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1. 发明申请

US20120128781A1 FUNCTIONALIZATION OF NANOPARTICLES BY GLUCOSAMINE DERIVATIVES 审中-公开
标题翻译：通过葡萄糖胺衍生物对纳米颗粒的功能化
公开(公告)号：US20120128781A1
公开(公告)日：2012-05-24
申请号：US12598410
申请日：2008-05-02
申请人： Jackie Y. Ying , Nikhil R. Jana , Nandanan Erathodiyil
发明人： Jackie Y. Ying , Nikhil R. Jana , Nandanan Erathodiyil
IPC分类号： A61K47/36 , C08B37/08 , A61K9/14 , B82Y5/00 , B82Y30/00 , B82Y40/00
CPC分类号： A61K9/5161 , A61K47/36 , A61K47/61 , A61K47/6923 , A61K47/6929 , B22F1/0018 , B22F1/0062 , B22F2998/00 , B82Y30/00 , C08B37/003 , C08L5/08 , B22F1/0025
摘要： The present invention relates to oligomeric or polymeric saccharide derivatives comprising glucosamine moieties, e.g. derivatives of oligomeric or polymeric glucosamines such as chitosan oligomers or polymers, in which one or more amine groups are substituted by anchoring groups that chemisorb to the surface of a nanoparticle or form an interdigitated bilayer with a surfactant layer surrounding the nanoparticle. The invention also relates to functionalized nanoparticles comprising such derivatives, a method for forming the functionalized particles and to uses thereof as molecular imaging agents, biosensing agents or drug delivery agents, or in the preparation of such agents.
摘要翻译：本发明涉及包含葡糖胺部分的低聚或聚合糖衍生物，例如低分子或聚合葡糖胺的衍生物，例如壳聚糖低聚物或聚合物，其中一个或多个胺基被化学吸附到纳米颗粒表面的锚定基团或与周围纳米颗粒的表面活性剂层形成叉指双层而被取代。本发明还涉及包含这种衍生物的官能化纳米颗粒，形成官能化颗粒的方法及其用作分子显像剂，生物传感剂或药物递送剂，或在制备这些试剂中。

2. 发明申请

US20110014473A1 POLYMER-COATED NANOPARTICLES 审中-公开
标题翻译：聚合物包覆纳米粒子
公开(公告)号：US20110014473A1
公开(公告)日：2011-01-20
申请号：US12449227
申请日：2007-01-31
申请人： Jackie Y. Ying , Nandanan ERATHODIYIL , Nikhil R. JANA
发明人： Jackie Y. Ying , Nandanan ERATHODIYIL , Nikhil R. JANA
IPC分类号： B32B27/00 , B05D3/00 , C07K2/00
CPC分类号： G01N33/54346 , B82Y5/00 , G01N33/54393 , Y10T428/2998
摘要： Polymers for coating nanoparticles (e.g., colloid nanoparticles and quantum dots) and methods associated therewith are provided. Such polymers may be derived from amino acids comprising suitable functional groups for associating the polymer to the nanoparticle. For example, in some embodiments, the polymer includes a polypeptide backbone (e.g., polyaspartic acid) with amino acid side groups (e.g., cysteine and/or methionine). Such a polymer can enable strong binding of the polymer to the nanoparticle surface via its multiple thiol groups, which can lead to excellent colloidal stability. Moreover, the carboxylic acid and amine functional groups of the polymer can facilitate attachment of binding partners (e.g., antibodies) to the polymer, which can allow the polymer-coated nanoparticle to be used in a variety of applications including protein detection and cell labeling.
摘要翻译：提供用于涂覆纳米颗粒的聚合物（例如，胶体纳米颗粒和量子点）以及与之相关的方法。这样的聚合物可以衍生自包含用于将聚合物与纳米颗粒缔合的合适官能团的氨基酸。例如，在一些实施方案中，聚合物包括具有氨基酸侧基（例如半胱氨酸和/或甲硫氨酸）的多肽主链（例如，聚天冬氨酸）。这样的聚合物可以通过其多个硫醇基团实现聚合物与纳米颗粒表面的强烈结合，这可导致优异的胶体稳定性。此外，聚合物的羧酸和胺官能团可促进结合配偶体（例如抗体）与聚合物的连接，这可以使聚合物包被的纳米颗粒用于多种应用，包括蛋白质检测和细胞标记。

