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1. 发明申请

US20180064709A1 PHARMACEUTICAL COMBINATIONS 审中-公开
公开(公告)号：US20180064709A1
公开(公告)日：2018-03-08
申请号：US15561209
申请日：2016-03-23
申请人： Nicole Buschmann , Robin Alec Fairhurst , Jorge Garcia Fortanet , Pascal Furet , Diana Graus Porta , Nafeeza Hafeez , Bo Han , Thomas Knoepfel , Matthew J. LaMarche , Catherine Leblanc
发明人： Nicole Buschmann , Robin Alec Fairhurst , Jorge Garcia Fortanet , Pascal Furet , Diana Graus Porta , Nafeeza Hafeez , Bo Han , Thomas Knoepfel , Matthew J. LaMarche , Catherine Leblanc
IPC分类号： A61K31/496 , A61K31/497
CPC分类号： A61K31/496 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K2300/00
摘要： A pharmaceutical combination comprising N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide, or a pharmaceutically acceptable salt thereof, and at least one active ingredient, as defined herein, or a pharmaceutically acceptable salt thereof, and optionally a pharmaceutically acceptable carrier, for simultaneous or sequential administration; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

2. 发明授权

US09802917B2 Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide 有权
公开(公告)号：US09802917B2
公开(公告)日：2017-10-31
申请号：US15073766
申请日：2016-03-18
申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Bo Han , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Franck Mallet , Julie Martz , Can Wang , Jing Xiong , Xianglin Zhao
发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Bo Han , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Franck Mallet , Julie Martz , Can Wang , Jing Xiong , Xianglin Zhao
IPC分类号： A61K31/496 , C07D471/04 , C07D401/14 , C07C51/41 , C07C59/265
CPC分类号： C07D401/14 , C07B2200/13 , C07C51/412 , C07C59/265 , C07D471/04
摘要： The present invention relates to particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide, to a process of making said particles, to pharmaceutical compositions comprising said particles and to method of treating cancers using said pharmaceutical compositions.

3. 发明申请

US20170182080A1 FUNCTIONAL SCAFFOLD FOR TISSUE REPAIR AND REGENERATION 审中-公开
公开(公告)号：US20170182080A1
公开(公告)日：2017-06-29
申请号：US15126133
申请日：2015-03-16
申请人： Bo HAN
发明人： Bo HAN
IPC分类号： A61K31/7068 , A61L27/14 , A61L27/10 , A61L27/54 , A61L27/04
CPC分类号： A61K31/7068 , A61K31/7052 , A61K31/715 , A61L27/04 , A61L27/10 , A61L27/14 , A61L27/54 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/426
摘要： A biocompatible scaffold is provided that includes a biocompatible scaffold substrate and an amount of a demethylation agent or a methylation inhibitor, in an amount effective to induce and/or promote tissue repair and regeneration. The demethylation agent or methylation inhibitor can be a cytidine analog. The scaffold can further include an effective amount of one or more of a target specific growth factor, a cytokine, a signaling molecule or a pharmaceutically acceptable carrier. The scaffold can be constructed of a natural or non-natural material; one alternative is a gel formed by the catalytic activity of transglutaminase.

