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1. 发明授权

US08809012B2 Labeling agent and methods for simultaneous sequencing and quantification of multiple peptides and proteins using the same 有权
标题翻译：用于同时测序和定量多种肽和蛋白质的标记试剂和方法
公开(公告)号：US08809012B2
公开(公告)日：2014-08-19
申请号：US13818489
申请日：2011-08-23
申请人： Seung Koo Shin , Hye Joo Yoon , Yong Sik Jung , Hee Yoon Lee , Min Soo Suh , Jong Cheol Seo
发明人： Seung Koo Shin , Hye Joo Yoon , Yong Sik Jung , Hee Yoon Lee , Min Soo Suh , Jong Cheol Seo
IPC分类号： C12Q1/37 , C07C237/12 , C07C237/20
CPC分类号： C07C237/12 , C07B2200/05 , C07C233/47 , C07C233/51 , C07C237/20 , G01N33/6848 , G01N2458/15 , G01N2560/00
摘要： The present invention provides a compound that can utilize hydrogen isotope and, at the same time, can quantify multiplexed samples at one time, as well as decreasing the cost for synthesis of the labeling agent. In addition, the present invention provides a novel method for quantitatively analyzing protein and peptide analytes having different quantities form each other using the labeling agent, wherein y-type fragment ions having a high mass which comprises the analyte remained after coupling the labeling agent with the analyte and then removing a part of the labeling agent through tandem mass spectrometry are utilized to conduct the quantitative analysis.
摘要翻译：本发明提供了可以利用氢同位素，同时可以一次量化多重样品的化合物，以及降低合成标记试剂的成本。另外，本发明提供了一种用于定量分析具有不同量的蛋白质和肽分析物的新方法，该分析物使用标记试剂彼此形成，其中包含分析物的质量高的Y型片段离子在将标记试剂与分析物，然后通过串联质谱法去除一部分标记试剂进行定量分析。

2. 发明申请

US20130183704A1 Labeling Agent and Methods for Simultaneous Sequencing and Quantification of Multiple Peptides and Proteins Using the Same 有权
标题翻译：用于同时测序和定量使用其的多肽和蛋白质的标记试剂和方法
公开(公告)号：US20130183704A1
公开(公告)日：2013-07-18
申请号：US13818489
申请日：2011-08-23
申请人： Seung Koo Shin , Hye Joo Yoon , Yong Sik Jung , Hee Yoon Lee , Min Soo Suh , Jong Cheol Seo
发明人： Seung Koo Shin , Hye Joo Yoon , Yong Sik Jung , Hee Yoon Lee , Min Soo Suh , Jong Cheol Seo
IPC分类号： C07C237/20 , C07C237/12
CPC分类号： C07C237/12 , C07B2200/05 , C07C233/47 , C07C233/51 , C07C237/20 , G01N33/6848 , G01N2458/15 , G01N2560/00
摘要： The present invention provides a compound that can utilize hydrogen isotope and, at the same time, can quantify multiplexed samples at one time, as well as decreasing the cost for synthesis of the labeling agent. In addition, the present invention provides a novel method for quantitatively analyzing protein and peptide analytes having different quantities form each other using the labeling agent, wherein y-type fragment ions having a high mass which comprises the analyte remained after coupling the labeling agent with the analyte and then removing a part of the labeling agent through tandem mass spectrometry are utilized to conduct the quantitative analysis.
摘要翻译：本发明提供了可以利用氢同位素，同时可以一次量化多重样品的化合物，以及降低合成标记试剂的成本。另外，本发明提供了一种用于定量分析具有不同量的蛋白质和肽分析物的新方法，该分析物使用标记试剂彼此形成，其中包含分析物的质量高的Y型片段离子在将标记试剂与分析物，然后通过串联质谱法去除一部分标记试剂进行定量分析。

