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1. 发明授权

US3935184A Synthetic polyoxin type nucleosides 失效
标题翻译：合成多氧化物型核苷
公开(公告)号：US3935184A
公开(公告)日：1976-01-27
申请号：US228366
申请日：1972-02-22
申请人： Gordon H. Jones , John G. Moffatt , Michael D. Edge
发明人： Gordon H. Jones , John G. Moffatt , Michael D. Edge
IPC分类号： C07H7/033 , C07H9/04 , C07H13/04 , C07H15/04 , C07H15/18 , C07H19/04 , C07H19/06 , C07H19/16 , C07H19/18 , C08B37/00
CPC分类号： C07H9/04 , C07H13/04 , C07H15/04 , C07H15/18 , C07H19/04 , C07H19/06 , C07H19/16 , C07H7/033
摘要： A novel class of intermediates from which a variety of uronic acid nucleosides can be produced, said class being represented by the following formula: ##SPC1##WhereR.sub.1 and R.sub.2 are lower alkyl radicals having one to six carbon atoms, or phenyl radicals;R.sub.3 is a lower alkyl radical having one to four carbon atoms; and the wavy line at the 5' position indicates both the 5'-D-allo and 5'-L-talo epimers.A process for producing these intermediates is described. A process for converting these intermediates to uronic acid nucleosides having the following formula: ##SPC2##WhereB is a pyrimidine or purine base, is also described.Novel uronic acid nucleosides, having structures falling within the general formula given above, are identified.
摘要翻译：可以生产各种糖醛酸核苷的新一类中间体，所述类由下式表示：

2. 发明授权

US4859765A Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture 失效
标题翻译：用于生物和药物应用的合成肽序列和制造方法
公开(公告)号：US4859765A
公开(公告)日：1989-08-22
申请号：US628678
申请日：1984-07-06
申请人： John J. Nestor, Jr. , John G. Moffatt , Hardy W. Chan
发明人： John J. Nestor, Jr. , John G. Moffatt , Hardy W. Chan
IPC分类号： A61K39/00 , C07K14/61
CPC分类号： C07K14/61 , A61K39/00 , Y10S930/12 , Y10S930/26
摘要： The present invention relates to novel synthetic antigens, conjugates and antibodies based upon specific peptide sequences and the production thereof. More particularly, the invention relates to a polypeptide which is a determinant site of a protein, the polypeptide having from 8 to 20 amino acid residues, having an amino-terminal amino acid and a carboxyl-terminal amino acid, wherein the polypeptide includes:(a) a four amino acid sequence which corresponds to the four amino acid sequence of a .beta.-turn of the protein;(b) a sequence of two to eight amino acid residues attached to the amino terminal (H.sub.2 N--) of the four amino acid sequence; and(c) a sequence of two to eight amino acid residues attached to the carboxyl terminal (--COOH) of the four amino acid sequence,wherein the amino acid residues of subparts (b) and (c) correspond to those attached to the amino terminal and the carboxyl terminal, respectively of the .beta.-turn of the protein, and the pharmaceutically acceptable salts of the polypeptide. The invention relates to a conjugate which comprises the polypeptide described above with a macromolecular carrier. The invention also relates to antibodies and the production thereof which are specific for the polypeptide or the conjugate of the peptide described above.The synthetic polypeptide sequences, peptide conjugates and antibodies thereof are useful as antigens in the production of vaccines, antiviral agents, diagnostic reagents and the like, for the detection and treatment of infectious and immune diseases such as polio and cancer, and the like in mammals, particularly human beings.
摘要翻译：本发明涉及基于特定肽序列的新型合成抗原，缀合物和抗体及其生产。更具体地，本发明涉及作为蛋白质的决定簇位点的多肽，所述多肽具有8至20个氨基酸残基，具有氨基末端氨基酸和羧基末端氨基酸，其中所述多肽包括：（ a）对应于蛋白质β转角的四个氨基酸序列的四个氨基酸序列; （b）连接在四个氨基酸序列的氨基末端（H2N-）上的2至8个氨基酸残基的序列; 和（c）连接到四个氨基酸序列的羧基末端（-COOH）的2至8个氨基酸残基的序列，其中（b）和（c）子部分的氨基酸残基对应于氨基酸末端和羧基末端，以及该多肽的药学上可接受的盐。本发明涉及包含上述多肽与大分子载体的缀合物。本发明还涉及对上述肽的多肽或缀合物特异的抗体及其生产。合成多肽序列，肽缀合物及其抗体在疫苗，抗病毒剂，诊断试剂等的生产中用作抗原，用于检测和治疗哺乳动物等感染性和免疫性疾病如脊髓灰质炎和癌症等，特别是人类。

