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1. 发明授权

US08545207B2 Roller type electrostatic spinning apparatus 有权
标题翻译：辊式静电纺丝装置
公开(公告)号：US08545207B2
公开(公告)日：2013-10-01
申请号：US12971201
申请日：2010-12-17
申请人： Haw-Jer Chang , Jen-Hsiung Lee , Yu-Chun Tang , Tzu-Hsiang Huang
发明人： Haw-Jer Chang , Jen-Hsiung Lee , Yu-Chun Tang , Tzu-Hsiang Huang
IPC分类号： B29C67/00
CPC分类号： D01D5/0069
摘要： A roller type electrostatic spinning apparatus is disclosed, which includes an electrostatic spinning solution impregnation mechanism having a tank for containing an electrostatic spinning solution and a sizing roller rolled in the tank, a chain emitting electrode touching the sizing roller to coat the electrostatic spinning solution onto the chain emitting electrode, a collecting electrode, and a high-voltage power supply connected to the chain emitting electrode and the collecting electrodes respectively.
摘要翻译：公开了一种辊式静电纺丝装置，其包括静电纺丝溶液浸渍机构，该静电纺丝溶液浸渍机构具有容纳静电纺丝溶液的罐和在罐中滚动的施胶辊，链条发射电极接触上浆辊以将静电纺丝溶液涂覆到链发射电极，集电极和连接到链发射电极和集电极的高压电源。

2. 发明授权

US08241537B2 Method for manufacturing polymeric fibrils 有权
标题翻译：制造聚合物原纤维的方法
公开(公告)号：US08241537B2
公开(公告)日：2012-08-14
申请号：US12782056
申请日：2010-05-18
申请人： Haw-Jer Chang , Hung-En Chen , Po-Hsiung Huang , Jen-Hsiung Lee , Ching-Hui Tseng
发明人： Haw-Jer Chang , Hung-En Chen , Po-Hsiung Huang , Jen-Hsiung Lee , Ching-Hui Tseng
IPC分类号： D01D5/18 , D04H1/72
CPC分类号： D01D5/0069 , D01D5/0076 , D01D5/18 , D01F13/00 , Y02P70/625
摘要： An electrospinning apparatus is described. The electrospinning apparatus has a rotary nozzle mechanism that moves simultaneously along a non-linear track for forming polymeric fibrils, so that the polymeric fibrils can be piled to form a uniform web on a receiving carrier from any receiving angle. Therefore, the electrospinning apparatus resolves problems of the prior polymeric fibrils, such as various distribution and slow production rate. In addition, a method of manufacturing polymeric fibrils in the aforementioned electrospinning apparatus is further described.
摘要翻译：描述了静电纺丝装置。静电纺丝装置具有旋转喷嘴机构，其沿着用于形成聚合物原纤维的非线性轨道同时移动，使得聚合物原纤维可以从任何接收角度堆叠在接收载体上以形成均匀的纤维网。因此，静电纺丝装置解决了现有聚合物原纤维的问题，如各种分布和生产速度慢。此外，进一步描述在上述静电纺丝装置中制造聚合物原纤维的方法。

3. 发明授权

US07600990B2 Electrostatic spinning apparatus 有权
标题翻译：静电纺丝机
公开(公告)号：US07600990B2
公开(公告)日：2009-10-13
申请号：US11647502
申请日：2006-12-28
申请人： Haw-Jer Chang , Jen-Hsiung Lee
发明人： Haw-Jer Chang , Jen-Hsiung Lee
IPC分类号： D01D5/00
CPC分类号： D01D5/0069
摘要： An electrostatic spinning apparatus includes a feeding device, at least one linear electrode, at least one collecting electrode, and a high-voltage power supply. The feeding device includes a tank and a roller and an electrostatic spinning solution is contained in the tank. The roller is rolled in the tank. The linear electrode is contact with the roller to absorb the electrostatic spinning solution onto the linear electrode. The collecting electrode is disposed equidistantly to the linear electrode. The high-voltage power supply is connected with the linear electrode and the collecting electrode to opposite charge the linear electrode and the collecting electrode. The electrostatic spinning solution is guided to the collecting electrode from linear electrode and formed an electrostatic spinning fiber.
摘要翻译：静电纺丝装置包括供给装置，至少一个直线电极，至少一个集电极和高压电源。进料装置包括罐和辊，并且静电纺丝溶液容纳在罐中。辊子在罐中滚动。线性电极与辊接触以将静电纺丝溶液吸收到线性电极上。集电极与线状电极等距设置。高压电源与直线电极和集电极连接，对直线电极和集电极进行反向充电。静电纺丝溶液从线性电极引导到集电电极，形成静电纺丝纤维。

