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1. 发明授权

US10012709B2 System for optimized low power MR imaging 有权
公开(公告)号：US10012709B2
公开(公告)日：2018-07-03
申请号：US13958654
申请日：2013-08-05
申请人： Ovidiu Andronesi , Bruce Rosen , Peter Caravan , Himanshu Bhat
发明人： Ovidiu Andronesi , Bruce Rosen , Peter Caravan , Himanshu Bhat
IPC分类号： G01V3/00 , G01R33/36 , G01R33/56 , A61B5/055 , G01R33/561
CPC分类号： G01R33/36 , A61B5/055 , G01R33/5602 , G01R33/5616 , G01R33/5617
摘要： A system acquires MR imaging data of a portion of patient anatomy associated with proton spin lattice relaxation time in a rotating frame using an RF (Radio Frequency) signal generator configured to generate RF excitation pulses and a magnetic field gradient generator configured to generate anatomical volume select magnetic field gradients for phase encoding and readout RF data acquisition. The RF signal generator and the gradient generator are configured to provide a rotating frame preparation pulse sequence comprising at least one of, (a) a T1 spin lattice relaxation in a rotating frame (T1ρ) preparation pulse sequence of adiabatic pulses comprising modulated RF pulses and modulated magnetic field gradients for slice selection and (b) a T2 spin-spin relaxation in a rotating frame (T2ρ) preparation pulse sequence of adiabatic pulses comprising modulated RF pulses and modulated magnetic field gradients for slice selection.

2. 发明申请

US20090254146A1 DEEP BRAIN STIMULATION IMPLANT WITH MICROCOIL ARRAY 有权
标题翻译：深层脑刺激与微阵列植入
公开(公告)号：US20090254146A1
公开(公告)日：2009-10-08
申请号：US12418324
申请日：2009-04-03
申请人： Giorgio Bonmassar , Matti S. Hamalainen , Bruce Rosen
发明人： Giorgio Bonmassar , Matti S. Hamalainen , Bruce Rosen
IPC分类号： A61N1/36
CPC分类号： A61N2/004 , A61N1/0531 , A61N1/0534 , A61N1/36082 , A61N1/40 , A61N2/006 , A61N2/02
摘要： An implant for deep brain stimulation (DBS) has an array of electromagnetic microcoils dispersed over the length of the implant. The microcoils produce magnetic fields that are directed into, and induce current in, the adjacent brain tissue. The microcoils may be selectively operated to direct and focus electrical stimulation to targeted areas of the brain. The implant is useful in studying or treating neurophysiological conditions associated with the deep regions of the brain such as Parkinson's disease, drug addiction, and depression.
摘要翻译：用于深部脑刺激的植入物（DBS）具有分散在植入物长度上的电磁微线圈阵列。微线圈产生导致相邻脑组织进入并诱导电流的磁场。可以选择性地操作微线圈以将电刺激引导并聚焦到脑的目标区域。植入物可用于研究或治疗与脑深部相关的神经生理学疾病，如帕金森病，药物成瘾和抑郁症。

3. 发明授权

US10661091B2 System and method for hyperthermia treatment using radiofrequency phased arrays 有权
公开(公告)号：US10661091B2
公开(公告)日：2020-05-26
申请号：US14668393
申请日：2015-03-25
申请人： Bastien Guerin , Lawrence L. Wald , Bruce Rosen
发明人： Bastien Guerin , Lawrence L. Wald , Bruce Rosen
IPC分类号： A61N1/40 , G01R33/48 , A61B34/10 , G01R33/561
摘要： Systems and methods for designing parallel transmission radiofrequency (RF) pulses for use in a RF treatment. The methods include selecting a target region in a subject, and providing a plurality of specific absorption rate (SAR) matrices for estimation of SAR at locations within the subject. The methods also include determining a first set of SAR matrices for locations in the target region using the provided SAR matrices, and determining a second set of SAR matrices for locations not in the target region using the provided SAR matrices. The methods further include designing a plurality of RF pulses for achieving a target power deposition in the target region by using the first set of SAR matrices and the second set of SAR matrices in an optimization that determines a set of RF waveforms that produce a target average local SAR using the first set of SAR matrices while minimizing a local SAR and a global SAR using the second set of SAR matrices.