3. 发明授权

US4493795A Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture 失效
标题翻译：用于生物和药物应用的合成肽序列和制造方法
公开(公告)号：US4493795A
公开(公告)日：1985-01-15
申请号：US542633
申请日：1983-10-17
申请人： John J. Nestor, Jr. , John G. Moffatt , Hardy W. Chan
发明人： John J. Nestor, Jr. , John G. Moffatt , Hardy W. Chan
IPC分类号： A61K39/00 , C07K14/61 , C07C103/52
CPC分类号： C07K14/61 , A61K39/00 , Y10S930/12 , Y10S930/26
摘要： The present invention relates to novel synthetic antigens, conjugates and antibodies based upon specific peptide sequences and the production thereof. More particularly, the invention relates to a polypeptide which is a determinant site of a protein, the polypeptide having from 8 to 20 amino acid residues, having an amino-terminal amino acid and a carboxyl-terminal amino acid, wherein the polypeptide includes:(a) a four amino acid sequence which corresponds to the four amino acid sequence of a .beta.-turn of the protein;(b) a sequence of two to eight amino acid residues attached to the amino terminal (H.sub.2 N--) of the four amino acid sequence; and(c) a sequence of two to eight amino acid residues attached to the carboxyl terminal (--COOH) of the four amino acid sequence,wherein the amino acid residues of subparts (b) and (c) correspond to those attached to the amino terminal and the carboxyl terminal, respectively of the .beta.-turn of the protein, and the pharmaceutically acceptable salts of the polypeptide. The invention relates to a conjugate which comprises the polypeptide described above with a macromolecular carrier. The invention also relates to antibodies and the production thereof which are specific for the polypeptide or the conjugate of the peptide described above.The synthetic polypeptide sequences, peptide conjugates and antibodies thereof are useful as antigens in the production of vaccines, antiviral agents, diagnostic reagents and the like, for the detection and treatment of infectious and immune diseases such as polio and cancer, and the like in mammals, particularly human beings.
摘要翻译：本发明涉及基于特定肽序列的新型合成抗原，缀合物和抗体及其生产。更具体地，本发明涉及作为蛋白质的决定簇位点的多肽，所述多肽具有8至20个氨基酸残基，具有氨基末端氨基酸和羧基末端氨基酸，其中所述多肽包括：（ a）对应于蛋白质β转角的四个氨基酸序列的四个氨基酸序列; （b）连接在四个氨基酸序列的氨基末端（H2N-）上的2至8个氨基酸残基的序列; 和（c）连接到四个氨基酸序列的羧基末端（-COOH）的2至8个氨基酸残基的序列，其中（b）和（c）子部分的氨基酸残基对应于氨基酸末端和羧基末端，以及该多肽的药学上可接受的盐。本发明涉及包含上述多肽与大分子载体的缀合物。本发明还涉及对上述肽的多肽或缀合物特异的抗体及其生产。合成多肽序列，肽缀合物及其抗体在疫苗，抗病毒剂，诊断试剂等的生产中用作抗原，用于检测和治疗哺乳动物等感染性和免疫性疾病如脊髓灰质炎和癌症等，特别是人类。

