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1. 发明申请

US20120302548A1 2-ARYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS 有权
标题翻译： 2-ARYLIMIDAZOLE DERIVATIVES PDE10A ENZYME INHIBITORS
公开(公告)号：US20120302548A1
公开(公告)日：2012-11-29
申请号：US13515325
申请日：2010-12-15
申请人： Ask Püschl , Jacob Nielsen , Jan Kehler , John Paul Kilburn , Mauro Marigo , Morten Langgård
发明人： Ask Püschl , Jacob Nielsen , Jan Kehler , John Paul Kilburn , Mauro Marigo , Morten Langgård
IPC分类号： A61K31/4985 , C07D471/04 , A61K31/437 , A61K31/551 , A61P25/30 , A61P25/28 , A61P25/18 , A61P25/32 , A61P25/36 , C07D487/04 , A61K31/554
CPC分类号： C07D487/04 , C07D471/04
摘要： This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
摘要翻译：本发明涉及PDE10A酶抑制剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了制备式I化合物的方法。本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明本发明还提供了治疗患有药物成瘾症的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明还提供了治疗患有精神病障碍患者的方法，包括给予治疗有效量的式I化合物。

2. 发明申请

US20120190685A1 NOVEL PHENYLIMIDAZOLE DERIVATIVE AS PDE10A ENZYME INHIBITOR 有权
标题翻译：新型苯乙烯胺衍生物作为PDE10A酶抑制剂
公开(公告)号：US20120190685A1
公开(公告)日：2012-07-26
申请号：US13378405
申请日：2010-06-17
申请人： Andreas Ritzén , Jan Kehler , Morten Langgård , Jacob Nielsen , John Paul Kilburn , Mohammed M. Farah
发明人： Andreas Ritzén , Jan Kehler , Morten Langgård , Jacob Nielsen , John Paul Kilburn , Mohammed M. Farah
IPC分类号： A61K31/4985 , A61P25/18 , A61P25/28
CPC分类号： C07D487/04 , C07D403/12 , C07D471/04
摘要： This invention provides the compound 5,8-Dimethyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]thazolo[1,5-a]pyrazine and pharmaceutically acceptable acid addition salts thereof.
摘要翻译：本发明提供化合物5,8-二甲基-2- [2-（1-甲基-4-苯基-1H-咪唑-2-基） - 乙基] - [1,2,4]噻唑并[1,5- a]吡嗪及其药学上可接受的酸加成盐。

3. 发明申请

US20070248082A1 Multicast switching in a credit based unicast and multicast switching architecture 有权
标题翻译：基于信用的单播和组播交换架构中的组播切换
公开(公告)号：US20070248082A1
公开(公告)日：2007-10-25
申请号：US11407038
申请日：2006-04-20
申请人： Jacob Nielsen
发明人： Jacob Nielsen
IPC分类号： H04L12/50
CPC分类号： H04L49/205 , H04L47/15 , H04L47/39 , H04L49/201 , H04L49/3027 , H04L49/3045
摘要： A system and method of switching packets and/or cells, which includes a switching apparatus having a plurality of input units that receive at least one packet to be transferred by the switching apparatus. A plurality of output units transfer the packet out of the switching apparatus. A switch unit transfers the packet from one of the input units to one of the output units. Each input unit includes at least one input queue that temporarily holds the packet to be transferred by the switching apparatus. Each input unit also includes a respective unicast credit count unit that allows the packet to be transferred out from the queue when a current unicast credit value determined by the unicast credit count unit is at least predetermined value. Each output unit includes at least one output queue that receives the packet as switched by the switch unit, and which is to be transferred out of the switching apparatus. Each output unit also includes a output port scheduler unit that generates credit tokens and that outputs credit messages based on the credit tokens generated. Multicast credit count units are provided for each QoS priority that a multicast packet can be set to, in which they maintain a current multicast credit value for the QoS priorities.
摘要翻译：一种切换分组和/或小区的系统和方法，包括具有多个输入单元的交换设备，所述多个输入单元接收要由所述交换设备传送的至少一个分组。多个输出单元将分组从交换设备传送出去。开关单元将分组从一个输入单元传送到输出单元之一。每个输入单元包括至少一个输入队列，其临时保存由切换装置传送的分组。每个输入单元还包括相应的单播信用计数单元，当由单播信用计数单元确定的当前单播信用值为至少预定值时，允许该数据包从队列传出。每个输出单元包括至少一个输出队列，其接收由开关单元切换并且要从交换设备传出的分组。每个输出单元还包括产生信用令牌的输出端口调度器单元，并且基于生成的信用令牌输出信用消息。为每个QoS优先级提供组播信用计数单位，组播分组可以被设置为，其中它们维护用于QoS优先级的当前多播信用值。

4. 外观设计

USD388476S Toy animal 失效
公开(公告)号：USD388476S
公开(公告)日：1997-12-30
申请号：US59811
申请日：1996-09-17
申请人： Jacob Nielsen , Lone Bj.o slashed.rnskov-Bartholdy , Per Steen Nielsen
设计人： Jacob Nielsen , Lone Bj.o slashed.rnskov-Bartholdy , Per Steen Nielsen