4. 发明授权

US08944985B2 Deep brain stimulation implant with microcoil array 有权
标题翻译：具有微线圈阵列的深脑刺激植入物
公开(公告)号：US08944985B2
公开(公告)日：2015-02-03
申请号：US12418324
申请日：2009-04-03
申请人： Giorgio Bonmassar , Matti S. Hamalainen , Bruce Rosen
发明人： Giorgio Bonmassar , Matti S. Hamalainen , Bruce Rosen
IPC分类号： A61N1/00 , A61N2/02 , A61N2/00 , A61N1/36 , A61N1/05 , A61N1/40
CPC分类号： A61N2/004 , A61N1/0531 , A61N1/0534 , A61N1/36082 , A61N1/40 , A61N2/006 , A61N2/02
摘要： An implant for deep brain stimulation (DBS) has an array of electromagnetic microcoils dispersed over the length of the implant. The microcoils produce magnetic fields that are directed into, and induce current in, the adjacent brain tissue. The microcoils may be selectively operated to direct and focus electrical stimulation to targeted areas of the brain. The implant is useful in studying or treating neurophysiological conditions associated with the deep regions of the brain such as Parkinson's disease, drug addiction, and depression.
摘要翻译：用于深部脑刺激的植入物（DBS）具有分散在植入物长度上的电磁微线圈阵列。微线圈产生导致相邻脑组织进入并诱导电流的磁场。微线圈可以选择性地操作以将电刺激引导并聚焦到脑的目标区域。植入物可用于研究或治疗与脑深部相关的神经生理学疾病，如帕金森病，药物成瘾和抑郁症。

5. 发明申请

US20060052635A1 Oxidation catalyst and its preparation 审中-公开
标题翻译：氧化催化剂及其制备方法
公开(公告)号：US20060052635A1
公开(公告)日：2006-03-09
申请号：US10543095
申请日：2003-12-11
申请人： Bruce Rosen
发明人： Bruce Rosen
IPC分类号： C07C51/16
CPC分类号： C07C51/25 , B01J21/04 , B01J23/002 , B01J23/56 , B01J23/6525 , B01J23/686 , B01J35/0026 , B01J35/10 , B01J35/1009 , B01J37/0045 , B01J2523/00 , C07C5/3332 , C07C51/215 , C07C2521/04 , C07C2523/68 , Y02P20/52 , C07C53/08 , B01J2523/19 , B01J2523/55 , B01J2523/56 , B01J2523/68 , C07C11/04
摘要： The present invention provides a method of preparation of a supported catalyst composition suitable for the oxidation of ethane to ethylene and/or acetic acid, and/or the oxidation of ethylene to acetic acid, which supported catalyst composition comprises a catalyst, comprising one or more metal components, on a support comprising alpha-alumina, and which method comprises (a) forming a slurry comprising the one or more metal components, and alpha-alumina support particles or an alpha-alumina support precursor, (b) spray-drying the slurry, and, optionally, (c) calcining the spray-dried slurry to form the supported catalyst composition. The present invention also provides a supported catalyst composition formed by the above method, and a process for the selective oxidation of ethane to ethylene and/or acetic acid, and/or the selective oxidation of ethylene to acetic acid utilising the supported catalyst composition.
摘要翻译：本发明提供了一种制备适用于将乙烷氧化成乙烯和/或乙酸的负载型催化剂组合物和/或将乙烯氧化成乙酸的方法，所述催化剂组合物包括催化剂，其包括一种或多种金属组分，在包含α-氧化铝的载体上，并且该方法包括（a）形成包含一种或多种金属组分和α-氧化铝载体颗粒或α-氧化铝载体前体的浆料，（b）将浆料，和任选地（c）煅烧喷雾干燥的浆料以形成负载的催化剂组合物。本发明还提供了一种通过上述方法形成的负载催化剂组合物，以及使用负载型催化剂组合物将乙烷选择性氧化成乙烯和/或乙酸，和/或将乙烯选择性氧化成乙酸的方法。