4. 发明申请

US20060278523A1 Real-time adjustable mechanism of shielding plate in sputtering vacuum chamber design 审中-公开
标题翻译：溅射真空室设计中屏蔽板的实时可调机构
公开(公告)号：US20060278523A1
公开(公告)日：2006-12-14
申请号：US11147338
申请日：2005-06-08
申请人： Geeng Sheu , Chung Liu , Jer Chang , Yu Liu , Tuan Yu , Tai Huang
发明人： Geeng Sheu , Chung Liu , Jer Chang , Yu Liu , Tuan Yu , Tai Huang
IPC分类号： C23C14/00
CPC分类号： C23C14/564
摘要： A sputtering system includes a chamber with two frames therein. Several shafts are pivoted on the frames for rotation and transport. A shielding plate is placed above the shafts, and several adjustable mechanisms are between the frames and the shielding plate. Each of the adjustable mechanisms has an operation member on an exterior side of the chamber and an inner member in the chamber, which is connected to the operation member and the shielding plate. The inner member has a first section with a threaded hole and a second section with a threaded post screwed into the threaded hole of the first section. As a result, when the operation member is turned, the relative length and position of the inner member is changed to elevate or lower the shielding plate, and hence the gap between the carrier and the shielding plate can be adjusted to the desired allowable value.
摘要翻译：溅射系统包括其中具有两个框架的室。几个轴在框架上枢转以旋转和运输。屏蔽板放置在轴的上方，并且几个可调节的机构在框架和屏蔽板之间。每个可调节机构在腔室的外侧具有操作构件，并且在腔室中具有连接到操作构件和屏蔽板的内部构件。内部构件具有带有螺纹孔的第一部分和具有螺纹连接到第一部分的螺纹孔中的螺纹柱的第二部分。结果，当操作构件转动时，内部构件的相对长度和位置被改变以升高或降低屏蔽板，因此载体和屏蔽板之间的间隙可以被调节到期望的允许值。

5. 发明申请

US20060024399A1 Apparatus and method for manufacturing polymeric fibrils 有权
标题翻译：用于制造聚合物原纤维的装置和方法
公开(公告)号：US20060024399A1
公开(公告)日：2006-02-02
申请号：US11190720
申请日：2005-07-27
申请人： Haw-Jer Chang , Hung-En Chen , Po-Hsiung Huang , Jen-Hsiung Lee , Ching-Hui Tseng
发明人： Haw-Jer Chang , Hung-En Chen , Po-Hsiung Huang , Jen-Hsiung Lee , Ching-Hui Tseng
IPC分类号： B29B9/00
CPC分类号： D01D5/0069 , D01D5/0076 , D01D5/18 , D01F13/00 , Y02P70/625
摘要： An electrospinning apparatus is described. The electrospinning apparatus has a rotary nozzle mechanism that moves simultaneously along a non-linear track for forming polymeric fibrils, so that the polymeric fibrils can be piled to form a uniform web on a receiving carrier from any receiving angle. Therefore, the electrospinning apparatus resolves problems of the prior polymeric fibrils, such as various distribution and slow production rate. In addition, a method of manufacturing polymeric fibrils in the aforementioned electrospinning apparatus is further described.
摘要翻译：描述了静电纺丝装置。静电纺丝装置具有旋转喷嘴机构，其沿着用于形成聚合物原纤维的非线性轨道同时移动，使得聚合物原纤维可以从任何接收角度堆叠在接收载体上以形成均匀的纤维网。因此，静电纺丝装置解决了现有聚合物原纤维的问题，如各种分布和生产速度慢。此外，进一步描述在上述静电纺丝装置中制造聚合物原纤维的方法。