3. 发明申请

US20080138845A1 Method of De Novo Sequencing of Peptide Using the Maldi Mass Spectrometry, Method and Apparatus for Preparing Sample for Maldi Mass Spectrometry 有权
标题翻译：使用Maldi质谱测定肽的新方法，Maldi质谱法制备样品的方法和装置
公开(公告)号：US20080138845A1
公开(公告)日：2008-06-12
申请号：US11817979
申请日：2006-03-08
申请人： Seung-Koo Shin , Kyung-Hwan Jeong , Hye-Joo Yoon , Min-Soo Suh , Jong-Cheol Seo
发明人： Seung-Koo Shin , Kyung-Hwan Jeong , Hye-Joo Yoon , Min-Soo Suh , Jong-Cheol Seo
IPC分类号： C12Q1/37 , G01N33/68 , C07K14/00 , H01J49/06
CPC分类号： G01N33/6851
摘要： The present invention relates to a method of peptide sequencing by MALDI (matrix-assisted laser desorption ionization) tandem mass spectrometry, which comprises the steps of chemically modifying a sample peptide with at least one chemical modification method selected from the group consisting of guanidination and esterification in order to change the ionization status of the peptide and performing mass spectrometry using a MALDI tandem mass spectrometer and programmed MALDI tandem mass spectrometry. The peptide sequencing method of the present invention is advantageous in that detection sensitivity of the peptide improves significantly and various daughter ions are detected uniformly, thereby enabling perfect de novo sequencing with tandem mass spectrometry only, without database search.
摘要翻译：本发明涉及通过MALDI（基质辅助激光解吸电离）串联质谱法进行肽测序的方法，其包括用至少一种选自胍基和酯化的化学修饰方法化学修饰样品肽的步骤以改变肽的电离状态，并使用MALDI串联质谱仪和程序化的MALDI串联质谱进行质谱分析。本发明的肽测序方法的优点在于，肽的检测灵敏度显着提高，并且均匀地检测各种子离子，从而仅通过串联质谱法即可完成从头测序，无需数据库检索。

4. 发明申请

US20060280024A1 Memory system with registered memory module and control method 失效
标题翻译：具有注册内存模块和控制方法的内存系统
公开(公告)号：US20060280024A1
公开(公告)日：2006-12-14
申请号：US11254696
申请日：2005-10-21
申请人： Young-Man Ahn , Seung-Jin Seo , Seung-Hee Mun , Jong-Cheol Seo , Jung-Kuk Lee , Soon-Deok Jang
发明人： Young-Man Ahn , Seung-Jin Seo , Seung-Hee Mun , Jong-Cheol Seo , Jung-Kuk Lee , Soon-Deok Jang
IPC分类号： G11C8/00
CPC分类号： G11C7/22 , G11C7/222 , G11C11/4076
摘要： A memory module and related method are disclosed. The memory module comprises a clock generator configured to generate first and second internal clock signals in relation to an external clock signal, and a register configured to receive the first and second internal clock signals. The register stores an external control/address signal in response to the first internal clock signal and transmits an internal control/address signal derived from the external control/address in response to the second internal control/address signal.
摘要翻译：公开了一种存储器模块及相关方法。存储器模块包括被配置为相对于外部时钟信号产生第一和第二内部时钟信号的时钟发生器以及被配置为接收第一和第二内部时钟信号的寄存器。寄存器响应于第一内部时钟信号存储外部控制/地址信号，并响应于第二内部控制/地址信号发送从外部控制/地址导出的内部控制/地址信号。