6. 发明申请

US20060128988A1 Catalyst composition and process for the selective oxidation of ethane and/or ethylene to acetic acid 审中-公开
标题翻译：用于将乙烷和/或乙烯选择性氧化成乙酸的催化剂组合物和方法
公开(公告)号：US20060128988A1
公开(公告)日：2006-06-15
申请号：US10555988
申请日：2004-04-28
申请人： James Brazdil , Richard George , Bruce Rosen
发明人： James Brazdil , Richard George , Bruce Rosen
IPC分类号： B01J27/187 , B01J27/198 , B01J27/188 , B01J27/19 , C07C51/16
CPC分类号： B01J21/06 , B01J21/063 , B01J23/002 , B01J23/20 , B01J23/28 , B01J23/30 , B01J23/652 , B01J23/686 , B01J37/0045 , B01J37/0236 , B01J2523/00 , C07C51/215 , C07C51/25 , C07C53/08 , B01J2523/19 , B01J2523/47 , B01J2523/55 , B01J2523/56 , B01J2523/68
摘要： An oxide catalyst composition comprising the elements molybdenum, vanadium, niobium and titanium and a process for making the catalyst composition. A process for the selective oxidation of ethane and/or ethylene and/or ethylene to acetic acid using the catalyst composition. The catalyst composition provides high selectivity to acetic acid with reduced selectivity to ethylene.
摘要翻译：包含元素钼，钒，铌和钛的氧化物催化剂组合物和制备催化剂组合物的方法。使用催化剂组合物选择性氧化乙烷和/或乙烯和/或乙烯至乙酸的方法。催化剂组合物对乙酸具有较高的选择性，同时乙烯的选择性降低。

7. 发明申请

US20050217498A1 Baking apparatuses and methods of use 失效
标题翻译：烘焙设备和使用方法
公开(公告)号：US20050217498A1
公开(公告)日：2005-10-06
申请号：US10817111
申请日：2004-04-02
申请人： Robert Miller , Bruce Rosen
发明人： Robert Miller , Bruce Rosen
IPC分类号： A47J37/01 , A47J43/18 , A47J43/20
CPC分类号： A47J43/20 , A47J37/01 , Y10S99/15
摘要： The present invention is directed to baking apparatuses that are adapted for use in baking cakes, custards and other dishes that involve the use of a water bath. In a disclosed embodiment of the invention a baking apparatus is disclosed that includes an inner and outer pan, which may be formed as an integral unit. The outer pan is preferably adapted to receive and hold water and the inner pan is adapted to receive a springform containing a cheesecake batter or other mixture. The side or sides of the inner pan are preferably watertight and prevent leakage of water into the inner pan. The present invention offers the advantage of water bath baking without the problem of water from the bath leaking into the springform that contains the cake batter.
摘要翻译：本发明涉及适用于烘烤涉及使用水浴的蛋糕，乳蛋糕和其他菜肴的烘焙设备。在本发明的公开实施例中，公开了一种烘烤装置，其包括可以形成为整体单元的内锅和外锅。外盘优选地适于接收和保持水，并且内盘适于容纳包含芝士蛋糕面糊或其它混合物的弹簧形。内盘的侧面或侧面优选是防水的并且防止水泄漏到内锅中。本发明提供了水浴烘烤的优点，而没有浴液中的水泄漏到含有蛋糕糊的弹性体的问题。

8. 发明申请

US20150273230A1 System and Method For Hyperthermia Treatment Using Radiofrequency Phased Arrays 审中-公开
标题翻译：使用射频相位阵列进行热疗治疗的系统和方法
公开(公告)号：US20150273230A1
公开(公告)日：2015-10-01
申请号：US14668393
申请日：2015-03-25
申请人： Bastien Guerin , Lawrence L. Wald , Bruce Rosen
发明人： Bastien Guerin , Lawrence L. Wald , Bruce Rosen
IPC分类号： A61N1/40 , G06F17/16 , G06F17/50 , G01R33/36 , A61B19/00
CPC分类号： A61N1/403 , G01R33/48 , G01R33/5612
摘要： Systems and methods for designing parallel transmission radiofrequency (RF) pulses for use in a RF treatment. The methods include selecting a target region in a subject, and providing a plurality of specific absorption rate (SAR) matrices for estimation of SAR at locations within the subject. The methods also include determining a first set of SAR matrices for locations in the target region using the provided SAR matrices, and determining a second set of SAR matrices for locations not in the target region using the provided SAR matrices. The methods further include designing a plurality of RF pulses for achieving a target power deposition in the target region by using the first set of SAR matrices and the second set of SAR matrices in an optimization that determines a set of RF waveforms that produce a target average local SAR using the first set of SAR matrices while minimizing a local SAR and a global SAR using the second set of SAR matrices.
摘要翻译：设计用于RF处理的并行传输射频（RF）脉冲的系统和方法。所述方法包括选择受试者中的目标区域，以及提供多个特定吸收率（SAR）矩阵，用于在受试者内的位置估计SAR。所述方法还包括使用所提供的SAR矩阵来确定目标区域中的位置的第一组SAR矩阵，以及使用所提供的SAR矩阵来确定不在目标区域中的位置的第二组SAR矩阵。所述方法还包括设计多个RF脉冲，以通过使用第一组SAR矩阵和在确定产生目标平均值的一组RF波形的优化中的第二组SAR矩阵来实现目标区域中的目标功率沉积使用第一组SAR矩阵，同时使用第二组SAR矩阵最小化局部SAR和全局SAR。