6. 发明授权

US06620804B2 Selenophene anti-tumor agents 失效
标题翻译：硒酚抗肿瘤药
公开(公告)号：US06620804B2
公开(公告)日：2003-09-16
申请号：US10061480
申请日：2002-02-01
申请人： Ching-jer Chang , Curtis L. Ashendel , Darrick Kim
发明人： Ching-jer Chang , Curtis L. Ashendel , Darrick Kim
IPC分类号： C07D42114
CPC分类号： C07D421/14 , A61K31/34 , A61K31/381 , A61K31/4025 , C07D307/46 , C07D333/22 , C07D345/00 , C07F7/0838
摘要： Novel selenophene compounds useful as anti-tumor agents are described. Preferred compounds include compounds of formula I: wherein R1 and R2 are independently selected from the group consisting of; H, CHO, CH2OH and CH2NH2; and X and Y are independently selected from the group consisting of Se, S, O, NCH3 and NH. Pharmaceutical compositions and a method for treating patients having tumors utilizing the disclosed selenophene compounds are also described.
摘要翻译：描述了可用作抗肿瘤剂的新型硒吩类化合物。优选的化合物包括式I化合物：其中R 1和R 2独立地选自H，CHO，CH 2 OH和CH 2 NH 2; X和Y独立地选自Se，S，O，NCH 3和NH。还描述了药物组合物和利用所公开的硒吩化合物治疗患有肿瘤的患者的方法。

7. 发明授权

US07740461B2 Apparatus and method for manufacturing polymeric fibrils 有权
标题翻译：用于制造聚合物原纤维的装置和方法
公开(公告)号：US07740461B2
公开(公告)日：2010-06-22
申请号：US11190720
申请日：2005-07-27
申请人： Haw-Jer Chang , Hung-En Chen , Po-Hsiung Huang , Jen-Hsiung Lee , Ching-Hui Tseng
发明人： Haw-Jer Chang , Hung-En Chen , Po-Hsiung Huang , Jen-Hsiung Lee , Ching-Hui Tseng
IPC分类号： D01D5/18 , D04H1/72
CPC分类号： D01D5/0069 , D01D5/0076 , D01D5/18 , D01F13/00 , Y02P70/625
摘要： An electrospinning apparatus is described. The electrospinning apparatus has a rotary nozzle mechanism that moves simultaneously along a non-linear track for forming polymeric fibrils, so that the polymeric fibrils can be piled to form a uniform web on a receiving carrier from any receiving angle. Therefore, the electrospinning apparatus resolves problems of the prior polymeric fibrils, such as various distribution and slow production rate. In addition, a method of manufacturing polymeric fibrils in the aforementioned electrospinning apparatus is further described.
摘要翻译：描述了静电纺丝装置。静电纺丝装置具有旋转喷嘴机构，其沿着用于形成聚合物原纤维的非线性轨道同时移动，使得聚合物原纤维可以从任何接收角度堆叠在接收载体上以形成均匀的纤维网。因此，静电纺丝装置解决了现有聚合物原纤维的问题，如各种分布和生产速度慢。此外，进一步描述在上述静电纺丝装置中制造聚合物原纤维的方法。