4. 发明授权

US3998807A Arabinofuranosyl cytosines and methods of making 失效
标题翻译：阿拉伯呋喃胞苷和其制备方法
公开(公告)号：US3998807A
公开(公告)日：1976-12-21
申请号：US231754
申请日：1972-03-03
申请人： John G. Moffatt
发明人： John G. Moffatt
IPC分类号： C07H19/09 , C07H19/06 , C07H19/12 , C07H19/08
CPC分类号： C07H19/06 , C07H19/12
摘要： 3'-O-Acyl- and 3-'-O-acyl-5-'-O-acyl- derivatives of 1-(.beta.-D-arabinofuranosyl)-cytosines and methods of preparing these compounds and also O.sup.2,2'-anhydro-1-(3'-O-acyl-5'-O-acyl-.beta.-D-arabinofuranosyl)-cytosine salts. The O.sup.2,2'-anhydro-1-(3'-O-acyl-5'-O-acyl-.beta.-D-arabinofuranosyl)-cytosine nucleoside salts are prepared by direct acid catalyzed acylation of the salts of the corresponding O.sup.2,2'-anhydro-1-(.beta.-D-arabinofuranosyl)-cytosines or 3'-O-acyl- derivatives, under carefully controlled conditions. The 3'-O-acyl- and 3'-O-acyl-5'-O-acyl-1-(.beta.-D-arabinofuranosyl)-cytosines are prepared from the corresponding O.sup.2,2'-anhydro nucleosides via selective cleavage of the O.sup.2,2'-anhydro bridge under carefully controlled conditions. The compounds exhibit anti-viral, cytotoxic and anti-neoplastic activity, and thus are useful for the treatment of mammals where such agents are indicated.

5. 发明授权

US4082735A Novel immunological adjuvant compounds and methods of preparation thereof 失效
公开(公告)号：US4082735A
公开(公告)日：1978-04-04
申请号：US680260
申请日：1976-04-26
申请人： Gordon H. Jones , John G. Moffatt , John J. Nestor, Jr.
发明人： Gordon H. Jones , John G. Moffatt , John J. Nestor, Jr.
IPC分类号： A61K38/00 , A61K31/70 , A61K31/7028 , A61K39/39 , A61P31/04 , A61P37/04 , C07H15/04 , C07K1/06 , C07K9/00 , C07C103/52 , A61K37/00
CPC分类号： C07K9/005
摘要： This application relates to novel immunological adjuvant compounds of the formula: ##STR1## wherein each of R and R.sup.1 are the same or different and are hydrogen or an acyl radical; R.sup.2 is an unsubstituted or substituted alkyl radical, or an unsubstituted or substituted aryl radical; X is an aminoacyl moiety; and Y is D-isoasparagine or D-isoglutamine.

6. 发明授权

US4473555A Nona- and dodecapeptides for augmenting natural killer cell activity 失效
标题翻译：非 - 和十二肽用于增强自然杀伤细胞活性
公开(公告)号：US4473555A
公开(公告)日：1984-09-25
申请号：US542632
申请日：1983-10-17
申请人： John J. Nestor, Jr. , John G. Moffatt , John M. Sims
发明人： John J. Nestor, Jr. , John G. Moffatt , John M. Sims
IPC分类号： C07K7/08 , A61K38/00 , A61P37/00 , C07K14/57 , A61K37/00 , C07C103/52
CPC分类号： C07K14/57 , A61K38/00
摘要： The abstract is disclosed herein are nonapeptides and dodecapeptides which augment natural killer cell activity.
摘要翻译：本文公开的摘要是增加自然杀伤细胞活性的非肽和十二肽。

7. 发明授权

US4082736A Novel immunological adjuvant compounds and methods of preparation thereof 失效
标题翻译：新型免疫调节剂及其制备方法
公开(公告)号：US4082736A
公开(公告)日：1978-04-04
申请号：US680618
申请日：1976-04-26
申请人： Gordon H. Jones , John G. Moffatt , John J. Nestor, Jr.
发明人： Gordon H. Jones , John G. Moffatt , John J. Nestor, Jr.
IPC分类号： C07K9/00 , C07C103/52 , A61K37/00
CPC分类号： C07K9/005
摘要： This application relates to novel immunological adjuvant compounds of the formula: ##STR1## wherein each of R and R.sup.1 are the same or different and are hydrogen or an acyl radical; R.sup.2 is an unsubstituted or substituted alkyl radical, or an unsubstituted or substituted aryl radical; R.sup.6 is an alkyl radical X is an aminoacyl moiety; and Y is D-isoasparagine or D-isoglutamine.

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