9. 发明申请

US20140035580A1 System for Optimized Low Power MR Imaging 有权
标题翻译：优化低功率MR成像系统
公开(公告)号：US20140035580A1
公开(公告)日：2014-02-06
申请号：US13958654
申请日：2013-08-05
申请人： Ovidiu Andronesi , Bruce Rosen , Peter Caravan , Himanshu Bhat
发明人： Ovidiu Andronesi , Bruce Rosen , Peter Caravan , Himanshu Bhat
IPC分类号： G01R33/36
CPC分类号： G01R33/36 , A61B5/055 , G01R33/5602 , G01R33/5616 , G01R33/5617
摘要： A system acquires MR imaging data of a portion of patient anatomy associated with proton spin lattice relaxation time in a rotating frame using an RF (Radio Frequency) signal generator configured to generate RF excitation pulses and a magnetic field gradient generator configured to generate anatomical volume select magnetic field gradients for phase encoding and readout RF data acquisition. The RF signal generator and the gradient generator are configured to provide a rotating frame preparation pulse sequence comprising at least one of, (a) a T1 spin lattice relaxation in a rotating frame (T1ρ) preparation pulse sequence of adiabatic pulses comprising modulated RF pulses and modulated magnetic field gradients for slice selection and (b) a T2 spin-spin relaxation in a rotating frame (T2ρ) preparation pulse sequence of adiabatic pulses comprising modulated RF pulses and modulated magnetic field gradients for slice selection
摘要翻译：系统使用被配置为产生RF激励脉冲的RF（射频）信号发生器和被配置为产生解剖体积选择的磁场梯度发生器来获取在旋转帧中与质子自旋晶格弛豫时间相关联的患者解剖结构的一部分的MR成像数据用于相位编码和读出RF数据采集的磁场梯度。 RF信号发生器和梯度发生器被配置为提供旋转帧准备脉冲序列，其包括以下中的至少一个：（a）包括调制的RF脉冲的绝热脉冲的旋转帧（T1rho）准备脉冲序列中的T1自旋晶格弛豫和用于切片选择的调制磁场梯度和（b）旋转框架（T2rho）的准备脉冲序列中的T2自旋 - 自旋松弛包括调制的RF脉冲和用于切片选择的调制的磁场梯度的绝热脉冲序列

10. 发明授权

US07478588B2 Baking apparatuses and methods of use 失效
标题翻译：烘焙设备和使用方法
公开(公告)号：US07478588B2
公开(公告)日：2009-01-20
申请号：US10817111
申请日：2004-04-02
申请人： Robert J. Miller , Bruce Rosen
发明人： Robert J. Miller , Bruce Rosen
IPC分类号： A47J43/18 , A47J43/20
CPC分类号： A47J43/20 , A47J37/01 , Y10S99/15
摘要： The present invention is directed to baking apparatuses that are adapted for use in baking cakes, custards and other dishes that involve the use of a water bath. In a disclosed embodiment of the invention a baking apparatus is disclosed that includes an inner and outer pan, which may be formed as an integral unit. The outer pan is preferably adapted to receive and hold water and the inner pan is adapted to receive a springform containing a cheesecake batter or other mixture. The side or sides of the inner pan are preferably watertight and prevent leakage of water into the inner pan. The present invention offers the advantage of water bath baking without the problem of water from the bath leaking into the springform that contains the cake batter.
摘要翻译：本发明涉及适用于烘烤涉及使用水浴的蛋糕，乳蛋糕和其他菜肴的烘焙设备。在本发明的公开实施例中，公开了一种烘烤装置，其包括可以形成为整体单元的内锅和外锅。外盘优选地适于接收和保持水，并且内盘适于容纳包含芝士蛋糕面糊或其它混合物的弹簧形。内盘的侧面或侧面优选是防水的并且防止水泄漏到内锅中。本发明提供了水浴烘烤的优点，而没有浴液中的水泄漏到含有蛋糕糊的弹性体的问题。

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