/0019 , A61K9/1647 , A61K9/19 , A61K9/2054 , A61K31/4015 , A61K31/41 , A61K31/5575 , A61K31/559
摘要： A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).
摘要翻译：用于预防和/或治疗与包含EP4激动剂作为活性成分的骨量减少相关的疾病的局部施用的药物组合物。包含具有前列腺素骨架的化合物作为代表的EP4激动剂具有促进骨形成的作用，因此可用于预防和/或治疗与骨质量减少有关的疾病（骨疾病如原发性骨质疏松症，继发性骨质疏松症骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失和骨坏死，术后成骨，骨移植的替代疗法）。

8. 发明授权

US07256211B1 8-azaprostaglandin derivatives and medical use thereof 失效
标题翻译： 8-氮杂普罗兰前列腺素衍生物及其医疗用途
公开(公告)号：US07256211B1
公开(公告)日：2007-08-14
申请号：US10542724
申请日：2004-01-20
申请人： Tohru Kambe , Toru Maruyama , Kaoru Kobayashi , Kousuke Tani , Yoshihiko Nakai , Toshihiko Nagase , Takayuki Maruyama , Kiyoto Sakata , Hideyuki Yoshida , Shinsei Fujimura , Akio Nishiura , Nobutaka Abe
发明人： Tohru Kambe , Toru Maruyama , Kaoru Kobayashi , Kousuke Tani , Yoshihiko Nakai , Toshihiko Nagase , Takayuki Maruyama , Kiyoto Sakata , Hideyuki Yoshida , Shinsei Fujimura , Akio Nishiura , Nobutaka Abe
IPC分类号： A61K31/40 , A61K31/426 , C07D207/12 , C07D207/36
CPC分类号： C07D417/12 , C07D417/14
摘要： The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I) (wherein, all the symbols have the same meanings as that of the specification) a salt thereof, a solvate thereof or a cyclodextrin clathrate thereof, or a prodrug thereof and them as active ingredient have EP4 agonistic action and thus are considered useful for the prevention and/or treatment of immunological diseases, asthma, neuronal cell death, arthritis, lung failure, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, liver damage, acute hepatitis, nephritis, renal insufficiency, hypertension, myocardial ischemia, systemic inflammatory response syndrome, sepsis, hemophagous syndrome, macrophage activation syndrome, Still's disease, Kawasaki disease, burn, systemic granulomatosis, ulcerative colitis, Crohn's disease, hypercytokinemia at dialysis, multiple organ failure, shock and glaucoma, etc. Furthermore, the compounds also have an action of accelerating bone formation, so it is expected to be useful for the prevention and/or treatment of diseases associated with loss in bone mass, for example, primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss, osteonecrosis, bone formation after bone operation, alternative treatment for bone grafting.
摘要翻译：该药物组合物包含本发明化合物，其具有式（I）表示的8-氮杂前列腺素骨架（其中所有符号具有与说明书相同的含义）其盐，其溶剂合物或环糊精包合物，或其前药和它们作为活性成分具有EP 4激动作用，因此被认为可用于预防和/或治疗免疫疾病，哮喘，神经元细胞死亡，关节炎，肺衰竭，肺纤维化，肺气肿，支气管炎，慢性阻塞性肺疾病，肝损伤，急性肝炎，肾炎，肾功能不全，高血压，心肌缺血，全身炎症反应综合征，败血症，血液综合征，巨噬细胞活化综合征，Still氏病，川崎病，烧伤，全身性肉芽肿病，溃疡性结肠炎，克罗恩病，透析中的高细胞因子血症，多器官功能衰竭，休克和青光眼等。该化合物还具有加速骨形成的作用，因此预期可用于预防和/或治疗与骨质量损失相关的疾病，例如原发性骨质疏松症，继发性骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失，骨坏死，骨手术后的骨形成，骨移植的替代治疗。