4. 发明授权

US09260593B2 Conjugated diene rubber modified with polar alkoxysilane, method and composition thereof 有权
标题翻译：用极性烷氧基硅烷改性的共轭二烯橡胶，其方法和组成
公开(公告)号：US09260593B2
公开(公告)日：2016-02-16
申请号：US13607450
申请日：2012-09-07
申请人： Chi-Chen Hsieh , Fu Lin , Chi-Ta Tsai , Hui-Kai Lin , Bo-Han Lin
发明人： Chi-Chen Hsieh , Fu Lin , Chi-Ta Tsai , Hui-Kai Lin , Bo-Han Lin
IPC分类号： C08C19/22 , C08L19/00 , C08F4/56 , C08F36/06 , C08F36/08 , C08F8/30 , C08C19/25 , C08C19/44 , C08F36/04
CPC分类号： C08L19/006 , C08C19/22 , C08C19/25 , C08C19/44 , C08F4/56 , C08F8/30 , C08F36/04 , C08F36/06 , C08F36/08
摘要： A modified conjugated diene rubber is disclosed. A method for producing the modified conjugated diene rubber includes providing an alkali metal ion-containing conjugated diene rubber; and reacting the alkali metal ion-containing conjugated diene rubber with an alkoxysilane to generate the modified conjugated diene rubber, the alkoxysilane being of the structural formula: wherein R1, R2, R3 are each independently selected from a group consisting of oxygen-containing C2-C12 group and nitrogen-containing C3-C12 group, the oxygen-containing C2-C12 group has a carbon atom directly connected to oxygen atom of the alkoxysilane, the nitrogen-containing C1-C12 group has a nitrogen atom directly connected to oxygen atom of the alkoxysilane, and R4 is selected from a group consisting of C3-C12 of alkyl, alkenyl, aryl, and alkoxy.
摘要翻译：公开了改性共轭二烯橡胶。改性共轭二烯橡胶的制造方法包括提供含碱金属离子的共轭二烯橡胶; 并使含有碱金属离子的共轭二烯橡胶与烷氧基硅烷反应以生成改性共轭二烯橡胶，该烷氧基硅烷具有以下结构式：其中R1，R2，R3各自独立地选自含氧C2- C12基和含氮C3-C12基，含氧C2-C12基具有与烷氧基硅烷的氧原子直接连接的碳原子，含氮C1-C12基具有与氧原子直接连接的氮原子烷氧基硅烷和R 4选自烷基，烯基，芳基和烷氧基的C 3 -C 12。

5. 发明授权

US09248165B2 Composite containing collagen and elastin as a dermal expander and tissue filler 有权
标题翻译：复合物含有胶原蛋白和弹性蛋白作为皮肤膨胀机和组织填料
公开(公告)号：US09248165B2
公开(公告)日：2016-02-02
申请号：US13127275
申请日：2009-11-03
申请人： Bo Han , Marcel E. Nimni
发明人： Bo Han , Marcel E. Nimni
IPC分类号： A61K38/39 , A61K8/64 , A61Q19/00
CPC分类号： A61L27/227 , A61K8/64 , A61K38/39 , A61K2800/91 , A61L2400/06 , A61Q19/00
摘要： An injectable composition having dermal filling and tissue expanding activity comprises (1) a quantity of elastin sufficient to bring about dermal filling and tissue expansion when injected into a subject in need of dermal filling and tissue expansion, and (2) a pharmaceutically acceptable carrier. The composition can further comprise collagen, in other alternatives, the composition can further comprise hyaluronic acid, and one or more of the elastin, the collagen, and the hyaluronic acid, if present can be cross-linked, either intramolecularly or intermolecularly. The elastin, however, is the primary filler, even if collagen or hyaluronic acid are included in the composition.
摘要翻译：具有皮肤填充和组织扩张活性的可注射组合物包括（1）当注射到需要皮肤填充和组织扩张的受试者中时，足以引起皮肤填充和组织扩张的弹性蛋白量，和（2）药学上可接受的载体。组合物可以进一步包含胶原，在其它替代方案中，组合物还可以包含透明质酸，并且弹性蛋白，胶原和透明质酸中的一种或多种（如果存在的话）可以在分子内或分子内交联。然而，弹性蛋白是主要的填充剂，即使胶原蛋白或透明质酸被包括在组合物中。