5. 发明授权

US07319635B2 Memory system with registered memory module and control method 失效
标题翻译：具有注册内存模块和控制方法的内存系统
公开(公告)号：US07319635B2
公开(公告)日：2008-01-15
申请号：US11254696
申请日：2005-10-21
申请人： Young-Man Ahn , Seung-Jin Seo , Seung-Hee Mun , Jong-Cheol Seo , Jung-Kuk Lee , Soon-Deok Jang
发明人： Young-Man Ahn , Seung-Jin Seo , Seung-Hee Mun , Jong-Cheol Seo , Jung-Kuk Lee , Soon-Deok Jang
IPC分类号： G11C8/00
CPC分类号： G11C7/22 , G11C7/222 , G11C11/4076
摘要： A memory module and related method are disclosed. The memory module comprises a clock generator configured to generate first and second internal clock signals in relation to an external clock signal, and a register configured to receive the first and second internal clock signals. The register stores an external control/address signal in response to the first internal clock signal and transmits an internal control/address signal derived from the external control/address in response to the second internal control/address signal.
摘要翻译：公开了一种存储器模块及相关方法。存储器模块包括被配置为相对于外部时钟信号产生第一和第二内部时钟信号的时钟发生器以及被配置为接收第一和第二内部时钟信号的寄存器。寄存器响应于第一内部时钟信号存储外部控制/地址信号，并响应于第二内部控制/地址信号发送从外部控制/地址导出的内部控制/地址信号。

6. 发明授权

US07233157B2 Test board for high-frequency system level test 有权
标题翻译：测试板进行高频系统级测试
公开(公告)号：US07233157B2
公开(公告)日：2007-06-19
申请号：US11025093
申请日：2004-12-28
申请人： Jung-Kuk Lee , Young-Man Ahn , Seung-Man Shin , Jong-Cheol Seo
发明人： Jung-Kuk Lee , Young-Man Ahn , Seung-Man Shin , Jong-Cheol Seo
IPC分类号： G01R31/02 , G01R31/26
CPC分类号： G01R31/2889 , G01R1/07378
摘要： A test board for a high-frequency system level test: The test board includes a main board having through holes filled with a conductive material. These holes may be located at a portion of the main board from which an existing module socket has been removed. An interface board has surface mounted device (SMD) pads on front and rear surfaces. The SMD pads on the front surface of the interface board are connected with the SMD pads on the rear surface thereof through cross connection wiring within the interface board for a pin swap. The through holes of the main board are connected with the SMD pads on the rear surface of the interface board via iron cores fixed at a guide. A test module socket is mounted on surfaces of the SMD pads on the front surface of the interface board.
摘要翻译：用于高频系统级测试的测试板：测试板包括具有填充有导电材料的通孔的主板。这些孔可以位于主板的已经从其移除的现有模块插座的部分。接口板在前表面和后表面上具有表面贴装（SMD）贴片。接口板前表面上的SMD焊盘通过接口板中的交叉连接线与后表面的SMD焊盘连接，用于引脚互换。主板的通孔通过固定在导轨上的铁芯与接口板背面的SMD焊盘连接。测试模块插座安装在接口板正面的SMD焊盘表面。

7. 发明授权

US07723917B2 Method of de novo sequencing of peptide using the MALDI mass spectrometry, method and apparatus for preparing sample for MALDI mass spectrometry 有权
标题翻译：使用MALDI质谱法对肽进行重新测序的方法，用于制备MALDI质谱的样品的方法和装置
公开(公告)号：US07723917B2
公开(公告)日：2010-05-25
申请号：US11817979
申请日：2006-03-08
申请人： Seung-Koo Shin , Kyung-Hwan Jeong , Hye-Joo Yoon , Min-Soo Suh , Jong-Cheol Seo
发明人： Seung-Koo Shin , Kyung-Hwan Jeong , Hye-Joo Yoon , Min-Soo Suh , Jong-Cheol Seo
IPC分类号： H01J17/26
CPC分类号： G01N33/6851
摘要： The present invention relates to a method of peptide sequencing by MALDI (matrix-assisted laser desorption ionization) tandem mass spectrometry, which comprises the steps of chemically modifying a sample peptide with at least one chemical modification method selected from the group consisting of guanidination and esterification in order to change the ionization status of the peptide and performing mass spectrometry using a MALDI tandem mass spectrometer and programmed MALDI tandem mass spectrometry. The peptide sequencing method of the present invention is advantageous in that detection sensitivity of the peptide improves significantly and various daughter ions are detected uniformly, thereby enabling perfect de novo sequencing with tandem mass spectrometry only, without database search.
摘要翻译：本发明涉及通过MALDI（基质辅助激光解吸电离）串联质谱法进行肽测序的方法，其包括用至少一种选自胍基和酯化的化学修饰方法化学修饰样品肽的步骤以改变肽的电离状态，并使用MALDI串联质谱仪和程序化的MALDI串联质谱法进行质谱分析。本发明的肽测序方法的优点在于，肽的检测灵敏度显着提高，并且均匀地检测各种子离子，从而仅通过串联质谱法即可完成从头测序，无需数据库检索。

