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1. 发明授权

US07986399B2 Portable sample preparation and analysis system for micron and sub-micron particle characterization using light scattering and absorption spectroscopy 有权
标题翻译：使用光散射和吸收光谱的微米和亚微米颗粒表征的便携式样品制备和分析系统
公开(公告)号：US07986399B2
公开(公告)日：2011-07-26
申请号：US11877136
申请日：2007-10-23
申请人： Peter C. Stark , Eduardo Zurek , Jeffrey V. Wheat , John M. Dunbar , Jose A. Olivares , Luis H. Garcia-Rubio , Michael D. Ward
发明人： Peter C. Stark , Eduardo Zurek , Jeffrey V. Wheat , John M. Dunbar , Jose A. Olivares , Luis H. Garcia-Rubio , Michael D. Ward
IPC分类号： G01N1/00
CPC分类号： G01N1/4077 , G01N2001/4088
摘要： There is provided a method and device for remote sampling, preparation and optical interrogation of a sample using light scattering and light absorption methods. The portable device is a filtration-based device that removes interfering background particle material from the sample matrix by segregating or filtering the chosen analyte from the sample solution or matrix while allowing the interfering background particles to be pumped out of the device. The segregated analyte is then suspended in a diluent for analysis. The device is capable of calculating an initial concentration of the analyte, as well as diluting the analyte such that reliable optical measurements can be made. Suitable analytes include cells, microorganisms, bioparticles, pathogens and diseases. Sample matrixes include biological fluids such as blood and urine, as well as environmental samples including waste water.
摘要翻译：提供了使用光散射和光吸收方法远程采样，准备和光学询问样品的方法和装置。便携式设备是基于过滤的设备，其通过从样品溶液或基质中分离或过滤所选择的分析物，同时允许将干扰背景颗粒泵出设备，从样品基质中除去干扰背景颗粒物质。然后将分离的分析物悬浮在稀释剂中用于分析。该装置能够计算分析物的初始浓度，以及稀释分析物，使得可以进行可靠的光学测量。合适的分析物包括细胞，微生物，生物颗粒，病原体和疾病。样品基质包括生物液体如血液和尿液，以及环境样品，包括废水。

2. 发明申请

US20090115996A1 DETECTING MICROORGANISMS IN BLOOD UTILIZING PHYSICAL AND CHEMICAL CHANGES IN BLOOD 有权
标题翻译：检测血液中微生物使用血液中的物理和化学变化
公开(公告)号：US20090115996A1
公开(公告)日：2009-05-07
申请号：US12263807
申请日：2008-11-03
申请人： Yulia M. SEREBRENNIKOVA , Debra Huffman , Jennifer M. Smith , Luis H. Garcia-Rubio , German F. Leparc
发明人： Yulia M. SEREBRENNIKOVA , Debra Huffman , Jennifer M. Smith , Luis H. Garcia-Rubio , German F. Leparc
IPC分类号： G01N33/48 , G01J3/28
CPC分类号： C12Q1/04 , G01N21/31 , G01N21/474 , G01N21/8507 , G01N2021/3144 , G01N2021/3155 , G01N2021/4747
摘要： An approach to detecting microorganisms in blood uses the changes of hemoglobin and the physical and chemical properties of blood to detect the presence of microorganisms in blood. Spectrophotometric measurements are taken several wavelengths across the UV-Vis-NIR portion of the electromagnetic spectrum, and a deconvolution is performed quantitatively to interpret distinct spectral characteristics of blood enabling the detection of microorganisms.
摘要翻译：检测血液中的微生物的方法使用血红蛋白的变化和血液的物理和化学性质来检测血液中微生物的存在。分光光度测量采用电磁波谱的UV-Vis-NIR部分的几个波长，定量地进行去卷积，以解释能够检测微生物的血液的不同光谱特征。