3. 发明申请

US20120135141A1 POLYMERIZATION ON PARTICLE SURFACE WITH REVERSE MICELLE 审中-公开
标题翻译：颗粒表面聚合与反向MICELLE
公开(公告)号：US20120135141A1
公开(公告)日：2012-05-31
申请号：US12674670
申请日：2008-08-22
申请人： Jackie Y. Ying , Nikhil R. Jana
发明人： Jackie Y. Ying , Nikhil R. Jana
IPC分类号： B05D7/24 , C08K5/13 , B82Y40/00
CPC分类号： C08F2/32 , C08F2/44 , C08F220/18 , C08F220/56 , C08F222/385 , C09D133/08
摘要： A method of coating particles comprises providing a solution comprising reverse micelles. The reverse micelles define discrete aqueous regions in the solution. Hydrophobic nanoparticles are dispersed in the solution. Amphiphilic monomers are added to the solution to attach the amphiphilic monomers to individual ones of the nanoparticles and to dissolve the individual nanoparticles attached with amphiphilic monomers in the discrete aqueous regions. The monomers attached to the nanoparticles are polymerized to form a polymer layer on the individual nanoparticles within the discrete aqueous regions. The polymerization comprises adding a cross-linker to the solution to cross-link the monomers attached to the individual nanoparticles. The solution for coating individual nanoparticles may comprise a microemulsion comprising a continuous phase and a discrete aqueous region defined by reverse micelles; hydrophobic nanoparticles dispersed in the microemulsion; amphiphilic polymerizable monomers attachable to the hydrophobic nanoparticles; and a cross-linker for polymerizing the monomers.
摘要翻译：涂布颗粒的方法包括提供包含反胶束的溶液。反胶束在溶液中定义离散的水性区域。疏水性纳米颗粒分散在溶液中。将两亲性单体加入到溶液中以将两亲性单体连接到单独的纳米颗粒，并将与两亲单体连接的单个纳米颗粒溶解在离散的水性区域中。连接到纳米颗粒的单体聚合以在离散的水性区域内的单个纳米颗粒上形成聚合物层。聚合包括向溶液中加入交联剂以交联连接到各个纳米颗粒上的单体。用于涂覆单个纳米颗粒的溶液可以包含微乳液，其包含连续相和由反胶束限定的离散水性区域; 分散在微乳液中的疏水性纳米颗粒; 两亲可聚合单体可附着于疏水性纳米粒子; 和用于聚合单体的交联剂。

4. 发明授权

US08097742B2 Water-soluble, surface-functionalized nanoparticle for bioconjugation via universal silane coupling 失效
标题翻译：用于通过通用硅烷偶联生物缀合的水溶性表面官能化纳米颗粒
公开(公告)号：US08097742B2
公开(公告)日：2012-01-17
申请号：US11795639
申请日：2005-01-20
申请人： Jackie Y. Ying , Nikhil R. Jana , Yuangang Zheng
发明人： Jackie Y. Ying , Nikhil R. Jana , Yuangang Zheng
IPC分类号： C07F7/08
CPC分类号： C07K17/14 , A61K47/6923 , A61K47/6929 , B82Y5/00 , C07B2200/11 , C07F7/1804 , C07F9/4012
摘要： The invention provides a process for the preparation of a surface-functionalized nanoparticle comprising: (a) reacting a nanoparticle with a functionalized silane and a base in a substantially non-aqueous solvent to obtain a partially conjugated silanated nanoparticle, wherein the functionalized silane and the base are present in relative amounts such that said functionalized silane undergoes substantially only a single hydrolysis reaction; (b) reacting the partially conjugated silanated nanoparticle formed in step (a) with a base in a solvent in which the partially conjugated silanated nanoparticle is substantially insoluble and in which the base is substantially soluble. The invention also provides a surface-functionalized nanoparticle prepared therefrom and a bioconjugate comprising said a surface-functionalized nanoparticle.
摘要翻译：本发明提供了制备表面官能化纳米颗粒的方法，其包括：（a）使纳米颗粒与官能化的硅烷和碱在基本上非水溶剂中反应，得到部分共轭的硅烷化纳米颗粒，其中官能化的硅烷和碱以相对量存在，使得所述官能化硅烷基本上仅经历单一水解反应; （b）使步骤（a）中形成的部分共轭的硅烷化纳米颗粒与碱在溶剂中反应，其中部分共轭的硅烷化纳米颗粒基本上不溶，其中碱基本上是可溶的。本发明还提供由其制备的表面官能化纳米颗粒和包含所述表面官能化纳米颗粒的生物共轭物。

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