5. 外观设计

USD385595S Toy Cow 失效
公开(公告)号：USD385595S
公开(公告)日：1997-10-28
申请号：US43984
申请日：1995-09-14
申请人： Christian Stephensen , Jacob Nielsen
设计人： Christian Stephensen , Jacob Nielsen

6. 外观设计

USD384999S Toy cow 失效
公开(公告)号：USD384999S
公开(公告)日：1997-10-14
申请号：US43993
申请日：1995-09-14
申请人： Christian Stephensen , Jacob Nielsen
设计人： Christian Stephensen , Jacob Nielsen

7. 外观设计

USD283149S Toy walrus figure 失效
公开(公告)号：USD283149S
公开(公告)日：1986-03-25
申请号：US561665
申请日：1983-12-15
申请人： Jacob Nielsen
设计人： Jacob Nielsen

8. 发明授权

US09096589B2 Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors 有权
标题翻译：杂芳基苯基咪唑衍生物作为PDE10A酶抑制剂
公开(公告)号：US09096589B2
公开(公告)日：2015-08-04
申请号：US13513867
申请日：2010-12-15
申请人： Ask Püschl , Jacob Nielsen , Jan Kehler , John Paul Kilburn , Mauro Marigo , Morten Langgård
发明人： Ask Püschl , Jacob Nielsen , Jan Kehler , John Paul Kilburn , Mauro Marigo , Morten Langgård
IPC分类号： C07D487/04 , C07D471/04 , A61P25/28 , A61P25/16 , A61P25/18 , A61P25/36 , A61P25/32 , A61P25/22 , A61P25/30 , A61P25/00
CPC分类号： A61K31/4985 , A61K45/06 , C07D471/04 , C07D487/04
摘要： This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
摘要翻译：本发明涉及PDE10A酶抑制剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了制备式I化合物的方法。本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明本发明还提供了治疗患有药物成瘾症的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明还提供了治疗患有精神病障碍患者的方法，包括给予治疗有效量的式I化合物。

9. 发明申请

US20120309764A1 Heteroaromatic aryl triazole derivatives as PDE10A enzyme inhibitors 有权
标题翻译：杂芳基三唑衍生物作为PDE10A酶抑制剂
公开(公告)号：US20120309764A1
公开(公告)日：2012-12-06
申请号：US13515351
申请日：2010-12-15
申请人： Ask Püschl , Jacob Nielsen , Jan Kehler , John Paul Kilburn , Mauro Marigo , Morten Langgård
发明人： Ask Püschl , Jacob Nielsen , Jan Kehler , John Paul Kilburn , Mauro Marigo , Morten Langgård
IPC分类号： A61K31/4985 , C07D487/04 , C07D471/04 , A61P25/16 , A61P25/18 , A61P25/28 , A61P25/32 , A61P25/30 , A61K31/437 , A61P25/00
CPC分类号： C07D487/04 , C07D471/04
摘要： This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
摘要翻译：本发明涉及PDE10A酶抑制剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了制备式I化合物的方法。本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明本发明还提供了治疗患有药物成瘾症的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明还提供了治疗患有精神病障碍患者的方法，包括给予治疗有效量的式I化合物。

10. 发明申请

US20120235739A1 PROGRAMMABLE GAIN AMPLIFIER WITH MULTI-RANGE OPERATION FOR USE IN BODY SENSOR INTERFACE APPLICATIONS 有权
标题翻译：可编程增益放大器，具有多种操作功能，可用于机身传感器接口应用
公开(公告)号：US20120235739A1
公开(公告)日：2012-09-20
申请号：US13228274
申请日：2011-09-08
申请人： Dustin Griesdorf , Jacob Nielsen , Volodymyr Yavorskyy
发明人： Dustin Griesdorf , Jacob Nielsen , Volodymyr Yavorskyy
IPC分类号： H03G3/20
CPC分类号： G01N27/3273 , A61B5/14532
摘要： A system for analyte measurement includes a programmable gain amplifier including a first input terminal operatively coupling to the output of a sensor for sensing an analyte, a second input terminal operatively coupling to a voltage source, and an output terminal for providing an output based on a difference between inputs on the first input terminal and the second input terminal A controller is operatively coupled to the programmable gain amplifier for configuring the operation range of the programmable gain amplifier and/or selecting the output of the programmable gain amplifier for analyte measurement. The method includes monitoring an output from a programmable gain amplifier operatively coupling to a sensor for sensing an analyte, and controlling the operation range of the programmable gain amplifier, and/or selecting the output of the programmable gain amplifier for analyte measurement.
摘要翻译：用于分析物测量的系统包括可编程增益放大器，其包括可操作地耦合到用于感测分析物的传感器的输出的第一输入端子，可操作地耦合到电压源的第二输入端子和用于提供基于第一输入端子和第二输入端子A控制器的输入之间的差异可操作地耦合到可编程增益放大器，用于配置可编程增益放大器的操作范围和/或选择用于分析物测量的可编程增益放大器的输出。该方法包括监测可编程增益放大器的输出，其可操作地耦合到用于感测分析物的传感器，以及控制可编程增益放大器的操作范围，和/或选择用于分析物测量的可编程增益放大器的输出。

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