6. 发明授权

US09014095B2 Method and apparatus for saving energy in mobile communication system base station 有权
标题翻译：移动通信系统基站节能方法及装置
公开(公告)号：US09014095B2
公开(公告)日：2015-04-21
申请号：US13700985
申请日：2011-07-19
申请人： Shiqiang Suo , Bo Han , Zhuo Gao
发明人： Shiqiang Suo , Bo Han , Zhuo Gao
IPC分类号： H04W52/02 , H04W88/08 , H04W72/00
CPC分类号： H04W52/0206 , H04W72/005 , H04W88/085 , Y02D70/1262 , Y02D70/25
摘要： A method for achieving energy-saving in a mobile communication system base station, for application in an LTE system, comprising: determining the average value of a downlink sub-frame traffic load; determining, when the average value of the downlink sub-frame traffic load is below a threshold value therefore, an MBSFN downlink sub-frame which is not carrying multicast traffic; and closing the radio frequency channel corresponding to the multicast symbol in the MBSFN downlink sub-frame which is not carrying multicast traffic. By using the method, the number of downlink sub-frames required to meet the communication traffic needs of a current cell is judged according to changes in the traffic load observed by measuring the traffic load values in that cell; sub-frames which can be closed are set as MBSFN downlink sub-frames which do not send multicast traffic; radio frequency channels occupied by the multicast symbol are closed, thereby reducing energy consumption.
摘要翻译：一种用于在LTE系统中应用的用于实现移动通信系统基站中的节能的方法，包括：确定下行链路子帧业务负载的平均值; 确定当下行链路子帧业务负载的平均值低于阈值时，确定不携带组播业务的MBSFN下行链路子帧; 并且在不携带组播业务的MBSFN下行链路子帧中关闭对应于多播符号的射频信道。通过使用该方法，根据通过测量该小区中的业务负载值观测到的业务负载的变化来判断满足当前小区的通信业务需求所需的下行链路子帧的数量; 可以关闭的子帧被设置为不发送多播业务的MBSFN下行链路子帧; 组播符号占用的射频信道关闭，从而降低能耗。

7. 发明授权

US08831347B2 Data segmenting apparatus and method 有权
标题翻译：数据分段装置及方法
公开(公告)号：US08831347B2
公开(公告)日：2014-09-09
申请号：US13342464
申请日：2012-01-03
申请人： Bo Han
发明人： Bo Han
IPC分类号： G06K9/34 , G06K9/00 , G06K9/68 , H04N5/14 , H04N9/64
CPC分类号： G06K9/34 , G06K9/00765 , G06K9/6878
摘要： Data segmenting apparatus and method are provided. An apparatus for segmenting an input data sequence includes: a boundary searching device configured to search for one or more candidate boundaries in the data sequence, to obtain one or more candidate segmenting schemes formed by different combinations of these candidate boundaries; and an evaluating device configured to generate, for each candidate segmenting scheme, an evaluation value of each candidate boundary in the scheme by evaluating a segmenting loss caused by using the candidate boundary to segment the data sequence, and determine whether the candidate boundary is valid in the candidate segmenting scheme according to the evaluation value reflecting association relationship between a pair of adjacent data segments adjoining to the candidate boundary and association relationship between each of one or more pairs of non-adjacent data segments, each of which includes two non-adjacent data segments located at two sides of the candidate boundary.
摘要翻译：提供数据分割装置和方法。一种用于分割输入数据序列的装置包括：边界搜索装置，被配置为搜索数据序列中的一个或多个候选边界，以获得由这些候选边界的不同组合形成的一个或多个候选分割方案; 以及评估装置，被配置为针对每个候选分割方案，通过评估由所述候选边界引起的分段损失来分割所述数据序列，并且确定所述候选边界是否有效，从而生成所述方案中的每个候选边界的评估值所述候选分割方案根据所述评估值反映出与所述候选边界相邻的一对相邻数据段之间的关联关系以及一对或多对非相邻数据段中的每一对之间的关联关系，每个所述非相邻数据段包括两个不相邻数据位于候选边界两侧的段。

8. 发明授权

US08709844B2 Light emitting diode package and method of fabricating the same 有权
标题翻译：发光二极管封装及其制造方法
公开(公告)号：US08709844B2
公开(公告)日：2014-04-29
申请号：US12972529
申请日：2010-12-20
申请人： Sin-Ho Kang , Tae-Hun Kim , Seung-Ho Jang , Kyoung-Bo Han , Jae-yong Choi
发明人： Sin-Ho Kang , Tae-Hun Kim , Seung-Ho Jang , Kyoung-Bo Han , Jae-yong Choi
IPC分类号： H01L21/00 , H01L27/15
CPC分类号： H01L33/486 , H01L33/504 , H01L33/58 , H01L33/62 , H01L2224/48091 , H01L2924/01322 , H01L2933/0066 , H01L2924/00014 , H01L2924/00
摘要： A light emitting diode (LED) package and a method of manufacturing a LED package is provided. The LED package includes a case having first and second lead frames disposed through the case; an LED chip disposed on the case, the LED chip having first and second electrodes directly connected to the first and second lead frames through a eutectic bond, respectively; and a lens disposed over the case covering the LED chip.
摘要翻译：提供一种发光二极管（LED）封装以及制造LED封装的方法。 LED封装包括具有穿过壳体设置的第一和第二引线框架的壳体; 设置在所述壳体上的LED芯片，所述LED芯片具有分别通过共晶键直接连接到所述第一引线框架和所述第二引线框架的第一和第二电极; 以及设置在覆盖LED芯片的壳体上的透镜。