8. 发明申请

US20050203077A1 Selenophene anti-tumor agents 审中-公开
标题翻译：硒酚抗肿瘤药
公开(公告)号：US20050203077A1
公开(公告)日：2005-09-15
申请号：US11103991
申请日：2005-04-12
申请人： Ching-jer Chang , Curtis Ashendel , Darrick Kim
发明人： Ching-jer Chang , Curtis Ashendel , Darrick Kim
IPC分类号： A61P35/00 , C07D345/00 , C07D421/14 , A61K31/4025 , A61K31/381 , A61K31/34
CPC分类号： C07D421/14 , A61K31/34 , A61K31/381 , A61K31/4025 , C07D307/46 , C07D333/22 , C07D345/00 , C07F7/0838
摘要： Novel selenophene compounds useful as anti-tumor agents are described. Preferred compounds include compounds of formula I: wherein R1 and R2 are independently selected from the group consisting of H, CHO, CH2OH and CH2NH2; and X and Y are independently selected from the group consisting of Se, S, O, NCH3, and NH. Pharmaceutical compositions and a method for treating patients having tumors utilizing the disclosed selenophene compounds are also described.
摘要翻译：描述了可用作抗肿瘤剂的新型硒吩类化合物。优选的化合物包括式I化合物：其中R 1和R 2独立地选自H，CHO，CH 2 OH 和CH 2 NH 2; X和Y独立地选自Se，S，O，NCH 3 N和NH。还描述了药物组合物和利用所公开的硒吩化合物治疗患有肿瘤的患者的方法。

9. 发明授权

US06894039B2 Selenophene anti-tumor agents 失效
标题翻译：硒酚抗肿瘤药
公开(公告)号：US06894039B2
公开(公告)日：2005-05-17
申请号：US10658175
申请日：2003-09-09
申请人： Ching-jer Chang , Curtis L. Ashendel , Darrick Kim
发明人： Ching-jer Chang , Curtis L. Ashendel , Darrick Kim
IPC分类号： A61P35/00 , C07D345/00 , C07D421/14 , C07D421/04 , A61K31/33 , A61K31/381 , A61K31/341
CPC分类号： C07D421/14 , A61K31/34 , A61K31/381 , A61K31/4025 , C07D307/46 , C07D333/22 , C07D345/00 , C07F7/0838
摘要： Novel selenophene compounds useful as anti-tumor agents are described. Preferred compounds include compounds of formula I: wherein R1 and R2 are independently selected from the group consisting of; H, CHO, CH2OH and CH2NH2; and X and Y are independently selected from the group consisting of Se, S, O, NCH3 and NH. Pharmaceutical compositions and a method for treating patients having tumors utilizing the disclosed selenophene compounds are also described.
摘要翻译：描述了可用作抗肿瘤剂的新型硒吩类化合物。优选的化合物包括式I化合物：其中R 1和R 2独立地选自： H，CHO，CH 2 OH和CH 2 NH 2; 并且X和Y独立地选自Se，S，O，NCH 3 N和NH。还描述了药物组合物和利用所公开的硒吩化合物治疗患有肿瘤的患者的方法。

10. 发明授权

US5741811A Polythiophene anti-tumor agents 失效
公开(公告)号：US5741811A
公开(公告)日：1998-04-21
申请号：US712854
申请日：1996-09-12
申请人： Ching Te Chang , Ching-Jer Chang , Chen-Tao Lee , Fen-Lan Lin , Jih-Dar Tsai , Curtis L. Ashendel , Thomas C. K. Chan , Robert L. Geahlen , David J. Waters
发明人： Ching Te Chang , Ching-Jer Chang , Chen-Tao Lee , Fen-Lan Lin , Jih-Dar Tsai , Curtis L. Ashendel , Thomas C. K. Chan , Robert L. Geahlen , David J. Waters
IPC分类号： A61K31/381 , C07D333/16 , C07D333/22 , C07D333/24 , A61K31/38 , C07D409/02
CPC分类号： A61K31/381 , C07D333/16 , C07D333/22 , C07D333/24
摘要： Novel polythiophene compounds useful as anti-tumor agents are described. Preferred compounds of the formula: ##STR1## wherein n is 0-2 and R.sub.2 and R.sub.3 are optionally substituted 2-thienyl or 3-thienyl have been found to exhibit selective cytotoxic activity against transformed human cells. Pharmaceutical compositions containing the described polythiophene compounds are expected to exhibit good chemotherapeutic activity against slow growing tumors based on tumor cell line assays. A method for treating patients having tumors utilizing the disclosed polythiophene compounds is also described.

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