8. 发明申请

US20060069948A1 Error detecting memory module and method 审中-公开
标题翻译：检测内存模块和方法错误
公开(公告)号：US20060069948A1
公开(公告)日：2006-03-30
申请号：US11181059
申请日：2005-07-13
申请人： Jong-Cheol Seo , Byung-Se So , Young-Man Ahn
发明人： Jong-Cheol Seo , Byung-Se So , Young-Man Ahn
IPC分类号： G06F11/00
CPC分类号： G11B20/1833 , G06F11/1016 , G11B2020/1823 , G11B2220/60
摘要： We describe and claim an error detecting memory module and method. The module comprises a plurality of memory devices, each memory device to receive an address signal and a command signal from a memory controller, and to detect an error in the address and command signals responsive to an input parity signal. In an embodiment, each memory device is adapted to provide an output parity signal to the memory controller responsive to the detection.
摘要翻译：我们描述和声明一个错误检测内存模块和方法。该模块包括多个存储器件，每个存储器件用于从存储器控制器接收地址信号和命令信号，以及响应于输入奇偶校验信号来检测地址和命令信号中的错误。在一个实施例中，每个存储器件适于响应于检测而向存储器控制器提供输出奇偶校验信号。

9. 发明申请

US20050258846A1 Test board for high-frequency system level test 有权
标题翻译：测试板进行高频系统级测试
公开(公告)号：US20050258846A1
公开(公告)日：2005-11-24
申请号：US11025093
申请日：2004-12-28
申请人： Jung-Kuk Lee , Young-Man Ahn , Seung-Man Shin , Jong-Cheol Seo
发明人： Jung-Kuk Lee , Young-Man Ahn , Seung-Man Shin , Jong-Cheol Seo
IPC分类号： G01R31/26 , G01R1/073 , G01R31/02 , G01R31/28 , H01L21/66
CPC分类号： G01R31/2889 , G01R1/07378
摘要： A test board for a high-frequency system level test: The test board includes a main board having through holes filled with a conductive material. These holes may be located at a portion of the main board from which an existing module socket has been removed. An interface board has surface mounted device (SMD) pads on front and rear surfaces. The SMD pads on the front surface of the interface board are connected with the SMD pads on the rear surface thereof through cross connection wiring within the interface board for a pin swap. The through holes of the main board are connected with the SMD pads on the rear surface of the interface board via iron cores fixed at a guide. A test module socket is mounted on surfaces of the SMD pads on the front surface of the interface board.
摘要翻译：用于高频系统级测试的测试板：测试板包括具有填充有导电材料的通孔的主板。这些孔可以位于主板的已经从其移除的现有模块插座的部分。接口板在前表面和后表面上具有表面贴装（SMD）贴片。接口板前表面上的SMD焊盘通过接口板中的交叉连接线与后表面的SMD焊盘连接，用于引脚互换。主板的通孔通过固定在导轨上的铁芯与接口板背面的SMD焊盘连接。测试模块插座安装在接口板正面的SMD焊盘表面。

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