9. 发明授权

US08483077B2 QoS in multi-hop wireless networks 有权
标题翻译：多跳无线网络中的QoS
公开(公告)号：US08483077B2
公开(公告)日：2013-07-09
申请号：US12561130
申请日：2009-09-16
申请人： Lusheng Ji , Bo Han , Robert R. Miller, II
发明人： Lusheng Ji , Bo Han , Robert R. Miller, II
IPC分类号： H04W40/12
CPC分类号： H04W40/12 , H04L45/00 , H04L45/38 , H04L47/10 , H04L47/125 , H04L47/14 , H04L47/2408 , H04L47/286 , H04W40/02
摘要： A path configuration message is sent to nodes in a multi-hop network along a path between a source node and destination nodes. The path configuration message includes path information and one or more special channel access parameters associated with the path information. The path configuration message temporarily changes the channel access priority for packets matching the path information in the special message. The nodes along the path therefore have higher channel access priority relative to other nearby nodes and other traffic flows. At the end of the a length of a time determined by a time to live parameter in the special message, the nodes resume using default channel access parameters in place of the special channel access parameters for packets matching the path information.
摘要翻译：路径配置消息沿着源节点和目的节点之间的路径发送到多跳网络中的节点。路径配置消息包括与路径信息相关联的路径信息和一个或多个特殊信道访问参数。路径配置消息临时更改与特殊消息中的路径信息匹配的数据包的通道访问优先级。因此，沿着路径的节点相对于其他附近的节点和其他业务流具有较高的信道接入优先级。在由特殊消息中的生存时间参数确定的时间长度结束时，节点恢复使用默认信道接入参数，代替与路径信息匹配的分组的特殊信道接入参数。

10. 发明授权

US07999280B2 Light emitting diode package employing lead terminal with reflecting surface 有权
标题翻译：发光二极管封装采用带反射面的引线端子
公开(公告)号：US07999280B2
公开(公告)日：2011-08-16
申请号：US11780051
申请日：2007-07-19
申请人： Hwa Ja Kim , Nam Young Kim , Myung Hee Lee , Kyoung Bo Han , Tae Kwang Kim , Ji Seop So
发明人： Hwa Ja Kim , Nam Young Kim , Myung Hee Lee , Kyoung Bo Han , Tae Kwang Kim , Ji Seop So
IPC分类号： H01L33/00
CPC分类号： H01L33/60 , H01L33/483 , H01L33/62 , H01L2224/48091 , H01L2224/48247 , H01L2924/01012 , H01L2924/01079 , H01L2924/00014
摘要： Disclosed is a light emitting diode (LED) package employing a lead terminal with a reflecting surface. The package includes first and second lead terminals that are spaced apart from each other. The first lead terminal has a lower portion with an LED chip mounting area, and at least one reflecting surface formed by being bent from the lower portion. Meanwhile, a package body supports the first and second lead terminals and forms a cavity through which the LED chip mounting area and the reflecting surface of the first lead terminal and a part of the second lead terminal are exposed. The first and second lead terminals extend outside of the package body. Accordingly, light emitted from an LED chip can be reflected on the reflecting surface with high reflectivity, so that the optical efficiency of the package can be improved.
摘要翻译：公开了一种采用具有反射表面的引线端子的发光二极管（LED）封装。该封装包括彼此间隔开的第一和第二引线端子。第一引线端子具有LED芯片安装区域的下部，以及从下部弯曲形成的至少一个反射面。同时，封装体支撑第一和第二引线端子并形成空腔，LED芯片安装区域和第一引线端子的反射表面和第二引线端子的一部分暴露在该空腔中。第一和第二引线端子延伸到封装体的外部。因此，从LED芯片发出的光可以以高反射率反射在反射面上，从而能够提高封装的光学效率。

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