3. 发明授权

US07027134B1 Spectrophotometric system and method for the identification and characterization of a particle in a bodily fluid 有权
标题翻译：分光光度法和用于鉴定和表征体液中颗粒的方法
公开(公告)号：US07027134B1
公开(公告)日：2006-04-11
申请号：US10934601
申请日：2004-09-03
申请人： Luis H. Garcia-Rubio , Catalina E. Alupoaei , Willard Harris , Alfredo Peguero , Edward P. Cutolo , German Felix Leparc
发明人： Luis H. Garcia-Rubio , Catalina E. Alupoaei , Willard Harris , Alfredo Peguero , Edward P. Cutolo , German Felix Leparc
IPC分类号： G01N33/48
CPC分类号： G01N21/31 , G01N21/49 , G01N33/6803 , Y02A50/53 , Y02A50/58
摘要： The present invention provides a method and apparatus for the detection of an infectious disease or disorder in a fluid, such as a mammalian blood sample, the detection of a specific protein in a urine sample, or the detection of a particle in a plasma. The identification of the particles of interest is enable by taking a transmission spectrum of a test sample in at least a portion of the ultraviolet, visible, near-infrared portion of the spectrum and comparing the spectrum with a standard sample spectrum. From the comparison it is then determined whether the fluid from the test sample contains an particle of interest, and an identity of the particle of interest is determined. Spectroscopic and multiwavelength turbidimetry techniques provide a rapid, inexpensive, and convenient means for diagnosis. The comparison and determination steps may be performed visually or by spectral deconvolution.
摘要翻译：本发明提供了用于检测流体（例如哺乳动物血液样品），尿样中特异性蛋白质的检测或血浆中的颗粒的检测中的感染性疾病或病症的方法和装置。通过在光谱的紫外线，可见光，近红外部分的至少一部分中获取测试样品的透射光谱并将光谱与标准样品光谱进行比较，可以实现感兴趣的颗粒的识别。从比较中，确定来自测试样品的流体是否含有感兴趣的颗粒，并确定感兴趣的颗粒的身份。光谱和多波长比浊法技术为诊断提供了快速，便宜和方便的手段。比较和确定步骤可以通过视觉或通过光谱去卷积来执行。

4. 发明授权

US5589932A Spectrophotometric method and apparatus for the characterization of blood and blood types 失效
标题翻译：用于表征血液和血液类型的分光光度法和仪器
公开(公告)号：US5589932A
公开(公告)日：1996-12-31
申请号：US385717
申请日：1995-02-08
申请人： Luis H. Garcia-Rubio , Manuel Bayona , Robert Potter , German Leparc
发明人： Luis H. Garcia-Rubio , Manuel Bayona , Robert Potter , German Leparc
IPC分类号： G01N21/31 , G01N21/49 , G01N33/80 , G01N33/48 , A61B5/00 , G06F15/00
CPC分类号： G01N33/80 , G01N21/31 , G01N21/49
摘要： A method and apparatus for determining the type of a blood sample are provided wherein a turbidity spectrum of the blood sample is collected over a predetermined wavelength range, from which is calculated an extinction spectrum. This extinction spectrum is then compared with a set of control spectra collected from control blood samples having known blood types, from which the type of the blood sample can be determined. A further method is provided for for detecting the presence of a substance in a bodily fluid sample, the substance having a size in the range of generally 0.5 to 20 .mu.m. Exemplary substances that could be of interest to detect include, but are not limited to, hemoglobin, bilirubin, red blood cell antigens, microorganisms, and viruses. This embodiment includes the additional step of deconvoluting the extinction spectrum to obtain a particle size distribution for comparison with a database of control samples.
摘要翻译：提供了一种用于确定血液样本类型的方法和装置，其中在预定波长范围内收集血液样本的浊度谱，由此计算消光谱。然后将该消光谱与从具有已知血型的对照血液样品收集的一组对照光谱进行比较，从该血液样品中可以确定血液样品的类型。提供了一种用于检测物质在体液样品中的存在的另一种方法，该物质的大小通常在0.5至20μm的范围内。可能感兴趣的检测的示例性物质包括但不限于血红蛋白，胆红素，红细胞抗原，微生物和病毒。该实施方案包括解卷积消光谱以获得粒度分布的附加步骤，用于与对照样品的数据库进行比较。

5. 发明授权

US07952693B2 Detecting microorganisms in blood utilizing physical and chemical changes in blood 有权
标题翻译：利用血液中的物理和化学变化检测血液中的微生物
公开(公告)号：US07952693B2
公开(公告)日：2011-05-31
申请号：US12263807
申请日：2008-11-03
申请人： Yulia M. Serebrennikova , Debra Huffman , Jennifer M. Smith , Luis H. Garcia-Rubio , German F. LeParc
发明人： Yulia M. Serebrennikova , Debra Huffman , Jennifer M. Smith , Luis H. Garcia-Rubio , German F. LeParc
IPC分类号： G01N33/48
CPC分类号： C12Q1/04 , G01N21/31 , G01N21/474 , G01N21/8507 , G01N2021/3144 , G01N2021/3155 , G01N2021/4747
摘要： An approach to detecting microorganisms in blood uses the changes of hemoglobin and the physical and chemical properties of blood to detect the presence of microorganisms in blood. Spectrophotometric measurements are taken several wavelengths across the UV-Vis-NIR portion of the electromagnetic spectrum, and a deconvolution is performed quantitatively to interpret distinct spectral characteristics of blood enabling the detection of microorganisms.
摘要翻译：检测血液中的微生物的方法使用血红蛋白的变化和血液的物理和化学性质来检测血液中微生物的存在。分光光度测量采用电磁波谱的UV-Vis-NIR部分的几个波长，定量地进行去卷积，以解释能够检测微生物的血液的不同光谱特征。