9. 发明授权

US5833591A Electronic component mounting apparatus and nozzle replacement 失效
标题翻译：电子元件安装装置和喷嘴更换
公开(公告)号：US5833591A
公开(公告)日：1998-11-10
申请号：US824055
申请日：1997-03-21
申请人： Nobutaka Abe , Akira Nishimura
发明人： Nobutaka Abe , Akira Nishimura
IPC分类号： B23P21/00 , B23Q3/155 , B23Q13/00 , B23Q17/22 , B23Q17/24 , B25J15/04 , H05K13/02 , H05K13/04
CPC分类号： H05K13/0408 , B23Q13/00 , B23Q17/22 , B23Q17/24 , B23Q3/15546 , H05K13/0413 , Y10T29/49131 , Y10T29/4978 , Y10T29/53091 , Y10T29/53178 , Y10T29/53191 , Y10T483/14 , Y10T483/18
摘要： An electronic component mounting apparatus for determining whether or not a nozzle replacement operation is successfully performed. A horizontal array of nozzles are accommodated in the holder in a nozzle stocker, and a light emitting device and a light receiving device are arranged so that the light path between both runs above the nozzles. The nozzle stocker is arranged in a travel path of a feeding head. The nozzle mount of the feeding head returns a used nozzle into the holder or mounts a new nozzle thereon. When any nozzle remains lifted from the holder intercepting the light path, a returning operation of the used nozzle is determined to be a failure. When a nozzle replacement is performed, its success or failure is reliably determined by detecting a intercepting height of light and release height of light by the nozzle and nozzle mount, respectively.
摘要翻译：一种用于确定是否成功执行喷嘴更换操作的电子部件安装装置。水平排列的喷嘴容纳在保持器中的喷嘴贮存器中，并且布置发光装置和光接收装置，使得两者之间的光路在喷嘴上方延伸。喷嘴储料器布置在进料头的行进路径中。进料头的喷嘴安装件将使用过的喷嘴返回到保持器中或在其上安装新的喷嘴。当任何喷嘴保持从夹持光路的保持器提升时，所使用的喷嘴的返回操作被确定为失败。当进行喷嘴更换时，通过分别检测光的遮断高度和通过喷嘴和喷嘴座分别释放光的高度，可靠地确定其成功或失败。

10. 发明申请

US20080033033A1 8-AZAPROSTAGLANDIN DERIVATIVES AND MEDICAL USE THEREOF 审中-公开
标题翻译： 8-AZAPROSTAGLANDIN衍生物及其医疗用途
公开(公告)号：US20080033033A1
公开(公告)日：2008-02-07
申请号：US11749531
申请日：2007-05-16
申请人： Tohru Kambe , Toru Maruyama , Kaoru Kobayashi , Kousuke Tani , Yoshihiko Nakai , Toshihiko Nagase , Takayuki Maruyama , Kiyoto Sakata , Hideyuki Yoshida , Shinsei Fujimura , Akio Nishiura , Nobutaka Abe
发明人： Tohru Kambe , Toru Maruyama , Kaoru Kobayashi , Kousuke Tani , Yoshihiko Nakai , Toshihiko Nagase , Takayuki Maruyama , Kiyoto Sakata , Hideyuki Yoshida , Shinsei Fujimura , Akio Nishiura , Nobutaka Abe
IPC分类号： A61K31/41 , A61K31/4015 , C07D207/18 , C07D257/04
CPC分类号： C07D417/12 , C07D417/14
摘要： The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I) (wherein, all the symbols have the same meanings as that of the specification.) a salt thereof, a solvate thereof or a cyclodextrin clathrate thereof, or a prodrug thereof and them as active ingredient have EP4 agonistic action and thus are considered useful for the prevention and/or treatment of immunological diseases, asthma, neuronal cell death, arthritis, lung failure, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, liver damage, acute hepatitis, nephritis, renal insufficiency, hypertension, myocardial ischemia, systemic inflammatory response syndrome, sepsis, hemophagous syndrome, macrophage activation syndrome, Still's disease, Kawasaki disease, burn, systemic granulomatosis, ulcerative colitis, Crohn's disease, hypercytokinemia at dialysis, multiple organ failure, shock and glaucoma, etc. Furthermore, the compounds also have an action of accelerating bone formation, so it is expected to be useful for the prevention and/or treatment of diseases associated with loss in bone mass, for example, primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss, osteonecrosis, bone formation after bone operation, alternative treatment for bone grafting.
摘要翻译：包含本发明化合物的盐，其盐，其溶剂合物或环糊精包合物，其具有由式（I）表示的8-氮杂前列腺素骨架（其中所有符号具有与说明书相同的含义）或其前药，并且它们作为活性成分具有EP 4激动作用，因此被认为可用于预防和/或治疗免疫疾病，哮喘，神经元细胞死亡，关节炎，肺衰竭，肺纤维化，肺气肿，支气管炎，慢性阻塞性肺疾病，肝损伤，急性肝炎，肾炎，肾功能不全，高血压，心肌缺血，全身炎症反应综合征，败血症，血液综合征，巨噬细胞活化综合征，静脉炎，川崎病，烧伤，系统性肉芽肿病，溃疡性结肠炎，克罗恩病，透析中的高细胞因子血症，多器官功能衰竭，休克和青光眼等。此外，化合物还具有促进骨形成的作用，因此预期可用于预防和/或治疗与骨量丧失相关的疾病，例如原发性骨质疏松症，继发性骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失，骨坏死，骨手术后的骨形成，骨移植的替代治疗。

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