6. 发明授权

US5907108A Continuous sampling and dilution system and method 失效
标题翻译：连续采样和稀释系统及方法
公开(公告)号：US5907108A
公开(公告)日：1999-05-25
申请号：US921888
申请日：1997-08-25
申请人： Luis H. Garcia-Rubio , Francisco Lanza , Paul J. Sacoto
发明人： Luis H. Garcia-Rubio , Francisco Lanza , Paul J. Sacoto
IPC分类号： G01N1/38 , G01N15/06 , G01N1/18
CPC分类号： G01N1/38 , G01N15/06
摘要： A system and method for the automatic sampling and dilution of homogeneous particle dispersions is developed that uses a multistep parallel dilution network system for the sample and diluent and includes variable dilution capabilities. The sample and diluent are combined and allowed to mix uniformly over a predetermined conduit length. Resampling from the first dilution step and recombining with another diluent line results in a second dilution step. The number of steps determines the dilution range; the manipulation of the sample and diluent flow rates provides a variable dilution ratio at each dilution step. An exemplary embodiment reduces the concentration of a latex sample for analysis with uv-vis spectrometry. In another embodiment, the emulsion polymerization of styrene is followed in real time with turbidity measurements taken on diluted samples.
摘要翻译：开发了用于自动取样和稀释均相颗粒分散体的系统和方法，其使用用于样品和稀释剂的多步平行稀释网络系统，并且包括可变稀释能力。将样品和稀释剂组合并允许在预定导管长度上均匀混合。从第一稀释步骤重新采样并与另一稀释液管线重新组合导致第二稀释步骤。步数确定稀释范围; 样品和稀释剂流速的操作在每个稀释步骤提供可变的稀释比。示例性实施方案降低了用于用紫外 - 可见分光光度法分析的胶乳样品的浓度。在另一个实施方案中，实时地跟踪苯乙烯的乳液聚合，并对稀释样品进行浊度测量。

7. 发明申请

US20090103086A1 PORTABLE SAMPLE PREPARATION AND ANALYSIS SYSTEM FOR MICRON AND SUB-MICRON PARTICLE CHARACTERIZATION USING LIGHT SCATTERING AND ABSORPTION SPECTROSCOPY 有权
标题翻译：使用光散射和吸收光谱的微型和亚微米粒子特征的便携式样品制备和分析系统
公开(公告)号：US20090103086A1
公开(公告)日：2009-04-23
申请号：US11877136
申请日：2007-10-23
申请人： Peter C. STARK , Eduardo ZUREK , Jeffrey V. WHEAT , John M. DUNBAR , Jose A. OLIVARES , Luis H. GARCIA-RUBIO , Michael D. WARD
发明人： Peter C. STARK , Eduardo ZUREK , Jeffrey V. WHEAT , John M. DUNBAR , Jose A. OLIVARES , Luis H. GARCIA-RUBIO , Michael D. WARD
IPC分类号： G01J3/28 , G01N1/28 , G01J3/42 , G01N33/48
CPC分类号： G01N1/4077 , G01N2001/4088
摘要： There is provided a method and device for remote sampling, preparation and optical interrogation of a sample using light scattering and light absorption methods. The portable device is a filtration-based device that removes interfering background particle material from the sample matrix by segregating or filtering the chosen analyte from the sample solution or matrix while allowing the interfering background particles to be pumped out of the device. The segregated analyte is then suspended in a diluent for analysis. The device is capable of calculating an initial concentration of the analyte, as well as diluting the analyte such that reliable optical measurements can be made. Suitable analytes include cells, microorganisms, bioparticles, pathogens and diseases. Sample matrixes include biological fluids such as blood and urine, as well as environmental samples including waste water.
摘要翻译：提供了使用光散射和光吸收方法远程采样，准备和光学询问样品的方法和装置。便携式设备是基于过滤的设备，其通过从样品溶液或基质中分离或过滤所选择的分析物，同时允许将干扰背景颗粒泵出设备，从样品基质中除去干扰背景颗粒物质。然后将分离的分析物悬浮在稀释剂中用于分析。该装置能够计算分析物的初始浓度，以及稀释分析物，使得可以进行可靠的光学测量。合适的分析物包括细胞，微生物，生物颗粒，病原体和疾病。样品基质包括生物液体如血液和尿液，以及环境样品，包括废水。

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